Cissus repairs ulcers?

  1. Banned
    Smoky's Avatar
    Join Date
    Nov 2005
    Age
    58
    Posts
    266
    Rep Power
    0
    Level
    13
    Lv. Percent
    94.83%

    Cissus repairs ulcers?


    Gastroprotective action of Cissus quadrangularis extract against NSAID induced gastric ulcer: Role of proinflammatory cytokines and oxidative damage.

    Jainu M, Devi CS.

    Department of Biochemistry, University of Madras, A.C. Tech, Guindy Campus, Chennai 600025, Tamil Nadu, India.

    The objective of this research was to analyse the gastroprotective effect of Cissus quadrangularis extract (CQE) along with its mechanism underlying the therapeutic action against the gastric mucosal damage induced by aspirin. In this study, we investigated the effect of CQE on the course of experimentally induced gastric ulcer by analyzing the levels of tumor necrosis factor-alpha (TNF-alpha), interleukin-1beta (IL-1beta), microvascular permeability, activity of nitric oxide synthase-2 (NOS-2), mitochondrial antioxidants, lipid peroxidation and DNA damage. A significant increase in vascular permeability, NOS-2 activity, TNF-alpha, IL-1beta levels and oxidative damage were noted in aspirin administered rats. Pretreatment with CQE (500mg/kg bw/day) by oral gavage for 7 days significantly attenuated these biochemical changes caused by aspirin in rats. Tissue damage was showed by decreased levels of glutathione (GSH), superoxide dismutase (SOD) and catalase (CAT) and an associated rise in lipid peroxidation (LPO) in mitochondria, which were reversed by CQE. In addition, CQE prevents oxidative damage of DNA by reducing DNA fragmentation indicating its block on cell death. Ulcer protection in CQE treated rats was confirmed by histoarchitecture, which was comprised of reduced size of ulcer crater and restoration of mucosal epithelium. Thus, reduced neutrophil infiltration, antiapoptotic and antioxidant action have a pivotal role in the gastroprotective effect of CQE.

    PMID: 16797507 [PubMed - in process]

  2. Diamond Member
    Jayhawkk's Avatar
    Stats
    5'8"  230 lbs.
    Join Date
    Dec 2003
    Age
    39
    Posts
    12,790
    Rep Power
    11682
    Level
    67
    Lv. Percent
    47.82%
    Achievements Activity AuthorityActivity ProPosting ProPosting AuthorityPosting Veteran

    Cissus is the new Tussin!


    Ma! I broke my arm!
    Aww honey, put some cissus on it.
  3. Binging on Pure ****ing Rage
    Mulletsoldier's Avatar
    Stats
    5'10"  215 lbs.
    Join Date
    Jan 2006
    Posts
    12,226
    Rep Power
    27066
    Level
    67
    Lv. Percent
    41.19%
    Achievements Activity AuthorityActivity ProPosting ProPosting AuthorityPosting Veteran

    Yeah, I have found very similar studies citing it's ability to block the inflammatory cytokines in the stomach.
    •   
       

  4. Board Sponsor
    rpen22's Avatar
    Join Date
    Feb 2006
    Posts
    3,702
    Rep Power
    11095
    Level
    42
    Lv. Percent
    13.36%
    Achievements Activity ProPosting Pro

    This also was posted by USPLabs about a year ago:

    Quote Originally Posted by USPLabs
    Journal of Medicinal Food
    Effect of Cissus quadrangularis on Gastric Mucosal Defensive Factors in Experimentally Induced Gastric UlcerA Comparative Study with Sucralfate
    Sep 2004, Vol. 7, No. 3: 372-376



    Mallika Jainu Department of Biochemistry, University of Madras, Guindy Campus, Chennai, India

    C.S. Shyamala Devi Department of Biochemistry, University of Madras, Guindy Campus, Chennai, India

    Cissus quadrangularis is an indigenous plant commonly mentioned in Ayurveda for treatment of gastric ulcers. The ulcer-protective effect of a methanolic extract of C. quadrangularis (CQE) was comparable to that of the reference drug sucralfate. Further, gastric juice and mucosal studies showed that CQE at a dose of 500 mg/kg given for 10 days significantly increased the mucosal defensive factors like mucin secretion, mucosal cell proliferation, glycoproteins, and life span of cells. The present investigation suggests that CQE not only strengthens mucosal resistance against ulcerogens but also promotes healing by inducing cellular proliferation. Thus, CQE has potential usefulness for treatment of peptic ulcer disease.
  5. New Member
    ECTOmorph's Avatar
    Join Date
    Mar 2006
    Posts
    378
    Rep Power
    297
    Level
    16
    Lv. Percent
    53.41%

    it actually states that in the new cissus rx writeup i believe
  6. Senior Member
    rampage jackson's Avatar
    Stats
    6'0"  255 lbs.
    Join Date
    Sep 2004
    Age
    32
    Posts
    1,255
    Rep Power
    755
    Level
    26
    Lv. Percent
    63.19%
    Achievements Posting Pro

    wow...I really may have to give cissus a try.
    E-Pharm Nutrition Representative
  7. Advanced Member
    BigMattTx's Avatar
    Join Date
    Apr 2005
    Age
    31
    Posts
    859
    Rep Power
    548
    Level
    22
    Lv. Percent
    87.03%

    Cissus is awesome!

    Aside from promoting general well-being, the anabolic effects and pumps are out of this world!
  

  
 

Similar Forum Threads

  1. igf-1 vs. hgh for tendon repair
    By BigBody in forum IGF-1/GH
    Replies: 9
    Last Post: 07-04-2011, 04:56 PM
  2. database repair??
    By taffer in forum General Chat
    Replies: 3
    Last Post: 12-14-2004, 05:31 PM
  3. Steroids May Improve Tendon Repair After Surgery
    By Beelzebub in forum Anabolics
    Replies: 8
    Last Post: 08-31-2004, 01:10 PM

Posting Permissions

  • You may not post new threads
  • You may not post replies
  • You may not post attachments
  • You may not edit your posts
  •  
Log in
Log in