62% Ethyl alcohol, doesn't dry out. Cheap. Just a thought.

Really???
What kind of carrier we talking about, oral or TD?
M.Ed. Ex Phys
I'm going to try it with caffeine tonight (MW: 194)
Paging Dr. Banner. . .
The general guideline is <300, but obviously other parameters (lipophilicity, polar charge, pKa) have an effect as well. Choice of carrier will make a difference (DMSO always helps, cyclodextrins help some molecules like DHEA quite a lot)
Paging Dr. Banner. . .
Huh?
You may get it to compund into soultions but without adequate and proper PE's you are probably going to waste your active.
"He will turn the hearts of the fathers to their children, and the hearts of the children to their fathers"
Caffeine, at least, didn't get into solution.
Paging Dr. Banner. . .
Give a man a fish, feed him for a day. Teach a man to fish, feed him for life. Lao Tse 6th century BC