For Your Viewing Pleasure, The Detailed RPM Write-up

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    Naringin makes PDE5 inhibitors more bioavaliable and last longer in the system (hint: Icariin is a PDE5 inhibitor)

    check out this study w/ slidenafil (Viagra)

    Clin Pharmacol Ther. 2002 Jan;71(1):21-9. Links

    Comment in:
    Clin Pharmacol Ther. 2005 Oct;78(4):441-3.

    Effects of grapefruit juice on the pharmacokinetics of sildenafil.

    * Jetter A,
    * Kinzig-Schippers M,
    * Walchner-Bonjean M,
    * Hering U,
    * Bulitta J,
    * Schreiner P,
    * Sorgel F,
    * Fuhr U.

    Institute for Pharmacology, Clinical Pharmacology, University of Koln, Germany. alexander.jetter@medizin.uni-koeln.de

    BACKGROUND AND OBJECTIVES: Because of extensive first-pass metabolism, oral bioavailability of sildenafil reaches only 40%. Formation of the primary metabolite, N -desmethylsildenafil, is mainly mediated by the cytochrome P450 enzyme CYP3A4. In this study we investigated the influence of grapefruit juice, containing inhibitors of intestinal CYP3A4, on the pharmacokinetics of sildenafil and N -desmethylsildenafil. METHODS: In a randomized crossover study, 24 healthy white male volunteers received single 50-mg doses of sildenafil. Two doses each of 250 ml grapefruit juice or water, respectively, were administered 1 hour before and together with the drug. Plasma concentrations of sildenafil and N -desmethylsildenafil were determined up to 24 hours post dose by use of liquid chromatography-tandem mass spectrometry (limit of quantification, 1 ng/ml). RESULTS: Grapefruit juice changed the area under the sildenafil plasma concentration-time curve from time zero to infinity [AUC(0-infinity) from 620 [1.53] ng/ml x h to 761 [1.58] ng/ml x h (geometric mean with geometric standard deviation), corresponding to a 23% increase (90% confidence interval, 13%-33%). N-Desmethyl sildenafil AUC(0-infinity) increased by 24% (90% confidence interval, 17%-32%). Maximum plasma concentrations (C(max)) of sildenafil and N -desmethylsildenafil were essentially unchanged. There was a trend toward a prolonged time to reach C(max) during the grapefruit juice period (from a median of 0.75 hour to a median of 1.13 hours), corresponding to an increase by 0.25 hour (90% confidence interval, 0-0.63 hour). Interindividual variability was pronounced in both periods. CONCLUSIONS: Grapefruit juice increases sildenafil bioavailability and tends to delay sildenafil absorption. Sildenafil pharmacokinetics may become less predictable with grapefruit juice. Although patients usually will not be endangered by concomitant use of grapefruit juice, it seems advisable to avoid this combination.

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    Quote Originally Posted by rms80 View Post
    I took 5 RPM two days ago b/c we were maxing on squats- hit 635 @ 202 lbs., and felt like I could have done 3 or 4!!!! Then I went and did a full track work out, and then played basketball (full court) for 80 minutes- I still wanted to work out more, but I had to make myself quit!!
    To be honest, I have tried many supplements, and if the tolerance does not build too fast, it's part of my arsenal
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    Quote Originally Posted by jjohn View Post
    To be honest, I have tried many supplements, and if the tolerance does not build too fast, it's part of my arsenal
    It doesn't seem to build a tolerance- I have been on it for 5 weeks, and it seems to be working even better each week- if that is possible!!
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    Quote Originally Posted by rms80 View Post
    It doesn't seem to build a tolerance- I have been on it for 5 weeks, and it seems to be working even better each week- if that is possible!!
    If it keeps getting better and better, I will have slept with all of the girls at my college by the end of the year
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    Quote Originally Posted by jjohn View Post
    If it keeps getting better and better, I will have slept with all of the girls at my college by the end of the year
    I miss college- carolina girls are the best in the world
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    Awesome NEWS GUYS!!!!

    JJ you are a mad man taking 8 prework out you are a CHAMP!!!!

    Glad to see the great results!!

    This stuff just keeps BUILDING IT NEVER STOPS!!!! I NEED MORE I RAN OUT!!!!

    But being a team player i want everyone on the board to get them i can wait!! I am already hooked!!!


