patc12303
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has anyone herd of these supplements? Do you know if they are safe, and is if-2 a steroid?
"Mess with your body" sounds so negative.............since I'm only 17 will the igf-2 mess with my body??
Mullet, no trouble caused.I do not wish to cause trouble, but may I pose a question about the product? The actual profile looks sick, but it seems redundant to combine a HGH and Insulin formula within the same product. As I see it, lowering serum glucose levels before sleep would cause the Liver to release glycogen once REM is induced. As I understand it, this would induce gluconeogenesis, which is not the greatest state to be in. Once again, I think this could be an amazing product, just wondering on the dose and timing..
I asked the owner of AN this question and here is what he replied:I do not wish to cause trouble, but may I pose a question about the product? The actual profile looks sick, but it seems redundant to combine a HGH and Insulin formula within the same product. As I see it, lowering serum glucose levels before sleep would cause the Liver to release glycogen once REM is induced. As I understand it, this would induce gluconeogenesis, which is not the greatest state to be in. Once again, I think this could be an amazing product, just wondering on the dose and timing..
I'm not really understanding what you are trying to ask- but here is what I can tell you:
1. IGF-2 is not a GH and insulin product- it promotes GH release, along with testosterone enhancement and a cortisol-lowering effect in a synergistic manner.
2. IGF-2 raises GH levels prior/during the first part of sleep, resulting in higher blood glucose levels, not lower- thus preserving the amino acid pool during the "nutritional dead time" of sleep- this has an actual muscle-sparing effect.
3. The night-time dose is meant to be taken on an empty stomach 30 minutes before bed time.
Does this answer your questions? If not, let us know.
D
No, I was referring to Lipotrophin PM. Let me ask you this: Do you not find it contradictory to include ingredients which raise natural HGH production, while simultaneously modulating Insulin? Though at the applied dosage no real health concern is present, HGH blunts Insulin response at the Skeletal Mucle Delivery stage; conversely, Corosolic Acid exerts its blood glucose regulatory effect at the Plasma Membrane stage of regulation. IMO, at least, it would seem contradictory to increase membrane permeability while subtracting the delivery system. No?Safe assumption that you have your answer, Mullet?
I see.No, I was referring to Lipotrophin PM. Let me ask you this: Do you not find it contradictory to include ingredients which raise natural HGH production, while simultaneously modulating Insulin? Though at the applied dosage no real health concern is present, HGH blunts Insulin response at the Skeletal Mucle Delivery stage; conversely, Corosolic Acid exerts its blood glucose regulatory effect at the Plasma Membrane stage of regulation. IMO, at least, it would seem contradictory to increase membrane permeability while subtracting the delivery system. No?
Mullet-No, I was referring to Lipotrophin PM. Let me ask you this: Do you not find it contradictory to include ingredients which raise natural HGH production, while simultaneously modulating Insulin? Though at the applied dosage no real health concern is present, HGH blunts Insulin response at the Skeletal Mucle Delivery stage; conversely, Corosolic Acid exerts its blood glucose regulatory effect at the Plasma Membrane stage of regulation. IMO, at least, it would seem contradictory to increase membrane permeability while subtracting the delivery system. No?
Well, I'll have to be honest: I couldn't have put it better myself.Mullet-
No- definitely not contradictory- we are one step ahead of you- we are trying to cover ALL our bases A concern in any GH-boosting product is insulin insensitivity, and banaba (through the tannic acid component) is excellent at preventing this from happening through GLUT4 translocation and alteration of the PPAR gene (which is required for adipogenesis) (1).
You are correct- HGH does blunt insulin in skeletal muscle, but at the same time, increased HGH (and any other hyperglycemic hormone for that matter) actually causes a concurrent increased indirect release of insulin (look it up, it is in any physiology book).
Mucuna Pruriens (the compound responsible for L-Dopa induced GH release) causes an increase in lipolysis, while at the same time increasing blood glucose and sparing muscle protein. Bacopa monnieri is also included in the product to optimize thyroid levels, and optimal thyroid levels mean increased GH secretion and up-regulation of GH receptors(2). The combination of these two products can promote a very favorable fat-burning enviroment through thyroid and GH-level optimization.
