Pregnenolone Transdermal?

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  1. I am in contact with a MD who operates out of AL. He told me through email that DMSO wouldn't work as a carrier for PREG. I think the issue here is getting the PREG to dissolve in the DMSO gel carrier. Could I just heat the DMSO gel up, and than add the raw PREG powder ?

    Also, Fina users report using a more primitive method of grinding the Fina pellets into a powder, applying to desirable skin region, and applying the DMSO gel after over the ground of Fina pellets.

    This morning, I applied the DMSO gel, ground up OTC Source Naturals 50mg PREG tablets (they are soo cheap, couldn't resist) and then placed the ground up powder over the DMSO app site. The DMSO stung a bit, but about 30 minutes later, all of the powder seemed to have been absorbed into the skin.

    Anyone tried this? Please help I am getting so much conflicting information !


    Quote Originally Posted by living2die View Post
    *bump


  2. Quote Originally Posted by living2die View Post
    I have vet grade DMSO (98.9 % pure DMSO). Could I just add some crushed up PREG tablets or raw PREG powder and apply to my skin for a cheap homemade TD ?

    Thanks
    The fillers wont dissolve and it will be grainy.

    Grab some PReg from beyond-a-century - cheap and high quality.

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  3. For 20 grams, that is a really good price at about $11 that is a really good price.

    The politics of finding a raw PREG powder aren't my concern, just the effective delivery method seems to be problematic. Mixed reports and the like about using DMSO as a carrier continue to vex me. Have you used the aforementioned PREG /DMSO carrier in the past ?

    Thanks!

    Quote Originally Posted by dsade View Post
    The fillers wont dissolve and it will be grainy.

    Grab some PReg from beyond-a-century - cheap and high quality.


  4. I would think penetrate would work with it, molecular weight is 316.483 g/mol and its hydrophobic.

    http://www.gaylordchemical.com/bulle...lletin102B.pdf

    shows 2.4g pregnenelone is soluble in 100ml DMSO

  5. Wow EasyEJL. I am forever in gratitude to you for finding this priceless gem of wisdom for me. When you can back up your statements with scientific evidence , you understand and practice the scientific method better than most.

    I am assuming that the DSMO stat sheet could extend to DMSO gel as well? Note the DMSO gel I have is vet grade at over 98% pure.

    Well once again, thanks a lot EasyEJL. If I knew how to give out rep points I would give you about 1000000. lol


    Quote Originally Posted by EasyEJL View Post
    I would think penetrate would work with it, molecular weight is 316.483 g/mol and its hydrophobic.

    http://www.gaylordchemical.com/bulle...lletin102B.pdf

    shows 2.4g pregnenelone is soluble in 100ml DMSO
    •   
       


  6. i'd say you could expect that same level into the gel, might have to warm it to get it all into solution as i'd imagine that mixing the gel is a pain.

    so lets say 2g per 100ml worth, 4oz bottle is a little over 100ml. used at 2ml a day thats 50 days worth of 40mg/day. Not sure how much you were planning on dosing a day, I've never really looked too deep into transdermal preg before

  7. Quote Originally Posted by living2die View Post
    For 20 grams, that is a really good price at about $11 that is a really good price.

    The politics of finding a raw PREG powder aren't my concern, just the effective delivery method seems to be problematic. Mixed reports and the like about using DMSO as a carrier continue to vex me. Have you used the aforementioned PREG /DMSO carrier in the past ?

    Thanks!
    I prefer a localized carrier. Benzyl Alcohol + DMSO would work, but would be very irritating.

    If you do this, follow up with an emmolient.
    Evolutionary Muse - Inspire to Evolve
    Flawless Skin Couture - We give you the tools to make you Flawless

  8. Why localized? and what sort of dosage would you think is good matt?

  9. Quote Originally Posted by EasyEJL View Post
    Why localized? and what sort of dosage would you think is good matt?
    Localized would give the best chance to be absorbed neurally.

    IIRC, I dissolved about 2 grams into 4 ounces...it doesn't take much at all.
    Evolutionary Muse - Inspire to Evolve
    Flawless Skin Couture - We give you the tools to make you Flawless

  10. What exactly is a localized carrier? Are you referring to the life-flo PREG product, which uses a bunch of oils and MSM as a TD carrier?

