Originally Posted by luclyluciano View Post
Disclaimer: I am not a biologist or chemist but I don't see how it would be possible for Formestane to lower estrogen and NOT indirectly boost Testosterone.
If you depress the entire HPTA by taking an anabolic agent, then both estrogen and testosterone are reduced. For example, if you take 30 mg/day of Superdrol, you will very quickly have minimal endogenous testosterone AND estrogen.

The question with formestane is how much it binds with the androgen receptor on its own -- and it does so, but somewhat weakly. This is probably why you see equivocal results as far as T levels.

To put it another way, if you have a body in normal homeostasis and introduce an aromatase inhibitor like Arimidex, studies show that this will lower estrogen, and then concomitantly raise testosterone as the body tries to maintain homeostasis. The difference is that Arimidex is not interacting with the androgen receptor and is not shutting down the entire HPTA.