Both naringin and piperine are being added to almost any supplement and nutraceutical lately it seems. They both inhibit enzymes that metabolize drugs in the human body, improving the halflife and absorption of the drug/supplement they are paired with (although not in all cases).
naringin inhibits CYP3A4 and CYP1A2.
Naringin - Wikipedia, the free encyclopedia
piperine (piperidine/pepper extract) inhibits CYP3A4 and P-glycoprotein
Piperine - Wikipedia, the free encyclopedia
Gene ResultOriginally Posted by CYP3A4
Gene ResultOriginally Posted by CYP1A2
P-glycoproteinOriginally Posted by P-glycoprotein
I have to wonder at the logic behind inhibiting enzymes that protect us from cancer and harmful substances in order to improve the absorption of a nutraceutical. It may have its use in sports supplements that are used sporadically for immediate benefits, but I'm curious as to the safety of daily ingestion of these products.
At the very least, avoid these supplements when taking any other drugs (legal or illegal). I'm personally considering removing these two ingredients from my cupboard. I'd like to hear what reps have to say however.