Studies on liver tumor promotion in the rat by orotic acid: dose and minimum exposure time required for dietary orotic acid to promote hepatocarcinogenesis -- Laconi et al. 14 (9): 1771 -- Carcinogenesis
Inhibition of DNA synthesis in primary cultures of hepatocytes by orotic acid -- Laconi et al. 9 (4): 675 -- Carcinogenesis
Other studies have noted OA's effect on the liver of causing impaired fatty acid synthesis and increased cholesterol synthesis
Early effects of dietary orotic acid upon liver lipid synthesis and bile cholesterol secretion in rats -- Tokmakjian and Haines 26 (4): 478 -- Journal of Lipid Research
So is OA really a powerful carcinogen that is being marketed/sold to us as some type of great bodybuilding supplement?