The first problem with this substance is that glycocyamine is known to increase our blood levels of homocysteine, which is thought to be a risk factor for cardiovascular disease. This means that we're more likely to have heart disease/atherosclerosis when our homocysteine levels are high. Oh, and don't forget that cardiovascular disease is still the #1 killer in the Western world.
It's recently been reported that the correlation between homocysteine levels and cardiovascular disease isn't as strong as once thought which some have used to justify their consumption of glycocyamine. To put it bluntly, this weaker correlation means that you're not quite as likely to die as once thought from consuming this substance.
...the worst part about glycocyamine has been described as "neurotoxic action" (6).
Among the effects of glycocyamine is an inhibitory effect on a brain enzyme called the sodium pump (8, 9). This isn't just any enzyme; the sodium pump is responsible for all nerve signals that happen in our body.
What's worse is that the sodium pump is so important that it exists not only in nerve cells, but in every single cell in the body. This means that although only the brain has been studied (so far), glycocyamine has the potential to disrupt the proper functioning of every cell.
To Summarize the Potential Problems Associated With Glycocyamine
Increased risk of cardiovascular disease
Increased oxidative damage
At best it is no better than creatine
More expensive than creatine
Inhibition of one of our most important enzymes (affects every cell)
Implicated in reducing muscle strength