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Icarrin and Absorption

whatastud08

Active member
I recently picked up some bulk Icarrin 50% and taking 1g ED. I know this may have already been answered and if so please point me in the right direction as I was unable to find it. Is Icarrin metabolized by the cytochrome P450 3A4, specifically? I have been taking it about 15 min after having 4-5 oz of GF juice, but I also don't want to unnecessarily alter my liver enzyme concentrations. My current supps are:

Maca
Icarrin 50%
Relora
Reset A.D
Adrenaline
Protein
Creatine
Fish Oil

I was just concerned if there were any interaction between the supps I am taking and grapefruit affecting absorption. Thanks for listening!
 
whatastud08; said:
I recently picked up some bulk Icarrin 50% and taking 1g ED. I know this may have already been answered and if so please point me in the right direction as I was unable to find it. Is Icarrin metabolized by the cytochrome P450 3A4, specifically? ...

As far as I recall, compounds known to be metabolized by the cytochrome P450 3A4 (CYP3A4) include calcium channel blockers, antihistamines, and compounds used to treat erectile dysfunction. Since Icariin (a cGMP-specific PDE5 inhibitor) can be used in the treatment of erectile dysfunction, it is a possible candidate.
 
whatastud08; said:
...
I was just concerned if there were any interaction between the supps I am taking and grapefruit affecting absorption. Thanks for listening!
Grapefruit should not be a problem. In fact, an active in grapefruit, naringin/naringenin that gives it its characteristic taste, helps intensify the perception of taste (if grapefruit is consumed as a fruit) and is responsible for extending the half-life of some other compounds supplemented simultaneously.
 
Very precise answer- who does that guy rep for- sign him up!!

no! we need him to stay unbiased. strategic, one other class of drugs you left out are serms, ie.tamoxifen etc. and possibly some ph's. but as always intelligent well thought out answers.:cheers:
 
I gotta say that everyone needs to be careful with the whole grapefruit thing. I tried this with a cycle of phera-plex and it went wrong. Yes the grapefruit juice will let you absorb more of the compound but you will also get more of the bad side effects also. I got a lot of estrogen related sides: bad bloating, high blood pressure, blood lipids went all to hell. You get the picture? You get more of the good and bad out of your supplements with grapefruit juice. Be Careful!!!
 
I gotta say that everyone needs to be careful with the whole grapefruit thing. I tried this with a cycle of phera-plex and it went wrong. Yes the grapefruit juice will let you absorb more of the compound but you will also get more of the bad side effects also. I got a lot of estrogen related sides: bad bloating, high blood pressure, blood lipids went all to hell. You get the picture? You get more of the good and bad out of your supplements with grapefruit juice. Be Careful!!!

Agreed- gotta be careful- take a look at this study.....

Contraception. 1996 Jan;53(1):41-7. Links
Can grapefruit juice influence ethinylestradiol bioavailability?Weber A, Jäger R, Börner A, Klinger G, Vollanth R, Matthey K, Balogh A.
Department of Clinical Pharmacology, Friedrich Schiller University of Jena, Germany.

The effects of grapefruit juice on the bioavailability of 17 alpha-ethinylestradiol (EE2) after a single oral administration of 50 micrograms EE2 have been investigated. The pharmacokinetics of EE2 were studied in an open, randomized, cross-over study in which 13 healthy volunteers were administered the drug with herbal tea or grapefruit juice (naringin, 887 mg/ml). In contrast to herbal tea, grapefruit juice increased the peak plasma concentration (Cmax) significantly to 137% (mean; range 64% to 214%, p = 0.0088) and increased the area under plasma concentration-time curve from 0 to 8 hours (AUC0-8) to 128% (mean; range 81% to 180%, p = 0.0186). This study shows that grapefruit juice increases the bioavailable amount of EE2. A possible explanation may be that grapefruit juice inhibits the metabolic degradation of EE2. Whether the increased bioavailability of EE2 following grapefruit juice administration is of clinical importance should be investigated in long-term studies.

