For Your Viewing Pleasure, The Detailed RPM Write-up
- 04-20-2007, 07:50 PM
Naringin is also a PDE inhibitor w/ vasodillatory properties as well
Implication of cyclic nucleotide phosphodiesterase inhibition in the vasorelaxant activity of the citrus-fruits flavonoid (+/-)-naringenin.
* Orallo F,
* Camina M,
* Alvarez E,
* Basaran H,
* Lugnier C.
Departamento de Farmacologia, Facultad de Farmacia, Universidad de Santiago de Compostela, Santiago de Compostela (La Coruna), Spain. [email protected]
The potential vasorelaxant, antioxidant and cyclic nucleotide phosphodiesterase (PDE) inhibitory effects of the citrus-fruit flavonoids naringin and (+/-)-naringenin were comparatively studied for the first time in this work. (+/-)-Naringenin (1 microM - 0.3 mM) did not affect the contractile response induced by okadaic acid (OA, 1 microM). However, (+/-)-naringenin relaxed, in a concentration-dependent manner, the contractions elicited by phenylephrine (PHE, 1 microM) or by a high extracellular KCl concentration (60 mM) in intact rat aortic rings. Mechanical removal of endothelium and/or pretreatment of aorta rings with glibenclamide (GB, 10 microM) or tetraethylammonium (TEA, 2 mM) did not significantly modify the vasorelaxant effects of this flavanone. (+/-)-Naringenin (10 microM - 0.1 mM) did not alter the basal uptake of 4) Ca2+ but decreased the influx of 45Ca2+ induced by PHE and KCl in endothelium-containing and endothelium-denuded rat aorta. (+/-)-Naringenin (10 microM - 0.1 mM) was ineffective to scavenge superoxide radicals (O*2-) generated by the hypoxanthine (HX)-xanthine oxidase (XO) system and/or to inhibit XO activity. (+/-)-Naringenin (0.1 mM) significantly increased the production of cGMP and cAMP decreased by PHE (1 microM) and high KCl (60 mM) in cultured rat aortic myocytes. (+/-)-Naringenin preferentially inhibited calmodulin (CaM)-activated PDE1, PDE4 and PDE5 isolated from bovine aorta with IC50 values of about 45 microM, 60 microM and 68 microM, respectively. In contrast, the 7-rhamnoglucoside of (+/-)-naringenin, naringin (1 microM - 0.3 mM), was totally inactive in all experiments. These results indicate that the vasorelaxant effects of (+/-)-naringenin seem to be basically related to the inhibition of PDE1, PDE4 and PDE5 activities.
- 04-20-2007, 08:15 PM
Okay, enough waiting! What have he attempted again? Enough questioning, and let's get this on!
As most of you know, I am logging X2 and had the opportunity to test this product. All I can say is: Surprising, subtile, and very good stuff. Okay, the dosage is 4 caps. I noticed that like some mentionned in this thread, that the magic stick is just getting crazy. Some might not want to hear this, but I had to beat the meat 3 times in one evening!! Enough of that subject. On with my crazy plans. I took 8 caps pre wo. Yes, 8 caps. I am in a recomp phase and training every set to failure. On top of that, they're all drop sets! AAAAAAAAARRRRRRRRRRRRGGGGGGGGG GGGHHHHHHHHHHHHHH! I WAS ON FIRE! GET OUT OF MY WAY YOU WEAKS! RPM at 8 caps made me pumped until the last rep. when putting my t-shirt, it felt so tight, it was incredible. I still am on a very high cal. diet, and let me tell you, I can't wait to train again monday!
04-20-2007, 08:22 PM
Bro you have got some BALLS!!!! 8!!!!?
The highest I have gone is 5 before a workout, and I seriously thought I was going to kill someone- it just gives you this super-intense DRIVE to not just complete the workout, but to kill the iron in the process- makes me aggressive as hell, and crazy focused.....
Don runs about 3 bills, and he is even afraid to take any more than 5- Johnny S. won't take more than 4- he says it makes him too aggressive!!!
04-20-2007, 08:25 PM
04-20-2007, 08:30 PM
I took 5 RPM two days ago b/c we were maxing on squats- hit 635 @ 202 lbs., and felt like I could have done 3 or 4!!!! Then I went and did a full track work out, and then played basketball (full court) for 80 minutes- I still wanted to work out more, but I had to make myself quit!!
04-20-2007, 08:35 PM
Naringin makes PDE5 inhibitors more bioavaliable and last longer in the system (hint: Icariin is a PDE5 inhibitor)
check out this study w/ slidenafil (Viagra)
Clin Pharmacol Ther. 2002 Jan;71(1):21-9. Links
Clin Pharmacol Ther. 2005 Oct;78(4):441-3.
Effects of grapefruit juice on the pharmacokinetics of sildenafil.
* Jetter A,
* Kinzig-Schippers M,
* Walchner-Bonjean M,
* Hering U,
* Bulitta J,
* Schreiner P,
* Sorgel F,
* Fuhr U.
