Anti-Aromatase Activity of Phytochemicals in White Button Mushrooms Agaricus bisporus

  1. Anti-Aromatase Activity of Phytochemicals in White Button Mushrooms Agaricus bisporus

    Cancer Res. 2006 Dec 15;66 (24):12026-34

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    Anti-Aromatase Activity of Phytochemicals in White Button Mushrooms (Agaricus bisporus).

    Shiuan Chen, Sei-Ryang Oh, Sheryl Phung, Gene Hur, Jing Jing Ye, Sum Ling Kwok, Gayle E Shrode, Martha Belury, Lynn S Adams, Dudley Williams

    White button mushrooms (Agaricus bisporous) are a potential breast cancer chemopreventive agent, as they suppress aromatase activity and estrogen biosynthesis. Therefore, we evaluated the activity of mushroom extracts in the estrogen receptor-positive/aromatase-positive MCF-7aro cell line in vitro and in vivo. Mushroom extract decreased testosterone-induced cell proliferation in MCF-7aro cells but had no effect on MCF-10A, a nontumorigenic cell line. Most potent mushroom chemicals are soluble in ethyl acetate. The major active compounds found in the ethyl acetate fraction are unsaturated fatty acids such as linoleic acid, linolenic acid, and conjugated linoleic acid. The interaction of linoleic acid and conjugated linoleic acid with aromatase mutants expressed in Chinese hamster ovary cells showed that these fatty acids inhibit aromatase with similar potency and that mutations at the active site regions affect its interaction with these two fatty acids. Whereas these results suggest that these two compounds bind to the active site of aromatase, the inhibition kinetic analysis indicates that they are noncompetitive inhibitors with respect to androstenedione. Because only conjugated linoleic acid was found to inhibit the testosterone-dependent proliferation of MCF-7aro cells, the physiologically relevant aromatase inhibitors in mushrooms are most likely conjugated linoleic acid and its derivatives. The in vivo action of mushroom chemicals was shown using nude mice injected with MCF-7aro cells. The studies showed that mushroom extract decreased both tumor cell proliferation and tumor weight with no effect on rate of apoptosis. Therefore, our studies illustrate the anticancer activity in vitro and in vivo of mushroom extract and its major fatty acid constituents. (Cancer Res 2006; 66(24): 12026-34).

  2. Isn't 6-bromo the AI from wbm, or was that aded or another ai all together?
    ~ Nothing can kill the Grimace!!

  3. White button mushroom extract is used in Rebound Reloaded for it's AI properties, along with 6-Bromo (listed separately).

    It as also in ALRI's Ultra Hot.t.e.r (discontinued now), before anyone really talked about 6-bromo.

  4. Just saw this in the Rebound Reloaded description:

    "Fundamentally, the core of AroMatrix™ is the combination of white button mushroom extract and 6-Bromotase™. White button mushroom and 6-Bromotase™ are both potent aromatase inhibitors, with different structures, which provide different effects."

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