However, increases in HGH have a mild diabetogenic effect, meaning that it is known to mimic the high blood sugar levels typical of diabetes mellitus, a situation which we wanted to prevent. That being said, banaba is not insulin, but does have a dose dependant curve similar to it, BUT at the same time, it has some very marked differences from insulin (1). Banaba actually slows the uptake of glucose into fat cells, something that is the exact opposite of insulin- the inclusion of banaba allows the user to maintain OPTIMAL insulin sensitivity while using the product.
Competitive bodybuilders do the same thing all the time- when injecting exogenous GH, they also take T3 to optimize GH levels, while at the same time taking injectible insulin to combat GH-induced hyperinsulemia (2). Our products are not as strong as their pharmaceutical cousins, but most pharmaceutical drugs on the market have had at least some derivation from plants .
That being said, the comment about plasma regulation at the membrane level- insulin and corosolic acid demonstrate similar phosphorylation of protein factors in the pathway that causes GLUT4 translocation (1). This really has nothing to do with how HGH exerts its effects- the receptors for insulin (and it seems corosolic acid) are completely different from those of HGH, so there is not any type of competition for the same receptor sites between the two compounds. This means while HGH and insulin are antagonistic, they still exert their effects on different receptors and target tissues. Your comment about membrane permeability really does not have any bearing in the argument- HGH does not have any type of effect on the receptor/substrate interaction of IRS-1 and PI 3-kinase and polypeptide insulin molecules.
1) Liu, X. Jae-kyung, K. Yunsheng, L. Jing, L, Liu, F. and Chen, X. (2005) Tannic Acid Stimulates Glucose Transport and Inhibits Adipocyte Differentiation in 3T3-L1 Cells. Bio. and Mol. Actions of Nut. 135: 165-171.
2) Haycock, Brian. (2005) Growing Beyond What Nature Intended: Growth Factors Take us to the Next Level of Sophistication in Bodybuilding. Part 3
Mullet-
No- definitely not contradictory- we are one step ahead of you- we are trying to cover ALL our bases A concern in any GH-boosting product is insulin insensitivity, and banaba (through the tannic acid component) is excellent at preventing this from happening through GLUT4 translocation and alteration of the PPAR gene (which is required for adipogenesis) (1).
You are correct- HGH does blunt insulin in skeletal muscle, but at the same time, increased HGH (and any other hyperglycemic hormone for that matter) actually causes a concurrent increased indirect release of insulin (look it up, it is in any physiology book).
Mucuna Pruriens (the compound responsible for L-Dopa induced GH release) causes an increase in lipolysis, while at the same time increasing blood glucose and sparing muscle protein. Bacopa monnieri is also included in the product to optimize thyroid levels, and optimal thyroid levels mean increased GH secretion and up-regulation of GH receptors(2). The combination of these two products can promote a very favorable fat-burning enviroment through thyroid and GH-level optimization.
However, increases in HGH have a mild diabetogenic effect, meaning that it is known to mimic the high blood sugar levels typical of diabetes mellitus, a situation which we wanted to prevent. That being said, banaba is not insulin, but does have a dose dependant curve similar to it, BUT at the same time, it has some very marked differences from insulin (1). Banaba actually slows the uptake of glucose into fat cells, something that is the exact opposite of insulin- the inclusion of banaba allows the user to maintain OPTIMAL insulin sensitivity while using the product.
Competitive bodybuilders do the same thing all the time- when injecting exogenous GH, they also take T3 to optimize GH levels, while at the same time taking injectible insulin to combat GH-induced hyperinsulemia (2). Our products are not as strong as their pharmaceutical cousins, but most pharmaceutical drugs on the market have had at least some derivation from plants .
That being said, the comment about plasma regulation at the membrane level- insulin and corosolic acid demonstrate similar phosphorylation of protein factors in the pathway that causes GLUT4 translocation (1). This really has nothing to do with how HGH exerts its effects- the receptors for insulin (and it seems corosolic acid) are completely different from those of HGH, so there is not any type of competition for the same receptor sites between the two compounds. This means while HGH and insulin are antagonistic, they still exert their effects on different receptors and target tissues. Your comment about membrane permeability really does not have any bearing in the argument- HGH does not have any type of effect on the receptor/substrate interaction of IRS-1 and PI 3-kinase and polypeptide insulin molecules.
