Natural COX-2 inhibitors to avoid while on X-Factor

  1. New Member
    Neil5585's Avatar
    Stats
    6'0"  230 lbs.
    Join Date
    Jan 2008
    Posts
    310
    Rep Power
    240
    Level
    14
    Lv. Percent
    64.38%

    Natural COX-2 inhibitors to avoid while on X-Factor


    Here is a quick list of natural COX-2 inhibitors that I found quickly searching around on the net. Keep in mind I haven't researched all of these a ton so not 100% sure on all of these. But wouldn't hurt to avoid if on a 50 day X-factor cycle.

    (note: apparently melatonin isn't good to take on X-Factor as well)


    Natural COX-2 inhibitors:

    Omega-3 fats
    Ginger
    Turmeric (curcumin)
    White willow bark
    Boswellia
    Devil's claw root
    Green tea
    Resveratrol (grape seed extract)
    Rosemary
    Bee propolis
    Hops
    Quercetin


    Polygonum cusipidatum root
    Phellodendron amurense bark


    Chamomile
    Celery seed
    Ginko
    Skullcap
    Barberry
    Goldenseal
    Goldthread
    Oregon grape
    Yelllow root (Berberine)
    Rhubarb
    Currant
    Cabbage
    Chives
    Clove
    Thyme
    Sage
    Lavender
    Marjoram
    Ginseng (form?)
    Cardamom
    Feverfew

  2. New Member
    Eyayo's Avatar
    Join Date
    Jun 2007
    Posts
    176
    Rep Power
    180
    Level
    11
    Lv. Percent
    44.18%

    Thumbs up


    Great post. I was acutally looking for things not to take while on x-factor.
  3. Senior Member
    Necroticism's Avatar
    Stats
    5'9"  200 lbs.
    Join Date
    Jul 2007
    Age
    31
    Posts
    1,079
    Rep Power
    630
    Level
    25
    Lv. Percent
    19.78%
    Achievements Posting Pro

    those turmeric and green tea are painful. im a curry fan, which i add extra turmeric to, and im a green tea addict. i suppose those are sacrifices i must make when i take x factor in the future.
    •   
       

  4. Diamond Member
    strategicmove's Avatar
    Join Date
    Jun 2007
    Posts
    10,754
    Rep Power
    774633
    Level
    68
    Lv. Percent
    25.26%
    Achievements Activity ProActivity AuthorityPosting ProPosting AuthorityPosting Veteran

    Neil5585's list is rather comprehensive. Avoiding all those may be a major challenge for arachidonic acid supplementation. To be fair, all the agents on that list are not equally potent in arachidonic-acid inhibition. Furthermore, the dosages used can also make a difference. Finally, a more potent arachidonic-acid inhibition response is obtained when more than one of those are used at effective dosages, because herbs display considerable potency when combined versus when used singly.

    A certain book, Beyond Aspirin (Newmark et al. 2000), discusses naturally-occuring cyclooxygenase-2 (COX-2) inhibitors. Some might find this useful.

    By the way, while discussing arachidonic-acid (AA) inhibition, it might help to recall that its complete inflammatory cascade includes COX-1, COX-2, and 5-Lipooxygenase (5-LOX).

    5-LOX is an enzyme that is produced in higher amounts by the body in response to an overload of arachidonic acid. 5-LOX functions to degrade arachidonic acid. However, 5-LOX directly stimulates the propagation of cancer cells. Furthermore, 5-LOX produces breakdown products from arachidonic acid. These products, leukotriene B4, 5-HETE, and hydroxylated fatty acids, motivate tissue destruction, chronic inflammation, as well as the increased resistance of tumor cells to apoptosis or programmed cell destruction.

    Apart from 5-LOX, the body produces other dangerous enzymes such as cyclooxygenase-1 (COX-1) and cyclooxygenase-2 (COX-2) that participate in the breakdown of arachidonic acid.

    COX-1 leads to the production of thromboxane A2. Thromboxane can enhance abnormal arterial blood clotting or thrombosis, leading to heart attack and stroke. Yet, COX-1, in base quantities, are required in many metabolic processes. This is why non-steriodal anti-inflammatory drugs (NSAIDs) that quench COX-1 also trigger certain health problems in our body, including bowel distress, amongst others. (NSAIDs express their pharmacological action via COX and prostaglandin synthase inhibition).