    Hey Rms can you set some carolina girls aside for me when i come and visit!!!!!
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    Quote Originally Posted by rms80 View Post
    I took 5 RPM two days ago b/c we were maxing on squats- hit 635 @ 202 lbs., and felt like I could have done 3 or 4!!!! Then I went and did a full track work out, and then played basketball (full court) for 80 minutes- I still wanted to work out more, but I had to make myself quit!!
    Yep, the Centaur nickname is gonna stick.................. haha... mighty impressive man!!!!!

    And yeah, jjohn, poppin 8 caps is MANIACAL. Any more than 4 for me and I'd probably go RPM-rage on some random passerby.

    Oh random: I got Cable internet hooked up at da crib.... I'm about to multiply my posts. lol
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    LAN We need to get together and POP 8 pills AND ROCK SOME WEIGHTS!! MAKE A VIDEO CAUSE THERE WILL BE BLOOD!!!!!
    PROB our own due to BLEED FROM THE EYES WITH INTENSITY!!!! AHHHHHH!!!!
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    Quote Originally Posted by buffhunk29 View Post
    LAN We need to get together and POP 8 pills AND ROCK SOME WEIGHTS!! MAKE A VIDEO CAUSE THERE WILL BE BLOOD!!!!!
    PROB our own due to BLEED FROM THE EYES WITH INTENSITY!!!! AHHHHHH!!!!


    LOL!
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    Exclamation


    Quote Originally Posted by rms80 View Post
    I took 5 RPM two days ago b/c we were maxing on squats- hit 635 @ 202 lbs., and felt like I could have done 3 or 4!!!! Then I went and did a full track work out, and then played basketball (full court) for 80 minutes- I still wanted to work out more, but I had to make myself quit!!
    I have taken and felt the amazing effects of this compound's synergy first-hand. It was amazing, and one (if not the ONLY) supplement that truly stands out from the rest and DELIVERS as it was hyped.


    Thank you AN & Dirk!

    -Aaron R Smith
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    Quote Originally Posted by AlphaAnabolic View Post
    I have taken and felt the amazing effects of this compound's synergy first-hand. It was amazing, and one (if not the ONLY) supplement that truly stands out from the rest and DELIVERS as it was hyped.


    Thank you AN & Dirk!

    -Aaron R Smith
    Oh... just as an aside, a week ago, I had a photo shoot with resident Buff Hunk, Heath - and with only 1/2 cup of oatmeal in my system , after months of dieting... I took (5) RPM pills, and here is what happened:





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    Lookin HHUGE AA!

    Carolina girls huh? Can you send me a sample of those too? See what kind of pump they are capable of.

    Buffhunk, I should have brought my cam, but it was stolen a few days ago in my car! Man, if I would have been there, they would be chopped in pieces, and fried to feed the cows!

    Holy SHIZZLE! My rep is going away HELP!!
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    Quote Originally Posted by jjohn View Post
    Lookin HHUGE AA!

    Carolina girls huh? Can you send me a sample of those too? See what kind of pump they are capable of.

    Buffhunk, I should have brought my cam, but it was stolen a few days ago in my car! Man, if I would have been there, they would be chopped in pieces, and fried to feed the cows!

    Holy SHIZZLE! My rep is going away HELP!!
    Off to the Metrolina- OB bro, you are missing out!!!! J- if I could bottle up some of that- I wouldn't have to sell supps!!!!

    Aaron- wow!!! That is impressive!! RPM will make you harder than hard!!!!
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    Quote Originally Posted by rms80 View Post
    Off to the Metrolina- OB bro, you are missing out!!!! J- if I could bottle up some of that- I wouldn't have to sell supps!!!!

    Aaron- wow!!! That is impressive!! RPM will make you harder than hard!!!!
    that is right keep rubbing it in

    AA ur ****in huge


    Today Im supposed to be in charlotte with teh AN crew mackin hoes

    instead my ******* wife decided to fill a slot at work without telling me so Im stuck babysitting my son

    there is no level to which the anger I have achieved.

    but i told her the next show, im going regardless.
    toes-on-the-nose.blogspot.com Deployed blogging
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    Aaron, is that a lat, or a freakin wing?
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    Hey AN guys - What is the caffeine dose like in this? I typically workout in the afternoon, and wondered when is the latest it should be taken?

    Or on the other hand, are there any plans for a non-stim version?

    Thanks
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    Quote Originally Posted by Mass_69 View Post
    Hey AN guys - What is the caffeine dose like in this? I typically workout in the afternoon, and wondered when is the latest it should be taken?

    Or on the other hand, are there any plans for a non-stim version?

