Abolishing Ageing: How to Live Forever

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  1. Quote Originally Posted by asianbabe View Post
    I second the veggie notion.

    Someone guessed my age yesterday and it was 5 years less than I am :/ My mum is in her mid-50s and does not look a day over 40.. I hope I look as young as her when I turn 50!

    We wolf down greens like no tomorrow, stay protected from the sun as much as we can, drink heaps of water and don't wear excessive amounts of skin clogging/killing makeup. And we try not to let stress get the better of us.

    This reminds me to get back on the alcar/ala, back on the anarchy stack!
    No racist but Asians due to seem to age much better than us whiteys. As you are aware my fiancee is Korean and she is in her 30's and people always think she is in her early 20's. Her mother is an absolute knockout and is in her upper 50's and her father looks about 45/50 and is actually 65. Good genes go a long way.


  2. And lest we forget...Good black don't crack!
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  3. Quote Originally Posted by whitedevil74 View Post
    No racist but Asians due to seem to age much better than us whiteys. As you are aware my fiancee is Korean and she is in her 30's and people always think she is in her early 20's. Her mother is an absolute knockout and is in her upper 50's and her father looks about 45/50 and is actually 65. Good genes go a long way.
    krngrl is hot!

  4. Quote Originally Posted by asianbabe View Post
    krngrl is hot!
    Who or what is "krngrl"?
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  5. Quote Originally Posted by whitedevil74 View Post
    No racist but Asians due to seem to age much better than us whiteys...
    Genes. Diet. Lifestyle.
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  6. Quote Originally Posted by strategicmove View Post
    Genes. Diet. Lifestyle.
    Genes. My girl drinks, smokes, eats McDonalds for almost every meal and is ripped, muscular and healthy as a horse. Her brother looks like a ripped bodybuilder and does not work out nor diet. He eats mostly fast food as well. Genes are by far the most important factor in determining a persons physique/appearance. Even when I was paying close attention to my diet, on a regular exercise and cardio schedule I could not even come close to his level of musculature. Jealous you ask? Very.

    Another example is a guy I play basketball with whose physique I would kill for. One night I asked him if he worked out or dieted and he said no diet but he did do 25 pushups and 50 situps every morning. Life is not fair.

  7. 10/10 article now how do we apply this?

    alcar/ala
    Resveratrol

    ?

  8. Quote Originally Posted by whitedevil74 View Post
    Genes. My girl drinks, smokes, eats McDonalds for almost every meal and is ripped, muscular and healthy as a horse. Her brother looks like a ripped bodybuilder and does not work out nor diet. He eats mostly fast food as well. Genes are by far the most important factor in determining a persons physique/appearance. Even when I was paying close attention to my diet, on a regular exercise and cardio schedule I could not even come close to his level of musculature. Jealous you ask? Very.

    Another example is a guy I play basketball with whose physique I would kill for. One night I asked him if he worked out or dieted and he said no diet but he did do 25 pushups and 50 situps every morning. Life is not fair.
    My bro is the same.. he is skinny but he has a six pack eating :burg: and has veins popping out everywhere

    He is Finally getting his lazy ass together and starting to get interested in lifting so we'll see how he progresses.

  9. Quote Originally Posted by neoborn View Post
    10/10 article now how do we apply this?

    alcar/ala
    Resveratrol

    ?
    i would throw some idebenone in there as well

  10. This is a very interesting and informative article. It's definitely very useful, too. I'll be keeping this in mind and probably printing it.

  11. So, if we consume Idebenone, ALCAR/ALA, and Resveratrol, then we should be beginning 'abolishing ageing,' correct?

  12. This article is interesting but not practical. What it comes down to is how can anyone / everyone apply these things to their daily lives, only then does it show any true value.

    I mean anyone can create an interesting article but proof is in the pudding as they say. Think test boosters ...everyone and your uncle has a test booster but how many boost omgwtf111 test 1000% to pack on jaw dropping mass....none as far as I know.

    The answer lies within FAQ's etc i.e.

    1. Take 'x' daily at 'x' dose mg

    2. Take 'y' daily at 'y' dose mg

    3. You will know this is working by 'z' results.

    What is the effective dose and method of dosing these things, how many times a day etc etc etc.

