All you need to know about Smart drugs, and then some! Nuero-Tropics

  1. Registered User
    Dr Liftalot's Avatar
    Join Date
    May 2006
    Location
    Washington
    Posts
    588
    Rep Power
    10908

    All you need to know about Smart drugs, and then some! Nuero-Tropics


    To start, You'll need the basic's

    Nutrition
    Sleep
    Working out(your brain and your body)

    When you have these down you may want to look into the following

    A good Multivitmin
    EFA/EPA Fish oil (Your Omega/3/6/9)
    And a very good premade(cost effective Neurotropic stack) Neuro-stim+C http://www.nutraplanet.com/product_i...roducts_id=815

    Now to go more in depth about Smart drugs and effective application.

  2. Registered User
    Dr Liftalot's Avatar
    Join Date
    May 2006
    Location
    Washington
    Posts
    588
    Rep Power
    10908

    Quick guide to the most popular nootropic supplements. All can be stacked, or taken alone. Neurostim +C is a good premade stack, though I like to add piracetam to it when I need to concentrate in order to learn (only 4 more months of grad school at night, yay). All of these typically take days to weeks to make a noticeable improvement on concentration and focus, and are best taken in longer periods (2-3 months) followed by down time of one month. As with all supplements, start with the basics, and move on from there.


    Piracetam (2-oxo-Pyrrolidine Acetamide) - is a derivative of the neurotransmitter GABA (Gamma Amino Butyric Acid). Chemically related to the amino acid Pyroglutamic Acid (Pyrrolidine Carboxylic acid), which occurs in cerebrospinal fluid and plays an important role in cognitive functioning.

    -Biochemical Effects-
    -Enhances Brain Metabolism (By increasing Glucose Utilization, Blood & Oxygen Flow){Boosts mental energy & cerebral circulation}
    -Increases Cerebral Phospholipids & Cellular Membrane Fluidity (By interacting with the polar head moieties of the phospholipid bilayer) {Supports healthy neuron communication & structure}.
    -Supports Cognitive Receptors (By amplifying the density of the Muscarinic Cholinergic {Frontal Cortex, Striatum, & Hippocampus}, NMDA (N-Methyl-D-Aspartate) {Hippocampus}, & AMPA (Alpha-amino-3-hydroxy-5-Methyl-4-isoxazole-Propionic Acid) Cerebral Cortex Receptors {Strengthens neurotransmitter receptors involved in memory and neuroprotection}
    -Stimulates the Corpus Callosum, an area of the brain that controls communication between the left and right hemispheres (Increases communication between both hemispheres) {Involved in speech and creative thinking}.
    - Stimulates the Locus Coeruleus, (specialized neurons) {Involved in information processing, attention, cortical/behavioral arousal, learning and memory}
    -Inhibits Platelet Aggregation (By increasing Red-White blood cells & Platelet deformability, inhibiting thromboxane A2 synthetase or antagonism of thromboxane A2, reducing von Willebrand's factor & fibrinogen levels) {Supports Healthy Blood Flow}.
    -Decreases EEG complexity (Increases cooperatively of brain functional processing) {Positively effects Neuro-Electrical Functioning}.
    -Has a significant antioxidant effect.

    -Overview-
    Piracetam positively supports healthy cognitive & cardiovascular functioning by a multifaceted means of action.

    -Notes-
    Approved & used since 1970’s worldwide (Europe, Asia, and South American) for various health conditions. Recommended by many healthcare professionals and health organizations, such as the Life Extension Foundation, as a Nootropic.
    Piracetum is the first step in the use of nootropics, it also stacks nicely with all of the following.

    -Dose-
    2-6 grams daily.

    -When can I feel it?-
    Works within an hour to a few days.
    -------------------------------------------------------------

    Aniracetam - Aniracetam (1-Anisoyl-2-pyrrolidinone) is a fat soluble potent analog of Piracetam.
    -Biochemical Effects-
    Similar to Piracetam, but due to its fat solubility its effects last longer and is far more potent.
    - Helps increase communication between your left and right sides of the brain, resulting in improved creatively, perception, and more.
    - Has an more potent AMPA receptor enhancing effect than Piracetam, resulting in better focus and concentration.
    - Been reported to be best ‘cetam for anti-anxiety effects

    -Dose-
    750-1,500 mg daily with meals.

    -When can I feel it?-
    Works within an hour to a few days.
    ---------------------------------------------------------------------------

    Oxiracetam - (4-hydroxy-2-oxo-1-pyrrolidinacetamide) is a potent fast acting water soluble analog of Piracetam. Works faster than all other racetams.

    -Biochemical Effects-
    Similar to Piracetam, but much stronger than Aniracetam and far faster acting. The preferred premium Nootropic for the elite smart drug user.
    - Supports multiple aspects of Cognition
    - Boosts Brain ATP levels (Mental Energy)
    - Increase Choline Acetylcholinetranferase the neuro-enzyme that creates Acetylcholine (in the cerebral cortex, hippocampus and striatum) {Memory Support}

    -Dose-
    800-1,600 mg daily.

