Update on research from BEVERLY
www.beverlyinternational.com/board/
Author: Roger Riedinger
Hi All! Here are references from Beverly research files on Muscle Synergy.
I hope this answers your questions as to why Beverly comes out
with an hmb product after 5 years. It's the synergistic effect
when combined with arginine and glutamine (and as a minor
consideration as John's research noted earlier with creatine.)
I'm going to list some url's you'll have to copy and paste into the browser.
Search for yourself at Pub Med
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?CMD=search&DB=PubMed
Search words: arginine hmb glutamine (type in all three)
Remember 1 kg = 2.2 lbs
1. First reference - Cancer patients losing up to 3lbs/month of
lean mass gained an average of 1.2kg fat free mass (over 2 lbs) in
4 weeks. Control group continued to lose muscle.
Am J Surg 2002 Apr;183(4):471-9
"Reversal of cancer-related wasting using oral supplementation
with a combination of beta-hydroxy- beta-methylbutyrate, arginine,
and glutamine." Am J Surg 2002 Apr;183(4):471-9 Books,
Thirty-two patients (14 control, 18 HMB/Arg/Gln) were evaluated
at the 4-week visit. The patients supplemented with
HMB/Arg/Gln gained 0.95 +/- 0.66 kg of body mass in 4 weeks,
whereas control subjects lost 0.26 +/- 0.78 kg during the
same time period. This gain was the result of a significant
increase in FFM in the HMB/Arg/Gln-supplemented group
(1.12 +/- 0.68 kg), whereas the subjects supplemented
with the control lost 1.34 +/- 0.78 kg of FFM (P = 0.02).
JPEN J Parenter Enteral Nutr 2000 May-Jun;24(3):133-9
2. HIV patients add average of 6.6 lbs lean mass in 8
weeks with arginine / hmb / glutamine
"Nutritional treatment for acquired immunodeficiency
virus-associated wasting using beta-hydroxy beta-methylbutyrate,
glutamine, and arginine: a randomized, double-blind,
placebo-controlled study."
Clark RH, Feleke G, Din M, Yasmin T, Singh G, Khan FA,
Rathmacher JA. Nassau County Medical Center, East Meadow,
New York, USA.
RESULTS: Forty-three subjects completed the 8-week protocol,
(placebo, n = 21; HMB/Arg/Gln, n = 22). At 8 weeks, the
subjects consuming the HMB/Arg/Gln mixture gained 3.0 +/- 0.5 kg of
BW while those supplemented with the placebo
gained 0.37 +/- 0.84 kg (p = .009). The BW gain in
the HMB/Arg/Gln-treated subjects was predominantly
LBM (2.55 +/- 0.75 kg) compared with the placebo-supplemented
subjects who lost lean mass (-0.70 +/- 0.69 kg, p = .003).
Hope this helped you see how we derived the formula. I'd
recommend supplemental glutamine with Muscle Synergy as
glutamine and arginine amounts were equal in the studies.