For Your Viewing Pleasure, The Detailed RPM Write-up

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  1. I popped 5 caps and felt more of stimulant buzz this time. Also my last meal was 2 hours prior unlike the first time, when it was an hour prior to 4 caps....

    Workout, was intense. Workouts are for fat loss, so I need the extra fuel to keep the intensity up...


  2. Quote Originally Posted by xjsynx View Post
    I popped 5 caps and felt more of stimulant buzz this time. Also my last meal was 2 hours prior unlike the first time, when it was an hour prior to 4 caps....

    Workout, was intense. Workouts are for fat loss, so I need the extra fuel to keep the intensity up...
    RPM is a great thermogenic as well- if I take 4 before a workout I literally get soaked with sweat- hell it makes you hot just sitting around!!!!

  3. Quote Originally Posted by rms80 View Post
    RPM is a great thermogenic as well- if I take 4 before a workout I literally get soaked with sweat- hell it makes you hot just sitting around!!!!
    you mean like this:


    Yeah, I sweated my a55 off...
    •   
       


  4. Quote Originally Posted by xjsynx View Post
    you mean like this:


    Yeah, I sweated my a55 off...
    Yep- 'bout like that!!

  5. lol great i sweat bad enough as it is.... oh well still cant wait.

  6. I received my samples today and I went ahead and took four of them even though today was an off day from working out (unable to wait until tomorrow) and I actually got a pretty decent pump just from doing some yard-work.

    I was somewhat skeptical about all the hype but it really did give me a sense of well being and energy unlike any other stim I have ever tried. Can't wait to buy this stuff...Thanks guys!!

  7. XJSynx,
    Thats a mean sweat you got goin'! I just got done in the gym.... was seriously thinking of getting myself an old school sweatband for Saturday's workout.....
    Applied Nutriceuticals Representative
    Better Results Through Science
    Success occurs when everything you have is APPLIED.
    Have you heard about N.O. Uptake? ;-)

  8. Got mine today. I am gonna rock 5 caps tomorrow before my DC workout of: chest/shoulders/tris/back width and thickness!
    DC is intense...lets see where this stuff takes it. OH, and I'm skipping my normal White Flood preworkout to see if this stuff works!

  9. Quote Originally Posted by rysigpi View Post
    Got mine today. I am gonna rock 5 caps tomorrow before my DC workout of: chest/shoulders/tris/back width and thickness!
    DC is intense...lets see where this stuff takes it. OH, and I'm skipping my normal White Flood preworkout to see if this stuff works!
    Rock it out!!

  10. Quote Originally Posted by rysigpi View Post
    Got mine today. I am gonna rock 5 caps tomorrow before my DC workout of: chest/shoulders/tris/back width and thickness!
    DC is intense...lets see where this stuff takes it. OH, and I'm skipping my normal White Flood preworkout to see if this stuff works!
    Be prepared for some PR's!!! I am doing a style of DC As well and let me tell you RPM+DC Training= FREAKING SIC INTENSE WORKOUT FULL OF NEW PR's!!!!

  11. Quote Originally Posted by buffhunk29 View Post
    Be prepared for some PR's!!! I am doing a style of DC As well and let me tell you RPM+DC Training= FREAKING SIC INTENSE WORKOUT FULL OF NEW PR's!!!!
    Absolutely be prepared, and welcome some of the MOST INTENSE and rewarding workouts of your life, with open arms!


    Geez, and the best part is... every serving you take, day after day, becomes EVEN MORE POWERFUL! I can't wait until I can take this product on a more steady basis, darn competitions! But, the good news is, it will all be over in 2 weeks! (Pittsburgh Pro, Mike Francois Classic, and then, DONE!)

    -Aaron R Smith

  12. Quote Originally Posted by AlphaAnabolic View Post
    Absolutely be prepared, and welcome some of the MOST INTENSE and rewarding workouts of your life, with open arms!


