[Arzi75]

Just ordered my first 6-OXO Extreme - as I have been struggling with some gyno for some time, I have used quite a few AIs to keep my gyno in check, plus, at same time wishing to gain some elevation in my T-levels.

As a consequence, I have developed some serious conditions in my joints, knees expecially, to the extent of not being able to walk up a flight of stairs without some orthopedic support on.

Should I expect to see the same type of exacerbation of my joint problems with 6-OXO or is 6-OXO more lenient on your joints i.e. will not dry out my joints like the most other ATD variants on the market currently?

I plan to dose the 6-OXO at a 100-300mg range to gain the most out of the LH elevation and to alleviate the effects it might have on my joints.

[coug42]

6-oxo extreme is going to dry you out just as much and won't do much at all for the gyno. If you can get your hands on some Nolvadex or liquid tamoxifen citrate i would use that. That will help a little with the gyno and also allow you to experience the positive effects of estrogen (ex: joint health) while also letting your LH levels recover. It does not completely crush your estrogen like an Aromatase inhibitor but it works rather as a SERM or Selective Estrogen Receptor Modulator thus preventing the negative effects of estrogen but not the positives. I would also try a natural test booster that doesn't contain an AI like ActivaTe extreme or Hypertest and then to help the Joints feel better i would get some Cissus. Cissus will make your joints feel a lot better.

-Tamoxifen Citrate
-Natural test booster (without an AI)
-Cissus

[armando201]

Hi

I just registered first time. Saw your comment regarding the use of Tamoxifen Citrate. I was reading up on it..Was very excited about this alternative being that I had the same problem. Million thanks to you for providing your info. Is it safe to use that you know... also the Nolvadex I noticed was really expensive rather than Tamoxifen Citrate. I guess I can get the Tamoxifen being that is cheaper and have same effect..... Anyway I'll get this Tamoxifen Citrate, just a bit scared of any negative side effects...

[thebigt]

Originally Posted by armando201

Hi

I just registered first time. Saw your comment regarding the use of Tamoxifen Citrate. I was reading up on it..Was very excited about this alternative being that I had the same problem. Million thanks to you for providing your info. Is it safe to use that you know... also the Nolvadex I noticed was really expensive rather than Tamoxifen Citrate. I guess I can get the Tamoxifen being that is cheaper and have same effect..... Anyway I'll get this Tamoxifen Citrate, just a bit scared of any negative side effects...

some people claim to have gotten much better chest appearance with formestane, ok im one of them. dont think it will 'cure' real gyno, but i think most people just have pseudo-gyno-chest fat. for what its worth my chest has never been better. lots of threads look um up.

[strategicmove]

Cissus and an EFA (Essential Fatty Acids) supplement with a good concentration and ratio of omega 3-6-9 should be part of the arsenal for fighting those joint problems.

[Patrick Arnold]

Originally Posted by coug42

6-oxo extreme is going to dry you out just as much and won't do much at all for the gyno. If you can get your hands on some Nolvadex or liquid tamoxifen citrate i would use that. That will help a little with the gyno and also allow you to experience the positive effects of estrogen (ex: joint health) while also letting your LH levels recover. It does not completely crush your estrogen like an Aromatase inhibitor but it works rather as a SERM or Selective Estrogen Receptor Modulator thus preventing the negative effects of estrogen but not the positives. I would also try a natural test booster that doesn't contain an AI like ActivaTe extreme or Hypertest and then to help the Joints feel better i would get some Cissus. Cissus will make your joints feel a lot better.

-Tamoxifen Citrate
-Natural test booster (without an AI)
-Cissus

resveratrol is a SERM and is in 6-oxo extreme. have gottten some good feedback regarding joint health from users. don't write it off

[jonny21]

Originally Posted by Patrick Arnold

resveratrol is a SERM

Huh? Please explain. I know it is a phytochemical but have never heard it called a SERM.

