What is NCG-CR?

[MrTotality]

Just saw an ad for BSN's new product called NCG-CR. It is listed as a "hypertrophic muscle activator and anabolic potentiator". Anyone heard of this?

 

[pistonpump]

cant find anything on it.

 

[MrTotality]

There is an add in Muscle and Fitness with Ronnie Coleman posing. It is supposed to be out this summer

 

[bLacKjAck.]

My guess is protein powder with added leucine..but what do I know..

 

[djbombsquad]

http://anabolicminds.com/forum/supplements/67646-ncgcr-bsn.html

 

[MrTotality]

http://anabolicminds.com/forum/supplements/67646-ncgcr-bsn.html

that was nothing new

 

[pistonpump]

There is an add in Muscle and Fitness with Ronnie Coleman posing. It is supposed to be out this summer

i think what he and we want to know is what is in it...

 

[djbombsquad]

Call up BSN they will tell you. It is for the public.

 

[MrTotality]

based on the add and description I was assuming it was a similar product to RPM, that is why I am curious

 

[sdmf45]

I think it may be a PH or PS but isn't it summer already...:think:

 

[djbombsquad]

Word.

 

[Pimp C]

i beleive it is there up and coming preworkout supplement. think of noxplode version 2. i don't think it's going to be out till the end of the year though.

 

[Big BAMA]

Normal Cost Gouging- Crap Really= NCG-CR. My bet is it is something that is overpriced and something else for the Magic Pill Crowd.

 

[djbombsquad]

Well I hope it is better than nanovapor, super pump 250 or no shotgun.

 

[MrTotality]

I am not a BSN guy by any means, but I hadnt heard anything so I was curious

 

[jdev]

http://anabolicminds.com/forum/nutraplanet/69617-bulk-n-carbamylglutamate.html

this may be it

 

[pistonpump]

i think so. fits the NCG part. now what is this CR?

 

[ugab37]

controlled release

 

[pistonpump]

haha yeah i was thinking that. now i wonder how much this stuff ACTUALLY costs and how much they are gonna rape people for...

 

[ShawnC]

For anyone that may be looking for more information on NCG-CR you can go to bsnonline and download their new catalog. One page 26 & 27 there is an insanely detailed explanation of what it is, how it works etc.

 

[pistonpump]

from the catalog:

Humans lacking the enzyme Nacetylglutamate
synthase (NAGS), which
catalyzes the synthesis of NAG, suff er from
hyper-ammonemia, or high blood ammonia
levels.3 Not good! As a means to
potentially treat this condition, researchers
found that supplementation with NAG was
ineff ective.4 As a result, in order to conquer
NAGS defi ciency, researchers needed to
fi nd a molecule that could act as the ‘key’
to the ignition of the urea cycle, CPS-I. On
that line, they discovered that our old friend
NCG, (remember, it’s a biological analogue
of NAG) was the remedy, as it is an allosteric
activating key for CPS-I, allowing the
urea cycle to function without NAG.
In addition to this function, NCG
also performs the same role as an allosteric
activating key for the enzyme pyrroline-5-
carboxylate synthase (P5CS) in enterocytes,
or intestinal cells. Pyrroline-5-carboxylate
(P5C) is an intermediate in Proline (an
amino acid) synthesis. Th is is important
given that a majority of Arginine is synthesized
from the Citrulline and Proline produced
in the small intestine, and ultimately
gets transported to the kidneys and liver
respectively. While Arginine is not produced
in the small intestine, CPS-I is still
activated by NCG to enable the conversion
of carbamoyl phosphate and Ornithine to
Citrulline. Simultaneously, NCG activates
P5CS which, similarly, enables the conversion
of P5C to Proline.
Knowing that a majority of Arginine is
synthesized from the amino acids Citrulline
and Proline, and further realizing that NCG
plays a role as an activating key for this
process, it should come as no surprise to
those scientifi cally inclined that NCG may
play a role in increasing plasma Arginine
concentration. In fact, previous research in
the fi eld has revealed that NCG is a
metabolically stable form of N-acetylglutamate,
the molecule that activates
carbamoyl phosphate synthase during
the urea cycle.
In 2004, a group of animal scientists
evaluated Arginine nutrition in
neonatal piglets and more recently, this
same group of scientists revisited that
same premise by conducting a study
on the eff ects of oral NCG supplementation
on muscle protein synthesis in
the skeletal muscle of piglets. Th is newly
uncovered research demonstrates that NCG
can lead to an increased plasma concentration
of the amino acids Arginine, Ornithine
and Citrulline. In this particular study, oral
administration of NCG on nursing piglets
was found to increase plasma Arginine concentrations
by 32% over control piglets.2
Th e graph above demonstrates an increase
in the synthesis of citrulline and arginine
from glutamate (left) and from proline
(right) in NCG versus control piglets.2
Researchers speculated that this
increase in Arginine concentration led to
an increase in the growth rate of the pigs.
[Now before you get up in arms about why
the study was conducted on piglets, keep
in mind that for years, investigators have
used pigs as a model in biomedical research
because of the similarities in physiology
to humans. Recently, researchers at the
University of Illinois at Champaign-Urbana
announced the unbelievable similarities
between the human and pig genomes.]
NCG also led to increased Somatotropin
(a growth hormone [GH] that stimulates
protein synthesis, muscle hypertrophy and
lipolysis). Th ese NCG eff ects are likely mediated
through two mechanisms1) NCG
works to improve the function of the urea
cycle, helping to enhance positive nitrogen
balance while, (2) Simultaneously facilitating
the conversion of Ornithine to the
Citrulline that will be converted to Arginine
in the kidneys.
So noteworthy is the discovery of this
NCG bio-analogue and its role in muscle
growth and athletic performance that BSN
is currently formulating and beta-testing a
new NCG supplement the likes of which
have never been seen before in sports
nutrition! NCG-CR™ as this product is
tentatively named will mediate its eff ects
through hypertrophic muscle activation and
anabolic potentiation, which could very
well alter the physiological mechanisms
involved in muscle growth vis á vis protein
synthesis! Stay tuned to Body & Style™
for more breaking news on NCG-CR™,
including results from the beta-testing
sample!

 

[thebull11]

link

jn.nutrition.org/content/137/2/315.full

Here ya go, bro.