I incorporate some GVT principles into my leg training. I like to do 10 sets of 10 on the squat rack, pushing myself as hard as I possible can, with just enough rest to let my training partner do his set between mine. After this I do 5 or so slow concentrated sets of leg curls to isolate the teardrop (which I'm trying to improve) and call it a day. The next few days my glutes, hams, abductors, aductors, and all of the quad is sore. I isolate hams on a different day.
I must say it has worked the best so far. I have tried all the machine\isolation work, and incorporating alot of different exercises into my leg routines and have never gotten the same results
Keep in mind: don't do this routine week after week, switch it up and do a lighter week here and there