    -When can I feel it?-
    Works within an hour to a few days.
    --------------------------------------------------------------

    Pramiracetam
    (N-{2-(diisopropylamino)ethyl}-2-oxo-1-pyrrolidine-acetamide) is a fat soluble potent analog of Piracetam, the most potent Racetam compound being about 15 times stronger than Piracetam.

    -Dose-
    100-300mg daily

    Availability
    Sporadic due to customs issues.
    ---------------------------------------------------------

    L-Huperzine - A is a natural plant alkaloid (extracted from Huperzia serrata), which quickly and potently boosts memory, learning, and concentration. Used worldwide for decades in adults and high school students. Is considered the most potent short term memory enhancer available.

    -Biochemical Effects-
    - Potently raises Acetylcholine (main memory neurotransmitter) by inhibiting its breakdown from Acetylcholinesterase.
    - Strengthens the Brain's NMDA receptors (Enhances Focus, Learning, and Brain Functioning)

    -Dose-
    Take 200-400 mcg daily for best results with meals.

    -When can I feel it?-
    Works within an hour to a few days.
    ------------------------------------------------------------------------

    Alpha GPC (Alpha L-GlycerylPhosphorylCholine), also known as choline alfoscerate, is an unique NeuroActive form of choline that rapidly penetrates the blood brain barrier, naturally found in small amounts in milk and soybeans.

    -Biochemical Effects-
    - A precursor for the neurotransmitter AcetylCholine [Supports Memory].
    - A precursor for PhosphatidylCholine [Supports Brain Structure]

    -Dose-
    300-2000 mg daily.

    -When can I feel it?-
    Works within a few days.
    ------------------------------------------------------------

    Vinpocetine (Ethyl Apovincamine) is a derivative of vincamine (a phytonootropic from periwinkle). While less potent as a mental stimulant than vincamine, Vinpocetine is the preferred nootropic for Enhancing blood flow to the Brain, Eyes, and Ears. Its effects on Cerebral Blood Flow far exceeds all other nootropics.

    -Biochemical Effects-
    -Enhances Brain Metabolism (By increasing Glucose Utilization, Blood & Oxygen Flow) (Boosts mental energy & cerebral circulation)
    - Stimulates the Locus Coeruleus, (specialized neurons) (Involved in information processing, attention, cortical/behavioral arousal, learning and memory)
    -Inhibits Platelet Aggregation (Reduces abnormal blood clots).
    -Has a significant antioxidant effect.

    -Dose-
    20-40 mg daily with meals.
    ------------------------------------------------------

    Theanine (gamma-ethylamino-L-glutamic acid) is an unique amino acid found in trace amounts in green tea. It converts in the brain into GABA, the neurochemical involved in inhibiting over active mental activities, such as stress, anxiety, worrying, and nervousness. Unlike herbs theanine protects & enhances Cognition, without causing sleepy or drowsiness.


    -Biochemical Effects-
    - Instant relaxation due to its potent effects on raising GABA
    - Unlike the supplement GABA it passes through the blood brain barrier readily and has superior GABA raising effects.
    - Has been studied compared to Paxil.

    -Notes-
    In Japan it is used in soft drinks much like caffeine is added in the US, but to relax rather than stimulate the mind.

    -Dose-
    200-1000mg daily.

    -When can I feel it?-
    Works within a few hours.
    -------------------------------------------------

    Acetyl-L-Carnitine (2-Acetoxy-3-(trimethylaminium)butanoic acid) is an amino acid-like compound related to Choline found in high levels in brain cells.

    -Biochemical Effects-
    - Increases Acetylation of Coenzyme A (a precursor to Acetylcholine) [Memory Enhancer]
    - Enhances transport of fatty acids into the mitochondria [Increased Cellular Energy Levels]

    -Dose-
    500-3000mg daily
    ------------------------------------------------------------------

    Choline supplements should be taken during the administration of all nootropics. Lecithin (caps and granules) is a cheap choline source. Lecithin should be taken in doses of 5-8 grams daily to support the nootropics. Alpha GPC (listed above) is another source for choline. It is more effective / more expensive, but only requires dosing in the 1-3 gram range to support choline levels in the brain.

    -------------------------------------------------------------------
    STACKS

    Simple Stack :
    1-2 grams piracetam every 8 hours with 5 grams lecithin daily.

