davidcyt
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i am about to start my havoc cycle, is it ok to use rpm during cycle? or during PCT?
what type of cycle are you on?i am about to start my havoc cycle, is it ok to use rpm during cycle? or during post cycle therapy?
Depending on your cycle, it has good uses during both cycle and PCT.Save it for post cycle therapy or after. Do NOT take it with orals or things like Nolva because the naringinen enhances the effects (to the point of possibly being dangerous) of many different drugs.
Well I took it one time while on orals... uh oh.Save it for post cycle therapy or after. Do NOT take it with orals or things like Nolva because the naringinen enhances the effects (to the point of possibly being dangerous) of many different drugs.
Agreed- naringin alters the pharmacokinetics of many drugs, extending their half-life in the body- this can be a good thing or a bad thing- it is simply something that someone needs to be aware of when taking RPM- especially when taking harsher 17-aa orals.It's just something to keep in mind. We know there are subtle problems with grapefruit juice and things like Nolva, so if taking anything that may stress the liver/be toxic, you may want to space out the dose so you're not taking them at the same time.
Well I took 6 RPM one day. On the same day I had taken 40 mg of epistane... sooo...Agreed- naringin alters the pharmacokinetics of many drugs, extending their half-life in the body- this can be a good thing or a bad thing- it is simply something that someone needs to be aware of when taking RPM- especially when taking harsher 17-aa orals.
I think RPM will stack extremely well with any of these compounds, and can be used effectively for post cycle therapy, or stacked with PS/PH, BUT the user needs to be extremely careful when mixing these compounds- b/c the naringin in RPM will optimize/extend the effects of anything taken along w/ it, so please use caution, and start small!!!
Sooo, if it is not hepatoxic...it should not be a big deal. For example, Ergo 1AD, Derm 4AD, and RPM should not be an issue? :think:Agreed- naringin alters the pharmacokinetics of many drugs, extending their half-life in the body- this can be a good thing or a bad thing- it is simply something that someone needs to be aware of when taking RPM- especially when taking harsher 17-aa orals.
I think RPM will stack extremely well with any of these compounds, and can be used effectively for post cycle therapy, or stacked with PS/PH, BUT the user needs to be extremely careful when mixing these compounds- b/c the naringin in RPM will optimize/extend the effects of anything taken along w/ it, so please use caution, and start small!!!
Just be careful- and be cogniscient of how the naringin effects things- as long as you know what your monkey is taking, and how everything effects said monkey (usually comes through some trial and error; always start small)- you will be OKSooo, if it is not hepatoxic...it should not be a big deal. For example, Ergo 1AD, Derm 4AD, and RPM should not be an issue? :think:
RPM was going to be my monkey's secret weapon on that stack!
Any thoughts?
Both my monkey and I thank you!Just be careful- and be cogniscient of how the naringin effects things- as long as you know what your monkey is taking, and how everything effects said monkey (usually comes through some trial and error; always start small)- you will be OK
More interesting findings about possible RPM interactions with SERMs
from CAT.INIST :
"Tamoxifen and toremifene have a bioavailability of approximately 100%, whereas that of raloxifene is only 2%. SERMs are very highly bound to plasma proteins (>95%). Tamoxifen and toremifene are metabolised by the cytochrome P450 enzyme system, and raloxifene is metabolised by glucuronide conjugation."
Naringin also inhibits this P450 enzyme system so might interact with tamoxifen and toremifene. However, they both have high bioavailability, suggesting that it won't be as big a problem.
If that is indeed the Scooby Doo "uh oh," I don't understand what it's for. I was implying that RPM would be alright to take with most things, and the naringin content should not have a big negative effect on prosteroid/prohormone or SERMs.rut ro
LOL, my bad, i misunderstood what you said.If that is indeed the Scooby Doo "uh oh," I don't understand what it's for. I was implying that RPM would be alright to take with most things, and the naringin content should not have a big negative effect on prosteroid/prohormone or SERMs.
Those with prescription meds for things like blood pressure or mood might want to definitely check with a doctor, though.
So this might suggest some unexpected or more pronounced toxicity issues if not careful about using RPM on a cycle or in post cycle therapy. Spacing apart the dosing of a PS/PH, oral, or SERM with that of RPM might help minimize this concern, but still keep the benefits of each about what they are regularly. Lowering dosages also could help if taking both together, but probably more risky since there's no definite answer right now on how much of an increase in bioavailability and half-life the naringin will cause.A very interesting approach- it has some pro's and con's- I can give you at least a little more insight.....
Here is what we do know:
- Naringin has been shown to increase the bioavaliability of cholesterol-based hormones (PH's,PS's, estradiol, oral anabolic steroids), caffeine, SERMs, PDE5 inhibitors, and numerous other compounds
- Naringin increases the half-life of cholesterol-based hormones, caffeine, SERMs, PDE5 inhibitors, and others in the body..
So you have a compound (Naringin) that lengthens the half-life and increases the bioavaliability of certain compounds
I think it's been most people's experience that there isn't a big problem in fluctuating blood levels of the oral that they're pulsing. This is just how I remember reading about it, but anyone who has experienced otherwise please say so.Taking RPM opposite the pulsed compound could be beneficial, but it is also dependant on the half-life of the pulsed compound- the half-life on most orals runs from 4-8 hours, this leads to a con- when taken in a one day on/one day off fashion, this will cause large fluctuations in blood levels of RPM, and whatever the pulsed compound is...
Good to know, thank you for explaining, sir!...Remember that while RPM works right away, it also has cumulative benefits- and many of these benefits arise from keeping relatively stable blood levels...
