[Flaw]

What do you feel is the best supplemental ways to increase dopamine?

I've heard of the combinations of D/L-Phenylalanine with deprenyl or tyrosine with deprenyl. Deprenyl can be quite expensive. Wondering if there's some other cost effective combinations.

Any other maoi's besides deprenyl that would work? thanks

[delton]

Originally Posted by Flaw

What do you feel is the best supplemental ways to increase dopamine?

I've heard of the combinations of D/L-Phenylalanine with deprenyl or tyrosine with deprenyl. Deprenyl can be quite expensive. Wondering if there's some other cost effective combinations.

Any other maoi's besides deprenyl that would work? thanks

USPLab's Powerfull is a direct dopamine supplement (herbal source of dopamine). It is not an MAOI. I've been using it for a month now, and the effects are striking -- so much so that I'm concerned about long-term adjustment of my natural dopamine levels. I'll try a two-week stop on it soon and see if their is a noticeable rebound. Anyway, if cost is a concern, you can get Powerfull in bulk from Nutraplanet. Some care is required in taking this... it must be taken on an empty stomach, 30 minutes before eating. And it should be spread out in multiple doses. The suggested dosing is three times per day, with the last dose at bedtime. On workout days, one of the doses should be 30 minutes before exercise (if that can be on an empty stomach... Powerfull is really not effective otherwsie).

Deprenyl is an MAO-B inhibitor, and so it's a lot more complicated than simply boosting dopamine. There are other benefits with deprenyl, having to do with neuro-protective effects, so I'm not knocking it. But it is expensive, difficult to obtain, and potentially more complex in its spectrum of effects.

[Ziricote]

Hmm, L-Dopa? ;P
USPLabs "1-carboxy-2-amino-3-pyrobenzol(3,4 diol)" aka 1-c is the main active in USPLabs PowerFULL responsible for the GH raising effect. Either PowerFULL or 1-c will work well for increasing GH via Dopamine.

PowerFULL@Nutra
«Genera Bulk 1-carboxy-2-amino-3-pyrobenzol(3,4 diol) - Discount Bodybuilding - Nutritional Supplements

[Flaw]

cool.. will the older version of powerfull work as well?

PowerFULL [130 Capsules] - $34.99$14.99

or this version does not contain the ingredients in the new one?

[Flaw]

Originally Posted by delton

USPLab's Powerfull is a direct dopamine supplement (herbal source of dopamine). It is not an MAOI. I've been using it for a month now, and the effects are striking -- so much so that I'm concerned about long-term adjustment of my natural dopamine levels. I'll try a two-week stop on it soon and see if their is a noticeable rebound. Anyway, if cost is a concern, you can get Powerfull in bulk from Nutraplanet. Some care is required in taking this... it must be taken on an empty stomach, 30 minutes before eating. And it should be spread out in multiple doses. The suggested dosing is three times per day, with the last dose at bedtime. On workout days, one of the doses should be 30 minutes before exercise (if that can be on an empty stomach... Powerfull is really not effective otherwsie).

cool.. do post the results. Very interested in powerfull now. I've used phenibut with some noticable effects on dopamine but it's effects are mainly on increasing gaba. This led me to believe that not only were my gaba receptors weak but possibly my dopamine if just that small amount of phenylalanine.. worked. Haven't tried phenylalanine on it's own. Have tried tyrosine with some noticable effects but i'm looking for something a little more serious but don't wanna go the illegal route. thanks for the info.

[Ziricote]

The old version works nicely, I still have ~10 bottles of it that I look forward to using before going onto the new version. I'm not sure I'd say it's as good as the new version but I haven't tried the new yet.

[Flaw]

Originally Posted by Ziricote

The old version works nicely, I still have ~10 bottles of it that I look forward to using before going onto the new version. I'm not sure I'd say it's as good as the new version but I haven't tried the new yet.

sweet. I think the bulk powder from nutraplanet looks like the best deal. Is there a tolerance to this stuff that you have noticed?

[WannaBeHulk]

why do you want to increase dopamine? have you gone through testing to determine neurotransmitter levels? are you depressed?

anyways, besides supps, this can be achieved through diet as well. i know brocolli and bananas have dopamine boosting effects. i know there are many others but im drawing a blank right now.

[delton]

Originally Posted by Flaw

cool.. do post the results. Very interested in powerfull now. I've used phenibut with some noticable effects on dopamine but it's effects are mainly on increasing gaba. This led me to believe that not only were my gaba receptors weak but possibly my dopamine if just that small amount of phenylalanine.. worked. Haven't tried phenylalanine on it's own. Have tried tyrosine with some noticable effects but i'm looking for something a little more serious but don't wanna go the illegal route. thanks for the info.

As I said, I've been using it for just one month. In the first two weeks, I noticed some definite tension/alertness that was different than caffeine or ephedrine. This has subsided. I still notice two major effects: 1) Pronounced effect on my sleep... much deeper, and 2) more intense and focused workouts. The sleep effect was more pronounced in the beginning, but it's still there. As recommended, I take a double dose now before exercise, and before sleep.

