This is from the CAMBRIDGE INTERNATIONAL INSTITUTE FOR MEDICAL SCIENCE
Please take the time to read all of the article as it is very informative and you will ever see the EFA's the sama way again!
Omega-3’s derivative PGE3 isn’t nearly as powerful or as effective as
Omega-6’s PGE1. The function of omega-6 and its derivatives like AA (arachadonic
acid) is to prevent, not cause inflammation (unless required by the
body to seal a wound). The mistake often made by researchers is the assumption
that increased AA automatically increases PGE2—an inflammatory. This
assumption is incorrect because the body manufactures PGE2 AS NEEDED.
All EFA derivatives are manufactured as needed and this is no exception.
Arachadonic acid is anything but harmful: AA is the precursor to prostacyclin—
the most potent anti-aggretory agent (a natural “blood thinner”)
The Scientific Calculation of the Optimum PEO™ Ratio
and inhibitor of platelet adhesion.18 AA contributes to smooth working of
vascular function and blood flow. AA provides eicosanoids for response to
injury—acting as a healer—helping to seal the wound. It is critical.
overdosing on omega-3 can lead to profuse
internal bleeding from eicosanoid overproduction!
“ In practice, AA is a major component of the endothelial [inner
arterial lining] phosphoglycerides, particularly on the inner cell
membrane layer. AA and adrenic acid are consistent companions
in other cell membranes. It is the precursor for prostacyclin: a
vasodilator and inhibitor of platelet adhesion.
“…AA acts as contributor to the smooth working of blood flow
and vascular function.”
“… If there is damage to the endothelium, such as in bruising,
infection or cutting, then the phospholipases release AA. In the free
form, and in conjunction with activated platelets, AA is peroxidized
to provide eicosanoids for the response to injury.
“Thus, they [AA] contribute to vasoconstriction and thrombosus to
seal the wound. Without this response we would be in trouble.” The
same principle applies to the inflammation response which again is
much needed for survival. AA is anything but the dark side.
“… The problem is that certain chronic disease conditions such
as arthritis and ischemic heart disease, the damage already done,
results in chronic stimulation of this response to injury… This is
not the fault of AA or DGLA, but of the original cause of damage
….” (Emphasis added.)
AA is critical. Don’t let anyone tell you that parent omega-6 causes a
“problem” in excess AA production. Arachidonic acid (AA) is a critical biochemical
component, and occurs in virtually every cell we have! It is the
building block of the most potent anti-aggretory (“helps blood thinning”)
agent known (prostacyclin). This omega-6 derivative also inhibits platelet
adhesion (a natural “blood thinner). AA helps SOLVE vascular problems as a response to injury in a fashion like cholesterol. So once again, just like
cholesterol, the “problem solver” is incorrectly blamed as the cause of the
problem. There is always a balance between opposing forces. For example,
one biological substance increases blood pressure and another one decreases
blood pressure. Even though we frequently hear the terms good and bad,
there is no “good” or “bad.” There is only complementary function. We must
ensure our bodies have enough biochemical substances to ensure both effects
can be carried out automatically.