1) Liu, X. Jae-kyung, K. Yunsheng, L. Jing, L, Liu, F. and Chen, X. (2005) Tannic Acid Stimulates Glucose Transport and Inhibits Adipocyte Differentiation in 3T3-L1 Cells. Bio. and Mol. Actions of Nut. 135: 165-171.
2) Haycock, Brian. (2005) Growing Beyond What Nature Intended: Growth Factors Take us to the Next Level of Sophistication in Bodybuilding. Part 3
The key word is opinion- I took endocrinology and plenty of anatomy and physiology (both undergraduate level and at the graduate level) as well- please refer to and re-read the FAQ's on our website- we recommend taking Lipo-PM ON AN EMPTY stomach 45 minutes before bedtime- I am familiar with the study you are referencing.In order for corosolic acid to work, you must consume carbohydrates. If you consume glucose, the release of dopamine induced HGH release is blunted.
If glucose is not consumed, you will release glucagon. Glucagon signals glycogenolysis (releas of glucose from the liver). When the liver stores are depleted, glucagon encourages gluconeogenisis(glucose from amino acids).
This is basic.
If you advocoate eating carbohydrates before taking Litp PM, Glucose blunts the release of HGH induced by l-dopa.
In 1975, Ajlouni and colleagues reported the effects of 500mg of oral L-dopa on eight normal and 8 non-obese insulin-dependent diabetic subjects. The normal subjects increased their plasma HGH from 1.5mg/ml before L-dopa, to an average 21mg/ml at 90 minutes post L-dopa, with all subjects showing at least a 10 mg/ml increase. The diabetics increased from 2.5mg/ml to 20mg/ml from 60-90 minutes post L-dopa. Giving glucose with, or 30 minutes after the drug totally suppressed the expected HGH increase (7).
Ajlouni, K. et al (1975) “Effect of glucose on the growth hormone response to L-dopa in normal and diabetic subjects” Diabetes 24:633-36.
This is really basic endocrinology one of my favorite courses in college.
We both have differing opinions thats obvious.
The key word is opinion- I took endocrinology and plenty of anatomy and physiology (both undergraduate level and at the graduate level) as well- please refer to and re-read the FAQ's on our website- we recommend taking Lipo-PM ON AN EMPTY stomach 45 minutes before bedtime- I am familiar with the study you are referencing.
Re-read the post- corosolic acid is included in the product to boost insulin sensitivity. The reasoning behind this is that corosolic acid down-regulates PPAR, and recent research has revealed a new polypeptide hormone, resistin, that has been discerned as one of the potential link between obesity and type II diabetes. PPAR and resistin are almost chemically identical and there is evidence that b/c CA can down-regulate PPAR, it can also also down-regulate resistin, resulting in greatly increased insulin sensitivity (2).
This finding is completely independent of the statement "In order for corosolic acid to work, you must consume carbohydrates" - this study (which you reference constantly in your write-ups), states that one of the main areas interest in CA/TA is preventing adipogenic activity and increasing insulin sensitivity- not just that corosolic acts like insulin in muscle cells (2).
CA stimulates glucose uptake through a different method than other anti-diabetic drugs on the market- that being said, the different classes on anti-diabetic drugs have different actions, but all 3 have something in common- they can still work without glucose/carbohydrates.
The product incorporates banaba strictly for its effects on GLUT4 translocation and insulin-sensitizing properties (through preventing PPAR/resistin expression in adipocytes). Mucuna Pruriens also has some blood-sugar lowering properties as well, yet it still causes GH release- and subsequent increased blood glucose- the effects seem to compliment/counterbalance one another (1). If it did not, Lipo-PM would not help people sleep longer, deeper, and better (signs of increased GH activity). If the banaba and mucuna contraindicated like you state, neither would work, yet both do. There have been no reports of hypoglycemia by our testers, and almost everyone who has used it claims deeper, more restful sleep, along with decreased body fat, which indicates greater GH release.