    Last night I swabbed the TD site with isopropyl alcohol, applied the DMSO gel, spread the ground up PREG powder tablets and waited...it was hot and irritating for about 15 minutes. I did notice the PREG requiem for a dream experience that many like dsade report. After it had been absorbed, it looked like I had a 3rd degree burn at the application site...localized redness lol. I could also taste garlic. But IMO, the garlic smelly stench that it suppose to go along with it is a farse...I didn't experience any of that.

    Quote Originally Posted by dsade View Post
    Localized would give the best chance to be absorbed neurally.

    IIRC, I dissolved about 2 grams into 4 ounces...it doesn't take much at all.

  11. Quote Originally Posted by living2die View Post
    What exactly is a localized carrier? Are you referring to the life-flo PREG product, which uses a bunch of oils and MSM as a TD carrier?

    Last night I swabbed the TD site with isopropyl alcohol, applied the DMSO gel, spread the ground up PREG powder tablets and waited...it was hot and irritating for about 15 minutes. I did notice the PREG requiem for a dream experience that many like dsade report. After it had been absorbed, it looked like I had a 3rd degree burn at the application site...localized redness lol. I could also taste garlic. But IMO, the garlic smelly stench that it suppose to go along with it is a farse...I didn't experience any of that.
    The localized carriers were pioneered by Avant Labs.

    The benzyl alcohol component is extremely efficient at transporting actives, and it speeds it through the dermal microvasculature more quickly than can be absorbed systemically, resulting in localized concentrations of the active. These are picked up and transported to nearby tissues, primarily.
    Evolutionary Muse - Inspire to Evolve
    Flawless Skin Couture - We give you the tools to make you Flawless

  12. dsade,
    I am not sure that I am understanding your DMSO/benzyl alcohol PREG carrier clearly, please forgive me. Please describe in laymen's terms your procedure from start to finish.

    Very Respektfully,
    l2d


    Quote Originally Posted by dsade View Post
    The localized carriers were pioneered by Avant Labs.

    The benzyl alcohol component is extremely efficient at transporting actives, and it speeds it through the dermal microvasculature more quickly than can be absorbed systemically, resulting in localized concentrations of the active. These are picked up and transported to nearby tissues, primarily.

  13. Has anyone covered the application site with a saran wrap in an attempt to maintain the PREG in a single site? i have tried this method today, and it seemed like after covering the application site with saran wrap, the saran wrap somehow managed to pull the preg out of the dmso and prevented full absorption. any comments ? i have heard of people who have used the saran wrap method along with dmso in order to apply finaplix pellets.

  14. what was in your carrier? How do you know it pulled the preg out, and you did not get full absorption?

    Organic solvents, carbonyls especially, have a tendency to disolve into plastics. There is a good chance it diffused into the plastic wrap.

    Covering the area in plastic wrap also causes you to sweat, causing an outward flow of fluid.

    I really wouldn't recommend wrapping an application site with plastic wrap, unless you are using an anabolic steroid in your carrier, and are planning to be in contact with women or children.

  15. blast! everytime i think i might have a good idea, it turns out to be completely retarded in retrospect.

    i reasoned that the PREG wasnt being topically absorbed in the right direction after looking through the transluscent clear saran wrap covering, and realizing that there was a lot of just raw white PREG remnants simply coagulated on the top of the skin layer where the dmso was applied.

    it might take a week or two to completely fine tune my protocol. but IMO, i mistakingly applied isopropyl alcohol to the site prior to adding the layer of dmso, and then the preg, and got MAJOR irritiation. the skin turned bright red, and i think that the skin became so inflamed that many cells actually died. a week after, the redness disappeared and i was left with a brown, splotchy discoloration, almost like what you might find a week after getting a slight sunburn. the skin that was effected just flaked off.

    thanks thesinner in pointing out this caveat to my dmso topical design. i dont have kids, so i guess i will just have to get my butt out of bed a bit earlier on in the morning to allow for the solvent dmso and preg combo to dry before going out to the grind.






    Quote Originally Posted by thesinner View Post
    what was in your carrier? How do you know it pulled the preg out, and you did not get full absorption?

