[LegalGear]

Why it works:

What used to disable the old prohormones is the same system we use to ACTIVATE our ANDROSTANES. I

It’s not the liver that causes the issues it’s the “gut” or intestinal systems! To quote a study “Our findings suggest that the gut, rather than the liver, is responsible for the failure of oral testosterone to provide effective androgen replacement therapy.”

Oral Stanolone (illegal active steroid) + Gut Enzymes (17bHSD) = Androstanedione (inactive prohormone) + Liver/Muscle Enzymes (3bHSD) = Androsterone (inactive prohormone)

Oral Androstanedione (illegal inactive prohormone) + Gut Enzymes (17bHSD) = Stanolone (active steroid) + Liver/Muscle Enzymes (3bHSD) = Androstanediol (inactive prohormone)

Oral Androstanediol (illegal inactive prohormone) + Gut Enzymes (17bHSD) = Androsterone (inactive prohormone) + Liver/Muscle Enzymes (3a/3bHSD) = Androstanedione (inactive prohormone)

So, you can see that with the prohormones of old, you get INACTIVE hormones in the muscle no matter what path you take, EXCEPT for Methyl Masterdrol V2’s Androstane ester:

Methyl Masterdrol V2 Androstane Ester (DSHEA compliant prohormone) + Gut Enzymes (17bHSD) = Androstanediol (prohormone) + Liver/Muscle Enzymes (3a/3bHSD) = Stanolone (ACTIVE STEROID)

Better conversion is due to taking advantage of the body's enzymes instead of working against them. As I stated in my Masterdrol write up, the gut is the primary deactivation site for 17b-OH steroids. Using a dione would be preferable, if it stopped there but there is also a fair amount of 3bHSD in the liver/muscle/blood so you end up with Androstane-3a/b-ol, 17-one the opposite of what you want. This is a theory but we are getting good results with Androsterone, equally as good as any Androstane prohormone that I can tell (3-alpha, 5aa etc...)

I stick heavily by my postion and I have tons of information supporting my arguement and theory. Including the papers showing 17bHSD in the gut and the studies showing titrated diols and dione conversions that show pretty conclusively that 3-HSD's are expressed somewhere outside the gut, but certainly occuring in the blood somehow... You may win debates, but Seth was a very competent pharmacologist, I miss his knowledge quite a bit. He thought my theory had merit, but he tended to agree with you that the diols had the best efficacy yet admitted that the theory I have is possible and has merit. I agree that 3a-HSD seems to be uni-directional but there are not many studies that show the effect of high doses of 3a hydroxyls that could potentially reverse the enzyme. You have to admit that all the HSD enzymes I know of are bi-directional. For example Methyl 5aA seemed to have much better activity than Methyl DHT...so it seems entirely possible that 3a-HSD is bi-directional as well.

Testosterone metabolism by the rat gastrointestinal tract, in vitro and in vivo.

We have shown previously that the capacity of the jejunal mucosa to oxidise testosterone to the weaker androgen, androstenedione, by the enzyme 17 beta-hydroxysteroid dehydrogenase (17 beta-HSD), is considerable. The present study extends these earlier observations by measuring 17 beta-HSD activity in different regions of the gastrointestinal tract, by investigating the potential for testosterone metabolism by slices and everted sacs of rat jejunum, and estimating the contribution of intestinal testosterone metabolites to circulating levels of plasma androgens, by portal vein sampling in the rat, in vivo. 17 beta-HSD activity in homogenates of gastric and duodenal mucosa was significantly higher than that in jejunum, and was also present in ileum and colon. In addition to androstenedione, slices and everted sacs of rat jejunum produced various metabolites, one of which was probably dihydrotestosterone. It was not, however, a major metabolite in vivo. It is suggested that 5 alpha-reduction may be favoured in vitro by a lower oxidation-reduction potential resulting from tissue anoxia. The major portal vein metabolite was androstenedione, the same major metabolite produced by mucosal homogenates. We conclude that oxidation of testosterone is the major metabolic pathway in intestinal mucosa and the capacity of the gastrointestinal tract to reduce the potency of testosterone is considerable. Our findings suggest that the gut, rather than the liver, is responsible for the failure of oral testosterone to provide effective androgen replacement therapy. The qualitative difference in testosterone metabolism between in vitro and in vivo preparations emphasises the need for caution in the interpretation of similar in vitro experiments.

[LegalGear]

Now, understand that 5aAndro like 3-Alpha, 5aA etc...were never mass builders, they are cutting/strength prohormones.

[Distilled Water]

Nice work LG. Def shines some like on the V2

[thahotboy]

Def give it a try soon !

[3clipseGT]

Hhhmmm im cutting hardcore right now and need to get down for my fight.. Maybe ill pick this up and see how it works for me.

[matthew76]

What about your pSARM product? Do you have a write up for it?

[t3stxlr4titud]

has any one tried this or any Legal Gear products?

-TF

[LegalGear]

I'll start another thread about pSARM if you want...

[mclovin]

i've tried masterdrol, masterdrol v2, methyl masterdrol, and now methyl masterdrol v2; liked the first three a lot but methyl masterdrol v2 i will not even think twice about it again not much of a strength change i guess a little leaner but imo i would pass it up

[LegalGear]

Man, you guys have trolls here too huh? fyi there was never a Masterdrol. MasterdrolV2 was the original...

[Condition1]

Originally Posted by LegalGear

Man, you guys have trolls here too huh? fyi there was never a Masterdrol. MasterdrolV2 was the original...

Maybe he meant liquid masterdrol.

[ProAnabolics]

Methyl Masterdrol was amazing, im interested in methyl masterdrol v2, whoever did that log on it liked it as well. Might be worth trying, PCT is required if i remember correctly?

[matthew76]

We try to refrain from refering to anyone as a Troll here... That type of stuff can stay at crybaby.com.

Originally Posted by LegalGear

Man, you guys have trolls here too huh? fyi there was never a Masterdrol. MasterdrolV2 was the original...

[FrankJ]

Originally Posted by t3stxlr4titud

has any one tried this or any Legal Gear products?

-TF

Guy at my gym did, noticed nothing.

He has been cycling steroids ( injectable Test, Deca and Tren, DBol and ABoms oral also ) for the last few years so it would have to be some pretty powerful stuff for him to notice.

Its definitely not stuff that will produce steroid type gains. He thought it was pro hormones so he was pretty disappointed.

[EasyEJL]

interesting

[Neil5585]

Originally Posted by t3stxlr4titud

has any one tried this or any Legal Gear products?

-TF

I've tried a number of their products from Methyl 1-D, 1-GH-1, Formadrol extreme, liquid masterdrol, NO Infuse, the topical fat burner, and Speed.

The only one I noticed anything from was the liquid masterdrol, but it felt mostly like a stimulant effect. I didn't notice getting any leaner or any dramatic strength gains. Methyl 1-D did absolutely nothing and I went through 2 expensive bottles. NO Infuse just gave me a rash and make me sticky and stinky. Didn't notice anything from 1-GH-1 but in all fairness I never "noticed" anything from glutamine on an empty stomach which is proven to increase GH levels, so that's not to say it didn't work, just that I didn't notice any changes from it. I was highly disappointed in basically all their stuff.

However in fairness not all products work for everyone, so YMMV. I'm only giving an honest account of what I noticed with myself.