Institute for Pharmacology, Clinical Pharmacology, University of Koln, Germany. [email protected]
BACKGROUND AND OBJECTIVES: Because of extensive first-pass metabolism, oral bioavailability of sildenafil reaches only 40%. Formation of the primary metabolite, N -desmethylsildenafil, is mainly mediated by the cytochrome P450 enzyme CYP3A4. In this study we investigated the influence of grapefruit juice, containing inhibitors of intestinal CYP3A4, on the pharmacokinetics of sildenafil and N -desmethylsildenafil. METHODS: In a randomized crossover study, 24 healthy white male volunteers received single 50-mg doses of sildenafil. Two doses each of 250 ml grapefruit juice or water, respectively, were administered 1 hour before and together with the drug. Plasma concentrations of sildenafil and N -desmethylsildenafil were determined up to 24 hours post dose by use of liquid chromatography-tandem mass spectrometry (limit of quantification, 1 ng/ml). RESULTS: Grapefruit juice changed the area under the sildenafil plasma concentration-time curve from time zero to infinity [AUC(0-infinity) from 620 [1.53] ng/ml x h to 761 [1.58] ng/ml x h (geometric mean with geometric standard deviation), corresponding to a 23% increase (90% confidence interval, 13%-33%). N-Desmethyl sildenafil AUC(0-infinity) increased by 24% (90% confidence interval, 17%-32%). Maximum plasma concentrations (C(max)) of sildenafil and N -desmethylsildenafil were essentially unchanged. There was a trend toward a prolonged time to reach C(max) during the grapefruit juice period (from a median of 0.75 hour to a median of 1.13 hours), corresponding to an increase by 0.25 hour (90% confidence interval, 0-0.63 hour). Interindividual variability was pronounced in both periods. CONCLUSIONS: Grapefruit juice increases sildenafil bioavailability and tends to delay sildenafil absorption. Sildenafil pharmacokinetics may become less predictable with grapefruit juice. Although patients usually will not be endangered by concomitant use of grapefruit juice, it seems advisable to avoid this combination.
04-20-2007, 08:36 PM
04-20-2007, 08:37 PM
04-20-2007, 08:55 PM
04-20-2007, 08:58 PM
04-20-2007, 09:19 PM
Awesome NEWS GUYS!!!!
JJ you are a mad man taking 8 prework out you are a CHAMP!!!!
Glad to see the great results!!
This stuff just keeps BUILDING IT NEVER STOPS!!!! I NEED MORE I RAN OUT!!!!
But being a team player i want everyone on the board to get them i can wait!! I am already hooked!!!
Hey Rms can you set some carolina girls aside for me when i come and visit!!!!!
04-20-2007, 09:47 PM
And yeah, jjohn, poppin 8 caps is MANIACAL. Any more than 4 for me and I'd probably go RPM-rage on some random passerby.
Oh random: I got Cable internet hooked up at da crib.... I'm about to multiply my posts. lol
04-20-2007, 09:50 PM
LAN We need to get together and POP 8 pills AND ROCK SOME WEIGHTS!! MAKE A VIDEO CAUSE THERE WILL BE BLOOD!!!!!
PROB our own due to BLEED FROM THE EYES WITH INTENSITY!!!! AHHHHHH!!!!
04-20-2007, 09:53 PM
04-21-2007, 02:29 AM
04-21-2007, 02:40 AM
04-21-2007, 08:23 AM
Lookin HHUGE AA!
Carolina girls huh? Can you send me a sample of those too? See what kind of pump they are capable of.
Buffhunk, I should have brought my cam, but it was stolen a few days ago in my car! Man, if I would have been there, they would be chopped in pieces, and fried to feed the cows!
Holy SHIZZLE! My rep is going away HELP!!
04-21-2007, 08:34 AM
04-21-2007, 09:05 AM
AA ur ****in huge
Today Im supposed to be in charlotte with teh AN crew mackin hoes
instead my ******* wife decided to fill a slot at work without telling me so Im stuck babysitting my son
there is no level to which the anger I have achieved.
but i told her the next show, im going regardless.
toes-on-the-nose.blogspot.com Deployed blogging
04-21-2007, 10:38 AM
04-21-2007, 11:41 AM
Hey AN guys - What is the caffeine dose like in this? I typically workout in the afternoon, and wondered when is the latest it should be taken?
Or on the other hand, are there any plans for a non-stim version?
04-21-2007, 11:42 AM
04-21-2007, 12:35 PM
04-21-2007, 12:54 PM
But, I assure you it is not a wing... because I just spent another $259 on a round-trip tix to Venice CA to see the real big boys at Max Muscle. JJ Cutty brother!
I just turned 22 five months ago... I'm 206 @ 5%, and 5'10''.
Jay Cutty: 33 years old... 267 @ 2% BF, and 5'10''.
YES... THOSE NUMBERS KEEP MY HEAD ON STRAIGHT HUMBLE!
-Aaron R Smith
PS: Applied Nutra, DIRK & Co... YOU'VE GOT MAIL
04-21-2007, 01:45 PM
635 at 202! that's awesome bro, i can't wait till i'm done my contest prep and i can bulk again, i wanna be doing 650lbs for reps, my best was 550lbs x2 and i was 272lbs doing that, but 202lbs wow.
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