    Cynically Yours,

    Neoborn

  13. Quote Originally Posted by neoborn View Post
    This article is interesting but not practical. What it comes down to is how can anyone / everyone apply these things to their daily lives, only then does it show any true value....
    I understand your cynicism, Neoborn. The difficulty in issuing a prescription is that different things work for different people. That is probably why one needs some type of stack with promising and, in some cases, clinically tried compounds. I would look at some of the following:

    1) Acetyl-L-Carnitine (mitochondrial action)/Propionyl-L-Carnitine (cardiovascular function)/Acetyl-L-Carnitine-Arginate (brain metabolism/neurite renewal)/Alpha Lipoic Acid (universal anti-oxidant)
    2) CoQ10 Ubiquinol (significantly more potent than conventional ubiquinone)/Idebenone (similar but different pathway versus ubiquinol)
    3) Omega-3 Fatty Acids (brain metabolism, cardiovascular protection, mitochondrial action, and so on)
    4) Resveratrol (calorie restriction mimetic, anti-aging compound, versatile benefits)/Quercetin (resveratrol co-factor and potent compound)/Bioperine or Piperidine (resveratrol absorption and general nutrient enhancer)
    5) Grape Seed Extract (potent anti-oxidant and booster)/Ginkgo Biloba (blood-flow enhancer to neural cells and extremities, tinnitus management, and so on)
    6) Carnosine (or Beta Alanine/L-Histidine), regarded by some as one of the most potent anti-aging compounds available
    7) Green Tea Extract (nutrient partitioning, thyroid synthesis, appetite modulation, fat synthesis, anti-oxidant, and so on)
    8) Vitamin C, both water soluble (ascorbic acid) and lipid soluble (ascorbyl palmitate).
    9) Good supply of fruits and vegetables
    10) Exercise

    This list is non-exhaustive. One can select one or more compounds from there, or add others.
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  14. Quote Originally Posted by strategicmove View Post
    I understand your cynicism, Neoborn. The difficulty in issuing a prescription is that different things work for different people. That is probably why one needs some type of stack with promising and, in some cases, clinically tried compounds. I would look at some of the following:

    1) Acetyl-L-Carnitine (mitochondrial action)/Propionyl-L-Carnitine (cardiovascular function)/Acetyl-L-Carnitine-Arginate (brain metabolism/neurite renewal)/Alpha Lipoic Acid (universal anti-oxidant)
    2) CoQ10 Ubiquinol (significantly more potent than conventional ubiquinone)/Idebenone (similar but different pathway versus ubiquinol)
    3) Omega-3 Fatty Acids (brain metabolism, cardiovascular protection, mitochondrial action, and so on)
    4) Resveratrol (calorie restriction mimetic, anti-aging compound, versatile benefits)/Quercetin (resveratrol co-factor and potent compound)/Bioperine or Piperidine (resveratrol absorption and general nutrient enhancer)
    5) Grape Seed Extract (potent anti-oxidant and booster)/Ginkgo Biloba (blood-flow enhancer to neural cells and extremities, tinnitus management, and so on)
    6) Carnosine (or Beta Alanine/L-Histidine), regarded by some as one of the most potent anti-aging compounds available
    7) Green Tea Extract (nutrient partitioning, thyroid synthesis, appetite modulation, fat synthesis, anti-oxidant, and so on)
    8) Vitamin C, both water soluble (ascorbic acid) and lipid soluble (ascorbyl palmitate).
    9) Good supply of fruits and vegetables
    10) Exercise

    This list is non-exhaustive. One can select one or more compounds from there, or add others.
    Excellent List Strat. M. I already take all of them except for the Quercetin, which I took for years mostly for BPH. Maybe I should reconsider that. In addition I recommend:
    11) Vitamin D major reduction in diabetes, cancer and coronary artery calcification. lowers agatston scores,
    12) Progesterone estrogen supression, stimulates p53 (apoptosis gene), positive effects on metabolism, blood clotting, bone production, inhibits alzheimers......
    14) Curcumin antitumor, antioxidant, antiarthritic, anti-amyloid and anti-inflammatory properties.
    15) Garlic fights cancer and diabetes, lowers blood homocysteine levels
    16)Creatine Anti-Parkinsons

    PS: Sharing a bottle of Cabernet Sauvignon with your significant other is another good step for one's health for its resveratrol properties and, to relax after taking so many damn pills and creams!!

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  16. is ALCARA really worth it. I remember it showed very good results in vitro but further studies were not carried out after that, which makes me a bit skeptical about it.

