benzo / gaba question
- 08-23-2007, 10:52 PM
- 08-23-2007, 11:45 PM
As far as I know
The Benzo have receptor protien binding sides in the area where the GABA is normally release causing the sedative effect. I am not sure if this is right but I think this occurs in a pregaglionic synapes in the limbic system.
Now I believe that the benzos dont directly antagonize the same receptors as the neurotransmitter but works in increase the about of GABA the inhibits the appropriate neuron... its been along time since I was in school so I hope some one else can offer more
08-24-2007, 02:59 AM
08-24-2007, 06:52 AM
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08-24-2007, 10:20 AM
11-09-2014, 09:37 AM
11-09-2014, 11:33 AM
11-09-2014, 12:57 PM
11-09-2014, 12:58 PM
11-09-2014, 12:58 PM
11-09-2014, 01:08 PM
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11-09-2014, 01:25 PM
11-09-2014, 01:27 PM
i didnt say those are same thing and didnt talked how they do it, i did say both make you calm but Serax is more effective i think i know (former panic attack guy) I got 5 hour straight calm effect the first 2 hours are the best. Gaba gives steady effect and i only use it when i cant get sleep, better than drugs but its not even close like effect as Serax gives.
11-09-2014, 01:27 PM
11-09-2014, 01:29 PM
11-09-2014, 01:31 PM
And another thing nowdays Pikatropin is my future choise simply that Pikatropin kicks in faster and harder and its gaba niacin combo. I use hybrid nutritions neuropump and after every workout the calm effect hits hard, strange the calm doesnt come when training only after as it is preworkout.
11-09-2014, 01:32 PM
11-09-2014, 01:38 PM
Oh... I mean Hybrid Neuropump. Cool preworkout if try to find preworkout like old jack3d and craze without caffeine that i cant use anymore B)
11-09-2014, 01:52 PM
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11-09-2014, 02:13 PM
Thanks i red the link looks interesting. Very bold claiming for they to say that it works better for the pumps than caffeine but i hope it does because the pump that comes from the brain is always more vascular than the pump effect that comes from normal arginine and so on ... Not that i say those suck but what i remember when i used old jack3d and craze
11-19-2014, 03:51 AM
They're agonists; which long term can cause down regulation. Picamilon is a good way to counter this as it causes upregulation of GabaA receptors
11-19-2014, 08:57 AM
11-19-2014, 09:27 AM
Granted it's discussing Piracetam as well; I ca certainly attest to a lowered benzo tolerance after use of Picamilon
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11-19-2014, 10:56 PM
author, journal, and date or a link please?
11-19-2014, 11:48 PM
11-20-2014, 12:06 AM
Thank you for the link Now, any articles in English? Dopamean1, did you read this article or are you going off the abstract?
11-20-2014, 12:17 AM
I'm interested too; I also would have thought it would cause receptor downregulation, not the opposite.
11-20-2014, 09:54 AM
I just pmd a guy about Benzos, I want to wean off Klonipin and am going to see my Doc about the best way to achieve this. Ive lost all motivation to do anything other than what I have to. I would love to hear anybody success or failure of getting off this med and how they went about getting off. Ive read alot of horror stories about weaning off. Need some AM help or suggestions on this.....
11-20-2014, 10:58 AM
Stick with whatever schedule your physician suggests to come off of it. I came off of it with no side effects because I was carefully titrated off. Xanax was the only one that gave me issues which were tolerable and lasted about 3 weeks.
11-20-2014, 01:11 PM
I plan on using the Docs protocol when I get in to see him, how long did it take U to get completely off and exactly how did he wean Ur dosages ???
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