Cissus Studies

BradCowin

BradCowin

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Does anyone have some good cissus references/studies?

I was at a chiropractor today for my back and he used to be into BB and PL. He asked if I was taking anything for joint/bone health and I told him glucosamine and cissus. Hes got a pretty big hard on for glucosamine, but hadnt heard about cissus before. I told him what little I knew off the top of my head and told him Id try to get some studies when I go back on Wednesday.

So please post any links or studies you know of. He had plenty of NOW brand supps there so Id bet there could be some business involved if he likes what he reads.
 
Vitruvian

Vitruvian

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Brad,

Please go to www.appnut.com, and look under products for Osteobolin-C. There's a technical writeup there, with a long list of references. Hope this helps man!!!!
 
rms80

rms80

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Lipids Health Dis. 2007 Feb 4;6:4.Click here to read Click here to read Links
The effect of Cissus quadrangularis (CQR-300) and a Cissus formulation (CORE) on obesity and obesity-induced oxidative stress.

* Oben JE,
* Enyegue DM,
* Fomekong GI,
* Soukontoua YB,
* Agbor GA.

Laboratory of Nutrition and Nutritional Biochemistry, Department of Biochemistry, University of Yaounde I, Yaounde, Cameroon. [email protected]

AIM: Obesity is generally linked to complications in lipid metabolism and oxidative stress. The aim of this study was to compare the effect of a proprietary extract of Cissus quadrangularis (CQR-300) to that of a proprietary formulation containing CQR-300 (CORE) on weight, blood lipids, and oxidative stress in overweight and obese people. METHODS: The first part of the study investigated the in vitro antioxidant properties of CQR-300 and CORE using 3 different methods, while the second part of the study was a double-blind placebo controlled design, involving initially 168 overweight and obese persons (38.7% males; 61.3% females; ages 19-54), of whom 153 completed the study. All participants received two daily doses of CQR-300, CORE, or placebo and were encouraged to maintain their normal levels of physical activity. Anthropometric measurements and blood sampling were done at the beginning and end of the study period. RESULTS: CQR-300 as well as CORE exhibited antioxidant properties in vitro. They also acted as in vivo antioxidants, bringing about significant (p < 0.001) reductions in plasma TBARS and carbonyls. Both CQR-300 and CORE also brought about significant reductions in weight, body fat, total cholesterol, LDL-cholesterol, triglycerides, and fasting blood glucose levels over the respective study periods. These changes were accompanied by a significant increase in HDL-cholesterol levels, plasma 5-HT, and creatinine. CONCLUSION: CQR-300 (300 mg daily) and CORE (1028 mg daily) brought about significant reductions in weight and blood glucose levels, while decreasing serum lipids thus improving cardiovascular risk factors. The increase in plasma 5-HT and creatinine for both groups hypothesizes a mechanism of controlling appetite and promoting the increase of lean muscle mass by Cissus quadrangularis, thereby supporting the clinical data for weight loss and improving cardiovascular health.

J Ethnopharmacol. 2007 Mar 21;110(2):264-70. Epub 2006 Sep 26.Click here to read Links
Analgesic, anti-inflammatory and venotonic effects of Cissus quadrangularis Linn.

* Panthong A,
* Supraditaporn W,
* Kanjanapothi D,
* Taesotikul T,
* Reutrakul V.

Department of Pharmacology, Faculty of Medicine, Chiang Mai University, Chiang Mai 50200, Thailand. [email protected]

Cissus quadrangularis, a medicinal plant indigenous to Asia and Africa, is used for many ailments, especially for the treatment of hemorrhoid. The effects associated with hemorrhoid, i.e. analgesic and anti-inflammatory activities as well as the venotonic effect of the methanol extract of C. quadrangularis (CQ) were assessed in comparison with reference drugs. In the analgesic test, CQ provoked a significant reduction of the number of writhes in acetic acid-induced writhing response in mice. CQ also significantly reduced the licking time in both phases of the formalin test. The results suggest peripheral and central analgesic activity of CQ. In acute phase of inflammation CQ elicited the inhibitory effect on the edema formation of the rats' ear induced by ethyl phenylpropiolate as well as on the formation of the paw edema in rats induced by both carrageenin and arachidonic acid. It is likely that CQ is a dual inhibitor of arachidonic acid metabolism. In addition, CQ exerted venotonic effect on isolated human umbilical vein similarly to the mixture of bioflavonoids, i.e. 90% diosmin and 10% hesperidin. The results obtained confirmed the traditional use of C. quadrangularis for the treatment of pain and inflammation associated with hemorrhoid as well as reducing the size of hemorrhoids.

Indian J Med Res. 2006 Jun;123(6):799-806.Click here to read Links
Gastroprotective effect of Cissus quadrangularis extract in rats with experimentally induced ulcer.

* Jainu M,
* Vijai Mohan K,
* Shyamala Devi CS.

