Acetyl-L-carnitine protects cortical neurons - AnabolicMinds.com

Acetyl-L-carnitine protects cortical neurons

  1. Elite Member
    yeahright's Avatar
    Join Date
    Jul 2005
    Posts
    6,368
    Rep Power
    10344

    Reputation

    Post Acetyl-L-carnitine protects cortical neurons


    Acetyl-L-carnitine may be useful as a therapeutic strategy for patients with Alzheimer disease

    NewsRx.com

    10-11-06

    Acetyl-L-carnitine-induced up-regulation of heat shock proteins protects cortical neurons against amyloid-beta peptide 1-42-mediated oxidative stress and neurotoxicity.

    Investigators in the United States report, "Alzheimer's disease (AD) is a progressive neurodegenerative disorder characterized by loss of memory and cognition and by senile plaques and neurofibrillary tangles in brain. Amyloid-beta peptide, particularly the 42-amino-acid peptide (A beta(1-42)), is a principal component of senile plaques and is thought to be central to the pathogenesis of the disease."

    "The AD brain is under significant oxidative stress, and A beta(1-42) peptide is known to cause oxidative stress in vitro and in vivo. Acetyl-L-carnitine (ALCAR) is an endogenous mitochondrial membrane compound that helps to maintain mitochondrial bioenergetics and lowers the increased oxidative stress associated with aging. Glutathione (GSH) is an important endogenous antioxidant, and its levels have been shown to decrease with aging. Administration of ALCAR increases cellular levels of GSH in rat astrocytes," wrote H.M. Abdul and colleagues, University of Kentucky.

    "In the current study, we investigated whether ALCAR plays a protective role in cortical neuronal cells against A beta(1-42)-mediated oxidative stress and neurotoxicity. Decreased cell survival in neuronal cultures treated with A beta(1-42) correlated with an increase in protein oxidation (protein carbonyl, 3-nitrotyrosine) and lipid peroxidation (4-hydroxy-2-nonenal) formation. Pretreatment of primary cortical neuronal cultures with ALCAR significantly attenuated A beta(1-42)-induced cytotoxicity, protein oxidation, lipid peroxidation, and apoptosis in a dose-dependent manner. Addition of ALCAR to neurons also led to an elevated cellular GSH and heat shock proteins (HSPs) levels compared with untreated control cells.

    "Our results suggest that ALCAR exerts protective effects against A beta(1-42) toxicity and oxidative stress in part by up-regulating the levels of GSH and HSPs. This evidence supports the pharmacological potential of acetyl carnitine in the management of A beta(1-42)-induced oxidative stress and neurotoxicity," the researchers summarized.

    "Therefore, ALCAR may be useful as a possible therapeutic strategy for patients with AD," the authors concluded.

    Abdul and colleagues published their study in the Journal of Neuroscience Research (Acetyl-L-carnitine-induced up-regulation of heat shock proteins protects cortical neurons against amyloid-beta peptide 1-42-mediated oxidative stress and neurotoxicity: Implications for Alzheimer's disease. J Neurosci Res, 2006;84(2):398-408).

    For additional information, contact D.A. Butterfield, University of Kentucky, Dept. of Chemical, Center Membrane Science, Lexington, KY 40506, USA.

    The publisher of the Journal of Neuroscience Research can be contacted at: Wiley-Liss, Division John Wiley & Sons Inc., 111 River St., Hoboken, NJ 07030, USA.

  2. New Member
    juggernaut333's Avatar
    Join Date
    Jan 2005
    Posts
    259
    Rep Power
    247

    Reputation

    one of the best supps on the planet imo and ive been taking it for a long time,before it became mainstream.
    are studies like this not allowed to mention specific dosages or what?
    been taking 1.5g twice a day with idebenone usually w/ meals
  3. Diamond Member
    John Smeton's Avatar
    Stats
    6'2"  225 lbs.
    Join Date
    Sep 2004
    Age
    33
    Posts
    10,014
    Rep Power
    33557

    Reputation

    ive been takign Alcar for about a year now. Gaba used to be my staple neurotropic but i like alcar 's effects better. It really is a great supplement. I take 3 grams first thing every morning. hop in the shower , then eat breakfast. This supplement has so many benifits, just look it up
    •   
       

  4. Board Sponsor
    macedaddy's Avatar
    Stats
    5'10"  172 lbs.
    Join Date
    Sep 2006
    Age
    36
    Posts
    6,068
    Rep Power
    3136

    Reputation

    thanks YR!!!

Similar Forum Threads

  1. Replies: 789
    Last Post: 09-06-2012, 03:29 PM
  2. Acetyl-L-carnitine (ALCAR)
    By the Cardinal in forum Supplements
    Replies: 5
    Last Post: 03-23-2007, 01:33 PM
  3. Can a Tolerance be Built to Acetyl-L-Carnitine?
    By CEDeoudes59 in forum Supplements
    Replies: 24
    Last Post: 07-24-2006, 06:59 AM
  4. Acetyl-L-Carnitine-Arginate
    By ENEMY in forum Supplements
    Replies: 3
    Last Post: 04-14-2005, 01:26 AM
  5. Acetyl-L Carnitine (ALCAR)
    By Kitchen Chemist in forum Supplements
    Replies: 2
    Last Post: 06-27-2003, 12:25 PM

Posting Permissions

  • You may not post new threads
  • You may not post replies
  • You may not post attachments
  • You may not edit your posts
  •  
Log in
Log in