    Thanks
    There shouldn't be any problems. I workout at 5:00, and 8 caps, I was able to sleep with a little bit of pheni. But at 4 caps. No problem.
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    At 8 caps isn't that dangerous?. Isn't there some point where the dangers outweigh the benifits?.
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    Quote Originally Posted by Lanbane View Post
    Aaron, is that a lat, or a freakin wing?
    You guys are hilarious... I have never thought I had good development. I see nothing but areas to improve, expand, perfect, harden.
    But, I assure you it is not a wing... because I just spent another $259 on a round-trip tix to Venice CA to see the real big boys at Max Muscle. JJ Cutty brother!

    I just turned 22 five months ago... I'm 206 @ 5%, and 5'10''.
    Jay Cutty: 33 years old... 267 @ 2% BF, and 5'10''.



    YES... THOSE NUMBERS KEEP MY HEAD ON STRAIGHT HUMBLE!




    -Aaron R Smith

    PS: Applied Nutra, DIRK & Co... YOU'VE GOT MAIL

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    635 at 202! that's awesome bro, i can't wait till i'm done my contest prep and i can bulk again, i wanna be doing 650lbs for reps, my best was 550lbs x2 and i was 272lbs doing that, but 202lbs wow.
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    Quote Originally Posted by Outside Backer View Post
    that is right keep rubbing it in

    AA ur ****in huge


    Today Im supposed to be in charlotte with teh AN crew mackin hoes

    instead my ******* wife decided to fill a slot at work without telling me so Im stuck babysitting my son

    there is no level to which the anger I have achieved.

    but i told her the next show, im going regardless.


    OB-
    You know you welcome to kick it with us ANY time- hell, you can come up during the week if you want to.......

    Bro- we understand - family comes first
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    Quote Originally Posted by Mass_69 View Post
    Hey AN guys - What is the caffeine dose like in this? I typically workout in the afternoon, and wondered when is the latest it should be taken?

    Or on the other hand, are there any plans for a non-stim version?

    Thanks
    There are plans for a non-stim version- the stim blend is actually mild, compared to some of the other products on the market- the real beauty of the product lays in the functional hardness/strength/aggression that occurs from the P-SARM aspects of Icariin, plus the AI/Anti-Estro characteristics of the compound- it makes for a compound that produces a DRIVE- no other way to explain it really...It makes you feel like you are 10 feet tall!!!
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    Quote Originally Posted by T-Bone View Post
    At 8 caps isn't that dangerous?. Isn't there some point where the dangers outweigh the benifits?.
    This is true with any compound-my advice is to start small- go by our body weight titrated dosages, and work your way up...
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    Quote Originally Posted by CHAPS View Post
    635 at 202! that's awesome bro, i can't wait till i'm done my contest prep and i can bulk again, i wanna be doing 650lbs for reps, my best was 550lbs x2 and i was 272lbs doing that, but 202lbs wow.
    I just lost about 20+ pounds for track, it REALLY helps- I did not seem to lose much if any strength- actually my strength has gone up over the last 5 weeks- I have been experimenting with the new PM diet system I ran by you guys- about 20-30 people I know have tried it, and it works wonders.....
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    Quote Originally Posted by AlphaAnabolic View Post
    You guys are hilarious... I have never thought I had good development. I see nothing but areas to improve, expand, perfect, harden.
    But, I assure you it is not a wing... because I just spent another $259 on a round-trip tix to Venice CA to see the real big boys at Max Muscle. JJ Cutty brother!

    I just turned 22 five months ago... I'm 206 @ 5%, and 5'10''.
    Jay Cutty: 33 years old... 267 @ 2% BF, and 5'10''.



    YES... THOSE NUMBERS KEEP MY HEAD ON STRAIGHT HUMBLE!




    -Aaron R Smith

    PS: Applied Nutra, DIRK & Co... YOU'VE GOT MAIL

    Back at ya big A...
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    Quote Originally Posted by rms80 View Post
    OB-
    You know you welcome to kick it with us ANY time- hell, you can come up during the week if you want to.......

    Bro- we understand - family comes first
    dont try to be all mature and responsible with me

    ur supposed to make fun of me and laugh at the good time i missed
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    Looking forward to stimulant free version
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    hey I LOST my little crown I had above my rep
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    Quote Originally Posted by Outside Backer View Post
    hey I LOST my little crown I had above my rep
    Me too OB.... we got got.
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    Quote Originally Posted by Lanbane View Post
    Me too OB.... we got got.
    were we negged:hot:

    lol

    i liked my crown
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