Saw Palmetto shown to be as effective as Finasteride for BPH - AnabolicMinds.com

Saw Palmetto shown to be as effective as Finasteride for BPH

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    Saw Palmetto shown to be as effective as Finasteride for BPH


    This's about the 3rd article I've seen now showing the potency of Saw Palmetto being about the same equivalent as 5mg of Finasteride for BPH. I'd love to see a similar study used for MPB.


    Comparing Saw Palmetto Extract and Finasteride for BPH

    Carraro JC, Raynaud JP, Koch G, et al. Comparison of phytotherapy (PermixonŽ) with finasteride in the treatment of benign prostate hyperplasia: A randomized international study of 1,098 patients. Prostate 1996; 29:231-40.

    Summary: A six month, double-blind randomized equivalence study compared the effects for the saw palmetto extract PermixonŽ to the 5a-reductase inhibitor, finasteride (ProscarŽ). The study enrolled 1,098 men over the age of 50 years with moderate benign prostatic hyperplasia (BPH) and used the International Prostate Symptom Score (IPSS) as the primary end-point. Men were randomized to receive either 160 mg of PermixonŽ twice daily or finasteride at a single daily dose of 5 mg. Patients who had received either a-adrenergic receptor antagonists or other phytomedicines (e.g. Pygeum africanum or nettle root) were required to undergo a 2 week washout period prior to beginning treatment. Each patient was evaluated pre-study, and at 6, 13, and 26 weeks. At each visit, peak and mean urinary flow rates were measured, the IPSS was determined, and the patient was asked to complete quality of life and sexual function questionnaires. Additionally, at weeks 13 and 26, patients underwent transrectal and abdominal ultrasound examinations to assess prostatic volume and postvoid residual urine as well as blood chemistries, CBC, and serum prostate-specific antigen (PSA) assay (a baseline PSA was also performed). Of the 1,098 patients randomized to treatment, 553 received PermixonŽ and 545 received finasteride. Of these 951 completed the study with a total dropout of 16% in the PermixonŽ group and 11% in the finasteride group. Both treatments were determined to decrease the symptoms of BPH equally. PermixonŽ decreased the IPSS by 37% compared to 39% for finasteride. Quality of life improved in both groups 38% for PermixonŽ and 41% for finasteride. Peak urinary flow improved by 25% in the PermixonŽ compared to 30% in the finasteride group. Finasteride markedly decreased prostatic volume (18%) and PSA (41%) while PermixonŽ had minimal effect on volume (6% decrease) and no effect on PSA. Patients receiving PermixonŽ had minimal complaints of decreased libido and impotence while this was more common in the finasteride group. Dysuria was more frequent in the finasteride group while urinary retention was higher for the PermixonŽ group, but the differences did not exceed 1% for these complications.

    Commentary: In the Feb/Mar 1997 TLfDP, I reported on the 3 year, open-label study with 435 BPH patients showing the efficacy of the commercial saw palmetto extract known in Europe as IDS 89.1 In the commentary, I made brief mention of this study which was unpublished at the time. The study was initially presented at the Third International Consultation on BPH in Monaco, June 26-29, 1995. According to an editorial in the same issue of Prostate, the presentation raised quite a stir at the conference.2 The editorial is largely complimentary and brings out some solid criticisms of the study including the lack of a placebo arm and the absence of a placebo run-in period. It is important to note that the study also indicates that finasteride did seem to work more effectively in reducing prostate size in men with larger prostates due to BPH while PermixonŽ was more effective in reducing the lower urinary tract symptoms (LUTS) of men with smaller prostate size. This is consistent with other studies on finasteride and one of the reasons it has recently come under fire.3 However, it also demonstrates the difficulty in trying to present clear parameters for demonstrating efficacy in the treatment of mild to moderate BPH. The use of LUTS has been recommended as a response to the lack of clarity in diagnosing BPH based on prostate size, urine flow, and subjective symptoms.

    PermixonŽ is the original liposterolic extract of saw palmetto berries (Serenoa repens) created by the pharmaceutical division of Pierre Fabre in France. The hexane extract is comprised of free (90%) and esterified (7%) fatty acids, sterols, polyprenic compounds, and flavonoids. This particular extract was the template for current liposterolic extracts manufactured using either ethanol or CO2 extraction. As is the case with all liposterolic extracts, the therapeutic dose is 320 mg daily. Therapeutic results should be expected in six to eight weeks but it is important to remember that the new rule of thumb for determining clinical efficacy with BPH is six months or longer. As has been reported in previous reviews on saw palmetto, the liposterolic extract is largely devoid of the side effects noted for prescription BPH drugs.