  17. Quote Originally Posted by Mo250;
    is ALCARA really worth it. I remember it showed very good results in vitro but further studies were not carried out after that, which makes me a bit skeptical about it.
    If you mean ALCAR, then it does in fact deliver results. Due to the dramatic dose-dependent elevation of mitochondrial action, it is usually recommended, though, to take it with alpha lipoic acid, the universal anti-oxidant.
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  18. actually I meant acetyl-l-carnitine arginate. I've seen some in vitro studies quite a while back but no further studies were conducted.

  19. I took a look at that article and it was pretty interesting. Like many others, I take some of those compounds without putting much thought into it, and now I am glad I do. I took a graduate course in Regenerative Biology and Medicine last semester at IU and we actually talked a bit about staying young and some of the problems behind doing so. My professor Dr. David Stocum, is a pioneer in the field of Regenerative Medicine at IU Med. School, and he actually proposed an idea that is being used by a company out of Las Vegas called Syngenics (not sure on spelling). Basically, the company is run by physicians who actually were competitive bodybuilders in their youth who have researched muscle physiology and the body's response to certain hormone treatments as well as strength training. They call for elderly applicants in their program to utilize a Slow Burn technique of lifting while injecting Testosterone and other Hormones such as hGH at a 20 year old's level. Accordingly they are to take a slew of other supplements/antioxidants etc. Apparently this is supposed to lead to a more youthful appearance as well as an increase in overall vitality. The reason for utilizing this Slow Burn philosophy of training was because it leads to a burst of a cellular molecule called MGF or Mechano Growth Factor. According to a study by Goldspan, the intense stress on the muscle leads to a burst of MGF along with other muscular splice variants such as IGF which in turn cause hypertrophy of myofibers and an increase in the activity of Satellite Cells in the muscle. Overall, this leads to increased muscle and a more youthful appearance. Actually, hGH leads to increases in MGF. The research behind the applications used by Syngenics seems sound being that the true reason for a lot of the less desirable effects of aging are due to decreases in hormone levels. Although, the Slow Burn technique is a bit out there. It basically utilizes more of a Powerlifter's philosophy of moving the most amount of weight for 1 rep, yet, at very slow speeds, ie. around 10 seconds up and 10 seconds down. They say to do this for 3 to 6 reps always going to failure. I powerlift myself, but for more than one rep at a time. I would assume applicants in this program would be taking joint medications in order to keep from inflaming the joints too much. I found this philosophy utilized by Syngenics to be interesting, especially since my 70+ year old professor was a big proponent of it. Being that he is older he is very interested in the utilization of Testosterone, hGH and Slow Burn training. If your interested, look into it. It seems plausible to beat the aging process with a bit of chemical help along with training.

  20. Dense
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  21. Quote Originally Posted by whitedevil74 View Post
    Genes. My girl drinks, smokes, eats McDonalds for almost every meal and is ripped, muscular and healthy as a horse. Her brother looks like a ripped bodybuilder and does not work out nor diet. He eats mostly fast food as well. Genes are by far the most important factor in determining a persons physique/appearance. Even when I was paying close attention to my diet, on a regular exercise and cardio schedule I could not even come close to his level of musculature. Jealous you ask? Very.

    Another example is a guy I play basketball with whose physique I would kill for. One night I asked him if he worked out or dieted and he said no diet but he did do 25 pushups and 50 situps every morning. Life is not fair.
    Looking good on the outside tells little about what is going on inside. The body can handle quite a challenge acutely, but your girl will likely develop problems soon enough (try to get her to understand). Of course epigenetic factors will determine how far we can control gene expressions and this is highly individualistic. So eat as close to natural as possible, exercise, keep stress low, have a family, and you should have quality and quantity in life. I strongly feel that a lot of people are overdoing it on all these substances and are actually doing more harm than good. Much too often we forget the concept of balance, and the little we know about oxidation and reduction (radicals certainly aren't all bad!). And, most are not studied in combination.

    Has everyone forgotten the little problem with resveratrol, it isn't bioavailable in humans up to 5g! Drug companies are developing other compounds, there are already much stronger SIRT1 activators and they will be on the market soon enough.

    Other compounds that extend life in lower forms may not necessarily work in humans. We have different protective mechanisms in some cases (search p53, for an example). One common thing that all of these "super beings" have in common so far, is that they have highly oxidative phenotypes. Bodybuilding obviously is at the other side of the tug o war there.

    If (when) we live forever it will probably be in a new form, I have little doubt that we'll be able to translate consciousness to electronic form soon enough. We'll be part machine either way.