Agreed about the tag lines/directions on RPM- we (at AN) are still learning how potent this compound really is long term (amazing!!), so the more feedback I get, the more I pass it on to our customers....Good to know, thank you for explaining, sir!
Now in the absence of all the other drug interaction junk we talked about:
This also means you'd recommend RPM as not strictly a pre-workout supplement, but possibly dosing a couple times of the day? I ask because the description and directions of RPM aren't clear about this. It's said to be a preworkout formula, but dosings are listed in capsules/day by bodyweight. Might want to get someone to reword those directions to make it clearer.
To my knowledge, based upon all avaliable research- there is no reason to cycle RPM- it seems to be safe over long periods of timethanks all you guys to explain this so detailed. This forum is much better than others.
i am thinking
RMS mationed that its good to use rpm in the long term, does that mean we dont have to cycle it(if only use it as a pre work out supplement)
thanks again for all you guys
Try RPM with it- but start small and work your way up- should be a potent stack!!!hmm got my RPM today but im taking methoxy TST currently.....
RPM has several Aromatase Inhibitors (grape seed, naringenin, and icariin) included in the formula in substantial amounts, and all AIs share a common action: SHBG inhibition- this is good for free test, but can have a negative effect on libido in some compounds that do prevent SHBG.How can RPM both inhibit SHBG AND be a libido booster? I seem to recall that the Activate and ReBound XT stack that I took a while back was a big SHBG inhibitor, and I had NO sex drive whatsoever. A lot of people report that with this stack. How can RPM do both?
Understatement of the year!it took a lot of trial-and-error, but I think the result turned out pretty well (RPM).
Let us know how it turns out!!Just took 4 caps and im about to go do some cardio. Im going to wait until about 2 or 3 to take my tst to make sure there isnt a negative reaction between the two just to be on the safe side.....im already feeling the surge of energy so i have a feeling this workout is gonna be kick ass!
Awesome!!Understatement of the year!
Pride leads to disgrace,but with humility comes wisdom. - Proverbs 11:2
Must be true!
My RPM should be waiting for me at my doorstep when I get home!
:dl: :squat: :clean:
today's cardio workout was insane. I was sweating way more than i ever had before and i didnt want to stop after 60 minutes so i had to force my self to. It's only day 1 but this sure seems to be the real deal.. GREAT PRODUCT AN!!!Let us know how it turns out!!
Thanks!!today's cardio workout was insane. I was sweating way more than i ever had before and i didnt want to stop after 60 minutes so i had to force my self to. It's only day 1 but this sure seems to be the real deal.. GREAT PRODUCT AN!!!
Just got it! Sweet caps! They are VERY cool!
I just posted in the old contest thread
RPM has several Aromatase Inhibitors (grape seed, naringenin, and icariin) included in the formula in substantial amounts, and all AIs share a common action: SHBG inhibition- this is good for free test, but can have a negative effect on libido in some compounds that do prevent SHBG.
There are many different compounds that allow for SHBG inhibition, but do not kill sex drive- testosterone has SHBG-inhibiting effects, as well as Viagra, Cialis, Icariin, Papaverine, and other PDE5 inhibitors. All of these compounds are also well-known sexual enhancers- so SHBG inhibition will not necessarily kill the libido.....
That being said, when I was formulating RPM, I kept this in mind- were there any compounds out there with AI characteristics (and subsequent SHBG inhibition/free test elevation), that could also yield heightened libido, cause PDE5 inhibition,allow for greater blood flow and vascularity, and greater sexual and functional DRIVE?
The answer is: of course!!! Icariin is a perfect fit, and grape seed extract also carries the same characteristics as well. Naringenin does not necessarily heighten libido, but it is known to positively (guess it depends on who you ask) effect the absorption of both steroid hormones, and PDE5 inhibitors.
It was kind of like putting a puzzle together, and taking into account inter-compound interactions- it took a lot of trial-and-error, but I think the result turned out pretty well (RPM).
Arimi makes my joints dry as a bone- I will never take it againThe loss of libido from Rebound or other AI's is more likely due to the heavy suppression of estrogen(s) which are critical to both the male and female libido.
In any case, they significantly alter E to T ratioes and likely have several other more nuanced effects that are harder to test for. ATD and RR kill my libido dead, RPM..quite the opposite. The PDE5 inhibition coupled with Icariin's well known effects on increasing semen volume make it unlikely that it will suppress libido. It's also not going to drive your E levels down as hard as an AI like 6 Bromo, ATD, Letro or Arimidex
It does sound reasonable, and the "rebounds" SHOULD theoretically be much, much better- our IGF-2 would be perfect as far as a test booster to stack with RPM on the rebounds- awesome stuff, and an awesome stack!!!I am considering pulsing epistane, as this seems to be the best method to use orals. If I use RPM during that cycle, will my "rebounds" be better? I would think that it would help prevent shutdown. Perhaps another test booster as well (Leviathan)? Then I would do mild post cycle therapy (maybe Nolva, proviron) with some cycle support or something. Does that seem like a reasonable plan?
You have just been an enormous help to me. Thank you.It does sound reasonable, and the "rebounds" SHOULD theoretically be much, much better- our IGF-2 would be perfect as far as a test booster to stack with RPM on the rebounds- awesome stuff, and an awesome stack!!!
PS- ditch the Proviron out of the post cycle therapy- it will keep you shut down
Stack in IGF-2/NeoVar/RPM and you will actually gain weight in post cycle therapy :bb2:
No problem bud!!You have just been an enormous help to me. Thank you.
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