I didn't want to hijack another thread, so I brought the conversation here. I am admittedly not well versed in this sort of biology and all of my knowledge of the topic is from this board. I would like to hear what those who are versed in biology have to say about the conversation below.
Good Luck, 383. I'll watch with interest.
I really wanna know if this stuff has the same libido boosting/lethargy fighting effects as original 4-AD. (I wanna stack it with Superdrol.)
Keep us informed...
Not to be an a$$, but stacking this with superdrol would just be insane. Superdrol is the most toxic designer available. Stacking it with a multiple methyl coumpound would certainly do some damage to your body on some level.
People make that argument all the time. But I feel that 10mg MethylX + 10mg MethylY = 20mg MethylZ, as far as toxicity is concerned. (This is an over-simplification, but you get the point.)
Over simplification...and more importantly, probably not accurate...do some searching and you'll see what I mean...I don't want to hijack this thread, but this seems appropriate in lieu of what has been said:
Sorry to have made such a long post, but I wanted to be clear on this subject.Stacking two methyls is not that bad, as long as people dont get excessive with the dosages. Its when I see a log with someone stacking 30mg superdrol with 80mg PP, that I start to worry for them a little. With products like these, I would rather try them on their own first, before stacking them, just so I know how I react to each of them. After that, I would stack away.This is completely untrue...
...If people actually attempted to find out how the liver works, they would know what the difference is.
The majority of the damage is not even done by the parent hormone but intermediate metabolites and by using two different subsntances you are greatly increasing the risk of buildup with intermediate metabolites creating a bad situation (metabolite buildup) with different stages of breaking said parent hormones down.There are intermediate stages in which sometimes the metabolite produced is harsher than than the parent hormone. Dbol is a great example because 17 methyl estradiol is much more potent than dbol itself. THe problem is that with the majority of the new substances the metabolites are unknown and you could very easily being introducing a fairly potent metabolite even though the paretn hormone is relatively weak/less toxic.
Its not really about one parent hormone or one enzyme. ITs about mutiple horones and multiple enzymes at various stages. At varisou time the the conversion of hormones into less and/or more substances causes the production of free radicals. YOu also have to understnad htat the liver does numerous tasks (packagin of HDL/LDL/ etc..., serves as the main glucose buffer, converst lactic acid to an important fule rather than a toxic substance, etc...the list goes on and on) so by stressing the liver can easily effect other areas. I remember many people reporting a feeling of hypoglycemia on M1T and Sdrol and this easily could be a results of its effects on the liver and its functioning as being the main glucose buffer (preventing to high or too low glucose levels).
So in the process's of oxidation, reduction, and hydrolysis which converts toxic checmicals into less toxic chemicals the risk of increased free adical products which can easily damage hepatocytes is raised. THis in turn can cause a host of problem with the above mentioned tasks that the liver can perform.
What you are describing specifically is caused induction, where one pathway is overloaded and you can have a buildup of toxins occur. The problem with this is that the majority of those toxins are fat soluble and will accumulate in fatty parts of the body, the main being the brain and hormonal glands. Accumulatin in these areas can cause brain dysfunction and hormonal inbalances in the long run.
Good luck 383. I'll be watching this one.
It's anything but clear to me. But that's probably my fault -- I'm no friggin scientist. And I'm no expert on "intermediate metabolites," but if Bobo says "jump," I say "how high?"
I tend to trust my instincts on "common sense" stuff like this, and I still lean towards the legitamacy of stacking 2 methyls at half strength. But I will entertain thoughtful opinions to the contrary...
So let me try to make some sense of this argument...
If Superdrol and this Methyl Extreme stuff happen to metabolize into compounds that require similar "pathways" of attention by the liver, then these particular pathways will be overloaded, causing a buildup of toxins, and over-stressing the liver.
[Be careful before you agree with this explanation, because there's an obvious flaw in its logic. But this really seems to be what you're saying.]