Grassroots is correct. In retrospect it had more to do with WHERE I was applying the TD, perhaps more than the length of the cycle. I ran ti for 13 weeks and I was suing high doses in a very high delivery version of Phlojel. I was applying 200 to 300 mgs a day and probably getting 30% delivery. The real issue was that I was rotating my applications sites to enhance drug delivery. One of ,my applications was upper chest. I was getting a large amount of aromatase inhibition at my THYROID. You can figure what happens if you shut your thyroid down right? Your endocrine system becomes compromised.