    Study Stack - Simple :
    1-2 grams piracetam every 8 hours / 5 grams lecithin / 10mg Vinpocetine every 8 hours

    Advanced Stack :
    2 grams piracetam every 8 hours
    500 mg aniracetam every 8 hours
    1 gram Alpha GPC every 8 hours

    Study Stack - advanced :
    1.5 grams piracetam every 8 hours
    500 mg aniracetam every 8 hours
    1.5 grams Alpha GPC every 8 hours
    15 mg Vinpocetine every 8 hours
    150 mcg Huperzine every 8 hours

    Anxiety / Concentration Stack :
    500 mg aniracetam every 8 hours
    200 mg theanine every 8 hours (plan for one dose prior to a speech or presentation)

    After all test are done stack :
    500mg Theanine
    1.5 grams Phenibut (do not study on phenibut)
    5 grams lecithin
    ----------------------------------------------------





    shawn74797 Posted: Jan 23 2006, 10:09 AM
    Advanced Member


    Group: Advanced Members
    Posts: 316
    Member No.: 74797
    Joined: 21-May 05
    Warn: (10%)





    May You Never Sleep: Cognition Enhancing Drugs
    by R.U. Sirius
    NOTICE: TO ALL CONCERNED Certain text files and messages contained on this site deal with activities and devices which would be in violation of various Federal, State, and local laws if actually carried out or constructed. The webmasters of this site do not advocate the breaking of any law. Our text files and message bases are for informational purposes only. We recommend that you contact your local law enforcement officials before undertaking any project based upon any information obtained from this or any other web site. We do not guarantee that any of the information contained on this system is correct, workable, or factual. We are not responsible for, nor do we assume any liability for, damages resulting from the use of any information on this site.

    INTELLIGENCE INCREASING DRUGS might be labeled "Cognitive Enhancers," "Memory Enhancers," or, in some cases, "Psychic Energizers." What many of these drugs and nutrients have in common is that they produce effects similar to effects people are seeking from popular stimulants such as caffeine, amphetamines and cocaine. These popular drugs temporarily enhance cognition and memory, and amp up the user's energy levels only to leave the user depleted. Cocaine and amphetamines might properly be labeled as short-term intelligence-increase drugs and long-term intelligence-decrease drugs.

    However, the drugs and nutrients discussed in this review are all believed to create long term improvements in memory and cognition. Some of them also provide the short-term high-energy states associated with the stimulant drugs. Also, there is virtually no tendency towards the kind of weirdness and darkness of the spirit which so often accompanies even the occasional speed or cocaine high. It seems that while the illicit stimulants cause short-term release, but long-term depletion of norepinephrin, many of the memory-enhancing drugs and nutrients work on the noradrenergic nervous system in a different way, apparently modulating nerve cell control mechanisms so that the cellular response is neither too great nor too little. This is a gross oversimplification. More precise information on each of these cognitive enhancers is easily available to the serious researcher. Accurate and concise information for the layperson is easily available through the popular written works of Durk Pearson and Sandy Shaw who, whatever one might think of their bucket-of-pills-a-day personal regimen, do carefully monitor all of the research in this field.

    This survey deals primarily with the short-term experiential effects of these compounds, since I only have the experience of a relative and imprecise ongoing use of one drug, Pemoline, and no scientific proof of any intelligence increase on my part. Besides, a three-hour play can be realistically reviewed. Reviewing a life is a somewhat more dubious prospect.

    In consideration of all this, I hereby present a review of intelligence-increasing drugs. May you never sleep.

    VASOPRESSIN - Definitely the most euphoric of the memory-enhancing intelligence-increase drugs outside of the one being called "Euphoria" (more on Euphoria later), Vasopressin is marketed as Diapid, a prescription drug made by our old friends Sandoz. It can also be ordered as Vasopressin through chemical supply houses by those who know the ropes. I had five squirts of Vasopressin out of a nasal inhaler. I was surprised by how strong the effects were. I had that charged-up hyperconfident rush that one experiences with cocaine, but combined with much clearer ideation and without the numbing and discomfort or the strange and disquieting hard edges which often accompany even the more euphoric coke highs. It didn't last very long, about two hours, most of which unfortunately spent riding the BART and walking. By the time I got home, the experience had pretty well dissipated. I did not have an opportunity to experience Vasopressin as a work/writing drug. It was clear, however, simply from reading (I was reading "Gravity's Rainbow" at the time and I consider that a fairly challenging test of comprehension) on the BART ride home, that Vasopressin is an excellent tool for rapid learning and comprehension of complex systems of thought.

    The only other time I had Vasopressin, it was in the form of Diapid. I had only two squirts at a party late at night on top of fairly substantial amounts of marijuana and alcohol. It didn't noticeably cut through the depressant effects of those drugs. However, I did experience an intensified and prolonged orgasm!

    HYDERGINE - The invention of one Dr. Albert Hoffmann of Sandoz Laboratories. I know of many people who got their hands on buckets of this stuff and I know of nobody who continues to take it. The effects are said to be cumulative rather than immediate and everybody seems to lose interest. "I forgot to take my Hydergine" is a term which one often hears from chagrined "intelligence agents," fully cognizant (even without Hydergine) of the ironies involved. This probably says more about the people that I hang out with than about Hydergine as an intelligence increase agent.

