pSARM - The Write Up - AnabolicMinds.com

pSARM - The Write Up

  1. Board Sponsor
    LG Sciences's Avatar
    Join Date
    Jan 2008
    Posts
    1,901
    Rep Power
    67552

    Reputation Reputation

    pSARM - The Write Up


    Excuse the hype...we are in GNC you know...

    pSARMs act like testosterone in specific tissues like muscle. This gives us the unique benefit of being anabolic without the negative side effects found with illegal anabolic steroids. The key to the pSARM is in the shape of the molecule which is similar to testosterone and acts like it in specific muscle tissues, giving the bodybuilder a very potent anabolic agent without the negative side effects. pSARMs are completely safe and effective. If you look at the diagram on the bottom of the page, you can see figure 1 is of the testosterone molecule in molecular position. Figure 2 is a molecular position diagram of osthole, the main pSARM in Methyl 1-D. In figure 3 you can see how they overlap and therefore have similar activity in tissues like muscle with out being negative on the liver or prostate. This overlap technology is what makes pSARMs so amazing. Let’s run down the list of ingredients so you can see for yourself.
    Cnidium is an herb that contains the natural pSARM osthole. The raw herb contains very little Osthole, but our special process standardizes the plant for only the pSARM osthole. Other companies may use a lower grade 10 or 20 percent osthole which doesn’t have the same effect as our 90% extract. Only the right dose of osthole will stimulate the pSARM effect and we have the unique process for standardizing the herb for the highest Osthole content. One test subject on just Osthole alone, added over 50lbs to his leg press in just two weeks! In the study titled [Effects of osthol on androgen level and nitric oxide synthase activity in castrate rats] the researchers found “RESULTS: Testosterone, LH and FSH were significantly increased at the high dose of osthol treatment. The high and low dose of osthol treatment significantly enhanced the activity of NOS (P < 0.01). CONCLUSION: Osthol could increase androgen, gonadotropin and nitric oxide synthase (NOS) activity. It suggested that osthol had androgen-like effect and gonadotropin-like effect.”. Only the high dose of Osthole will have this positive effect and we have standardized to contain over 90% Osthole, making Methyl 1-D very potent.
    Hibiscus Rosa Sinensis is an herb that is proven to have anabolic and pSARM effects. We use the highest standardized extract to achieve a higher concentration of pSARMS from the Hibiscus plant, the 5:1 extraction method gives us the most potent Hibiscus extract available in a sports supplement. This amazing herbal pSARM is proven in the scientific literature to increase recovery time, improve NOS and reduce inflammation. However it’s anabolic qualities are what we are after! In the study Anabolic effect of Hibiscus rosasinensis Linn. leaf extracts in immature albino male rats we find that the extract of Hibiscus Rosa Sinensis has pSARM effects and can reduce both estrogen and stimulate testosterone.. This is the conclusion drawn from that amazing study “RESULTS: Over the 8 weeks of treatment, the control, the cold aqueous extract dosed, hot aqueous extract dosed and alcoholic extract dosed rats gained 8%, 15%, 18% and 22% in body weights respectively. The increase in the weight of testis, epididymis, seminal vesicle and prostate of the alcoholic extract dosed rats was 19%, 30%, 31% and 40% respectively. CONCLUSION: The anabolic effect of the leaf extracts of H. rosasinensis is hereby established.”

    Additionally, many species of Hibuscus are shown to be anabolic, they just didn't check this particular one, however many species share commonalities. There is a lot of research behind Hibiscus and of course Osthole rocks as a phyto_androgen.
    Attached Images Attached Images  

  2. Board Sponsor
    LG Sciences's Avatar
    Join Date
    Jan 2008
    Posts
    1,901
    Rep Power
    67552

    Reputation Reputation

    Of course, much of everything in sports supplements is theory, but hibiscus species have a lot of really good studies behind them and of course a few negative. The way we know if something really works is to have a pool of testers and see how it works. I will tell you this, people love pSARM.

