IDS DHB Anabolic Amplifier
- 06-27-2003, 09:12 PM
IDS DHB Anabolic Amplifier
Anybody hear of this? Looks promising as an oral absorption enhancer, but then again so did naringin!
Anabolic Amplifier TM
Over 500% more active Testosterone to your bloodstream with your Current Prohormone dose ?
What if someone had told you there was an inexpensive product that could a testosterone supplement effect so dramatically that you could get from 287% to over 500% more active testosterone in your bloodstream with your current pro hormone or oral steroid dose ? Even cutting your daily dose in half while taking it could actually result in dramatically higher levels of anabolic testosterone in your bloodstream and dramatically more muscle!
The ?Chemistry ? ?
How is this groundbreaking anabolic agent accomplishing these unbelievable results? Break out your PDR, Chemistry and Anatomy books for this one. The active ingredient in DHB Anabolic Amplifier TM is derived from the furanocoumarin family. There are literally hundreds of studies on this natural extract phenomenon in conjunction with pharmaceuticals showing dramatic, really dramatic increases in plasma (blood) drug concentrations when people ingest DHB with or around the same timeframe. These results are especially impressive in drugs with notoriously low oral bioavailability, i.e. Drugs with a high first pass metabolism (Over 60% of drugs are destroyed by the first pass metabolism). The results of DHB use with pharmaceuticals have been so significant that Pharmacists and Doctors now warn against ingesting foods containing DHB with certain medications! The DHB could increase the blood plasma levels of drugs with normally low toxicity to dangerous levels!
DHB Anabolic Amplifier binds immediately to enzymes which break down drugs and prohormones to carry them away?
I know that there is one phrase above that may have caught your attention, ? First Pass Metabolism? . How many times have you heard that oral steroids and their close cousins prohormones are destroyed or ? Metabolized ? in the first pass through the small intestine and liver? Large percentages of these anabolic hormone compounds are all metabolized (destroyed) by the isoenzymes CYP and P450 before they are able to enter the bloodstream. DHB Anabolic Amplifier TM actually prevents these enzymes from metabolizing or breaking down anabolic hormones!!
During the trip through the GI tract to the bloodstream, testosterone supplements travel through a destructive mine field laden with enzymes deadly to these hormone agents. This area begins in the small intestine and continues once the hormone enters the liver. These crucial sections of the digestive system contain enzymes, which are highly effective at attaching to anabolic molecules of testosterone making them inert and useless. These are the enzymes from which pharmaceutical companies as well as supplement companies have spent millions of dollars trying to protect drugs and supplements.
Attacking the CYP and P450 Enzymes is most inexpensive and effective way protecting testosterone?
It has been said that the simplest answer is usually the correct one. DHB Supplement Amplifier TM is a simple answer for this very complex and expensive problem. After years of attempts by IDS and other companies to alter the prohormones to protect from enzymes, with some degree of success, IDS decided to the enzymes themselves.
DHB Supplement Amplifier TM is designed to compete with the substrate hormone to attach itself to the enzyme. DHB Supplement Amplifier TM has a stronger affinity to the enzyme than the hormone product resulting in these destructive enzymes attaching themselves harmlessly to DHB Anabolic Amplifier TM . The body then washes the enzyme harmlessly from the out of the body! Again, the enzymes CYP and P450 are the enzymes responsible for metabolizing and destroying steroids and prohormones. They can be removed from your body, paving the way for anabolic hormones to flood your bloodstream to yield massive muscle growth like never before!
This is truly a new class of product. Possibly the most significant advancement in sports supplement technology since the anabolic steroid itself!
- 06-27-2003, 09:13 PM
Grapefruit juice anyone?
Studies Involving Cytochrome P450 CYP3A4
We and others have shown that co-administration of grapefruit juice can reduce the observed pre-systemic metabolism of a number of drugs by inhibition of CYP3A4, the major cytochrome P450 drug metabolizing enzyme in the gut. A number of psoralens, coumarins, and flavonoids found in grapefruit have been hypothesized to produce this inhibition. We recently reported the and identification of 6',7'-dihydroxybergamottin (6,7-DHB), a derivative of the previously described furanocoumarin bergamottin, from a methylene chloride extract of grapefruit juice. Although 6,7-DHB had previously been identified as a component of grapefruit (but not orange) juice, our data was the first to suggest that it acts as a potent inhibitor of CYP3A4. 6,7-DHB and its analogues could theoretically find therapeutic use as agents to increase the oral bioavailability of certain drugs, and/or to prevent the activation of carcinogens, by inhibiting CYP3A4-mediated gut metabolism in vivo. For this reason, we sought to develop an efficient synthesis of 6,7-DHB that could be readily adapted to the production of rationally designed analogues. A synthesis leading to bergamottin (1) has been reported, (10% overall yield for two steps), and a preparation of 6,7-DHB (2) from 1 has also appeared in the literature. However, the extremely low yield resulting from these syntheses is not satisfactory for the efficient production of either 1 or 2. The synthetic route used by our group to afford 6,7-DHB is outlined in Scheme 3 below.
The commercially available furanocoumarin bergapten (3) was demethylated using a previously published procedure, producing the corresponding phenolic derivative bergaptol, 4. Geranylation of 4 under phase transfer conditions (geranyl bromide, benzyl tributylammonium bromide, NaOH) then afforded bergamottin 1 in 98% yield. Subsequent treatment of 1 with m-chloroperbenzoic acid then resulted in selective epoxidation of the terminal double bond of the geranyl sidechain, affording bergamottin-6,7-epoxide 5 in 65% yield. Opening of the epoxide (3% perchloric acid in dioxane) then produced the desired 6,7-DHB 2 in 70% yield. We have recently used this synthetic route to produce the proposed irreversible inhibitor 6-vinylbergamottin, and this analogue is now being evaluated as an inhibitor of CYP 3A4.
06-27-2003, 09:14 PM
67 DHB Grapefruit Inhibitor - 96-387
The invention comprises a composition and methods for inhibiting cytochrome P450 enzyme activity and, in particular, inhibiting the activity of the cytochrome P450 3A sub-family of enzymes, specifically, CYP3A4. It is believed that 6’,7'-dihydroxybergamottin, a furanocoumarin, is the compound primarily responsible for the inhibitory effects of grapefruit juice on cytochrome P450 enzyme activity. The compound is potentially useful as an inhibitor of cytochrome P450 by incorporating 67DHB into the formulation of a drug for the purpose of improving the bioavailability of the drug. It may also be useful by itself as a chemopreventive agent to reduce cancer risk. U.S. Patent #6,160,006 Contact: Fred Reinhart.
06-28-2003, 06:15 AM
06-29-2003, 09:11 PM
06-29-2003, 09:16 PM
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