    Incidentally, Dr. Hoffmann told a friend of mine that one can get exactly the same effects one gets from daily megadoses of Hydergine by using 25 micrograms of LSD daily. I have not experimented with subthreshold acid as an IQ substance, so I cannot comment.

    LECITHIN, CHOLINE with INOSITOL, PHENYLALANINE (with VITAMIN C and B6) - While perhaps less intriguing and glamorous to technophilic reality hackers, most of these easily available cognitive enhancers have a substantially perceptible effect. LECITHIN seems to be the exception. Even at "Durk and Sandy" dosage levels there was no noticeable enhancement of focus, recall, etc. CHOLINE and INOSITOL, at about three grams each, produce mild but definite results with no discomfort and can be used daily. I did this once for about a month and found myself losing my sense of humor. However, if you're already humorless you might just as well give this a go. PHENYLALANINE is quite speedy. While it can be used for creativity and focus, it tends to make one irritable. For emergency use only.

    DEANER - This is getting really popular with the "health food set." Experientially, the effect is very subtle but noticeable. I've tried this a few times and what I've found is that if I already have a task to do, I will do it and, in retrospect, I will realize that I sustained my attention for an unusually long time without flagging or needing a break. However, if I use this (as I often do with other cognitive enhancers) without a precise sense of what the task at hand is, it doesn't clarify and help to motivate activity. This is an important point. Drugs such as Vasopressin, Pemoline, Euphoria and THA can actually cut through confusion and ennui and help invoke will. My guess is that most of these substances also work, to varying degrees, on the pleasure centers of the brain, provoking one's natural 'joie di vivre' and thereby provoking enthusiasm for creative and organizational activities.

    PEMOLINE (usually combined with Magnesium) - The information most frequently passed around in reference to MAGNESIUM PEMOLINE was published by the Church of the Tree of Life some years ago in their publication "Bark Leaf". It recommends taking "Mag-Pem" at 50-100 mgs. every day for two months in order to substantially increase your I.Q. OUCH! This program is a sure ticket to severe headaches and extreme nervousness. However, in the 20-30 milligram range, I've found that this can be used twice weekly with excellent results. The lift is very substantial and noticeable. I, and several of my friends, find it particularly good for writing, both creative and functional. For rapid-fire associations and grand synthesis just combine it with moderate amounts of Cannabis (Sativa, if possible). It lasts about twelve hours, coming on slowly and having its greatest effect at around the fifth through the tenth hours. Clarity and verbal acuity are the strong points here. At times, the sheer mass of information, new thoughts and connections can overwhelm and put one into a rather confused state, particularly if one is not applying oneself to something. When this occurs I find that I can slow down my thoughts to a point where there is coherence simply by verbalizing them or writing them down. Unlike its close cousin "EUPHORIA," Pemoline is emotionally bland. It is not a pleasure drug. WARNING: from my observations, approximately one in every ten people get nothin' but headaches from even small doses of Pemoline.

    EUPHORIA - Well, someone took Pemoline, twisted it around a little bit and put a whole lot of pleasure into the equation. This might be a Dangerous drug! There are lot of different things that seem to happen with Euphoria. The first time I took it (40 milligrams - I've learned since that 25 mg. is considered your basic dose) I got really charged up. This is definitely a High and it comes on suddenly (about 45 minutes after ingestion). My first response upon coming on to it was an experience of an intense rush of perceived personal power. I found myself goosestepping down the busy Berkeley streets thinking about how good I felt, how successful I was destined to be, and knowing that the world was my oyster. After about 15 minutes of this as I found myself leaping down the BART escalator, I had to tell myself to slow down for fear that I would be completely drained later on. Although I didn't really slow down at all during this experience, I did bring myself into a somewhat more humane mindset and I spent the subway ride having an almost methoxylated amphetamine (MDMA, MDA, etc.)-type ideations. In other words, I wasn't just feeling good about myself, I was feeling good about most everybody else. The world was everybody's oyster.

    Arriving at my office, I immediately found myself doing organizational work at about three times the normal rate with far more self-assurance and fewer mistakes than usual. Simultaneously, I was entertaining perspectives on the nature of my true will and making important phonecalls which I had put off for some time. I did about thirty hours worth of work in about ten hours. I literally could not stop. I tried to make myself take a break for about ten minutes. Within a minute, I found my hand going into a drawer to pull out another file which needed reorganizing. Believe me, this is very unusual behavior. I hate organizational work.

    This all might sound like the first blushes of an amphetamine high, but he emotional overtones and the mentation under this substance is of a softer and more inwardly whole (less alienated) quality. As I've already indicated, the Euphoria high seems to have a slight methoxylated amphetamine quality to it. All in all, this was a very powerful experiencing of clarity, self-assurance and cognitive ability. The following day, I experienced the same sort of effects at about one-third the intensity. There was no burnout at all in aftermath.