    We used to get dogged a lot for product X. Product X gave 4-5lbs of muscle in a month and that is about what people expect these days...somehow back in the days of M1T it wasn't good enough.
  3. Professional Member
    warbird01's Avatar
    Stats
    6'1"  224 lbs.
    Join Date
    Jun 2007
    Posts
    3,419
    Rep Power
    585813

    Reputation Reputation Reputation Reputation Reputation Reputation Reputation Reputation Reputation

    Hopefully its a good product but i loled at the MS paint diagrams
    Serious Nutrition Solutions Representative
    X-GELS THE Prohormone alternative!
    anabolicminds.com/forum/supplements/246394-arachidonic-acid-help.html
    •   
       

  4. Board Sponsor
    LG Sciences's Avatar
    Join Date
    Jan 2008
    Posts
    1,901
    Rep Power
    67552

    Reputation Reputation

    It's a theory on why it could have androgenic activity and is just that a theory. It still works!
  5. Board Sponsor
    Aggravated's Avatar
    Join Date
    Sep 2007
    Posts
    2,746
    Rep Power
    1500

    Reputation

    Quote Originally Posted by warbird01 View Post
    Hopefully its a good product but i loled at the MS paint diagrams
    Apparently it shows innovation?
  6. O.G. Appnut
    Vitruvian's Avatar
    Join Date
    Dec 2005
    Posts
    5,203
    Rep Power
    85508

    Reputation Reputation

    I love the name
    Applied Nutriceuticals Representative
    Better Results Through Science
    Success occurs when everything you have is APPLIED.
    Have you heard about N.O. Uptake? ;-)
  7. Senior Member
    slow-mun's Avatar
    Join Date
    Aug 2006
    Age
    35
    Posts
    2,149
    Rep Power
    1173

    Reputation

    What's the expected release date for this one(ballpark figure)? It seems like an interesting product that I'd like to use if it is available in a month or two. What is a decent estimate of the going price?
  8. Board Sponsor
    poison's Avatar
    Stats
    6'0"  190 lbs.
    Join Date
    Oct 2004
    Age
    40
    Posts
    5,904
    Rep Power
    37730

    Reputation

    Quote Originally Posted by Lanbane View Post
    I love the name
    I wonder who came up with it?
  9. Diamond Member
    John Smeton's Avatar
    Stats
    6'2"  225 lbs.
    Join Date
    Sep 2004
    Age
    33
    Posts
    10,014
    Rep Power
    33557

    Reputation

    Sarms were in there beginning stages in 2006 and I think they said to realy get SARMS down it would be 2011. Thats just what Ive heard no facts just hear say well looks like a SARm has some work out into it
    Follow me on facebook, twitter and youtube, where I share information and videos to help you achieve your physique goals, John Smeton Ftness
  10. Advanced Member
    JBerto's Avatar
    Join Date
    Jul 2007
    Posts
    561
    Rep Power
    381

    Reputation

    Question


    Is there any clinical study of the anabolic effect of SARM on Humans?
  11. New Member
    luke1984's Avatar
    Stats
    6'1"  240 lbs.
    Join Date
    Dec 2006
    Age
    30
    Posts
    369
    Rep Power
    279

    Reputation

    Quote Originally Posted by JBerto View Post
    Is there any clinical study of the anabolic effect of SARM on Humans?
    Actually there is.
    I found this somewhere online:

    GTx, Inc. Initiates Phase I Clinical Trial for Its Second SARM Ostarine

    MEMPHIS, Tenn., February 01, 2005 /PRNewswire-FirstCall/ -- GTx, a biopharmaceutical company dedicated to the discovery, development and commercialization of therapeutics for serious men's health conditions, today announced that it has initiated a Phase I clinical trial for ostarine, GTx's second selective androgen receptor modulator (SARM) compound to be tested in clinical trials.

    "We are very excited about the promising preclinical ostarine data and are pleased to initiate this clinical trial," stated Mitchell Steiner, M.D., Vice Chairman and CEO of GTx. "This shows that we have the proven ability to create compounds in the laboratory and move them into the clinic as we continue to position GTx as the lead SARM company."

    The Phase I study will evaluate the safety, tolerability and pharmacokinetic profile of ostarine using a single ascending dose, double- blind, placebo-controlled design in healthy volunteers.

