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Bioavailability of glucosamine/chondroitin

AM07

Well-known member
What are the absorption rates of glucosamine and chondroitin in capsule form? I've read that it's small, so it's almost not worth it to get it in capsule form, and to use a topical product such as VPX Glucosacream, or something else. Anyone else have anymore information?
 
AM07; said:
What are the absorption rates of glucosamine and chondroitin in capsule form? I've read that it's small, so it's almost not worth it to get it in capsule form, and to use a topical product such as VPX Glucosacream, or something else. Anyone else have anymore information?
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Chondroitin sulfate and shark cartilage are composed of relative large molecules, making absorption difficult. The absorption rate for chondroitin sulfate is between zero and about 8%. Glucosamine sulfate, on the other hand, is composed of relatively small molecules, delivering a comparatively high absorption rate of about 98%, orally administered.
By the way, after absorption, glucosamine sulfate is preferentially soaked up by cartilage and other joint structures and stimulates the integration of sulfur into cartilage. At this point, glucosamine triggers the manufacture of chondroitin sulfate and other compounds known as mucopolysaccharides.
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I have read several studies on the bioavailability of Chondroitin Sulfate; all studies showed benefit of taking an oral CS but there were higher absorption rates with the lower molecular weight CS.

It wouldn't matter if you took the CS in capsule or tablet or powder form, it would depend on the molecular weight of the CS being used, which isn't typically disclosed by supplement companies.
 
strategicmove said:
Chondroitin sulfate and shark cartilage are composed of relative large molecules, making absorption difficult. The absorption rate for chondroitin sulfate is between zero and about 8%. Glucosamine sulfate, on the other hand, is composed of relatively small molecules, delivering a comparatively high absorption rate of about 98%, orally administered.
By the way, after absorption, glucosamine sulfate is preferentially soaked up by cartilage and other joint structures and stimulates the integration of sulfur into cartilage. At this point, glucosamine triggers the manufacture of chondroitin sulfate and other compounds known as mucopolysaccharides.
.
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So it would be okay to just load up on glucosamine then, considering it results in the synthesis of chondroitin?

I just want my bad ankle sprain to heal faster. It happened about 4 months ago, and it's a lot better, but I just want to be able to jog and run again without fear of spraining it again. Still don't have full ROM.
 
according to authorities org chondroitin is useless but glucosamine hydrochloride is a better choice.
 
AM07; said:
So it would be okay to just load up on glucosamine then, considering it results in the synthesis of chondroitin?

I just want my bad ankle sprain to heal faster. It happened about 4 months ago, and it's a lot better, but I just want to be able to jog and run again without fear of spraining it again. Still don't have full ROM.
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Yes, prefer loading glucosamine sulfate. You might also want to consider adding a cissus product for general ligament, bone, tendon, and joint support, as well as for enhanced recovery.
 
Celadrin is good as well. I never heard this about Chrondroiton, so basically it is useless it is lower molecular weight. Good info.
 
djbombsquad said:
according to authorities org chondroitin is useless but glucosamine hydrochloride is a better choice.
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There are more scientific clinical studies performed on Glucosamine Sulfate. Glucosamine HCl is cheaper, that is why the so-called authorities are telling you that.

There are many studies that show benefits of chondroiton sulfate even with poor bioavailibilty which probably means we don't know all the mechanisms of action for CS yet.
 
Typo on my part. I ment to say Arthritis not authorities. my bad.
 
Ordered some glucosamine sulfate because it's supposed to be better than HCL, correct?
 
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