    Subsequent experiments have shown Euphoria to be predictable as an effective tool for organizing binges, brainstorming sessions and radio talk-show appearances. It also seems to induce ongoing personal growth in terms of clarity of personal will. (I've received three other testimonies in this same direction.) As a writing tool, I've found Euphoria to be variable. It seems that verbal acuity comes on strong but the verbal circuits burn out quickly from intensity of use and one has to move on to less verbally oriented tasks. In other words, this is generally good for creative flashes and outlining grand syntheses but not too good for actual completion of written work. It gives one an impatience for minutiae and the kind of careful faceting that it takes to bring a work to completion. In terms of appreciation and comprehension of aesthetics and information, this seems the opposite of its close cousin Pemoline. The accessing mode favored is visual. One wants to explore a painting or photograph or watch a movie rather than read a book.

    My only complaint about Euphoria is that it lasts 16 hours, which feels about 4 hours too long. In two of my five experiences, the last four hours were spent feeling slightly "headachy" and weary, although there was still no burnout following sleep. I would say, at this point, that Euphoria should not be used more often than once a week since it is so powerful and so much energy is expended in the experience. This is easily the most Fun of the intelligence increasers and, as such, is probably the most likely to be abused.

    PRL-8-53 - Untried by your reviewer at this time. However, Durk Pearson is quoted in 'High Frontiers' as saying that "PRL-8-53 is a terrific memory enhancer. Normally you can memorize about seven or eight digits just by looking at them for a second. PRL-8-53 gives the average person a memory span of about 21 to 22 digits." He also reported that one amnesia victim was cured with one dose.

    THA - Untried by your reviewer at this time. Again, Durk Pearson, this time in 'High Frontiers/Reality Hackers Newsletter:' "In combination with arecoline, THA has been found to be remarkably effective as a memory improver ... it's important that the dosage be individualized ... too much will actually impair memory and produce sweating, excessive muscle tone and mouth-watering." The standard dosage is "1 to 2 mg." however, Durk recommends that you start with a quarter of that every two to four hours and work up - if you get those side effects, back off.

    ============================== ========== ===

    Letter to the Editor in response to the R.U.Sirius article above.

    From the Summer 1988 issue of "Whole Earth Review"

    ---

    IF THESE DRUGS HAD BOTTLES, HERE'S WHAT THE WARNING LABELS WOULD SAY

    I have been a big fan of your magazine for many years now, and I am a firm believer in the principle that the free exchange of information is a necessity to the survival and progress of our species. I commend you for your efforts in this area.

    Unfortunately, when it comes to psychopharmacology the old saying, that a little knowledge is far more dangerous than none at all, is quite often true. Specifically I am referring to the article of winter '87 on page 56, "Cognitive Enhancers." I am not upset that you would print this sort of information; there is both interesting and important research going on in this field right now. What I object to is the uncritical, inaccurate, and incomplete information given in an area that has Serious implications on your reader's health. Here are some errata and addenda for that article, most of this information is available in the "Physician's Desk Reference" and the "Merck Index".

    VASOPRESSIN - It is a naturally occurring peptide that can cause a wide variety of effects beyond those mentioned in the article. It strains the heart by reducing the heart's food and oxygen supply and increasing the heart's workload by increasing blood pressure. In individuals with hidden or overt heart problems, this can mean a heart attack. In addition vasopressin can cause a dangerous elevation in brain fluid pressure, leading to stroke, coma, or death. Also it can produce vertigo, circumoral pallor, pounding headaches, cramps, diarrhea, gas, nausea, vomiting, urticaria, difficulty breathing, anaphylactic shock, and normal shock. It is dangerous to use in people with a history of epilepsy, migraine, asthma, heart failure, or poor kidney function. Vasopressin can have dangerous interactions with most stimulants, including pemoline, caffeine, diet pills, and cold medications. Overall vasopressin is a real Pandora's Box, but fortunately there is ongoing research to develop safer and more effective alternatives.

    CHOLINE, INOSITOL, VITAMIN B6, PHENYLALANINE, and DEANER - These compounds are both basically safe and effective if not spectacular. I would add a few notes though. Use caution with these if you have a history of epilepsy. Choline may be more effective when taken with inositol. B6 is more effective and better for you when taken in wide-spectrum mega-B vitamin supplements. PHENYLALANINE is neurotoxic and can cause brain damage in about 2% of the population [uploader's note: the 2% with the metabolic disorder PKU, that is], and it's probably not good in large doses for anyone. TYROSINE on the other hand is not toxic and is a more effective substitute. DEANER can be made more effective by combining it with METHIONINE, but be cautious of large doses of methionine if you have a history of psychosis. In addition, there are other nutrients that are save and effective in increasing psychological energy in most people, INOSINE, CYTOCHROME C, LYSINE, and GINSENG.

