New Idea for increase Bioavailability.

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    New Idea for increase Bioavailability.


    Incredibly novel and possibly silly idea.

    There are many great compounds out there that we as humans simply do not use, because of the absolutely terrible bioavailability.

    The studies show amazing, out-of-this-world benefits using lets say 50mg of an injected supplement.

    We see these studies, run to the nearest store and take 50mg of this same supplement orally, then wait... nothing happens. Why? Because of the 50mg we took of whatever the supplement is at the time, only 0.25mg made it pass the liver.

    Here comes the novel idea.

    Booze. ....

    If the liver is preoccupied with dealing with alcohol, is it possible that we could get more active supplement by it?

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    Clarify: Serious question?
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    Well, yeah. Silly, but serious.

    I was reading some theories on the French Parodox on various boards, and some people came up with the theory that~

    Although Resveratrol has something like 0% Bioavailability in humans, wine drinkers somehow get a lot of the benefits of it (Resveratrol).

    One of the answers I saw a few posters come up with was that...

    Resveratrol got by the liver in wine drinkers to administer its amazing effects, because the liver was preoccupied dealing with the alcohol content of the wine.
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    Quote Originally Posted by TheTom View Post
    Well, yeah. Silly, but serious.

    I was reading some theories on the French Parodox on various boards, and some people came up with the theory that~

    Although Resveratrol has something like 0% Bioavailability in humans, wine drinkers somehow get a lot of the benefits of it (Resveratrol).

    One of the answers I saw a few posters come up with was that...

    Resveratrol got by the liver in wine drinkers to administer its amazing effects, because the liver was preoccupied dealing with the alcohol content of the wine.
    Sorry the liver is not preoccupied with one substance which allows other substances to pass through unaltered or undetedcted, the liver does not function like that. The bioavailibility of reseveratol in wine is probably the result of other substances in the wine that increase the body's ability to absorb it, think almost like how adding a methyl group to certain steroids increases there oral bioavailibility, same principle at work. But no the liver is not busy dealing with another substance, put that idea to rest.
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    Quote Originally Posted by whitedevil74 View Post
    Sorry the liver is not preoccupied with one substance which allows other substances to pass through unaltered or undetedcted, the liver does not function like that. .
    x2.....
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    uhhhhhhhh, hmmmmm........ok
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    transdermals or injections of everything!

    grapefruit juice helps with bioavailablity of orals.
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    Quote Originally Posted by whitedevil74 View Post
    Sorry the liver is not preoccupied with one substance which allows other substances to pass through unaltered or undetedcted, the liver does not function like that. The bioavailibility of reseveratol in wine is probably the result of other substances in the wine that increase the body's ability to absorb it, think almost like how adding a methyl group to certain steroids increases there oral bioavailibility, same principle at work. But no the liver is not busy dealing with another substance, put that idea to rest.
    Explain why you think the liver can not be preoccupied by alcohol, resulting in higher bioavailability in Resveratrol.

    You've given me absolutely nothing thought-provoking or convincing, except an "I don't think that will work" answer.

    How do we know alcohol doesn't disrupt the normal routines of the brain and organs, for reduced functioning?

    Also, using alcohol to skew the efficiency screening of the Liver, and adding a methyl group to a steroid, are nowhere near the realm, of the same thing.

    First off, "adding" a methyl group, completely changes the compound to a different one, with completely different effects.

    Alcohol wouldn't change the effect of the compound to a different one, it would remain in the intended state, but hopefully with increased bioavailability.
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    Quote Originally Posted by TheTom View Post
    Explain why you think the liver can not be preoccupied by alcohol, resulting in higher bioavailability in Resveratrol.
    Because the liver is not a person who can get distracted by some Hogan's Heroes trickery. You can't preferentially task the liver to concentrate upon one thing (the alcohol) so that other things can sneak past it like a befuddled Sgt. Schultz.
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    Quote Originally Posted by yeahright View Post
    Because the liver is not a person who can get distracted by some Hogan's Heroes trickery. You can't preferentially task the liver to concentrate upon one thing (the alcohol) so that other things can sneak past it like a befuddled Sgt. Schultz.
    Awesome Hogan's Heroes reference!