It's too early to say about the possible GH boost effects... I do notice some body recomposition happening with some new muscle, but I'm also taking Anabolic Pump (muscle-specific insulin mimic), so it's hard to say.

I haven't noticed a testosterone boosting effect. This may be age related (I'm 41). I get more effect from things like Activate, Rebound Reloaded, and (especially) clomid.

Anyway, the effect is very real and noticeable. Just take care to follow the dosing directions (empty stomach, 30 minutes before eating, spread out through the day, before exercise and before sleep).

[Sir Savage]

HEAT raises dopamine, among other things. You might look into it when it's back in stock.

[Jim Sadler]

Originally Posted by Sir Savage

HEAT raises dopamine, among other things. You might look into it when it's back in stock.

Is it coming back in its original formula? Are you guys releasing another "fat burner" in parallel?

I always liked HEAT. No caffeine makes it easy to use in conjunction with other products. (Like AMP.)

[Sir Savage]

Yeah, HEAT is coming back. We're just out right now.

And yeah, a new thermo/stimulant will be released in parallel.

[Lanbane]

You know I have to chime in....

Applied Nutriceutical's IGF-2

Quote from AN's technical writeup:
L-Dopa and its effects on Testosterone and Human Growth Hormone
Another important chemical mechanism of IGF-2™ is L-Dopa-induced growth hormone (GH) release, and increased testosterone secretion through prolactin inhibition. Prolactin is a hormone that regulates testosterone production, and too much of it can suppress the secretion of gonadotropins, which hinders testosterone production. By inhibiting prolactin, IGF-2 increases endogenous testosterone levels dramatically. The variety of Mucuna Pruriens used in IGF-2™ is standardized to 25% L-Dopa, delivering large amounts of this active ingredient per capsule (27). L-Dopa is a precursor to Dopamine, a powerful biogenic amine, and L-Dopa is the only method of transport of Dopamine through the blood-barrier(3,15,16). Dopamine is a potent GH and testosterone agonist, meaning that dopamine inhibits prolactin release and hypothalamic somatostatin secretion, which allows for a greater stimulatory effect of growth hormone-releasing hormone (GHRH) and secretion of testosterone by the testes. GHRH signals the pituitary to release GH, a polypeptide hormone produced by the somatotropic cells of the anterior pituitary (3,11,12,14,15,16). GH stimulates skeletal muscle cells to grow and, in some cases, divide. Acting directly, GH mobilizes fats from fat depots and decreases the rate of glucose intake and metabolism. In mammals, GH exerts most of its anabolic effects through being mediated by IGF; IGF is also known as somatomedin, which stimulates the uptake of amino acids from the blood and into skeletal muscle, providing for a variety of anabolic effects in the human body. This is important, as IGF-2™ provides the biochemical stimulus for the aforementioned muscle-building processes.

[Flaw]

Very informative post. I could definetly use a dopamine kick.

[WannaBeHulk]

Originally Posted by Lanbane

You know I have to chime in....

Applied Nutriceutical's IGF-2

Quote from AN's technical writeup:
L-Dopa and its effects on Testosterone and Human Growth Hormone
Another important chemical mechanism of IGF-2™ is L-Dopa-induced growth hormone (GH) release, and increased testosterone secretion through prolactin inhibition. Prolactin is a hormone that regulates testosterone production, and too much of it can suppress the secretion of gonadotropins, which hinders testosterone production. By inhibiting prolactin, IGF-2 increases endogenous testosterone levels dramatically. The variety of Mucuna Pruriens used in IGF-2™ is standardized to 25% L-Dopa, delivering large amounts of this active ingredient per capsule (27). L-Dopa is a precursor to Dopamine, a powerful biogenic amine, and L-Dopa is the only method of transport of Dopamine through the blood-barrier(3,15,16). Dopamine is a potent GH and testosterone agonist, meaning that dopamine inhibits prolactin release and hypothalamic somatostatin secretion, which allows for a greater stimulatory effect of growth hormone-releasing hormone (GHRH) and secretion of testosterone by the testes. GHRH signals the pituitary to release GH, a polypeptide hormone produced by the somatotropic cells of the anterior pituitary (3,11,12,14,15,16). GH stimulates skeletal muscle cells to grow and, in some cases, divide. Acting directly, GH mobilizes fats from fat depots and decreases the rate of glucose intake and metabolism. In mammals, GH exerts most of its anabolic effects through being mediated by IGF; IGF is also known as somatomedin, which stimulates the uptake of amino acids from the blood and into skeletal muscle, providing for a variety of anabolic effects in the human body. This is important, as IGF-2™ provides the biochemical stimulus for the aforementioned muscle-building processes.

ive wondered this for awhile and it seems appropriate to ask here. would L-dopa desensitize your receptors or would it help upregulate them? if your body becomes accustomed to obtaining L-dopa through supplementation, wouldnt this hinder the natural production of dopamine?

[Lanbane]

Originally Posted by WannaBeHulk

ive wondered this for awhile and it seems appropriate to ask here. would L-dopa desensitize your receptors or would it help upregulate them? if your body becomes accustomed to obtaining L-dopa through supplementation, wouldnt this hinder the natural production