Department of Biochemistry, University of Madras, Chennai, India. [email protected]

BACKGROUND & OBJECTIVES: Most of the non-steroidal anti-inflammatory drugs (NSAIDs) including aspirin cause gastric ulcer. In order to study the gastroprotective effect of Cissus quadrangularis extract (CQE), this study was undertaken on aspirin-induced ulcerogenesis in pyloric ligated (ASP-PL) model in rats. METHODS: To assess the possible antiulcer effect of CQE, lesion index, gastric secretions glycoprotein levels, non-protein sulphydryls (NPSH) and adherent mucus content were determined in ASP-PL induced gastric mucosal injury in rats. RESULTS: Pretreatment with CQE significantly prevented the gastric mucosal lesion development and decreased the gastric toxicity produced by ulcerogen. In addition, ulcerated rats showed depletion of gastric wall mucus, glycoproteins and NPSH levels whereas treatment with CQE reverted this decline in ASP-PL induced rats. Histological studies confirmed the results. INTERPRETATION & CONCLUSION: The present finding suggests that CQE promotes ulcer protection by the decrease in ulcer index, gastric secretions and increase in the glycoprotein level, gastric mucin content and NPSH concentration. CQE may protect the gastric mucosa against ulceration by its antisecretory and cytoprotective property.

Chem Biol Interact. 2006 Jul 10;161(3):262-70. Epub 2006 May 1.Click here to read Links
Gastroprotective action of Cissus quadrangularis extract against NSAID induced gastric ulcer: role of proinflammatory cytokines and oxidative damage.

* Jainu M,
* Devi CS.

Department of Biochemistry, University of Madras, A.C. Tech, Guindy Campus, Chennai 600025, Tamil Nadu, India. [email protected]

The objective of this research was to analyse the gastroprotective effect of Cissus quadrangularis extract (CQE) along with its mechanism underlying the therapeutic action against the gastric mucosal damage induced by aspirin. In this study, we investigated the effect of CQE on the course of experimentally induced gastric ulcer by analyzing the levels of tumor necrosis factor-alpha (TNF-alpha), interleukin-1beta (IL-1beta), microvascular permeability, activity of nitric oxide synthase-2 (NOS-2), mitochondrial antioxidants, lipid peroxidation and DNA damage. A significant increase in vascular permeability, NOS-2 activity, TNF-alpha, IL-1beta levels and oxidative damage were noted in aspirin administered rats. Pretreatment with CQE (500 mg/kg bw/day) by oral gavage for 7 days significantly attenuated these biochemical changes caused by aspirin in rats. Tissue damage was showed by decreased levels of glutathione (GSH), superoxide dismutase (SOD) and catalase (CAT) and an associated rise in lipid peroxidation (LPO) in mitochondria, which were reversed by CQE. In addition, CQE prevents oxidative damage of DNA by reducing DNA fragmentation indicating its block on cell death. Ulcer protection in CQE treated rats was confirmed by histoarchitecture, which was comprised of reduced size of ulcer crater and restoration of mucosal epithelium. Thus, reduced neutrophil infiltration, antiapoptotic and antioxidant action have a pivotal role in the gastroprotective effect of CQE.
 
rms80

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J Herb Pharmacother. 2005;5(3):33-42. Links
Attenuation of neutrophil infiltration and proinflammatory cytokines by Cissus quadrangularis: a possible prevention against gastric ulcerogenesis.

* Jainu M,
* Shyamala Devi CS.

Department of Biochemistry, University of Madras, Guindy Campus, Chennai, Tamil Nadu, India.

Reactive oxygen species, neutrophil infiltration and proinflammatory cytokines play an important role in the pathogenesis of gastric ulcers caused by aspirin. The present study demonstrates the healing effect of Cissus quadrangularis extract (CQE) through inhibitory action on generation of lipid peroxidation, proinflammatory cytokines and neutrophil infiltration. The concentration ofmalondialdehye (MDA), protein carbonyl content, conjugated dienes, mucosal (SH) sulphydryls, uric acid, tumor necrosis factor-alpha (TNF-alpha), and activities of myeloperoxidase (MPO), xanthine oxidase (XO) and antioxidative enzymes were determined in the gastric mucosa. Administration of CQE significantly attenuated the gastric lesions induced by aspirin and this was accompanied by the rise in uric acid, antioxidative enzymes, SH groups, and a significant decrease in lipid peroxidase, TNF-alpha, MPO and XO activities.
These findings suggest that the significant gastroprotective activity could be mediated by the antioxidant activity as well as by the attenuation of oxidative mechanism and proinflammatory cytokines.

J Ethnopharmacol. 2006 Apr 6;104(3):302-5. Epub 2005 Dec 9.Click here to read Links
Protective effect of Cissus quadrangularis on neutrophil mediated tissue injury induced by aspirin in rats.

* Jainu M,
* Mohan KV,
* Devi CS.

Department of Biochemistry, University of Madras, Guindy Campus, Chennai 600025, India.