    Geez, and the best part is... every serving you take, day after day, becomes EVEN MORE POWERFUL! I can't wait until I can take this product on a more steady basis, darn competitions! But, the good news is, it will all be over in 2 weeks! (Pittsburgh Pro, Mike Francois Classic, and then, DONE!)

    -Aaron R Smith
    A-
    Good to see you brotha!!!

  13. LEts sees...

    Dosed 5 caps at 3 pm.

    3:15 pm noticed a funny feeling in my head. Slight buzz almost. 3:30 this turned into a focus and definately stimulating. Like whole body stimulating. Just after that I ate 60 grams of protein, 60 grams carbs, and 15g fat meal. I got to the gym about 4 and lifting slightly there after.

    Strength: Can't make any note here. This is my second week back after a contest and taking a week off....first day doing this specific exercises for DC.

    Focus: focus was very good. I was zoned in for sure. Note: my drive to the gym was weird...its like I should not have been driving cause all i was doing was looking ahead and not paying attention to my pheripherals!

    -Definate thermo effect. I felt warm, quite warm all over within 20 min of taking 5 caps. More so than any other fat burner (stim x, venom, scorch, basic cuts)

    -Energy was good, but my drive to lift was the best. Endurance seemed up as well.

    -Feeling of muscle fullness was evident, I was very surprised here. I don't understand how that worked, it was like a muscle pump within 20 min of taking it and I was just sitting around.....
    -Incread vascularity.

    All in all a really good experience. I can see how this has potential to really set some big arse PR's!:bb:
    Sign me up!

  14. Quote Originally Posted by rysigpi View Post
    LEts sees...

    Dosed 5 caps at 3 pm.

    3:15 pm noticed a funny feeling in my head. Slight buzz almost. 3:30 this turned into a focus and definately stimulating. Like whole body stimulating. Just after that I ate 60 grams of protein, 60 grams carbs, and 15g fat meal. I got to the gym about 4 and lifting slightly there after.

    Strength: Can't make any note here. This is my second week back after a contest and taking a week off....first day doing this specific exercises for DC.

    Focus: focus was very good. I was zoned in for sure. Note: my drive to the gym was weird...its like I should not have been driving cause all i was doing was looking ahead and not paying attention to my pheripherals!

    -Definate thermo effect. I felt warm, quite warm all over within 20 min of taking 5 caps. More so than any other fat burner (stim x, venom, scorch, basic cuts)

    -Energy was good, but my drive to lift was the best. Endurance seemed up as well.

    -Feeling of muscle fullness was evident, I was very surprised here. I don't understand how that worked, it was like a muscle pump within 20 min of taking it and I was just sitting around.....
    -Incread vascularity.

    All in all a really good experience. I can see how this has potential to really set some big arse PR's!:bb:
    Sign me up!
    r- the pump is caused by PDE5 inhibition- icariin works very similarly to Viagra in this regard

    Asian J Androl. 2005 Dec;7(4):381-8.Click here to read Links
    Effects of icariin on erectile function and expression of nitric oxide synthase isoforms in castrated rats.

    * Liu WJ,
    * Xin ZC,
    * Xin H,
    * Yuan YM,
    * Tian L,
    * Guo YL.

    Andrology Center of Peking University First Hospital, Beijing 100009, China.