    By the time most of us reach old age, freezing techniques will be even better and we're already starting to develop ways to revive lifeless things (mouse heart).

    Put your resveratrol money in the bank and by the time you are unfrozen you'll have a nice interest sum

  22. Quote Originally Posted by fitnecise View Post
    Put your resveratrol money in the bank and by the time you are unfrozen you'll have a nice interest sum
    Not if your bank account is denominated in dollars.

  23. saying resveratrol isn't bioavailable is nice and all, I've noticed distinct significant effects from dosing 2g a day. There is also actual clinical data showing sperm count changes in humans, so i'm not sure how a non-bioavailable product would cause that. Its bioavailability sucks, yes, no question there, but thats not the same as no bioavailability. teflon has no bioavailability

  24. Quote Originally Posted by fitnecise View Post
    ...So eat as close to natural as possible, exercise, keep stress low, have a family, and you should have quality and quantity in life...
    This is sometimes easier said than done

    Quote Originally Posted by fitnecise View Post
    I strongly feel that a lot of people are overdoing it on all these substances and are actually doing more harm than good...
    This is true in some cases, but definitely not related to the compounds we have discussed here.

    Quote Originally Posted by fitnecise View Post
    ...And, most are not studied in combination...
    All the possible and useful combinations would take millennia to be studied together. Some of us do not have that time

    Quote Originally Posted by fitnecise View Post
    ...Has everyone forgotten the little problem with resveratrol, it isn't bioavailable in humans up to 5g!...
    This is why trans-resveratrol uptake is dramatically improved with simultaneous quercetin supplementation. Not to mention the additional impact of including absorption enhancers such as Bioperine, Naringin, and Dihydroxybergamottin.[/QUOTE]

    Quote Originally Posted by fitnecise View Post
    ...By the time most of us reach old age, freezing techniques will be even better and we're already starting to develop ways to revive lifeless things (mouse heart).

    Put your resveratrol money in the bank and by the time you are unfrozen you'll have a nice interest sum
    One risk is that by the time you are unfrozen, a currency change could have been implemented and your "money" in the bank will be a bunch or worthless paper
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  25. Quote Originally Posted by strategicmove View Post


    This is why trans-resveratrol uptake is dramatically improved with simultaneous quercetin supplementation. Not to mention the additional impact of including absorption enhancers such as Bioperine, Naringin, and Dihydroxybergamottin.
    And what about the consequences of manipulating systems that eliminate toxins? Or the negative properties of the substances themselves? In small amounts in diet they may be generally beneficial, but chronically through supplementation, who knows.

    Hot off the press:

    : Int J Mol Med. 2008 Feb;21(2):223-32.
    Related Articles, Links
    Click here to read
    Aging and anti-aging: Unexpected side effects of everyday medication through sirtuin1 modulation.

    Engel N, Mahlknecht U.

    Department of Hematology/Oncology, University of Heidelberg Medical Center, Im Neuenheimer Feld 410, D-69120 Heidelberg, Germany.

    The sirtuin 1 protein (SIRT1) is a member of the class III NAD+-dependent histone deacetylases, which are also referred to as the 'sirtuins'. The sirtuins and silent information regulator 1 (SIRT1) in particular, are known to play a role in the response to DNA damage, metabolism, longevity and carcinogenesis. SIRT1 regulates different cellular processes such as proliferation, differentiation and apoptosis through deacetylation of important regulatory proteins such as p53, FOXO3a and NFkappaB. A number of different modifiers of SIRT1 expression and activity have been discovered and even food and cosmetic additives (e.g. resveratrol and dihydrocoumarin) have been suggested to either activate or inhibit the activity of human SIRT1. We screened a panel of 18 different drugs which are frequently used in everyday clinical practice with regard to their influence on cell survival and SIRT1 expression in freshly isolated peripheral blood mononuclear cells (PBMCs) from young and healthy volunteers. In this context, we identified L-thyroxin, insulin and sodium nitroprusside to be potent activators of human SIRT1 expression. In addition, treatment of PBMCs with sodium nitroprusside was associated with a significant cellular lifespan extension, while L-thyroxin and insulin were unable to prolong lifespan, suggesting that isolated upregulation of SIRT1 is in fact insufficient to promote longevity. These findings have an important impact on the long-term use of a number of frequently used clinical agents in the treatment of chronic disease with respect to aging and carcinogenesis.

    PMID: 18204789 [PubMed - in process]
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