    This study establishes another milestone for saw palmetto extract as a viable option in the management of mild to moderate BPH. More long-term trials are still needed as well as the logical comparison of saw palmetto extract with a-adrenergic receptor antagonists. It may be that the diverse mechanisms of action found for saw palmetto and other phytomedicines are the best approach to a condition for which we continue to have poor clinical understanding.

    References

    1. Bach D, Ebeling L. Long-term drug treatment of benign prostatic hyperplasia results of a prospective 3-year multicenter study using Sabal extract IDS 89. Phytomed 1996; 3:105-11.

    2. Denis LJ. Editorial review of Comparison of phytotherapy (PermixonŽ) with finasteride in the treatment of benign prostate hyperplasia: A randomized international study of 1,098 patients. Prostate 1996: 29:241-2.

    3. Boyle P, Gould AL. Prostate volume predicts outcome of treatment of BPH with finasteride: Meta-analysis of randomized clinical trials. J Urol 1996; 155:572A.

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    You my friend are a freak!!! Nice find brother, nice find! Looks like I've been saving myself money for a good reason all this time and not just being a Cheap ass!!lol......
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    Quote Originally Posted by BlackSheep View Post
    You my friend are a freak!!! Nice find brother, nice find! Looks like I've been saving myself money for a good reason all this time and not just being a Cheap ass!!lol......
    Thanks BS, I found myself some nice Saw Palmetto liquid gels a while back on NP. They also have some nettle extract, pumpkin seed oil, and a few other goodies in 'em too.
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    Quote Originally Posted by Ziquor View Post
    Thanks BS, I found myself some nice Saw Palmetto liquid gels a while back on NP. They also have some nettle extract, pumpkin seed oil, and a few other goodies in 'em too.
    got a link?
    Follow me on facebook, twitter and youtube, where I share information and videos to help you achieve your physique goals, John Smeton Ftness
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    Quote Originally Posted by smeton_yea View Post
    got a link?

    Sure do - I got these as they seemed to have a great combo of ingredients in them. I also seen them on a consumer site where they test natural supplements for quality/ingedients and these passed with high remarks. Also NP's price is outstanding as always. 60 day supply for $21.99!

    The Official AnabolicMinds Supplement Store
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    I have always wondered whether or not Saw Palmetto would be able to inhibit androgenic action at the scalp as well. Ziquor, you should run a Saw Palmetto TD w/ Nizoral Shampoo.
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    Quote Originally Posted by Mulletsoldier View Post
    I have always wondered whether or not Saw Palmetto would be able to inhibit androgenic action at the scalp as well. Ziquor, you should run a Saw Palmetto TD w/ Nizoral Shampoo.
    Actually I already have a bottle of Nizoral too, though it's the 1% non prescription strength. I considered adding some original 4AD in my upcoming cycle, that'd probably be a good run to test it with.
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    I have some Nizoral on hand too. I should buy some Saw and give it a try.
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    6-OXO+Saw Palmetto= more testosterone ?
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    Quote Originally Posted by ReaperX View Post
    6-OXO+Saw Palmetto= more testosterone ?
    That may be a decent stack for someone who wants to stay away from regular hormones. The studies I've seen on 6-OXO showed it increases DHT pretty substantially and SP may offset this nicely.
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    That's what I was thinking about too.


    Saw Palmetto+6-OXO+Stinging Nettle Extract.
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    Not looking at it too seriously, but if you eliminate the estrogen, increase free testosterone, and allegedly decrease DHT production, you should theoretically have a decent test. boost.
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    Quote Originally Posted by ReaperX View Post
    That's what I was thinking about too.


    Saw Palmetto+6-OXO+Stinging Nettle Extract.
    testostolyze by species nutrition

    just doesnt have the stinging nettle

    o and it has 90 pills
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    Quote Originally Posted by crazyfool405 View Post
    testostolyze by species nutrition

    just doesnt have the stinging nettle

    o and it has 90 pills
    Good find fool. If only the Saw Palmetto were standardized a bit higher, 45% isn't ideal. The 160mg twice daily dose is based on 90% extract.

    Someone should jump on making a capped product with 6-OXO, Saw Palmetto, and Divanil.
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    I'm not sure what the percentage extract I am taking of Saw Palmetto is but I take 6 caps/ED which is like 1.8g or something like that.


    I've taken Saw Palmetto+6-bromo which wasn't that bad actually.

    I've also taken 6-OXO+ActivaTe which also was pretty good.