Moral of the story is: if you are using something that aromatizes with grapefruit juice/naringin- the half-life of ALL circulating steroid hormones will be extended, not just testosterone :D
 
thanks for the back-up rms80!!!! I also would like to know if anyone can tell me when CNW might have the horny goat weed powder (40% icariin) available? I tried to send them an e-mail but it wouldn't go through. Someone help, I need some!!!
 
thanks for the back-up rms80!!!! I also would like to know if anyone can tell me when CNW might have the horny goat weed powder (40% icariin) available? I tried to send them an e-mail but it wouldn't go through. Someone help, I need some!!!

Nutra Planet has it.
 
Yeah, I know nutraplanet has it. But theirs is 50% icariin and costs 3 times as much. I'll have to wait on CNW. Thanks anyway!!!
 
I recently picked up some bulk Icarrin 50% and taking 1g ED. I know this may have already been answered and if so please point me in the right direction as I was unable to find it. Is Icarrin metabolized by the cytochrome P450 3A4, specifically? I have been taking it about 15 min after having 4-5 oz of GF juice, but I also don't want to unnecessarily alter my liver enzyme concentrations. My current supps are:

Maca
Icarrin 50%
Relora
Reset A.D
Adrenaline
Protein
Creatine
Fish Oil

I was just concerned if there were any interaction between the supps I am taking and grapefruit affecting absorption. Thanks for listening!

do you take this on empty stomach in the morning or at night?
 
Grapefruit should not be a problem. In fact, an active in grapefruit, naringin/naringenin that gives it its characteristic taste, helps intensify the perception of taste (if grapefruit is consumed as a fruit) and is responsible for extending the half-life of some other compounds supplemented simultaneously.

I actually thought 6,7-dihidroxybergamottin was responsible for that.
 
luke1984; said:
I actually thought 6,7-dihidroxybergamottin was responsible for that.
1) Naringin is responsible for grape seed's characteristic taste
2) Naringin has pharmacological effects, which include, but are not limited to, selected inhibition of cytochrome P450 enzymes (CYP3A4 / CYP1A2). This inhibition can eliminate the oxidate metabolism of certain compounds by the enzyme, possibly leading to drug interactions. Furthermore, effects and levels of some compounds, including, but not limited to caffeine, can be influenced by simultaneous consumption of naringin. As a matter of fact, naringin has a cumulative effect, a property that can also affect absorption and bioavailability of other compounds.
3) 6’,7’-dihydroxybergamottin is also a particular inhibitor of the CYP34A isoform of the cytochrome P450 enzyme and can trigger similar pharmacological effects as naringin.
 
do you take this on empty stomach in the morning or at night?

I've recently been splitting my dose to 500mg morning/ 500mg before bed on an empty/mostly empty stomach. This has been working amazingly for me, I've really been feeling the libido effects much more this way. I know a prebed dose is generally advised against, to avoid sleeping problems, etc. I haven't experienced any sleep disturbances besides more frequent sex-driven dreams.:twisted: No bathroom issues either.
 
I've recently been splitting my dose to 500mg morning/ 500mg before bed on an empty/mostly empty stomach. This has been working amazingly for me, I've really been feeling the libido effects much more this way. I know a prebed dose is generally advised against, to avoid sleeping problems, etc. I haven't experienced any sleep disturbances besides more frequent sex-driven dreams.:twisted: No bathroom issues either.
:thumbsup:
 
I've recently been splitting my dose to 500mg morning/ 500mg before bed on an empty/mostly empty stomach. This has been working amazingly for me, I've really been feeling the libido effects much more this way. I know a prebed dose is generally advised against, to avoid sleeping problems, etc. I haven't experienced any sleep disturbances besides more frequent sex-driven dreams.:twisted: No bathroom issues either.

aweasome! thanks for the help bro!
 
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