Nicotine and EC...same pathways?

Cody3308

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Was wondering if they work through the same pathways...was thinking about doing:

Week 1 and 2 EC
Week 3 and 4 Nicotine, then repeat...?

Anyone else ever try this, or any thoughts on this?
 
TeamSavage

TeamSavage

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No, they do not work through the same pathways.

Nicotine affects "nicotinic" receptors. These are the same receptors affected by acetylcholine, although acetylcholine also affects muscarinic receptors. (Basically, there are two cholinergic receptors and nicotine only agonizes one of them.)

Caffeine antagonizes adenosine receptors. Adenosine is an inhibitory neurotransmitter. Caffeine binds to these receptors and blocks them.

Ephedrine stimulates dopamine and norepinephrine receptors.

Obviously, there is interaction between all these chemical pathways, and it's impossible to affect one without affecting the other. But the pathways directly affected are different for all three compounds.

Generally, use of one will not produce a cross-tolerance for the others.
 

Cody3308

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Thanks for the help...

You must spread some Reputation around before giving it to TeamSavage again
 
Stay Puft

Stay Puft

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Generally, use of one will not produce a cross-tolerance for the others.
And in some cases the effects of products taken together is greater than the sum of their parts. EC is an example, as is NYC, and ECN for that matter.

Good post, TS.
 

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