    HYDERGINE - It is an ergot alkaloid, the same chemical class as LSD, but with no psychedelic or immediate effects. It is currently prescribed to help alleviate some of the symptoms of Alzheimer's disease, but, despite the tremendous numbers of people with this affliction, Hydergine is not widely used, mainly because it is only effective in about 1/3 of the people using it. As a matter of fact it worsens cognition in about 1/3 of people. It is dangerous to use in individuals with any history of psychosis, low or high blood pressure, heart disease, pregnant women (at any point in pregnancy), or a history of migraines. Hydergine has caused rashes, drug fever, headaches, dizziness, vision problems, appetite loss, nausea, vomiting, cramps, fainting, sluggishness, drowsiness, emotional withdrawal, apathy, nervousness, hostility, confusion, depression, weakness, collapse, and coma.

    EUPHORIA - The section on Euphoria is really in a muddle. First of all it is not clear what Euphoria is. The chemical structure shown is the article is MDA (methylenedioxy amphetamine), a drug rejected long ago by both psychologists and users as inferior to MDMA (XTC); it is also Highly Illegal. The other name given for Euphoria was 3,4-Methylenedimethoxy Methamphetamine. This is an impossible chemical structure. Technically speaking, a chemical structure can contain a methylenedioxy group or have 2 methoxy groups; there is no such thing as a methylenedimethoxy group. None the less I can guess about Euphoria's toxicology from the effects R.U.Sirius describes and the class of drugs to which he claims it belongs. Like crystal methedrine it is almost certainly capable of precipitating paranoid psychosis, even in psychologically stable people. Though Sirius noticed no crash, he may have just been lucky. Amphetamines almost always have a crash. In general they also create tremendously large egos, and over confidence, so No judgement on mental improvement made by people under their influence can be trusted. Finally Euphoria is relatively untested, both scientifically and on the street. Its long and short term health effects are unknown by based on its chemical structure it would not be unreasonable to expect it to cause heart damage, brain damage, or cancer. I do not expect Euphoria to be any better than Coke or Speed, in the long run. I don't mean to sound cruel or cynical, but let some lab rats die before you put your neck on the line.

    PEMOLINE is an interesting drug at the center of some current research. Unfortunately, it is not known how the drug works. If it was, a safer alternative could be found. Pemoline has caused fatal liver failure, still births, La Tourette's Syndrome, seizures, hallucinations, uncontrollable movements of the tongue, lips, face, eyes, and extremities, depression, delirium, dizziness, irritability, headaches, drowsiness, insomnia, anorexia, nausea, and cramps. Caution should be used when combining it with any other drug because it is known to have strong dangerous interactions with many drugs. Finally, pemoline, a controlled substance, is recognized by the government as having an abuse/addiction liability.

    PRL-8-53 - I could find no information on this, even in the most up to date references. The fact that it still is referred to by its code number probably means that it is still highly experimental; they may not even know what its structure is yet. It might be safe, but you are playing neurochemical roulette.

    THA - This is potentially very dangerous. It is an acetylcholinesterase inhibitor making its actions closely related to Nerve Gas, Pesticides and Strychnine. BE CAREFUL!

    I wish you all good luck in your quest for personal growth. I am sure in the near future science will come up with many things to help you. Please do not let enthusiasm interfere with accuracy and safety

    Name withheld upon request

    ============================== ========== ========== ========================

    Uploader's Notes:

    The previous letter is interesting in that the writer makes an erroneous assumption about the structure of Euphoria based on an erroneous and mislabeled diagram in the original R.U.Sirius article. Euphoria is NOT related to the methamphetamine class of drugs as this writer assumes! Euphoria IS however related to Pemoline (as R.U.Sirius implies in the text of his article), so the warnings above about Pemoline may well apply to Euphoria.

    The writer of this letter also makes a wrong assumption about PRL-8-53; namely, that it is so new that there's no info about it available yet. At the end of this file, there's an article out of "The Daily Breeze" Newspaper (which I don't have a date for, but it was published in either 1980 or 1981) that explains the origin of PRL-8-53.

    Strangely, R.U.Sirius didn't identify the chemical structure of PRL-8-53 either, even though he knew it was being investigated by Durk Pearson!

    ============================== ========== ========== ======================

    Yet More Letters to the Editor in response to the R.U.Sirius article above.

    From the Winter 1988 issue of "Whole Earth Review"

    ---

    NO EUPHORIA ABOUT CHEMICAL STRUCTURE

    In your Winter '87 issue, you ran an article by 'R.U.Sirius' entitled: "May You Never Sleep" dealing with personal use(s) of experimental or FDA licensed materials which your article collectively termed 'cognitive enhancers.' Some of these are prescription only drugs, others come from underground chemistry. Psychedelics generally have continued to receive erroneous, confused & even hysterical press stemming from the LSD chromosome scare of the mid-sixties through & into today's supposedly better informed press & reporters having, among other things, computer technology to aid in getting the facts straight. Or so one would think. Or at least hope.

