Transdermal PDE5 Inhibitors

  1. Question Transdermal PDE5 Inhibitors


    Hi


    Is Possible make a like:

    Tadalafil Citrate(Cialis)
    Sildenafil itrate (Viagra)
    Vardenafil (Levitra)


    maybe is not a good idea but i like to know.


  2. Any reason for doing that?
    M.Ed. Ex Phys


  3. Quote Originally Posted by Rodja View Post
    Any reason for doing that?
    no Rod only a question around my mind what do you think?
    •   
       


  4. The MW is kinda high and they work orally. Seems pointless.
    M.Ed. Ex Phys


  5. hmmmmmmm

  6. No, all of them have a high molecular weight, higher than warranted for trans-dermal. Cialis is close, but still to high.

    Just go the the penis shot.... let us know how that works out for you.
    The Historic PES Legend

  7. what is the MW?

    a TD formula of this enter in your bloodstream much faster than digesting a pill right?

  8. Quote Originally Posted by MAxximal View Post
    what is the MW?

    a TD formula of this enter in your bloodstream much faster than digesting a pill right?
    In theory, but it's pointless. The lowest MW is ~390 for Cialis.

    I think you're missing the point of a transdermal. They're used when the oral availability is low. These drugs are definitely potent.
    M.Ed. Ex Phys


  9. Rodja is right. You will only gain at the top end 25% product absorbtion, whilst oral is much higher than that for these products. It is much slower to enter the blood stream actually, with a slower release of upward of 12 hours. You want bang for these products, so oral is the way to go. Plus, slathering yourself up with PDE5 inhibitors then going for a naked roll in the sheets with your lady friend may not be a good idea due to transfer.
    The Historic PES Legend

  10. yeap i understand guys!
  

  
 

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