    AIM: To investigate the effect of icariin on erectile function and the expression of nitric oxide synthase (NOS) isoforms in castrated rats. METHODS: Thirty-two adult male Wistar rats were randomly divided into one sham-operated group (A) and three castrated groups (B, C and D). One week after surgery, rats were treated with normal saline (groups A and B) or oral icariin (1 mg/[kg.day] for group C and 5 mg/[kg.day] for group D) for 4 weeks. One week after treatment, the erectile function of the rats was assessed by measuring intracavernosal pressure (ICP) during electrostimulation of the cavernosal nerve. The serum testosterone (ST) levels, the percent of smooth muscle (PSM) in trabecular tissue, and the expression of mRNA and proteins of neuronal nitric oxide synthase (nNOS), inducible nitric oxide synthase (iNOS), endothelial nitric oxide synthase (eNOS) and phosphodiesterase V (PDE5) in corpus cavernosum (CC) were also evaluated. RESULTS: ICP, PSM, ST and the expression of nNOS, iNOS, eNOS and PDE5 were significantly decreased in group B compared with those in group A (P 0.01). However, ICP, PSM and the expression of nNOS and iNOS were increased in groups C and D compared with those in group B (P 0.05). Changes in ST and the expression of eNOS and PDE5 were not significant (P 0.05) in groups C and D compared with those in group B. CONCLUSION: Oral treatment with icariin ( 98.6 % purity) for 4 weeks potentially improves erectile function. This effect is correlated with an increase in PSM and the expression of certain NOS in the CC of castrated rats. These results suggest that icariin may have a therapeutic effect on erectile dysfunction.

    Urology. 2006 Dec;68(6):1350-4.Click here to read Links
    Effects of icariin on phosphodiesterase-5 activity in vitro and cyclic guanosine monophosphate level in cavernous smooth muscle cells.

    * Ning H,
    * Xin ZC,
    * Lin G,
    * Banie L,
    * Lue TF,
    * Lin CS.

    Knuppe Molecular Urology Laboratory, Department of Urology, University of California, San Francisco, School of Medicine, San Francisco, California 94115, USA.

    OBJECTIVES: To investigate the effect of icariin on the cyclic guanosine monophosphate (cGMP)-hydrolytic activity of phosphodiesterase-5 (PDE5) isoforms and the cGMP levels in cavernous smooth muscle cells treated with sodium nitroprusside (SNP). METHODS: PDE5 isoforms (PDE5A1, A2, and A3) were isolated from sf9 insect cells infected with baculoviruses carrying PDE5 isoform cDNA. Icariin was isolated from Epimedii herba. Varying amounts (10(-6) to 10(-11) M) of icariin or zaprinast were added to reaction mixtures containing PDE5 isoforms and cGMP. The inhibitory effects of icariin and zaprinast were analyzed by GraphPad Software and are expressed as concentration that inhibits 50% (IC50) values. Cavernous smooth muscle cells were isolated from 3-month-old rats, treated with icariin (100 and 200 microM) or zaprinast (200 microM) for 15 minutes, and then with 10 microM SNP for 30, 60, 120, 240, and 360 minutes. The cells were then analyzed for the cGMP concentration using an enzyme immunoassay system. RESULTS: Icariin inhibited PDE5A1, A2, and A3 with an IC50 value of 1.0, 0.75, and 1.1 microM, respectively. The corresponding IC50 values for zaprinast were 0.33, 0.23, and 0.32 microM. Icariin consistently outperformed the control (SNP-only treatment) in maintaining greater cGMP levels, particularly at the greater concentration of 200 microM. In contrast, zaprinast at 200 microM did better than the control only at 60 and 360 minutes. CONCLUSIONS: Icariin was inhibitory to all three PDE5 isoforms with similar IC50 values, which were approximately three times greater than those for zaprinast. Icariin was able to enhance cGMP levels in SNP-treated cavernous smooth muscle cells.

    J Huazhong Univ Sci Technolog Med Sci. 2006;26(4):460-2.
    Effect of icariin on cyclic GMP levels and on the mRNA expression of cGMP-binding cGMP-specific phosphodiesterase (PDE5) in penile cavernosum.

    * Jiang Z,
    * Hu B,
    * Wang J,
    * Tang Q,
    * Tan Y,
    * Xiang J,
    * Liu J.

    Department of Pharmacology, School of Basic Medical Sciences, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China.