    Ostarine is a nonsteroidal SARM that is designed to have positive anabolic effects without having an impact on the prostate and is being developed for andropause as well as other conditions associated with aging, such as sarcopenia. Sarcopenia is defined as the loss of muscle mass associated with aging leading to frailty and loss of independence.

    As people age they undergo hormonal and metabolic changes. Each year after age 30 people gain an average of a pound of fat every year and lose a half a pound of muscle every year. Thus, men may lose 50% of muscle between the ages of 30 and 90. Muscle provides strength and endurance, supports the skeletal system and helps protect the body from illness. Loss of muscle can cause frailty, loss of independence, and worsens other conditions such as osteoarthritis and osteoporosis. There are 17 million Americans alive over the age of 75 who suffer from sarcopenia and currently there are no approved treatment options available.

    GTx's SARM Discovery Program

    GTx believes that the ability to selectively target and modulate the androgen receptor will allow the development of many new drugs that are crucial for men's health. In fact, different compounds within the SARM class have demonstrated in preclinical studies unique pharmacologic activities, with varying effects on endocrine feedback, prostatic stimulation, spermatogenesis, muscle growth, bone growth and sexual behavior, highlighting the untapped potential of these novel drugs for treatment of other diseases, including benign prostatic hyperplasia (BPH), male infertility, and low libido.

    About GTx

    GTx is a biopharmaceutical company dedicated to the discovery, development and commercialization of therapeutics for serious men's health conditions.

    GTx's drug discovery and development programs are focused on small molecules that selectively modulate the effects of estrogens and androgens.

    GTx currently has four clinical programs. In two of the clinical programs, the company is developing ACAPODENE(TM), its most advanced product candidate, through clinical trials for two separate indications: (1) a pivotal Phase III clinical trial for the prevention of prostate cancer in high risk men and (2) a pivotal Phase III clinical trial for the treatment of serious side effects of androgen deprivation therapy for advanced prostate cancer. [Link]

    In its third clinical program, GTx and its partner, Ortho Biotech Products, L.P., a subsidiary of Johnson & Johnson, are developing andarine, a selective androgen receptor modulator (SARM), which is expected to enter a Phase II clinical trial in 2005.

    In its fourth clinical program, GTx is developing its own SARM, ostarine, for andropause and other conditions related to aging, including sarcopenia.

    In addition, GTx has a deep pipeline generated from its own discovery program which includes specific preclinical product candidates prostarine, a SARM, for benign prostatic hyperplasia (BPH), and andromustine, an anticancer drug, for hormone refractory prostate cancer.
    There's probably much more to find on this.

    But I seriously doubt you're going to find a working SARM in a supplement for the next 10 years.
  12. New Member
    merderah's Avatar
    Join Date
    Jan 2008
    Posts
    22
    Rep Power
    0

    Reputation

    GTx currently has four clinical programs. In two of the clinical programs, the company is developing ACAPODENE(TM), its most advanced product candidate, through clinical trials for two separate indications: (1) a pivotal Phase III clinical trial for the prevention of prostate cancer in high risk men and (2) a pivotal Phase III clinical trial for the treatment of serious side effects of androgen deprivation therapy for advanced prostate cancer.

    isn't acapodene toremifene citrate.... FARESTON? it's not a SARM, it's a SERM. people use it in PCT, albeit you can't get your hands on acapodene, fareston is GREAT for PCT
  13. New Member
    Dr Nick's Avatar
    Join Date
    Dec 2006
    Posts
    178
    Rep Power
    185

    Reputation

    What kind of results have you had with psarm?
    Is it good to use on a cutter?
  14. Board Sponsor
    LG Sciences's Avatar
    Join Date
    Jan 2008
    Posts
    1,901
    Rep Power
    67552

    Reputation Reputation

    Yeah, it is probably best on a cutting cycle. It's not a huge bulking product, just makes you stronger and more vascular...
  15. New Member
    hailxenu's Avatar
    Join Date
    May 2009
    Posts
    1
    Rep Power
    66

    Reputation

    the most hydrophilic parts of the molecules have completely been moved around and two ring structures are not there anymore at all which will result in totally different bond angles.this would be completely clear in a 3d rendering with electron density mapping.

    what does the 'p' stand for? it doesn't appear your product has anything in common structurally with current sarms (it isnt derived from quinolinone, tetrahydro-quinoline, aryl propionamide or hydantoin).

