Pregnenolone Transdermal?

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  1. Pregnenolone Transdermal?


    How might one go about making a Pregnenolone Transdermal ?

    I have gotten mixed responses on this issue. Some have told me DMSO wouldn't work, and Pregnenolone is a stubborn compound which is difficultly to disperse into a carrier. Because PREG isn't a controlled substance, it is very easy to obtain for cheap.

    Could someone please give me a recipe for making PREG TD homebrew? Would dermabolics and or primordial performance TD work as a carrier ?

    Respekt.

  2. Never enough
    EasyEJL's Avatar

    i dont have an answer, but i'm interested to hear what others say. IIRC, there is a prescription pregnenelone td that is used by some doctors for hormone replacement
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  3. being a hydrophobic carboxylate, you would think it might be soluble in other hydrophobic carboxylates, like an MCT oil based carrier.

    You do know you can buy a jar of preg cream for like $10.

    What is your reasoning/need for a transdermal preg?
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  4. Go over to the allthingsmale website which hosts a board moderated by Dr. John Crisler (top notch HRT doc) called muscle chatroom. Dr. John is an advocate of TD PREG because he has seen in his patients a night and day difference with supplementing TD PREG vs. Oral PREG. Dr. John believes that oral PREG raises PROG while TD PREG doesn't. Some of this is speculation because there isn't a reliable test for PREG in serum blood testing. He also believes that TD PREG provides a anti-anxiety effect while PREG oral also accomplishes this but in a different fashion, causing sedation.

    I am a noob as far as homebrew is concerned, but because that PREG is a legal OTC substance, I have no problem speaking frank with you on this matter.

    What in the world is an MCT based carrier? lol. Could you fill me in on this ?

    Also, yes I am aware that there are various TD PREG skin creams sold over the counter. I have used both youngagain and life-flo TD PREG cream and have liked them both. Dr. John advocates for 50mg/day of TD PREG in his hrt patients. The life-flo and youngagain formulations only contain about 600mg in 2 ounces, which means that one bottle of either substance would only last me about 12 days. I want to maximize my bang for my buck, which is why I want to homebrew my own PREG cream.

    BTW, what PREG cream are you referring too? Have you used it before?

    Respekt.



    Quote Originally Posted by thesinner View Post
    being a hydrophobic carboxylate, you would think it might be soluble in other hydrophobic carboxylates, like an MCT oil based carrier.

    You do know you can buy a jar of preg cream for like $10.

    What is your reasoning/need for a transdermal preg?

  5. MCT = Medium Chain Triglyceride. I'm pretty sure Dermabolics and NP's Penetrate contain this. They'll call it something like "triglyceride complex".

    The thing with Transdermals, and part of the reason I might have come off snooty in the previous post is that transdermals come with a lot more variables, and might not necessarily be better. Oral A will work just like oral B. Transdermal A and Transdermal B are two different things. Look at the research stats on Androgel and Testim.

    As per the preg I had referred to, I just did a price search on young again preg cream. I am not a preg cream user, but sometimes use preg for its nootropic capabilities.


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  6. Never enough
    EasyEJL's Avatar

    Quote Originally Posted by thesinner View Post
    MCT = Medium Chain Triglyceride. I'm pretty sure Dermabolics and NP's Penetrate contain this. They'll call it something like "triglyceride complex".
    coconut/palm oils
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  7. So are you saying that I can use a simple coconut/PREG powder mix in order to get my PREG into the bloodstream? This just seems so overly simplified. What about BigCats Transdermal carrier forumla:

    How to make your own TPDS :

    Take the product you wish to deliver, then add benzyl alcohol until it is entirely dissolved, even a few drops more (adequate benzyl for product). Then add a mixture of 4 parts acetone and 5 parts isopropanol, until you get the volume that gives you the desired concentration of drug per ml, and then apply as many ml as necessary to the site of application, twice daily.

  8. Quote Originally Posted by EasyEJL View Post
    coconut/palm oils
    that would be a little crude to use, but those are some sources
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  9. Could you look at BigCat's transdermal recipe that I posted above? What did you think about it ?

