Pregnenolone Transdermal?

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  1. what interests me about this is that unlike most transdermals, there isn't much of a transfer risk in terms of negative sides


  2. Quote Originally Posted by EasyEJL View Post
    I buy 1gal pails of it nowadays
    I may be at that levels of addiction soon. My 12oz. is over half empty in 2 days, somehow I'm ODing lol I just started the NOW brand, and it sort of tingles the tongue, thats probably whats got me hooked. THe last DME CO I used tasted too "plastic-y".

    Quote Originally Posted by thesinner View Post
    I am not a fan of the acetone in there.

    You can usually fine a decent grade of liquid MCT oil for pretty cheap at some supplement stores.
    How would you rank our http://www.nutraplanet.com/product/u...old-32-oz.html . $16 shipped for 32oz. is pretty convenient
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  3. I have vet grade DMSO (98.9 % pure DMSO). Could I just add some crushed up PREG tablets or raw PREG powder and apply to my skin for a cheap homemade TD ?

    Thanks


    Quote Originally Posted by dsade View Post
    DMSO pretty much bulldozes anything through.
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  4. I am in contact with a MD who operates out of AL. He told me through email that DMSO wouldn't work as a carrier for PREG. I think the issue here is getting the PREG to dissolve in the DMSO gel carrier. Could I just heat the DMSO gel up, and than add the raw PREG powder ?

    Also, Fina users report using a more primitive method of grinding the Fina pellets into a powder, applying to desirable skin region, and applying the DMSO gel after over the ground of Fina pellets.

    This morning, I applied the DMSO gel, ground up OTC Source Naturals 50mg PREG tablets (they are soo cheap, couldn't resist) and then placed the ground up powder over the DMSO app site. The DMSO stung a bit, but about 30 minutes later, all of the powder seemed to have been absorbed into the skin.

    Anyone tried this? Please help I am getting so much conflicting information !


    Quote Originally Posted by living2die View Post
    *bump

  5. Quote Originally Posted by living2die View Post
    I have vet grade DMSO (98.9 % pure DMSO). Could I just add some crushed up PREG tablets or raw PREG powder and apply to my skin for a cheap homemade TD ?

    Thanks
    The fillers wont dissolve and it will be grainy.

    Grab some PReg from beyond-a-century - cheap and high quality.


  6. For 20 grams, that is a really good price at about $11 that is a really good price.

    The politics of finding a raw PREG powder aren't my concern, just the effective delivery method seems to be problematic. Mixed reports and the like about using DMSO as a carrier continue to vex me. Have you used the aforementioned PREG /DMSO carrier in the past ?

    Thanks!

    Quote Originally Posted by dsade View Post
    The fillers wont dissolve and it will be grainy.

    Grab some PReg from beyond-a-century - cheap and high quality.


  7. I would think penetrate would work with it, molecular weight is 316.483 g/mol and its hydrophobic.

    http://www.gaylordchemical.com/bulle...lletin102B.pdf

    shows 2.4g pregnenelone is soluble in 100ml DMSO

  8. Wow EasyEJL. I am forever in gratitude to you for finding this priceless gem of wisdom for me. When you can back up your statements with scientific evidence , you understand and practice the scientific method better than most.

    I am assuming that the DSMO stat sheet could extend to DMSO gel as well? Note the DMSO gel I have is vet grade at over 98% pure.

    Well once again, thanks a lot EasyEJL. If I knew how to give out rep points I would give you about 1000000. lol


    Quote Originally Posted by EasyEJL View Post
    I would think penetrate would work with it, molecular weight is 316.483 g/mol and its hydrophobic.

    http://www.gaylordchemical.com/bulle...lletin102B.pdf

    shows 2.4g pregnenelone is soluble in 100ml DMSO

  9. i'd say you could expect that same level into the gel, might have to warm it to get it all into solution as i'd imagine that mixing the gel is a pain.

    so lets say 2g per 100ml worth, 4oz bottle is a little over 100ml. used at 2ml a day thats 50 days worth of 40mg/day. Not sure how much you were planning on dosing a day, I've never really looked too deep into transdermal preg before

  10. Quote Originally Posted by living2die View Post
    For 20 grams, that is a really good price at about $11 that is a really good price.

    The politics of finding a raw PREG powder aren't my concern, just the effective delivery method seems to be problematic. Mixed reports and the like about using DMSO as a carrier continue to vex me. Have you used the aforementioned PREG /DMSO carrier in the past ?

    Thanks!
    I prefer a localized carrier. Benzyl Alcohol + DMSO would work, but would be very irritating.

    If you do this, follow up with an emmolient.
    Evolutionary Muse - Inspire to Evolve
    Flawless Skin Couture - We give you the tools to make you Flawless

  11. Why localized? and what sort of dosage would you think is good matt?

  12. Quote Originally Posted by EasyEJL View Post
    Why localized? and what sort of dosage would you think is good matt?
    Localized would give the best chance to be absorbed neurally.

    IIRC, I dissolved about 2 grams into 4 ounces...it doesn't take much at all.
    Evolutionary Muse - Inspire to Evolve
    Flawless Skin Couture - We give you the tools to make you Flawless

  13. What exactly is a localized carrier? Are you referring to the life-flo PREG product, which uses a bunch of oils and MSM as a TD carrier?

