Increasing Resveratrol dosage DOES NOT increase blood levels.

  1. Doctor Science
    LakeMountD's Avatar
    Join Date
    Feb 2003
    Posts
    4,251
    Rep Power
    2557
    Level
    46
    Lv. Percent
    93.03%
    Achievements Activity ProPosting Pro

    Increasing Resveratrol dosage DOES NOT increase blood levels.


    This is another reason that we made Reverse. As the article states the bioavailability is low despite the dosage and the rate of absorption is very slow.



    Pharm Res. 2008 Jul 16. [Epub ahead of print]
    The Impact of Aqueous Solubility and Dose on the Pharmacokinetic Profiles of Resveratrol.
    Das S, Lin HS, Ho PC, Ng KY.
    Department of Pharmacy, Faculty of Science, National University of Singapore, Building S4, Rm 05-02, 18 Science Drive 4, Singapore, 117543, Singapore.

    PURPOSE: This study aimed at the investigation of the impact of aqueous solubility and dose manipulation on the pharmacokinetics of resveratrol. METHODS: Water soluble intravenous and oral formulations of resveratrol were prepared with hydroxypropyl-beta-cyclodextrin (HP-beta-CD) and randomly methylated-beta-cyclodextrin (RM-beta-CD), respectively. Sodium salt and suspension of resveratrol in carboxymethyl cellulose (CMC) were used as the reference intravenous and oral formulations, respectively. The pharmacokinetics of resveratrol was assessed in Sprague-Dawley rats. Plasma resveratrol concentrations were measured by high performance liquid chromatography (HPLC). RESULTS: Both HP-beta-CD and RM-beta-CD enhanced the aqueous solubility of resveratrol. After intravenous administration, rapid elimination of resveratrol was observed at all tested doses (5, 10, and 25 mg kg(-1)) regardless of formulation types; with non-linear elimination occurring at the dose of 25 mg kg(-1). RM-beta-CD significantly increased the maximal plasma concentration of orally administered resveratrol, but, it did not increase the oral bioavailability in comparison with the CMC suspension. Furthermore, the oral bioavailability remained unchanged among all tested doses (15, 25, and 50 mg kg(-1)). CONCLUSIONS: Aqueous solubility barrier might affect the speed but not the extent of resveratrol absorption. Further, dose manipulation (up to 50 mg kg(-1)) did not have a significant impact on the oral bioavailability of resveratrol.

  2. New Member
    craig20's Avatar
    Join Date
    Mar 2009
    Posts
    1
    Rep Power
    70
    Level
    1
    Lv. Percent
    33%

    Very Interesting..

    I saw something about this on Oprah the other day.
  3. Senior Member
    TexasTitan's Avatar
    Join Date
    Dec 2008
    Posts
    1,186
    Rep Power
    667
    Level
    26
    Lv. Percent
    63.52%
    Achievements Posting Pro

    Well hold on, it says it doesnt increase oral bioavailibity. Not necessarily how much is absorbed if you up the dosage. Unless Im reading that wrong, which is very likely.
    •   
       

  4. New Member
    Cinn's Avatar
    Join Date
    Jun 2005
    Age
    30
    Posts
    184
    Rep Power
    456
    Level
    11
    Lv. Percent
    71.94%

    Quote Originally Posted by TexasTitan View Post
    Well hold on, it says it doesnt increase oral bioavailibity. Not necessarily how much is absorbed if you up the dosage. Unless Im reading that wrong, which is very likely.
    Dose escalation was shown to not have an effect on plasma concentrations.

Similar Forum Threads

  1. Increasing DHT levels
    By Broly in forum Anabolics
    Replies: 31
    Last Post: 05-03-2012, 03:33 PM
  2. M-drol blood pressure levels increasing
    By grega60438 in forum Anabolics
    Replies: 17
    Last Post: 06-17-2011, 10:50 AM
  3. How can Trans-D Tropin increase HGH levels while reducing IGF-1 levels?
    By superone in forum Male Anti-Aging Medicine
    Replies: 0
    Last Post: 05-21-2009, 01:49 PM
  4. For Dr. D and others... increasing test levels
    By NO MERCY in forum Supplements
    Replies: 107
    Last Post: 02-20-2006, 09:01 PM
  5. Replies: 3
    Last Post: 07-23-2003, 06:06 PM

Posting Permissions

  • You may not post new threads
  • You may not post replies
  • You may not post attachments
  • You may not edit your posts
  •  
Log in