Cissus quadrangularis (family: Vitaceae) is well known for the treatment of gastric disorders in traditional medicine, owing to its rich source of carotenoids, triterpenoids and ascorbic acid, and has received considerable attention regarding its role in human nutrition. In the search of new potential antiulcer agents, the present study evaluated the ethanol extract of Cissus quadrangularis (CQE) against the gastric toxicity induced by aspirin in rats. The optimum protective dose of 500 mg/kg of extract was selected by the pretreatment of gastric ulcers with different doses of CQE (250, 500 and 750 mg/kg) for 7 days which showed ulcer protection by 40, 71.2 and 72.6%, respectively, as compared to ranitidine (RTD) (30 mg/kg) by 71.9% in the aspirin model. In addition, results have shown that administration of aspirin increases lipid peroxidation status, xanthine oxidase (XO), myeloperoxidase and decrease in selenium-glutathione peroxidase activities in the gastric mucosa, resulting in mucosal damage at both cellular and subcellular level. Pretreatment with CQE ameliorated the observed effect significantly in the gastric mucosa of ulcerated rats. These findings suggest that the gastroprotective activity of CQE could be mediated possibly through its antioxidant effect as well as by the attenuation of the oxidative mechanism and neutrophil infiltration.

J Med Food. 2004 Fall;7(3):372-6.Click here to read Links
Effect of Cissus quadrangularis on gastric mucosal defensive factors in experimentally induced gastric ulcer-a comparative study with sucralfate.

* Jainu M,
* Devi CS.

Department of Biochemistry, University of Madras, Guindy Campus, Chennai, India.

Cissus quadrangularis is an indigenous plant commonly mentioned in Ayurveda for treatment of gastric ulcers. The ulcer-protective effect of a methanolic extract of C. quadrangularis (CQE) was comparable to that of the reference drug sucralfate. Further, gastric juice and mucosal studies showed that CQE at a dose of 500 mg/kg given for 10 days significantly increased the mucosal defensive factors like mucin secretion, mucosal cell proliferation, glycoproteins, and life span of cells. The present investigation suggests that CQE not only strengthens mucosal resistance against ulcerogens but also promotes healing by inducing cellular proliferation. Thus, CQE has potential usefulness for treatment of peptic ulcer disease.

J Ethnopharmacol. 2003 Dec;89(2-3):245-50.Click here to read Links
Antiosteoporotic effect of ethanol extract of Cissus quadrangularis Linn. on ovariectomized rat.

* Shirwaikar A,
* Khan S,
* Malini S.

Department of Pharmacognosy, College of Pharmaceutical Sciences, Manipal, India. [email protected]

Ethanol extract of Cissus quadrangularis was evaluated for its anti-osteoporotic activity in ovariectomized rat model of osteoporosis at two different dose levels of 500 and 750 mg/kg per day. Healthy female albino rats were divided into five groups of six animals each. First group was sham operated and served as control. All the remaining groups were ovariectomized. Group 2 was fed with equivolume of saline and served as ovariectomized control. Groups 3-5 were orally treated with Raloxifen (5.4 mg/kg) and ethanol extract of Cissus quadrangularis (500 and 750 mg/kg), respectively. The findings assessed on the basis of biomechanical, biochemical and histopathological parameters showed that the ethanol extract of the plant had a definite antiosteoporotic effect.
 
rms80

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J Med Food. 2003 Summer;6(2):99-105.Click here to read Links
Antioxidant and antimicrobial activity of Cissus quadrangularis L.

* Chidambara Murthy KN,
* Vanitha A,
* Mahadeva Swamy M,
* Ravishankar GA.

Cell Biotechnology Department, Central Food Technological Research Institute, Mysore 570 013, India.

Extracts of Cissus quadrangularis L. were tested for antioxidant activity by beta-carotene linoleic acid model and also by 1,1-diphenyl-2-picrylhydrazyl model. The ethyl acetate fraction of both fresh and dry stem extracts at a concentration of 100 ppm showed 64.8% antioxidant activity in the beta-carotene linoleic acid system and 61.6% in the 1,1-diphenyl-2-picrylhydrazyl system. This fraction showed the presence of sterols, vitamin C, and tannins as phytoconstituents. The antioxidant activity of methanol extract and aqueous extract were comparatively less significant than that of ethyl acetate extract, and n-hexane extract showed the least activity. The ethyl acetate extract and methanol extract of both fresh and dry stems further exhibited antimicrobial activity against Gram-positive bacteria, including Bacillus subtilis, Bacillus cereus, Staphylococcus aureus, and Streptococcus species. The results of the study have implications in the use of C. quadrangularis as an antibacterial agent and more so as an antioxidant in several applications requiring these properties.

Discussion:

I would print all these out and take them to your doc- and emphasize all of the research done on cissus and cytokine inhibition- this is probably the most important healing aspect of the herb, b/c when cytokines interact with otherwise healthy cartilage, a toxic reaction occurs, causing the loss of connective tissue- this is the main underlying factor in arthritis and other joint-degenerative diseases.....
 
BradCowin

BradCowin

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Sweet guys. Thank you. Feel free to post any more that you know of though
 

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