    However, I'm sorry to say that 'Whole Earth Review' has perpetuated this same disregard for the facts of the matter not in one issue (Winter 1987) but again in your Summer 1988 issue, surrounding the same subject - U4Euh (Euphoria). In Sirius' original piece, he presented a completely False chemical identification diagram re: U4Euh, showing instead that if MDA, a completely different substance altogether. We all make mistakes, but Sirius AGAIN put his foot in his mouth, appearing in the June issue of 'Whole Mind" & calling U4Euh N-Methyl Aminorex, which is again false.

    In the Summer WER there is a letter of rebuttal to Sirius' article which attempted to once & for all (I suppose) set the facts straight, particularly about U4Euh. Here again, an attempt at correction dis-information IN ACTUALITY ends up spreading further myths surrounding U4Euh & psychedelics.

    The letter writer states: "finally, U4Euh is relatively untested, both scientifically & on the street, etc...."

    OK. Let's get some facts straight & clear up a lot of confusion about this substance U4Euh. U4Euh (4-Methyl Aminorex) was 1st discovered by a research group headed by Georde Poos at McNeil Laboratory in Ft. Walsh, PA. in the early 1960's. The 1st published report appeared in 'The Journal of Med. Chem." in 1963 [1] & several other patents were issued in Belgium, France & the US [2,3,4]. Three other papers were published regarding U4Euh in 1963 & 1966 [5,6,7].

    In the mid 1980's, U4Euh was resurrected within the underground & noncontrolled experiments were carried out on humans. The substance's new spokesman was named The Friendly Stranger & samples were studied at, among other places, the Continental Rainbow Gatherings. Both instructional manuals as WELL as ongoing research results were distributed to those having interest & concern about U4Euh & its effects.

    There are two forms of U4Euh currently available via the underground - the free-base & the hydrochloride. Prices range from $75 pre gram for the hydrochloride upwards to $150 per gram for the most powerful free-base.

    This substance (4-Methyl Aminorex) was placed on schedule I by the DEA & the FDA in 1987. The resultant scheduling report presented by the DEA shows a Death associated with its use (or abuse).

    Unfortunately psychedelics or 'cognitive enhancers' remain the legendary, obscurely attractive sources for 'bad press' - & are kept illegal - BECAUSE false, misleading, obtuse or hysterical reporting (like that perpetuated in your WER) outweighs the true facts of the matter.

    I hope that author R.U.Sirius & WER continue to provide insightful articles in the area(s) of drug use/abuse. However, some attempt must be made to provide accurate reporting, especially in areas already worked over by too much of the same.

    Best wishes, Thomas Lyttle, Publisher, Psychedelic Monographs and Essays

    References:

    [1] Journal of Medicinal Chemistry 6, 266 (1963) [2] Belgian Patent 628,803, June 16, 1963 [3] French Patent M2448, May 4, 1964 [4] U.S.Patents 3,161,650 Dec 15, 1964 and 3,278,382 Oct 11,1966 [5] Archives Int. Pharmacodyn. Ther. 164(2) 412-18 (1966) [6] Journal of Pharm. & Experim. Therapeutics 140: 367-374 (1963) [7] Ibid. 141:180-84 (1964) [8] Journ. Clin. Pharmacology 7:296-302 (1967) [9] Science 1982 218(457)487-490 [10] Annual Reviews of Med. Chemistry 1965 51-58 (1966)44-47

    The above mentioned references were provided by 'Psychedelic Monographs & Essays' from an upcoming piece entitled: "A Chemical and Pharmacological Review of Euphoria or Intellex" by 'The New Age Chemist'.

    This piece will appear in the Autumn 1988 (vol.4) issue of PM&E.

    ---

    ANOTHER ALCHEMIST WHO AGREES

    Dear Friends,

    I read with interest the article in issue #57 on intelligence drugs by "R.U.Sirius." I also read the same author's letter correcting the depicted structure and identification of "Euphoria" in issue #58.

    I too noticed that the chemical structure on page 58(#57) was that of 3,4-methylene dioxymethamphetamine (mistakenly spelled as "3,4-Methylene Dimethoxy Methamphetamine"). while it was incorrectly labeled as "EUPHORIA." The label was meant to say "chemically related to MDA." The label was however, correct in stating that it was "Ecstacy."

    In "Sirius's" letter (#58, page 140) correcting his article in issue #57, he (?) states that "Euphoria is N-Methyl Aminorex and looks like this -

    C6H5 O NH2 \/ \/ | || [uploader's note: THIS IS THE CORRECT U4EUH.] |___N / CH3

    Well, this structure is not that of N-Methyl Aminorex. It is correctly called 4-Methyl Aminorex.