Edit: actually, after some research I found:
CANCER
Resveratrol has been shown to inhibit cancer initiation and promotion [2] It acts as a selective estrogen receptor modulator (SERM) and regulates proteins involved in DNA synthesis and cell cycle. Resveratrol also affects the activity of transcriptional factors involved in proliferation and stress responses, such as NF-kB, AP1 and Egr1. [3]

SPERM PRODUCTION
In a study, researchers administered 20 mg/(kg . d) of trans-resveratrol for 90 days. Compared to a control group, the diameter of the seminiferous tubules was significantly reduced from 437.5 +/- 0.1 mum in the controls to 310.9 +/- 0.1 mum. This decrease was accompanied by a significant increase in tubular density. Sperm counts were significantly greater in the resveratrol-treated rats than in the control group, but sperm quality did not differ.

BTW: got a kick out of the HBO special. Props to you.

[thesinner]

"Technically" a SERM is reserved for synthetic drugs, but resveratrol definitely does a comparable job as a phytochemical.

Who would have thought something found in peanuts would grow your peanuts as well.

[Patrick Arnold]

Originally Posted by thesinner

"Technically" a SERM is reserved for synthetic drugs, but resveratrol definitely does a comparable job as a phytochemical.

Who would have thought something found in peanuts would grow your peanuts as well.

SERM has never really been specific towards synthetic drugs, though in the bodybuilding world it first gained recognition in the context of such

[thesinner]

Originally Posted by Patrick Arnold

SERM has never really been specific towards synthetic drugs, though in the bodybuilding world it first gained recognition in the context of such

yeah, it's more of a connotation thing, I guess.

[steve777]

Originally Posted by Patrick Arnold

resveratrol is a SERM and is in 6-oxo extreme. have gottten some good feedback regarding joint health from users. don't write it off

Any comments regarding the oral bioavailability of resveratrol? re:

http://anabolicminds.com/forum/ibe-t...sveratrol.html

[steve777]

Originally Posted by strategicmove

Cissus and an EFA (Essential Fatty Acids) supplement with a good concentration and ratio of omega 3-6-9 should be part of the arsenal for fighting those joint problems.

I have also had success with MSM, Chondrotin and Glucosamine sulfate. Also have ordered some Celedrin and boswellia extract. Used to have nagging tendons in the shoulder areas frequently. Not any more.

[EasyEJL]

Originally Posted by steve777

Any comments regarding the oral bioavailability of resveratrol? re:

http://anabolicminds.com/forum/ibe-t...sveratrol.html

If you are concerned about oral availability, there is always Dermacrine or Dermacrine Sustain from Primordial Performance. Has Resveratrol as an ingredient. I like 6-oxo extreme as well, just took 5 caps

[Patrick Arnold]

Originally Posted by steve777

Any comments regarding the oral bioavailability of resveratrol? re:

http://anabolicminds.com/forum/ibe-t...sveratrol.html

resveratrol's bioavailability can be improved by including compounds that inhibit glucuronidation and sulfation, which are its major deactivation pathways

or you can just take large dosages, since resveratrol can inhibit its own deactivation (probably due to enzyme overload)

[Patrick Arnold]

Originally Posted by EasyEJL

If you are concerned about oral availability, there is always Dermacrine or Dermacrine Sustain from Primordial Performance. Has Resveratrol as an ingredient. I like 6-oxo extreme as well, just took 5 caps

i don't see resveratrol being very well absorbed transdermally. it has terrible solubility properties

plus you still are going to get rapid extensive deactivation even through the transdermal route

[steve777]

Originally Posted by Patrick Arnold

resveratrol's bioavailability can be improved by including compounds that inhibit glucuronidation and sulfation, which are its major deactivation pathways

or you can just take large dosages, since resveratrol can inhibit its own deactivation (probably due to enzyme overload)

For us laymen, what would those inhibiting compounds be? And what would be considered a "large" dose? I am using a powder Trans resveratrol powder 50% polygomum cuspidatum dosing at 100mg trans-resveratrol 2X/day. The thread referenced also gets into concerns about the stability of resveratrol. The argument is that since it is an anti-oxidant, it is subject to breakdown even in air.