GLA + Endothil-Cr= Amazing stack?

[Socrates44]

Ok, GLA (gamma-linoleic acid) is an Omega-6 fatty acid. It is commonly found in Evening Primrose Oil, marketed towards women.
Seeing as I am a cheap-a$$ I have come to realize GLA is converted into Arachidonic Acid in the body. This fatty acid eventually creates leukotrienes which are bad news for asthmatics, but good news for lifters.

Now i have personally used Endothil with great success. Since endothil helps to recruit stem-cells for new muscle growth after you have tricked your body into thinking it was dying, couldnt you use the inflammatory effect of GLA to prolong and accelerate the endothils affect?

Anyone tried this? Does this sound like a killer stack to anyone else or am I a dolt?

[emiliozapata]

havent tried it but borage oil is an even greater source of the GLA than what EPO is

[Vipersg123]

endothil is literally green tomato...

[Socrates44]

endothil is literally green tomato...

I know, and it ticks me off... I am super skeptical of everything I try, but I got like 40 tabs from the Arnold and I tried it out. I trained to failure and it worked amazingly. I have no idea why or how, but it definitely put some mass and strength on me.

[cervasa1977]

I know, and it ticks me off... I am super skeptical of everything I try, but I got like 40 tabs from the Arnold and I tried it out. I trained to failure and it worked amazingly. I have no idea why or how, but it definitely put some mass and strength on me.

maybe it was you training to failure that put the mass on endothil is a joke..........

[emiliozapata]

Apparently black currant seed oil is the stuff to get for GLA content, interesting that it converts to ARA in the body, i wonder how efficient the conversion is, mg for mg.

[Socrates44]

Yea because if something in that endothil actually works (and im not claiming miracles) and it does what it says, if you induce inflammation and work out to failure, you could be seeing some serious mass gains.

[thesinner]

I could've sworn ARA was an essential fatty acid, meaning you're body cannot produce it.

[Socrates44]

GTE (Green Tomato Extract) has been shown to cause angiogenesis in small quanities. Angiogenesis is the creating of new blood vessels. Endothil, gets its name from endothelial, the endothelial cells are those that line the interior of the artery. These cells contain certain receptors called alpha 7-nicotinic acetylcholine receptor (a-7ACR) for short. These receptors are the target of the GTE. When they interact, the a-7ACR uses the GTE as its substrate and activates a cascade that causes angiogenesis. However, this will only take place under hypoxia or inflammation (commonly found in muscle wasting diseases such ALS and Muscular Dystrophy). Side note: endothil was actually made for these disorders.


Like I said before, I am an endo and I can put on muscle really easy. After two weeks of using this stuff I put on 5-7lbs and my strength shot up. I can't wait to try it again with some GLA.

[Socrates44]

I could've sworn ARA was an essential fatty acid, meaning you're body cannot produce it.

Your body can only produce omega 3 fatty acids. However, since you are bringing in an exogenous omega 6, your body can transduce GLA into AA, giving you the inflammatory properties.

[thesinner]

Good luck socrates, let us know how this pans out.

[Wordz_Worf]

Interesting stuff.

[Aeternitatis]

I have come to realize GLA is converted into Arachidonic Acid in the body. This fatty acid eventually creates leukotrienes which are bad news for asthmatics, but good news for lifters.

Unfortunately for you, it doesn't actually work that way.

The only way to utilize the increased anabolism from arachidonic acid is to consume arachidonic acid. May I suggest X-Factor?

[Socrates44]

Unfortunately for you, it doesn't actually work that way.

The only way to utilize the increased anabolism from arachidonic acid is to consume arachidonic acid. May I suggest X-Factor?

Actually GLA is transduced down into AA and Dihomo-gamma-linoleic acid and I think EPA correct?

Now taking a pro-inflammatory agent like AA is one of the most absurd things I can think of. You are turning on Thromboxane which causes a myriad of problems (increased vasoconstriction, increases platelet aggregation which increases the risk of embolies and clots). With GLA you are getting the slight inflammatory period of AA, but then having it wiped clean by the EPA and DHLA (merely a contraindication of pro-inflammatory and anti-inflammatory). While I am not bashing your product, I believe people need to be truly informed about AA before it is widely accepted as an everyday supplement.

