Is Chrysin Underrated as an Aromatase Inhibitor?

[strategicmove]

As we all know, Chrysin, or 5,7-dihydroxyflavone, is an isoflavone found in significant quantities in Passiflora and is known to inhibit aromatase, the enzyme responsible for the conversion of testosterone into estradiol and androstenedione into estrone. Chrysin has been used by bodybuilders to boost testosterone via aromatase inhibition. Yet, chrysin does not get prominent recommendation when aromatase inhibitors are sought. Why is this so?

- Because it is typically underdosed (upwards of 1.5g per day is required)?
- Because most users for whom it did not work used it without an absorption enhancer such as Naringin, Bioperine/Piperine?

What is your take on Chrysin? If you have used it, did it work for you? How did you dose it? Would you prefer to combine Chrysin with other natural aromatase inhibitors/estrogen modulators such as quercetin, Diindolemethane (DIM), Indole-3-Carbinol (I3C), Resveratrol, Calcium D-Glutarate, Nettle Root, and so on?

[TheMyth]

stragpedia, are you and Dirk on to something I don't know about?

[strategicmove]

stragpedia, are you and Dirk on to something I don't know about?

Not that I know of. I have not contacted Dirk in exactly 10 years!

[haiz69]

I have yet to see any research in vivo that confirms chrysin's anti-aromatase effects. In-vitro results are positive, but thats it.

Also, there is a little evidence that Chrysin can block the conversion of T4 to T3...Not good.

[heebs10]

i have not used it but from what i read it has minimal affects at best when taken orally but apparently transdermal it works well, i believe it is in derm sust, as im sure you already know. IMO if you were not to use it TD i would just go with a steroidal AI, on the other hand i dont know what you are using it for.

[strategicmove]

I have yet to see any research in vivo that confirms chrysin's anti-aromatase effects. In-vitro results are positive, but thats it.

Also, there is a little evidence that Chrysin can block the conversion of T4 to T3...Not good.

Why should Chrysin block the conversion of T4 into metabolically active T3 at all? And isn't elevation of T3 activity a positive outcome for thyroid synthesis?

[haiz69]

Why should Chrysin block the conversion of T4 into metabolically active T3 at all? And isn't elevation of T3 activity a positive outcome for thyroid synthesis?

It could do it because of chrysins inhibition of the enzyme deiodinase.14

[haiz69]

However, Chrysin in a transdermal with something to aid solubility (like DMSO), should/would work VERY well for E levels.