No grapefruit with RRY?

[RedwolfWV]

I was recently told to not eat or drink grapefruit while using red rice yeast, however no explaination was given. I cant find anything on the net about this. Anyone else ever hear this?

 

[Big BAMA]

I have been warned about eating or drinking Grapefruit when taking certain medications. I think it has something to do with the Type of acid that is in grapefruit and how it reacts when combined with stomach acid and other products.

 

[Bionic]

I think it has to do w/a chemical in grapefruit that suppresses a liver enzyme that breaks things down. Basically, you will get waaaaay more of the active into your system which could result in a toxic dose. There are several supps that contain this chemical but I don't think I'd ever mess w/ it.

 

[Mass_69]

I think it has to do w/a chemical in grapefruit that suppresses a liver enzyme that breaks things down. Basically, you will get waaaaay more of the active into your system which could result in a toxic dose.

That's it there. Grapefruit contains bergamottin, which inhibits an enzyme (I think CYP-450) responsible for breaking down substances in the liver. It also container narinigin, which can extend the 1/2 life of some medications (not sure which, but I believe many stimulants would be on that list).

 

[RedwolfWV]

Interesting. Thanks for the info guys. I'll keep looking and post if I find any additional information on it.

 

[Chad]

so if i mix my no xplode with grapefruit juice ill lose my freaking mind?