    Last night I swabbed the TD site with isopropyl alcohol, applied the DMSO gel, spread the ground up PREG powder tablets and waited...it was hot and irritating for about 15 minutes. I did notice the PREG requiem for a dream experience that many like dsade report. After it had been absorbed, it looked like I had a 3rd degree burn at the application site...localized redness lol. I could also taste garlic. But IMO, the garlic smelly stench that it suppose to go along with it is a farse...I didn't experience any of that.

    Quote Originally Posted by dsade View Post
    Localized would give the best chance to be absorbed neurally.

    IIRC, I dissolved about 2 grams into 4 ounces...it doesn't take much at all.

  14. Quote Originally Posted by living2die View Post
    What exactly is a localized carrier? Are you referring to the life-flo PREG product, which uses a bunch of oils and MSM as a TD carrier?

    Last night I swabbed the TD site with isopropyl alcohol, applied the DMSO gel, spread the ground up PREG powder tablets and waited...it was hot and irritating for about 15 minutes. I did notice the PREG requiem for a dream experience that many like dsade report. After it had been absorbed, it looked like I had a 3rd degree burn at the application site...localized redness lol. I could also taste garlic. But IMO, the garlic smelly stench that it suppose to go along with it is a farse...I didn't experience any of that.
    The localized carriers were pioneered by Avant Labs.

    The benzyl alcohol component is extremely efficient at transporting actives, and it speeds it through the dermal microvasculature more quickly than can be absorbed systemically, resulting in localized concentrations of the active. These are picked up and transported to nearby tissues, primarily.
    Evolutionary Muse - Inspire to Evolve
    Flawless Skin Couture - We give you the tools to make you Flawless

  15. dsade,
    I am not sure that I am understanding your DMSO/benzyl alcohol PREG carrier clearly, please forgive me. Please describe in laymen's terms your procedure from start to finish.

    Very Respektfully,
    l2d


    Quote Originally Posted by dsade View Post
    The localized carriers were pioneered by Avant Labs.

    The benzyl alcohol component is extremely efficient at transporting actives, and it speeds it through the dermal microvasculature more quickly than can be absorbed systemically, resulting in localized concentrations of the active. These are picked up and transported to nearby tissues, primarily.

  16. Has anyone covered the application site with a saran wrap in an attempt to maintain the PREG in a single site? i have tried this method today, and it seemed like after covering the application site with saran wrap, the saran wrap somehow managed to pull the preg out of the dmso and prevented full absorption. any comments ? i have heard of people who have used the saran wrap method along with dmso in order to apply finaplix pellets.

  17. what was in your carrier? How do you know it pulled the preg out, and you did not get full absorption?

    Organic solvents, carbonyls especially, have a tendency to disolve into plastics. There is a good chance it diffused into the plastic wrap.

    Covering the area in plastic wrap also causes you to sweat, causing an outward flow of fluid.

    I really wouldn't recommend wrapping an application site with plastic wrap, unless you are using an anabolic steroid in your carrier, and are planning to be in contact with women or children.

  18. blast! everytime i think i might have a good idea, it turns out to be completely retarded in retrospect.

    i reasoned that the PREG wasnt being topically absorbed in the right direction after looking through the transluscent clear saran wrap covering, and realizing that there was a lot of just raw white PREG remnants simply coagulated on the top of the skin layer where the dmso was applied.

    it might take a week or two to completely fine tune my protocol. but IMO, i mistakingly applied isopropyl alcohol to the site prior to adding the layer of dmso, and then the preg, and got MAJOR irritiation. the skin turned bright red, and i think that the skin became so inflamed that many cells actually died. a week after, the redness disappeared and i was left with a brown, splotchy discoloration, almost like what you might find a week after getting a slight sunburn. the skin that was effected just flaked off.

    thanks thesinner in pointing out this caveat to my dmso topical design. i dont have kids, so i guess i will just have to get my butt out of bed a bit earlier on in the morning to allow for the solvent dmso and preg combo to dry before going out to the grind.






    Quote Originally Posted by thesinner View Post
    what was in your carrier? How do you know it pulled the preg out, and you did not get full absorption?

    Organic solvents, carbonyls especially, have a tendency to disolve into plastics. There is a good chance it diffused into the plastic wrap.

    Covering the area in plastic wrap also causes you to sweat, causing an outward flow of fluid.

    I really wouldn't recommend wrapping an application site with plastic wrap, unless you are using an anabolic steroid in your carrier, and are planning to be in contact with women or children.

  19. Why wouldn't you just mix the Iso alcohol, DMSO, and preg together...then apply?
    Evolutionary Muse - Inspire to Evolve
    Flawless Skin Couture - We give you the tools to make you Flawless

  20. well right now i only have dmso gel, not the liquid form. i like the gel a lot, and have never used the liquid so cannot comment. in regard to the iso alcohol, everytime i have used it i get a major inflammatory reaction at the application site. again, normally i rub the application site down with the iso, than apply dmso gel, than cover with a layer of PREG powder and massage in.

    i think your method would work, even though i do only have the gel. ill give it a whirl sometime this week and report back.

    respekt

    Quote Originally Posted by dsade View Post
    Why wouldn't you just mix the Iso alcohol, DMSO, and preg together...then apply?

  21. thanks sinner for the help. do you think the IPA will evaporate prior towards being pushed into the skin by the DMSO or what? i have noticed that the IPA helps absorption greatly, but as i have mentioned before, irritates badly.

    Quote Originally Posted by thesinner View Post
    ....why not mix the DMSO gel, IPA, and Preg together?

    There's no reason to do it the way you are setting it up, and if you really want to go about it this way, apply the DMSO first, the the preg, and massage in with IPA.
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