- 08-02-2003, 04:41 AM
Originally posted by Chemo
BTW, we are not terribly creative with naming our products. We feel that companies naming their products things like "testabol" and "dianobolex" are misleading their customers and they basically suck ass. UCP-1 stands for Usnic acid, Carnitine, Pyruvate, 1st in a series.
"Uncoupling protein 1 (UCP1) was the first of this protein family to be identified and is found only in brown adipose tissue. UCP1 functions in non-shivering thermogenesis by transporting protons and monovalent anions such as chloride. UCP1 is activated by free fatty acids and inhibited by purine nucleoside di- and triphosphate. UCP1 is located within the inner mitochondrial membrane and "uncouples" oxidative phosphorylation; i.e., energy released from chemical bonds is dissipated as heat instead of forming new ATP. A proton transport mechanism was discussed. This proposed mechanism is based on a H+ donor-acceptor theory that utilizes fatty acid catabolism to supply the H+ ions. It was proposed that a binding/dissociation reaction occurred at the nucleotide binding site of UCP1. Site directed mutagenesis studies identified a number of charged amino acid residues within the UCP protein that were active in the transport of H+ or Cl- ions. Additionally, charged amino acid residues that are important for nucleotide binding were identified."
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