Arachidonic Acid
1.)platelet aggregation
2.)Vasoconstriction
3.)Leukotriene synthesis (causes bronchoconstriction)

The GLA will have the slight inflammatory effect of AA with the excellent health benefits of Omega-3 fatty acids.


Also, if I am not mistaken, you probably reccommend that people not use Omega-3 supplementation while using X-Factor correct?

[Aeternitatis]

I'm not arguing the metabolism of GLA at all. What I'm saying is that the theory doesn't work out in the real world.

Have you used XF before? I think it's important that you have in order to compare the results. But I'm willing to wager that not only will GLA NOT provide the anabolism associated with X-Factor supplementation, but it may be counterproductive at such high doses.

I encourage you to try this out though. Preferably without any other supplements to confound the results.

[Aeternitatis]

Actually GLA is transduced down into AA and Dihomo-gamma-linoleic acid and I think EPA correct?

Now taking a pro-inflammatory agent like AA is one of the most absurd things I can think of. You are turning on Thromboxane which causes a myriad of problems (increased vasoconstriction, increases platelet aggregation which increases the risk of embolies and clots). With GLA you are getting the slight inflammatory period of AA, but then having it wiped clean by the EPA and DHLA (merely a contraindication of pro-inflammatory and anti-inflammatory). While I am not bashing your product, I believe people need to be truly informed about AA before it is widely accepted as an everyday supplement.

Arachidonic Acid
1.)platelet aggregation
2.)Vasoconstriction
3.)Leukotriene synthesis (causes bronchoconstriction)

I guess you haven't seen the studies showing AA supplementation at 4.7 grams per day for 50 days showing no signs of the above markers.

[Socrates44]

I guess you haven't seen the studies showing AA supplementation at 4.7 grams per day for 50 days showing no signs of the above markers.

No I have not, but if you have the link I would enjoy the read. I am a pharmacologist first, lifter second, and I have been wanting to hear good news about AA for a long time from a reliable second-party.

Not saying you arent reliable, but you may be a little biased

[Aeternitatis]

No I have not, but if you have the link I would enjoy the read. I am a pharmacologist first, lifter second, and I have been wanting to hear good news about AA for a long time from a reliable second-party.

Not saying you arent reliable, but you may be a little biased

Sure, I'll go find it. It's what we based our 50 day cycle recommendation on.

[Aeternitatis]

Okay, here's this for now. Still looking for that other one. I don't think I saved it with my regular X-Factor info, so it might take me a while to find it.


"... adding 1.5 g/d of dietary AA for 50 d to a typical Western diet containing about 200 mg of AA produces no observable physiological changes in blood coagulation and thrombotic tendencies in healthy, adult males compared to the unsupplemented diet. " - Lipids. 1997 Apr;32(4):421-5

"AA (1.5 g/d) was incorporated into the diet of six men from day 16 to 65... the lack of any adverse effects on immune response indicates that supplementation with AA may be done safely when needed for other health reasons.' - Lipids. 1997 Apr;32(4):449-56.

"Normal healthy male volunteers (n = 10) were fed diets (high-AA) containing 1.7 g/d of arachidonic acid (AA) for 50 d... Dietary AA had no statistically significant effect on the blood cholesterol levels, lipoprotein distribution, or apoprotein levels. ... the results demonstrate that dietary AA does not alter blood lipids or lipoprotein levels or have obvious adverse health effects at this level and duration of feeding. " - Lipids. 1997 Apr;32(4):427-33.

[kdent7]

GLA -> DGLA (Anti-Inflammatory conversions).

DGLA -> AA (Pro-Inflammatory conversions).

DGLA is metabolized to AA via Delta-5 Desaturase. Delta-5 is the enzyme used for both conversion to AA and also for further conversion of EPA to anti-inflammatory compounds.

Delta-5 is preferential (binding affinity maybe) towards further EPA conversions as opposed to DGLA -> AA conversion.

Additionally Delta-5 is inhibited by Sesamin intake. (further Anti-Inflammation).

Am I going to source all of this...not a chance, laziness abound

I'm currently attempting to fight inflammation with a stack of Super EPA (NOW), GLA (Borage, EPO), Sesamin and Curcumin Extract w/ Bioperine.