    To further investigate the mechanisms of action of icariin (ICA), we assessed the effects of ICA on the in vitro formation of cGMP and cAMP in isolated rabbit corpus cavernosum. Isolated segments of rabbit corpus cavernosum were exposed to increasing concentrations of ICA and the dose-dependent accumulation of cGMP and cAMP was determined in the tissues samples by means of 125I radioimmunoassay. Responses of the isolated tissues preparations to ICA were compared with those obtained with the reference compounds sildenafil (Sild). Furthermore, the effects of ICA on the mRNA expression of specific cGMP-binding phosphodiesterase type V (PDE5) in rat penis were also observed. After incubation with ICA for 6 h or 14 h respectively, the levels of PDE5 mRNA were examined by reverse transcriptase polymerase chain reaction (RT-PCR). The results showed that ICA increased cGMP concentrations directly (P < 0.05), but there was no significant effect on cAMP concentrations (P > 0.05). [B]In the presence of sodium nitroprusside (SNP), a stimulatory agent of cGMP, both ICA and Sild increased cGMP concentrations with increasing dose (P < 0.01). Their EC50 was 4.62 (ICA) and 0.42 (Sild) micromol/L respectively. There were PDE5A1 and PDE5A2 mRNA expressions in rat corpus cavernosum with PDE5A2 being the dominant isoform. ICA could obviously inhibit these two isoforms mRNA expression in rat penis, and decrease PDE5A1 more pronouncedly (P < 0.01). The present study indicated that the aphrodisiac mechanisms of icariin involved the NO-cGMP signal transduction pathway, with increasing cGMP levels in the corpus cavernosum smooth muscle. The inhibitory effect of icariin on PDE5 mRNA expression, especially on PDE5A1, might account for its molecular mechanisms for its long-term activity.

  15. The fullness and pump from RPM are just another added bonus to the product- we are not even marketing these as the primary effects- as we don't want this to be compared to all the other NO products....but they are extremely noticeable!!!!

    RPM exerts such a positive effect in so many different areas, that we did not really even know where to start!!!

  16. Quote Originally Posted by Lanbane View Post
    XJSynx,
    Thats a mean sweat you got goin'! I just got done in the gym.... was seriously thinking of getting myself an old school sweatband for Saturday's workout.....

    I can see your workout now Oliva!, You know you're hardcore when you workout like this!,


  17. L-O-Freakin' L!!!!!!!!!!!!!!!!!!!!!!!!!!!!! !!!!!!!
    Applied Nutriceuticals Representative
    Better Results Through Science
    Success occurs when everything you have is APPLIED.
    Have you heard about N.O. Uptake? ;-)

  18. Quote Originally Posted by rms80 View Post

    RPM exerts such a positive effect in so many different areas, that we did not really even know where to start!!!
    It's actually a good thing here.... most companies are droppin' supplements that they have to TELL you what to expect.

    We could've just said "you tell us".
    Applied Nutriceuticals Representative
    Better Results Through Science
    Success occurs when everything you have is APPLIED.
    Have you heard about N.O. Uptake? ;-)

  19. Quote Originally Posted by T-Bone View Post
    I can see your workout now Oliva!, You know you're hardcore when you workout like this!,

    LOL
    Dirk Tanis, BA, MSci
    Chief Operating Officer, Applied Nutriceuticals

  20. Bump for fitmodel
    Applied Nutriceuticals Representative
    Better Results Through Science
    Success occurs when everything you have is APPLIED.
    Have you heard about N.O. Uptake? ;-)

  21. I can't wait to get my hands on this stuff, it looks amazing! Great job Applied Nutraceuticals!


    Workin

  22. Quote Originally Posted by workin2005 View Post
    I can't wait to get my hands on this stuff, it looks amazing! Great job Applied Nutraceuticals!