    COX-2 participates directly in cancer cell propagation. Its breakdown product, prostaglandin E2 fosters chronic inflammation.

    It is useful to note that when COX-2 is inhibited, arachidonic acid expresses itself through 5-LOX, so a complete strategy would involve both COX-2 and 5-LOX inhibition.


    Lastly, I would like to add one or tow things to Neil5585's post.

    1) Sesamin/Sesame lignans are direct arachidonic-acid inhibitors.
    2) Silymarin/Silibinin, actives in Milk Thistle, also COX-2 inhibitors.
    3) High insulin levels trigger the conversion of arachidonic acid into inflammatory prostaglandins.
    4) CLA has a dose-dependent ability to suppress aracidonic acid, and is sometimes used as chemopreventive (because arachidonic acid triggers inflammatory mediators that can support cancer initiation and progression).
    5) Curcumin inhibits COX-2 and thromboxane A2, a highly unstable, but biologically active compound created by COX from AA. Furthermore, curcumin also effectively inhibits 5-LOX and HETE.
    6) Gamma tocopherol is a dose-dependent COX-2 inhibitor.
    7) Ginger not only suppresses COX-2, it also supports the positive effects of COX-1.
    8) Feverfew contains apigenin and melatonin, both COX-2 inhibitors. Besides, Feverfew also possesses 5-LOX-inhibiting properties.
    9) Berberine and berberine-containing herbs (goldenseal, barberry, goldthread, oregon grape) not only inhibit COX-2, but also support the beneficial actions of COX-1.
    10) Green Tea's COX-2-inhibiting actions occur via two pathways. 1) Salicylic acid, the main anti-inflammatory component of aspirin, naturally occurs in Green Tea, giving it its COX-2 inhibition abilities; 2) The polyphenols and flavonoids in Green Tea also exhibit COX-2 inhibition.
    11) A special extract of the Boswellia plant known as AKBA (3-O-acetyl-11-keto-ß-boswellic acid) is one of the most potent selective 5-LOX inhibitors around.
    Product Educator | USPowders
    Statements made by this online persona are the sole property of the owner, and do not necessarily reflect USPowders’ opinion as a whole.
  5. Senior Member
    nelix's Avatar
    Join Date
    May 2007
    Posts
    1,329
    Rep Power
    757
    Level
    27
    Lv. Percent
    47.47%
    Achievements Posting Pro

    It is my understanding that inhibiting some AA by products would increase the amount of AA you have to turn into more useful things, so there for curcummon for instance might actually work really well with AA? While you might not notice as many side effects, you might still be getting the gains?
  6. Diamond Member
    strategicmove's Avatar
    Join Date
    Jun 2007
    Posts
    10,754
    Rep Power
    774633
    Level
    68
    Lv. Percent
    25.26%
    Achievements Activity ProActivity AuthorityPosting ProPosting AuthorityPosting Veteran

    Quote Originally Posted by nelix View Post
    It is my understanding that inhibiting some AA by products would increase the amount of AA you have to turn into more useful things, so there for curcummon for instance might actually work really well with AA? While you might not notice as many side effects, you might still be getting the gains?
    Arachidonic acid, as such, is not bad. It is only a question of the how much of it is present in our system.
    Product Educator | USPowders
    Statements made by this online persona are the sole property of the owner, and do not necessarily reflect USPowders’ opinion as a whole.
  

  
 

Similar Forum Threads

  1. Any fat burners to avoid while on an SSRI?
    By lboston in forum Supplements
    Replies: 56
    Last Post: 06-22-2012, 07:07 PM
  2. Cycle SUpport avoidance while on x-factor
    By Vipersg123 in forum Molecular Nutrition
    Replies: 3
    Last Post: 04-28-2007, 08:24 AM
  3. Mistakes to avoid while on Gear
    By gten79 in forum Anabolics
    Replies: 7
    Last Post: 08-20-2006, 07:51 AM
  4. supps to avoid while on B.P. meds
    By RipdnTxs2 in forum OTC Drug
    Replies: 25
    Last Post: 11-10-2005, 06:13 PM
  5. Best Protein to use while on PHs?
    By EPe9686518 in forum Supplements
    Replies: 8
    Last Post: 03-10-2003, 02:02 PM

Posting Permissions

  • You may not post new threads
  • You may not post replies
  • You may not post attachments
  • You may not edit your posts
  •  
Log in
Log in