    (this post was edited because I don't feel like getting banned from the first post).
  16. Senior Member
    capnsavem's Avatar
    Stats
    5'11"  222 lbs.
    Join Date
    Jul 2008
    Posts
    2,226
    Rep Power
    1241

    Reputation

    ...*slowly backs out of thread*...
  17. Elite Member
    MAxximal's Avatar
    Stats
    5'11"  235 lbs.
    Join Date
    Jan 2009
    Age
    37
    Posts
    6,901
    Rep Power
    122079

    Reputation Reputation Reputation

    Hello

    I can stack pSARM with whatever supplements?


    thanks
  18. Board Sponsor
    LG Sciences's Avatar
    Join Date
    Jan 2008
    Posts
    1,901
    Rep Power
    67552

    Reputation Reputation

    The p is for Phyto...many of these seem to have growth potential without the hair/prostate effects of testosterone analogs. They are not true SARM's since those are obviously pharmaceutical products...
  19. Elite Member
    Craigmatthew's Avatar
    Stats
    6'1"  206 lbs.
    Join Date
    Dec 2007
    Posts
    6,009
    Rep Power
    21034

    Reputation

    Quote Originally Posted by MAxximal View Post
    Hello

    I can stack pSARM with whatever supplements?


    thanks
    Indeed you can, what stack you thinking of running?
  20. Elite Member
    MAxximal's Avatar
    Stats
    5'11"  235 lbs.
    Join Date
    Jan 2009
    Age
    37
    Posts
    6,901
    Rep Power
    122079

    Reputation Reputation Reputation

    Quote Originally Posted by Craigmatthew View Post
    Indeed you can, what stack you thinking of running?
    not PH`s only the normal CLA, Green Tea, stims, EFA`s something like that!
  21. Elite Member
    Craigmatthew's Avatar
    Stats
    6'1"  206 lbs.
    Join Date
    Dec 2007
    Posts
    6,009
    Rep Power
    21034

    Reputation

    Quote Originally Posted by MAxximal View Post
    not PH`s only the normal CLA, Green Tea, stims, EFA`s something like that!
    That would be fine man. Just take the psamr solo first time, get a feel for it, then slowly add things.
  22. Elite Member
    MAxximal's Avatar
    Stats
    5'11"  235 lbs.
    Join Date
    Jan 2009
    Age
    37
    Posts
    6,901
    Rep Power
    122079

    Reputation Reputation Reputation

    Quote Originally Posted by Craigmatthew View Post
    That would be fine man. Just take the psamr solo first time, get a feel for it, then slowly add things.
    cool man i found a site that`s sell 2 bottles for the price of one i give a try.

    thanks
  23. Elite Member
    Craigmatthew's Avatar
    Stats
    6'1"  206 lbs.
    Join Date
    Dec 2007
    Posts
    6,009
    Rep Power
    21034

    Reputation

    Quote Originally Posted by MAxximal View Post
    cool man i found a site that`s sell 2 bottles for the price of one i give a try.

    thanks
    Awesome deal! Let us know how you find it.
  24. Elite Member
    MAxximal's Avatar
    Stats
    5'11"  235 lbs.
    Join Date
    Jan 2009
    Age
    37
    Posts
    6,901
    Rep Power
    122079

    Reputation Reputation Reputation

    Quote Originally Posted by Craigmatthew View Post
    Awesome deal! Let us know how you find it.
    LG Sciences P Sarm - pSarm *BUY ONE GET ONE FREE!! - 2 x 100 Cap Btls
  25. New Member
    the GUNSHOW's Avatar
    Stats
    5'10"  215 lbs.
    Join Date
    Dec 2008
    Posts
    429
    Rep Power
    291

    Reputation

    so no PCT?... and what kind of gains do some people see?
  26. Elite Member
    rochabp's Avatar
    Stats
    5'8"  200 lbs.
    Join Date
    May 2009
    Posts
    5,195
    Rep Power
    216446

    Reputation Reputation Reputation Reputation Reputation

    would this help a youngster like me for strengt hgains or possibly recomp
    The difference between who you are and who you want to be is what you do.
  27. Elite Member
    Craigmatthew's Avatar
    Stats
    6'1"  206 lbs.
    Join Date
    Dec 2007
    Posts
    6,009
    Rep Power
    21034