    Organic solvents, carbonyls especially, have a tendency to disolve into plastics. There is a good chance it diffused into the plastic wrap.

    Covering the area in plastic wrap also causes you to sweat, causing an outward flow of fluid.

    I really wouldn't recommend wrapping an application site with plastic wrap, unless you are using an anabolic steroid in your carrier, and are planning to be in contact with women or children.

  16. Why wouldn't you just mix the Iso alcohol, DMSO, and preg together...then apply?
    Evolutionary Muse - Inspire to Evolve
    Flawless Skin Couture - We give you the tools to make you Flawless

  17. well right now i only have dmso gel, not the liquid form. i like the gel a lot, and have never used the liquid so cannot comment. in regard to the iso alcohol, everytime i have used it i get a major inflammatory reaction at the application site. again, normally i rub the application site down with the iso, than apply dmso gel, than cover with a layer of PREG powder and massage in.

    i think your method would work, even though i do only have the gel. ill give it a whirl sometime this week and report back.

    respekt

    Quote Originally Posted by dsade View Post
    Why wouldn't you just mix the Iso alcohol, DMSO, and preg together...then apply?

  18. thanks sinner for the help. do you think the IPA will evaporate prior towards being pushed into the skin by the DMSO or what? i have noticed that the IPA helps absorption greatly, but as i have mentioned before, irritates badly.

    Quote Originally Posted by thesinner View Post
    ....why not mix the DMSO gel, IPA, and Preg together?

    There's no reason to do it the way you are setting it up, and if you really want to go about it this way, apply the DMSO first, the the preg, and massage in with IPA.

  19. yeh..i might have been using too much isopropryl alcohol than was needed. i tried washing the app site with some glycerin aloe all natural naked soap, applied a small amount of rubbing alcohol, and than applied a layer of dmso with a thin layer of PREG sprinkled on top. i didnt suffer any real ill irritation.

    SWEET FANCY MOSES THOUGH
    the residue that i reported earlier, attributing it too non-absorbed PREG, in actuality ( i think) was dissolved saran wrap!!! the consistency is too rubbery and smells like burnt plastic...FYI don't apply any type of plastic covering in the future to an application site!!! it will eat through the saran wrap and partially dissolve it!!!

    Quote Originally Posted by thesinner View Post
    I don't think rubbing alcohol is the culprit behind any skin irritation you may be experiencing with this stack.

  20. Quote Originally Posted by dsade View Post
    Grab some PReg from beyond-a-century - cheap and high quality.
    Bump for BAC - been doing business w/ them for what, 15 years?

  21. Quote Originally Posted by dsade View Post
    The localized carriers were pioneered by Avant Labs.

    The benzyl alcohol component is extremely efficient at transporting actives, and it speeds it through the dermal microvasculature more quickly than can be absorbed systemically, resulting in localized concentrations of the active. These are picked up and transported to nearby tissues, primarily.
    Thanks for that: BA in TD now snaps into focus for me!

    You must spread some Reputation around before giving it to dsade again.

  22. Quote Originally Posted by BodyWizard View Post
    Bump for BAC - been doing business w/ them for what, 15 years?
    I've been doing with them for about 6 years...always excellent quality, and a nice bunch of guys. He runs it with his family.

    before I go into production with a new-ish ingredient, I always check them to see if they have it in small quantities for experimentation.
    Evolutionary Muse - Inspire to Evolve
    Flawless Skin Couture - We give you the tools to make you Flawless

  23. Quote Originally Posted by living2die View Post
    yeh..i might have been using too much isopropryl alcohol than was needed. i tried washing the app site with some glycerin aloe all natural naked soap, applied a small amount of rubbing alcohol, and than applied a layer of dmso with a thin layer of PREG sprinkled on top. i didnt suffer any real ill irritation.

    SWEET FANCY MOSES THOUGH
    the residue that i reported earlier, attributing it too non-absorbed PREG, in actuality ( i think) was dissolved saran wrap!!! the consistency is too rubbery and smells like burnt plastic...FYI don't apply any type of plastic covering in the future to an application site!!! it will eat through the saran wrap and partially dissolve it!!!
    Honestly, DMSO is insanely potent. this is what I would do -

    Dissolve the Preg into Iso Alcohol. Then, in an open bowl start spooning in the DMSO gel. Keep stirring with a wooden stick as you add. While the Preg solution will thin out the DMSO gel, you will also get a good dispersion. You don't need much at all .