    Quote Originally Posted by thesinner View Post
    that would be a little crude to use, but those are some sources

  10. Quote Originally Posted by EasyEJL View Post
    coconut/palm oils
    And while we're on this topic, the OP might find interesting
    heart disease), while restoring the thyroid hormone brings cholesterol down to normal.

    In this situation, however, thyroid isn't suppressing the synthesis of cholesterol, but rather is promoting its use to form hormones and bile salts. When the thyroid is functioning properly, the amount of cholesterol in the blood entering the ovary governs the amount of progesterone being produced by the ovary, and the same situation exists in all steroid-forming tissues, such as the adrenal glands and the brain.

    Progesterone and its precursor, pregnenolone, have a generalized protective function: antioxidant, anti-seizure, antitoxin, anti-spasm, anti-clot, anticancer, pro-memory, pro-myelination, pro-attention, etc. Any interference with the formation of cholesterol will interfere with all of these exceedingly important protective functions.

    As far as the evidence goes, it suggests that coconut oil, added regularly to a balanced diet, lowers cholesterol to normal by promoting its conversion into pregnenolone.
    http://www.shirleys-wellness-cafe.com/coconut.htm

    You can pick up 20oz. for $10 shipped 'til Monday . I just finished a 5page article on CO, but the benefits are huge. I try and take 2tbsp daily to build up the lauric and monolaurin levels in my body.

  11. Fun times = rub a very small amount of TD Preg onto your temples.


    trust me.

    /yes, serious
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  12. All you chem whizzes (definatley not me) do you think that life-flo's Pregnenolone Transdermal formulation is conducive to maximum absorption? Here is the ingredients list...

    Purified Water, Aloe Vera Gel, Caprylic/Capric Triglycerides, Sunflower Seed Oil, Shea Butter, Stearic Acid, Natural Pregnenolone, Glycerine, Glyceryl Stearate, MSM (Methylsulfonylmethane), Evening Primrose Oil (Oeonothera Biennis), Lecithin, Tocotrienol (Natural Super Vitamin E), Hyaluronic Acid (Sodium Hyaluronate), Sodium Bicarbonate, Allantoin, Carbomer, Potassium Sorbate, Grape Seed Extract.

  13. I would add some isopropyl alcohol.
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  14. dsade, I think the reason for the quick, acute buzz which a person psychologically experiences after applying PREG TD in the manner in which you prescribe is due to the thin epidermis in the area of the temple region, thus maximizing quick rapid absorption. Other great areas IMO is the area behind the ears, the front of the neck, and the scrotum (I know this is generally unorthodox).

    Dsade, what brand do you use ?


    Quote Originally Posted by dsade View Post
    Fun times = rub a very small amount of TD Preg onto your temples.


    trust me.

    /yes, serious

  15. isopropyl alcohol to the life-flo PREG ? also, I have some DMSO gel, could I rub that over the surface where the cream is to be applied, and than apply the life-flo PREG TD cream for increased absorption bio availability ?

    Quote Originally Posted by dsade View Post
    I would add some isopropyl alcohol.

  16. Quote Originally Posted by living2die View Post
    dsade, I think the reason for the quick, acute buzz which a person psychologically experiences after applying PREG TD in the manner in which you prescribe is due to the thin epidermis in the area of the temple region, thus maximizing quick rapid absorption. Other great areas IMO is the area behind the ears, the front of the neck, and the scrotum (I know this is generally unorthodox).

    Dsade, what brand do you use ?
    I believe it's due to that, but also the proximity to the brain, which results in a rapid effect there - slight euphoria (enough to make your eyes roll) and an instant calming effect. HUGE sense of well-being.