1. Rathi, SS. Grover, JK and Vats, V The effect of Momordica charantia and Mucuna pruriens in experimental diabetes and their effect on key metabolic enzymes involved in carbohydrate metabolism. Dept. of Pharmacology, New Delhi
2. Liu, X. Jae-kyung, K. Yunsheng, L. Jing, L, Liu, F. and Chen, X. (2005) Tannic Acid Stimulates Glucose Transport and Inhibits Adipocyte Differentiation in 3T3-L1 Cells. Bio. and Mol. Actions of Nut. 135: 165-171.
...but, what if tha tank is full (or close to it) prior to sleep?Yes the supplement works but where is the glucose comming from?
Justifying why I put an ingredient in what is an extremely effective compound (which I just did, in detail), is now getting to the point of apples and oranges. Read and re-read my posts, everything on them is referenced, and is true- if you want to play interpretive biology, it is up to you. Like you have said numerous times before, what the consumer decides is up to the consumer. You prefer to state opinion, I prefer to state fact. The thread is on NeoVar/IGF-2, and if you have anything constructive to add, please do.To quote a medical Biochemistry text book
Stores of readily available glucose to supply the tissues with an oxidizable energy source are found principally in the liver, as glycogen. A second major source of stored glucose is the glycogen of skeletal muscle. However, muscle glycogen is not generally available to other tissues, because muscle lacks the enzyme glucose-6-phosphatase.
The major site of daily glucose consumption (75%) is the brain via aerobic pathways. Most of the remainder of is utilized by erythrocytes, skeletal muscle, and heart muscle. The body obtains glucose either directly from the diet or from amino acids and lactate via gluconeogenesis. Glucose obtained from these two primary sources either remains soluble in the body fluids or is stored in a polymeric form, glycogen. Glycogen is considered the principal storage form of glucose and is found mainly in liver and muscle, with kidney and intestines adding minor storage sites. With up to 10% of its weight as glycogen, the liver has the highest specific content of any body tissue. Muscle has a much lower amount of glycogen per unit mass of tissue, but since the total mass of muscle is so much greater than that of liver, total glycogen stored in muscle is about twice that of liver. Stores of glycogen in the liver are considered the main buffer of blood glucose levels.
reccomending a glucose like compound(almost as strong as insulin) before bed is not the best idea. But Hey, I WAS NOT THE BRAINS behind USPLabs..
Take Anabolic Pump before sleep and you will turn into a hypoglycemic mess.
Thank you, Lanbane.Ok, seriously. It's done.
This forum does not need to dissolve into a certain other forum full of personal attacks and putdowns. Besides, I am sure it will not be allowed to come to this.
If you have argument against the supplements, take it up with the customer service email provided on the website. This is not the type of thing that needs to be brought up in the manner you are trying to do it, as your purpose is evident. I have no doubts whatsoever that USPlabs does not want the "attacks" to suddenly go both directions. Think before you talk.
This is as far as I personally will take this. I was a USPLabs supplement user for quite awhile, and hold no personal grudges. I have personally defended the company and Jacob as a person numerous times. But I will just as soon stand up for someone else when they are right in a given situation. No further replies.
Moderators, obviously the purpose of this thread was fulfilled long ago. Closure is in order.
https://www.blackstarlabs.com/blackstarlabs_old/product_info.php?products_id=46Random question: Toad, does BSL still make Go!? I liked that stuff.
Lanbane - your right....no further commentary needed.
MOD EDIT: Thank you
On a different note...since the Lipotrophin was brought up...The Applied Nutriceutical website has a before/after component to it in the customer pics/logs section. There are a couple people who have submitted their before pics. I think this will be a great section to showcase the fatburning abilities of Lipotrophin-AM & PM...as well as other AN products. I will definitely be checking in to see the updates!
Gianni
Nice....I wish you the best!!! There is nothing more inspirational than seeing a great transformation.Wait till you see what I can do! Iam sending me pics. Yeah man, I'm gonna look good
Thanks man. I want to win the contest is there is one. Can you let me know if there is a prize? Thought you would like the pic i choseizza: LOLNice....I wish you the best!!! There is nothing more inspirational than seeing a great transformation.
Gianni
We have an awesome contest coming very soon...just wait and see.Thanks man. I want to win the contest is there is one. Can you let me know if there is a prize? Thought you would like the pic i choseizza: LOL