It may not be entirely correct to imply that vitamin b6 is non-toxic.
Apart from differences in our metabolic reactions, some people such as smokers and heavy coffee drinkers have a low level of b6, because smoking and heavy coffee-consumption deplete the vitamin. These individuals would need relatively higher levels of b6 to hit some saturation point versus typical non-smokers.
Furthermore, users of drugs against inflammatory problems of the eyes, GI, skin, and other body parts, as well as antibiotics, and even the estrogen agonist, Raloxifene, would experience depleted b6 levels. Consequently, they would need more b6 than non-users of these drugs, leading to an elevation of the doses required to show toxicity in their bodies.
So, B6, though a water-soluble vitamin, can still be toxic at high doses. A high dose is different for different individuals. Yet, there are some signs of b6 toxicity. These include: tingling and numbness in hands and feet, as well as problems to maintain balance. Fortunately, these symptoms subside when the dose of b6 is reduced.