5-htp should not be used by those hypersensitive to any component of a 5-HTP-containing product. It is also contraindicated in people with carcinoid tumors, and during or within 2 weeks after discontinuation of an MAOI.
Large doses of 5-HTP can trigger excess of serotonin formation in tissues other than the target organ and cause significant adverse effects. It should not be used concurrently with any antidepressant, including SSRIS, tricyclics, or MAOIs. Concurrent 5-HTP use with an antidepressant may increase the risk of adverse reactions. 5-HTP should not be used by those with ischemic heart disease, coronary artery spasm, uncontrolled hypertension and any other significant cardiovascular disease.
Some people taking 5-HTP have reported experiencing eosinophilia and eosinophilia-myalgia syndrome (EMS). EMS is similar to that caused by L-tryptophan and was linked to contaminants in 5-HTP’s preparation, rather than 5-HTP itself. Changing the 5-HTP resolved the EMS in one group of patients. In some people taking 5-HTP in conjunction with carbidopa, a scleroderma-like skin condition has been reported.
Other side effects reported include appetite loss, vomiting, difficulty breathing, diarrhea, and nausea. Neurological side effects, including dilation of the pupils, loss of muscle coordination, blurring of vision and abnormally sensitive reflexes, have been reported in those taking large doses. Cardiac dysrhythmias have also been reported by some.
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