    Workin
    Thank you sir!!
    Dirk Tanis, BA, MSci
    Chief Operating Officer, Applied Nutriceuticals

  23. Hold on a sec..... Workin, you haven't received any yet?
    Applied Nutriceuticals Representative
    Better Results Through Science
    Success occurs when everything you have is APPLIED.
    Have you heard about N.O. Uptake? ;-)

  24. Quote Originally Posted by Lanbane View Post
    Hold on a sec..... Workin, you haven't received any yet?
    Yup- sending his in a minute Gotta get Buffhunk caught up too!!!
    Dirk Tanis, BA, MSci
    Chief Operating Officer, Applied Nutriceuticals

  25. Buffhunk has more energy and drive than he knows what to do with as it is! LOL
    Applied Nutriceuticals Representative
    Better Results Through Science
    Success occurs when everything you have is APPLIED.
    Have you heard about N.O. Uptake? ;-)

  26. when and where to buy fellas? Read a lot of innovation now I want to feel it! :clean:

  27. There's a list of AN retailers on the AN homepage, accessible through www.appnut.com

    My personal recommendation is good ol' NutraPlanet! RPM should be widely available within the next couple weeks.... keep your fingers crossed!!! I'm predicting it will move fast!
    Applied Nutriceuticals Representative
    Better Results Through Science
    Success occurs when everything you have is APPLIED.
    Have you heard about N.O. Uptake? ;-)

  28. Did you request a sample yet B?
    If not, email Dirkt@bellsouth.net

    Easy for me to volunteer up his services
    Applied Nutriceuticals Representative
    Better Results Through Science
    Success occurs when everything you have is APPLIED.
    Have you heard about N.O. Uptake? ;-)

  29. Quote Originally Posted by BigBbrowning View Post
    when and where to buy fellas? Read a lot of innovation now I want to feel it! :clean:
    you know you got somethin great with folks makin their first post in regards to your product..... so is it here yet.

  30. Hadn't even noticed that.....

    Anyways, so is what here yet?

    Oh, hold on a sec guys... gotta move all these bottles of RPM out of the way so I can see the screen better.............
    Applied Nutriceuticals Representative
    Better Results Through Science
    Success occurs when everything you have is APPLIED.
    Have you heard about N.O. Uptake? ;-)

  31. hahahah cute.... so where you at again.... dont look over your shoulder....

  32. ITS POOP!!!!!!! lol wow so any update yet on your non stim version?????????

  33. Quote Originally Posted by poopypants View Post
    ITS POOP!!!!!!! lol wow so any update yet on your non stim version?????????
    L and I are working on it!! Got some good stuff so far!!!
    Dirk Tanis, BA, MSci
    Chief Operating Officer, Applied Nutriceuticals

  34. Quote Originally Posted by poopypants View Post
    hahahah cute.... so where you at again.... dont look over your shoulder....
    I'm here.... not sure if you can see me... I'll wiggle my hand..... I'm stuck under all these bottles of RPM...... might have to fire up a flare.....SOS
    Applied Nutriceuticals Representative
    Better Results Through Science
    Success occurs when everything you have is APPLIED.
    Have you heard about N.O. Uptake? ;-)

  35. Quote Originally Posted by poopypants View Post
    ITS POOP!!!!!!! lol wow so any update yet on your non stim version?????????

    hahaha... he called the sh%t poop!
    Applied Nutriceuticals Representative
    Better Results Through Science
    Success occurs when everything you have is APPLIED.
    Have you heard about N.O. Uptake? ;-)

  36. lol...ahh...soon...soon

  37. Quote Originally Posted by Lanbane View Post
    hahaha... he called the sh%t poop!
    LOL ya i had to remove that from under my name to make room for the new one <----- i wasnt all that mad.

  38. Is that newly official? If so, Congrats man!!
    Applied Nutriceuticals Representative
    Better Results Through Science
    Success occurs when everything you have is APPLIED.
    Have you heard about N.O. Uptake? ;-)

  39. Quote Originally Posted by rms80 View Post
    L and I are working on it!! Got some good stuff so far!!!
    hmmm cant wait to see wht you fellas do with it... i know ill be impressed.

  40. Quote Originally Posted by Lanbane View Post
    Is that newly official? If so, Congrats man!!
    ya sure is! im just waitin for the color change.

    very honored to be brought onto such a stellar team and innovative comp!
  

  
 

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