Alpha Lipoic acid
- 05-07-2003, 03:37 PM
- 05-07-2003, 03:40 PM
Effects of exercise training and antioxidant R-ALA on glucose transport in insulin-sensitive rat skeletal muscle.
Saengsirisuwan V, Perez FR, Kinnick TR, Henriksen EJ.
Muscle Metabolism Laboratory, Department of Physiology, University of Arizona, College of Medicine, Tucson, Arizona 85721-0093, USA.
We have recently demonstrated (Saengsirisuwan V, Kinnick TR, Schmit MB, and Henriksen EJ, J Appl Physiol 91: 145-153, 2001) that exercise training (ET) and the antioxidant R-(+)-alpha-lipoic acid (R-ALA) interact in an additive fashion to improve insulin action in insulin-resistant obese Zucker (fa/fa) rats. The purpose of the present study was to assess the interactions of ET and R-ALA on insulin action and oxidative stress in a model of normal insulin sensitivity, the lean Zucker (fa/-) rat. For 6 wk, animals either remained sedentary, received R-ALA (30 mg. kg body wt(-1). day(-1)), performed ET (treadmill running), or underwent both R-ALA treatment and ET. ET alone or in combination with R-ALA significantly increased (P < 0.05) peak oxygen consumption (28-31%) and maximum run time (52-63%). During an oral glucose tolerance test, ET alone or in combination with R-ALA resulted in a significant lowering of the glucose response (17-36%) at 15 min relative to R-ALA alone and of the insulin response (19-36%) at 15 min compared with sedentary controls. Insulin-mediated glucose transport activity was increased by ET alone in isolated epitrochlearis (30%) and soleus (50%) muscles, and this was associated with increased GLUT-4 protein levels. Insulin action was not improved by R-ALA alone, and ET-associated improvements in these variables were not further with combined ET and R-ALA. Although ET and R-ALA caused reductions in soleus protein carbonyls (an index of oxidative stress), these alterations were not significantly correlated with insulin-mediated soleus glucose transport. These results indicate that the beneficial interactive effects of ET and R-ALA on skeletal muscle insulin action observed previously in insulin-resistant obese Zucker rats are not apparent in insulin-sensitive lean Zucker rats.For answers to board issues, read the Suggestion and News forum at the bottom of the main page.
05-07-2003, 04:21 PM
I have seen that same study before but have never fully believed it. Are you saying Bobo that ALA has no effect on glucose disposal at all? If no, then what reason do you have for taking it? I had thought there were others saying that ALA acted on different pathways then simply insulin spiking or mimicry.
05-07-2003, 04:32 PM
It has more effect on people who are insulin resistant, hence the reason its used in type II diabetics. If you have normal insulin sensitivity, I don't see much benefit. The study hints towards this. It does work on a different pathway than insulin and is another reason why its used with diabetics. I myself am mildly insulin resistance as it runs in the family so therefore its good for me. Older men can benefit from this too as insulin resiistance becomes an everyday thing as you get older. Younger men who have normal insulin sensitivity won't benefit from it much.
Its a good anti-oxidant though in everyone.
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