    I used the Eviscerate carrier (it also has 7-OXO DHEA) as it is localized, but now I would probably modify the carrier with Emu Oil as that particular carrier can tend to irritate delicate skin.
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  17. Quote Originally Posted by living2die View Post
    isopropyl alcohol to the life-flo PREG ? also, I have some DMSO gel, could I rub that over the surface where the cream is to be applied, and than apply the life-flo PREG TD cream for increased absorption bio availability ?
    DMSO pretty much bulldozes anything through.
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  18. Never enough
    EasyEJL's Avatar

    Quote Originally Posted by Steveoph View Post
    And while we're on this topic, the OP might find interesting


    http://www.shirleys-wellness-cafe.com/coconut.htm

    You can pick up 20oz. for $10 shipped 'til Monday . I just finished a 5page article on CO, but the benefits are huge. I try and take 2tbsp daily to build up the lauric and monolaurin levels in my body.
    I buy 1gal pails of it nowadays
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  19. Quote Originally Posted by dsade View Post
    Fun times = rub a very small amount of TD Preg onto your temples.


    trust me.

    /yes, serious
    I wonder if this would help w/ hair regrowth?

  20. Probably would have a negative effect. Go over and look at Ray Sahelian's site, a lot of the general audience note hair loss in general as a potential side effect if you have the genes.

    Quote Originally Posted by dsade View Post
    I would add some isopropyl alcohol.
    Quote Originally Posted by Urban Monk View Post
    I wonder if this would help w/ hair regrowth?
  21. Never enough
    EasyEJL's Avatar

    yeah, its the hormone chain

    pregnenelone->dhea->testosterone->DHT
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  22. Quote Originally Posted by living2die View Post
    Could you look at BigCat's transdermal recipe that I posted above? What did you think about it ?

    I am not a fan of the acetone in there.

    You can usually fine a decent grade of liquid MCT oil for pretty cheap at some supplement stores.
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  23. Quote Originally Posted by dsade View Post
    Fun times = rub a very small amount of TD Preg onto your temples.


    trust me.

    /yes, serious
    Does this lead to high neurosteroid action?

    That could be fun.
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  24. Quote Originally Posted by EasyEJL View Post
    yeah, its the hormone chain

    pregnenelone->dhea->testosterone->DHT
    Oh, but that's only half of it

    It also goes to

    preg -> progesterone -> cortisone -> cortisol -> aldosterone

    Progesterone can go to estrone as well
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  25. Quote Originally Posted by dsade View Post
    I would add some isopropyl alcohol.
    When in doubt, add IPA.
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  26. Never enough
    EasyEJL's Avatar

    what interests me about this is that unlike most transdermals, there isn't much of a transfer risk in terms of negative sides
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  27. Quote Originally Posted by EasyEJL View Post
    I buy 1gal pails of it nowadays
    I may be at that levels of addiction soon. My 12oz. is over half empty in 2 days, somehow I'm ODing lol I just started the NOW brand, and it sort of tingles the tongue, thats probably whats got me hooked. THe last DME CO I used tasted too "plastic-y".

    Quote Originally Posted by thesinner View Post
    I am not a fan of the acetone in there.

    You can usually fine a decent grade of liquid MCT oil for pretty cheap at some supplement stores.
    How would you rank our http://www.nutraplanet.com/product/u...old-32-oz.html . $16 shipped for 32oz. is pretty convenient

  28. Yeah, I was gonna say, i thought nutra sold MCT oil.
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  29. I have vet grade DMSO (98.9 % pure DMSO). Could I just add some crushed up PREG tablets or raw PREG powder and apply to my skin for a cheap homemade TD ?

    Thanks


    Quote Originally Posted by dsade View Post
    DMSO pretty much bulldozes anything through.

  30. I am in contact with a MD who operates out of AL. He told me through email that DMSO wouldn't work as a carrier for PREG. I think the issue here is getting the PREG to dissolve in the DMSO gel carrier. Could I just heat the DMSO gel up, and than add the raw PREG powder ?

    Also, Fina users report using a more primitive method of grinding the Fina pellets into a powder, applying to desirable skin region, and applying the DMSO gel after over the ground of Fina pellets.

    This morning, I applied the DMSO gel, ground up OTC Source Naturals 50mg PREG tablets (they are soo cheap, couldn't resist) and then placed the ground up powder over the DMSO app site. The DMSO stung a bit, but about 30 minutes later, all of the powder seemed to have been absorbed into the skin.