    When you've added sufficient amount to give you the concentration preg/ml you want, simply apply the combined product on.

    Seems like you are making this needlessly multistep.
    Evolutionary Muse - Inspire to Evolve
    Flawless Skin Couture - We give you the tools to make you Flawless

  24. Thanks for the advice dsade. i agree with you that the dmso that i am using at 98% purity might be simply too strong. it would be ideal to dilute it with a little bit of isopropyl alcohol. the iso isnt pure, it is 70% iso, which i think would be beneficial as it seems like i am having irritiation issues from using too strongly potent dmso and iso ingredients.

    the wooden stick is also a good idea because the dmso willn't dissolve wood laden products, but it does show an affinity for dissolving plastic compounds.

    respekt

    Quote Originally Posted by dsade View Post
    Honestly, DMSO is insanely potent. this is what I would do -

    Dissolve the Preg into Iso Alcohol. Then, in an open bowl start spooning in the DMSO gel. Keep stirring with a wooden stick as you add. While the Preg solution will thin out the DMSO gel, you will also get a good dispersion. You don't need much at all .

    When you've added sufficient amount to give you the concentration preg/ml you want, simply apply the combined product on.

    Seems like you are making this needlessly multistep.

  25. I've read that DMSO needs to be diluted to around 75% (which would be 3 parts DMSO to 1 part distilled water). Had good luck so far using it that way - it 'solvents' better & supposedly improves penetration and carrying capacity

  26. bodywizard:
    you must be correct, because i am using only small amounts of 98% vet grade pure DMSO, and even if i use sparse amounts, it still is quite irritating on contact. i think i might combine your method along with a lil ISO alcohol.

    also, what transdermal hormone are you using? I am using preg. what is your washing, cleaning protocol prior to application. i wash myself down with axe bodywash(no i am not one of the those low rise brief guys) and then use a aloe/glycerin soap free of fragrances and dyes on the application site, all prior to applying the dmso and PREG.

    peace



    Quote Originally Posted by BodyWizard View Post
    I've read that DMSO needs to be diluted to around 75% (which would be 3 parts DMSO to 1 part distilled water). Had good luck so far using it that way - it 'solvents' better & supposedly improves penetration and carrying capacity

  27. Formestane.

    Washing is straightforward. I scrub all over lightly with an unscented glycerine soap. I get most of the water off w/ a regular towel, then use a hand towel to briskly rub the application areas until they are red and stimulated - and dry.

    BTW - DMSO is a penetration agent, and a solvent - great at both those - but it's not the greatest carrier; you really should be using an actual medium like Phlogel, or Penetrate. Your results are almost certain to be hit-or-miss otherwise.

  28. ideally, yes i should prolly be using a better carrier. but for me, it comes down to economics: 1) i only use doses of +/- 25mg PREG in each DMSO application. Basically, I am using such a small quantity of PREG on a mg for mg basis, that I dont really need an effective carrier because there simply arent a lot of mg's that i need to be carried. 2) i am also using the DMSO gel, which i think is better able to hold the PREG together in an almost paste like vehicle that is better than just DMSO liquid in holding the PREG together.

    i guess i wont really know how much absorption i am getting from the DMSO carrier until i get some blood work done, and even then, that is sketchy business because the PREG assay is worthless supposedly. better to test for pregnanediol (PROG metabolite) to surmise the effectiveness of absorption.

    Quote Originally Posted by BodyWizard View Post
    Formestane.

    Washing is straightforward. I scrub all over lightly with an unscented glycerine soap. I get most of the water off w/ a regular towel, then use a hand towel to briskly rub the application areas until they are red and stimulated - and dry.

    BTW - DMSO is a penetration agent, and a solvent - great at both those - but it's not the greatest carrier; you really should be using an actual medium like Phlogel, or Penetrate. Your results are almost certain to be hit-or-miss otherwise.
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