benzo / gaba question

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    Question benzo / gaba question


    Are benzos GABA agonist?, or are they synthetic GABA neurotransmitters?

    Ex. Does xanax stimulate the brain to release more GABA or does it just bind to the the GABA A receptor sites and stimulate them that way?

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    As far as I know


    The Benzo have receptor protien binding sides in the area where the GABA is normally release causing the sedative effect. I am not sure if this is right but I think this occurs in a pregaglionic synapes in the limbic system.


    Now I believe that the benzos dont directly antagonize the same receptors as the neurotransmitter but works in increase the about of GABA the inhibits the appropriate neuron... its been along time since I was in school so I hope some one else can offer more

    Roman
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    Quote Originally Posted by sdb88m361 View Post
    Are benzos GABA agonist?, or are they synthetic GABA neurotransmitters?

    Ex. Does xanax stimulate the brain to release more GABA or does it just bind to the the GABA A receptor sites and stimulate them that way?
    Binds to stereospecific benzo receptors at several sites in the CNS, resulting in enhancement of the inhibitory affect of GABA.
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    And always remember

    Enters breast milk/not recommended for Lactating nipples

    Knowing is half the battle!
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    So would somthing like phenibut be safer then say valium?
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