Accutane is very harsh on the liver, as you well know. Most Dermatologists won't even prescribe Accutane to you unless they know that you are going to come in monthly for blood tests to assure your liver isnt suffering. So as far as supplements go I would advise you not to take any. I would also take some liver support OTC's like fish oil and milk thistle. You need to take this time in your life and revert back to basics while your body gets rid of the acne. Get on a very lean clean diet and make sure that you are getting all the nutrients that you need. Remember that your muscles develop memory so that even if you lose some weight once your are done with the Acctane you can regain it back quite quickly. Accutane is NO joke, but it works.