    Reputation

    Quote Originally Posted by rochabp View Post
    would this help a youngster like me for strengt hgains or possibly recomp
    How old are you?
  28. Senior Member
    matthias7's Avatar
    Stats
    6'3"  215 lbs.
    Join Date
    May 2009
    Posts
    1,627
    Rep Power
    879

    Reputation

    I've yet to give it a whirl but will add to my test booster review. I noted the AI was stacked in there.

    pSARM will stack (like you can't stack two AIs - or at least I can't). Stacking pSARM, an AI and Divanil - could kick.

    Keep in mind Tribulus was never shown to boost test in humans, nor phyto-tests compounds.
    Just cause it may not boost muscle it may be doing other stuff that is beneficial.

    Tribulus does seem to have nootropic effects - make you feel loaded with test. Has Long jack ever been shown to boost test? ActivaTE Xtreme I think is a great product BTW.

    It would be nice to give a direct comparison against icariin. This is the one natty test booster that really gives results. Whats the max. dosage per day? I'd want to try 'full throttle'
  29. Elite Member
    rochabp's Avatar
    Stats
    5'8"  200 lbs.
    Join Date
    May 2009
    Posts
    5,195
    Rep Power
    216446

    Reputation Reputation Reputation Reputation Reputation

    Quote Originally Posted by Craigmatthew View Post
    How old are you?
    almost 18 ina like 2 months
    The difference between who you are and who you want to be is what you do.
  30. Senior Member
    matthias7's Avatar
    Stats
    6'3"  215 lbs.
    Join Date
    May 2009
    Posts
    1,627
    Rep Power
    879

    Reputation

    I've got it and will be testing it against ActivaTE, Mass FX and DTHC. What really looking at is the role of icariin in test boosters and how best to deliver it.

    It'll be a while before I get to pSARM. Potentially interesting, it would stack a SBG inhibitor and an AI.
  31. Board Sponsor
    flightposite's Avatar
    Stats
    6'3"  205 lbs.
    Join Date
    Sep 2008
    Posts
    2,954
    Rep Power
    311225

    Reputation Reputation Reputation Reputation Reputation Reputation Reputation

    is the Y free version out?
    Athletic Xtreme Team REP
    http://www.AthleticX.net/
    AXHOLE BY NATURE
  32. Senior Member
    matthias7's Avatar
    Stats
    6'3"  215 lbs.
    Join Date
    May 2009
    Posts
    1,627
    Rep Power
    879

    Reputation

    Quote Originally Posted by JBerto View Post
    Is there any clinical study of the anabolic effect of SARM on Humans?
    Its a good question. I've got pSarm and its AI.

    I'm going to run it 2010. I could check test levels before and after (see link for log of other stuff).

    I am not planning on logging it. I think if I notice something dramatic then I'll start a log.
  33. Senior Member
    freezito's Avatar
    Stats
    6'0"  270 lbs.
    Join Date
    Oct 2006
    Posts
    2,973
    Rep Power
    26191

    Reputation

    i got two bottles sitting here, havent decided what to do with yet
  34. Elite Member
    MAxximal's Avatar
    Stats
    5'11"  235 lbs.
    Join Date
    Jan 2009
    Age
    37
    Posts
    6,901
    Rep Power
    122079

    Reputation Reputation Reputation

    Osthole free version
    SNS Online Representative
    Maxximal @ seriousnutritionsolutions.com

    Got Glycophase ...?


  •   

      
     

Similar Forum Threads

  1. Replies: 4
    Last Post: 01-01-2013, 03:19 PM
  2. GHenerate [THE WRITE UP]!!
    By Craigmatthew in forum Company Promotions
    Replies: 9
    Last Post: 10-27-2009, 04:41 AM
  3. Replies: 30
    Last Post: 01-06-2009, 05:02 PM
  4. Replies: 397
    Last Post: 05-15-2007, 05:06 PM

Posting Permissions

  • You may not post new threads
  • You may not post replies
  • You may not post attachments
  • You may not edit your posts
  •  
Log in
Log in