    You must spread some Reputation around before giving it to yeahright again.
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    Quote Originally Posted by yeahright View Post
    Because the liver is not a person who can get distracted by some Hogan's Heroes trickery. You can't preferentially task the liver to concentrate upon one thing (the alcohol) so that other things can sneak past it like a befuddled Sgt. Schultz.
    now thats original.....
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    Quote Originally Posted by TheTom View Post
    ]

    Booze. ....

    If the liver is preoccupied with dealing with alcohol, is it possible that we could get more active supplement by it?
    Not to be mean, but if this happens it means that your liver is permanently damaged in some way
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    Quote Originally Posted by TheTom View Post
    Explain why you think the liver can not be preoccupied by alcohol, resulting in higher bioavailability in Resveratrol.

    .
    Short answer is that your liver is not "selective" in what it metabolizes. It works on a first come bases metabolizing whatever shows up on it doorstep in the order it shows up.
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    Ive heard of people making orals into transdermals in the transdermal section, but im not sure.
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    Correction


    Quote Originally Posted by whitedevil74 View Post
    Sorry the liver is not preoccupied with one substance which allows other substances to pass through unaltered or undetedcted, the liver does not function like that. The bioavailibility of reseveratol in wine is probably the result of other substances in the wine that increase the body's ability to absorb it, think almost like how adding a methyl group to certain steroids increases there oral bioavailibility, same principle at work. But no the liver is not busy dealing with another substance, put that idea to rest.
    Sorry but this is not true. As a pharmacist of 30 yrs I can say this categorically.

    For more information about this, read "bioavailability" article in Wikipedia.

    Dave K
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    Quote Originally Posted by TheTom View Post
    Incredibly novel and possibly silly idea.

    There are many great compounds out there that we as humans simply do not use, because of the absolutely terrible bioavailability.

    The studies show amazing, out-of-this-world benefits using lets say 50mg of an injected supplement.

    We see these studies, run to the nearest store and take 50mg of this same supplement orally, then wait... nothing happens. Why? Because of the 50mg we took of whatever the supplement is at the time, only 0.25mg made it pass the liver.

    Here comes the novel idea.

    Booze. ....

    If the liver is preoccupied with dealing with alcohol, is it possible that we could get more active supplement by it?
    depends on how much you drink, there are 2 pathways, the ADH pathway and MEOS pathway, you can only upregulate the MEOS pathway (the ones that the orals we take use) by using it a lot. the more you use it the more tolerant you get especially with alcohol.

    the thing is in occational drinkers we only use the ADH pathway which is why more damage occurs to binge drinkers as oppoesed to alcoholics (brain vs liver respectivly)
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    Quote Originally Posted by whitedevil74 View Post
    Sorry the liver is not preoccupied with one substance which allows other substances to pass through unaltered or undetedcted, the liver does not function like that. The bioavailibility of reseveratol in wine is probably the result of other substances in the wine that increase the body's ability to absorb it, think almost like how adding a methyl group to certain steroids increases there oral bioavailibility, same principle at work. But no the liver is not busy dealing with another substance, put that idea to rest.
    it is more pre occupied with the alcohol if we drink first, which allows the other substances to basically all pass through instead of break down, so instead of getting .25 mg of a 1mg xanax you will get more.
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    sounds like a great way to fu*k yourself over and possibly stress damage your liver at the same time...
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    Just buy "Sustain alpha" [non-prohormone thread]. Its transdermal that solves most of the problem.
    Stomach->liver.
    Transdermal->all over the body.

    *sigh*
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    lol you can't pull a fast one on organs in your body
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    Depends on how much time you have, and what magazine you're looking at.
    Quote Originally Posted by generalmayhem View Post
    lol you can't pull a fast one on organs in your body
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    While this is a weird idea.. I've always thought that certain supps should be sublingual.. such as NO products: The sublingual route is shunted directly to your veins and your heart: leading to faster substance effects in your arteries and veins- a sublingual NO product should be fast acting and more effective!
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    Quote Originally Posted by crazyfool405 View Post
    it is more pre occupied with the alcohol if we drink first, which allows the other substances to basically all pass through instead of break down, so instead of getting .25 mg of a 1mg xanax you will get more.
    Do you know if xanax puts stress on the liver like alcohol would, whilst on a cycle?
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    Increasing bioavailability of a substance by decreasing the effeciency of your liver via bombardment with alcohol is asinine.
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    Quote Originally Posted by Iron Lungz View Post
    Depends on how much time you have, and what magazine you're looking at.
    lol you got me there
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