    Anyone tried this? Please help I am getting so much conflicting information !


    Quote Originally Posted by living2die View Post
    *bump

  31. Quote Originally Posted by living2die View Post
    I have vet grade DMSO (98.9 % pure DMSO). Could I just add some crushed up PREG tablets or raw PREG powder and apply to my skin for a cheap homemade TD ?

    Thanks
    The fillers wont dissolve and it will be grainy.

    Grab some PReg from beyond-a-century - cheap and high quality.


  32. For 20 grams, that is a really good price at about $11 that is a really good price.

    The politics of finding a raw PREG powder aren't my concern, just the effective delivery method seems to be problematic. Mixed reports and the like about using DMSO as a carrier continue to vex me. Have you used the aforementioned PREG /DMSO carrier in the past ?

    Thanks!

    Quote Originally Posted by dsade View Post
    The fillers wont dissolve and it will be grainy.

    Grab some PReg from beyond-a-century - cheap and high quality.

  33. Never enough
    EasyEJL's Avatar

    I would think penetrate would work with it, molecular weight is 316.483 g/mol and its hydrophobic.

    http://www.gaylordchemical.com/bulle...lletin102B.pdf

    shows 2.4g pregnenelone is soluble in 100ml DMSO
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  34. Wow EasyEJL. I am forever in gratitude to you for finding this priceless gem of wisdom for me. When you can back up your statements with scientific evidence , you understand and practice the scientific method better than most.

    I am assuming that the DSMO stat sheet could extend to DMSO gel as well? Note the DMSO gel I have is vet grade at over 98% pure.

    Well once again, thanks a lot EasyEJL. If I knew how to give out rep points I would give you about 1000000. lol


    Quote Originally Posted by EasyEJL View Post
    I would think penetrate would work with it, molecular weight is 316.483 g/mol and its hydrophobic.

    http://www.gaylordchemical.com/bulle...lletin102B.pdf

    shows 2.4g pregnenelone is soluble in 100ml DMSO
  35. Never enough
    EasyEJL's Avatar

    i'd say you could expect that same level into the gel, might have to warm it to get it all into solution as i'd imagine that mixing the gel is a pain.

    so lets say 2g per 100ml worth, 4oz bottle is a little over 100ml. used at 2ml a day thats 50 days worth of 40mg/day. Not sure how much you were planning on dosing a day, I've never really looked too deep into transdermal preg before
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  36. Quote Originally Posted by living2die View Post
    For 20 grams, that is a really good price at about $11 that is a really good price.

    The politics of finding a raw PREG powder aren't my concern, just the effective delivery method seems to be problematic. Mixed reports and the like about using DMSO as a carrier continue to vex me. Have you used the aforementioned PREG /DMSO carrier in the past ?

    Thanks!
    I prefer a localized carrier. Benzyl Alcohol + DMSO would work, but would be very irritating.

    If you do this, follow up with an emmolient.
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  37. Never enough
    EasyEJL's Avatar

    Why localized? and what sort of dosage would you think is good matt?
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  38. Quote Originally Posted by EasyEJL View Post
    Why localized? and what sort of dosage would you think is good matt?
    Localized would give the best chance to be absorbed neurally.

    IIRC, I dissolved about 2 grams into 4 ounces...it doesn't take much at all.
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  39. What exactly is a localized carrier? Are you referring to the life-flo PREG product, which uses a bunch of oils and MSM as a TD carrier?

    Last night I swabbed the TD site with isopropyl alcohol, applied the DMSO gel, spread the ground up PREG powder tablets and waited...it was hot and irritating for about 15 minutes. I did notice the PREG requiem for a dream experience that many like dsade report. After it had been absorbed, it looked like I had a 3rd degree burn at the application site...localized redness lol. I could also taste garlic. But IMO, the garlic smelly stench that it suppose to go along with it is a farse...I didn't experience any of that.

    Quote Originally Posted by dsade View Post
    Localized would give the best chance to be absorbed neurally.

    IIRC, I dissolved about 2 grams into 4 ounces...it doesn't take much at all.
  

  
 

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