    I'd be interested in taking 6-OXO+ActivaTe+Saw Palmetto.


    I might plan that out for something later on in a few months.








    ..............I'm surprised there hasn't been a noob post yet saying, 'I'm gonna STACK this and run this tight CYCLE'.

    I figured people would already have jumped on this ship by now.
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    I'd like to make sure I'm getting a quality Saw Palmetto extract. My stuff is extracted from the berry.



    btw, good find on the article.
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    Nice find Z!

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    Quote Originally Posted by Mulletsoldier View Post
    I have always wondered whether or not Saw Palmetto would be able to inhibit androgenic action at the scalp as well. Ziquor, you should run a Saw Palmetto TD w/ Nizoral Shampoo.
    Shoot... i ran a good test cycle, with Oral Saw, and Nizoral, and had no issues with hair loss. And those were all I utilized for prevention.

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    Hm, that's interesting. BigVrunga showed me an interesting topical SP supplement yesterday; it contained Tea Tree Oil, B6, SP, and Grape Seed extract.
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    Quote Originally Posted by DAdams91982 View Post
    Shoot... i ran a good test cycle, with Oral Saw, and Nizoral, and had no issues with hair loss. And those were all I utilized for prevention.

    Adams

    Good news, was the Nizoral 1 or 2?
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    Quote Originally Posted by Ziquor View Post
    Good news, was the Nizoral 1 or 2?
    2%. I grabbed that since it was pretty much the same price.

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    Nizoral + Emu Oil + Spiro + Minox/AA solution is what I will be using.
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    Quote Originally Posted by Mulletsoldier View Post
    Nizoral + Emu Oil + Spiro + Minox/AA solution is what I will be using.
    You will be lookin like a lion king mutha ****a. Mane and all.

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    Quote Originally Posted by DAdams91982 View Post
    You will be lookin like a lion king mutha ****a. Mane and all.

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    I'm just an incredibly vain pr!ck, lol.
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    Quote Originally Posted by Mulletsoldier View Post
    I'm just an incredibly vain pr!ck, lol.
    It happens to the best of us.

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    One thing I wonder, when using multiple shampoo's, is it good to use them all together or cycle them around? BTW I found a decent priced SP shampoo:

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    Isn't Saw Palmetto only good when ingested vs. topical applications ?
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    Quote Originally Posted by Ziquor View Post
    One thing I wonder, when using multiple shampoo's, is it good to use them all together or cycle them around? BTW I found a decent priced SP shampoo:

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    Depends what is in it. You don't want to mix topicals with ingredients which have adverse systemic effects.
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    Quote Originally Posted by ReaperX View Post
    Isn't Saw Palmetto only good when ingested vs. topical applications ?
    I'm not sure if there's enough solid proof either way, from what I've seen. I seen a test that was done on thinning men where topical SP was shown to stop hair loss vs. a placebo but it's the only test I've seen - and it wasn't in vitro.
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    That clears up a side effect I was having from 6-OXO stacked with ZMA and 25mg of DHEA.... itchy scalp... itched bad... I quit this stack just 2 days ago and am much better already.
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    Quote Originally Posted by travis0712 View Post
    That clears up a side effect I was having from 6-OXO stacked with ZMA and 25mg of DHEA.... itchy scalp... itched bad... I quit this stack just 2 days ago and am much better already.
    Are you using SP? I know some people who've had really bad thinning from Dhea solo.
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    Not sure what SP is, sorry, I am a bit of a newb to advanced stuff here on AM - but I love the site, I am learning a lot!
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    Quote Originally Posted by travis0712 View Post
    Not sure what SP is, sorry, I am a bit of a newb to advanced stuff here on AM - but I love the site, I am learning a lot!
    Saw Palmetto
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    No, I just heard of SP today, on this site. I stopped using 6-oxo and dhea due to the side affects. I might try it again though. Have to research how much to take first and see if others are having success with it.
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    Any great articles about it being good against prostate cancer. I have many articles, but I've nothing that i consider great.
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    i lost hair from an extreemely short cycle of havoc (3 weeks) is it reverseable? no 1 in family is close to baldin
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    Quote Originally Posted by musclehead666 View Post
    i lost hair from an extreemely short cycle of havoc (3 weeks) is it reverseable? no 1 in family is close to baldin
    It all depends, if you had a future of alopecia to already look forward to, you just sped up the inevitable and it may not return. However if there's no genetic history, it can return to normal.
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    Quote Originally Posted by Ziquor View Post
    I'd love to see a similar study used for MPB.
    ^ THIS!!!
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