    Aminorex has the structure:

    [Diagram of Aminorex]

    And the structure of N-Methyl Aminorex is as follows:

    [Diagram of N-Methyl Aminorex]

    I am not yet sure what the correct chemical structure of "Euphoria" is but I am sure of the above information. Perhaps this will help clear up the misunderstanding.

    "Sirius," maybe you could try again to enlighten us? What is the correct structure and name of "Euphoria"?

    Yours sincerely, The Alchemist Vashon, Washington

    Article from "The Daily Breeze" newspaper, published around 1980 or 1981

    Chemical Found to Improve Memory

    OMAHA (AP) - Creighton University researchers say they have discovered an organic chemical compound which apparently improves memory and intellectual performance that normally deteriorate with aging.

    Dr. Nikolaus Hansl, associate professor of medical chemistry and a member of the team of scientists, said the compound, known as PRL-8-53, counters the destruction of certain chemical pathways in the brain by "making up the slack chemically."

    In a clinical study at Creighton, Hansl said, 58 college students performed better on intellectual tasks when they were given the compound, which he described as similar to an amino acid.

    In another study published in 1978, researchers compared the compound's effects on performance of college students with that of persons who were over 30.

    The participants were asked to remember lists of "nonsense syllables," geometric objects and other tasks, Hansl said.

    "The older group showed a 130% to 140% improvement in memory over the college students," he said.

    He said the effect of the compound lasted about seven hours, and added that even after the effect faded, memory was better.

    "Experiences from the past that were fading were recalled better" with no detectable side effects, he said.

    Hansl said the compound could help "the geriatric population - anyone over 30 - such as the elderly man who forgets his glasses or loses a thought in midsentence. I would like to make them more self-sufficient."

    Another use, he said, could aid those "in intellectual stress situations, such as a businessman or student, to perform tasks better."

    But Hansl added there have been no indications that people with brain damage could benefit from the compound.

    He said the research team is working on a related compound which could produce even better results. They are now evaluating the clinical effects of the compound.

    Hansl, who had been involved in the research project for more than 15 years, said the chemical is one of a new group of compounds that were studied in the search for a new tranquilizer that would not slow down intellectual functions.

    ==============================

    Uploader's Note:

    On the back of the above news clipping I wrote:

    "PRL-8-53 is 3-(2-benzylmethylamino ethyl) benzoic acid methyl ester"

    I don't recall where I found that piece of info, but I suspect it was from an item in "Science News".

    The Reader's Guide to Periodic Literature lists the following reference to PRL-8-53:

    "Learning and Memory Improvment Through Chemistry: Dream or Reality in the Offing." (PRL-8-53) by Nicolas Hansl & A.B. Hansl in the "Phi Delta Kappan" 61:264-5 December 1979

    But I haven't been able to get a copy of that article yet.

    ---

    Finally, the magazine "Reality Hackers/High Frontiers" which R.U.Sirius edits is available from:

    Fun City MegaMedia/Mondo 2000 PO Box 49271, Berkeley, CA 94704 (415)845-9018

    And the "Whole Earth Review" is available from:

    Whole Earth Review PO Box 15187, Santa Ana, CA 92705-9913

    ---

    ============================== ========== ========== ======================= ENHANCER.TXT 14-JUL-90

    NEW DRUGS THAT MAKE YOU SMART by John Morgenthaler from MONDO 2000 - issue #2

    The term nootropic comes from the Greek word meaning "acting on the mind." Since the invention of Piracetam by UBC laboratories in Belgium, other drug companies have been scrambling to develop their own nootropics. Some of them being researched now include; Vinpocetine, Aniracetam, Pramiracetam, and Oxiracetam. As yet, there is no nootropic drug that is FDA approved for sale in the United States, but there is plenty of motivation on the part of the drug companies to get that approval - financial analysts expect the U.S. market for cognitive enhancers - smart pills - to soon be in excess of one billion dollars per year!

    Nootropics are very interesting because of their lack of any demonstrable toxicity. They are not, however, the only substances that increase intelligence. There are over 30 chemicals that have been shown to improve animal and/or human intelligence (learning and data processing of particular types of tasks.) Here I propose to present a practical, drug-by-drug guide to the use of the most interesting of these cognitive enhancement compounds, and where you can get them.

    Disclaimer: This article should not be interpreted as medical advice or an attempt to encourage the use of cognitive enhancement dru... uh, compounds. You must consult with a licensed physician for such medical advice. We don't even want you to EXPERIMENT WITH THESE COMPOUNDS. Nor do we wish to imply, in any way, that you should try to INCREASE YOUR INTELLIGENCE or MAKE YOURSELF INTO A SUPERBEING. Heaven forfend!

    --------------- CENTROPHENOXINE (Trade Name: Lucidril)

    Centrophenoxine is an intelligence booster and also an effective anti-aging therapy. It has been shown to cause improvements in various aspects of memory function and a 30% increase in lifespan of laboratory animals.

    One of the most widely recognized aspects of aging is the buildup of lipofuscin in brain cells (lipofuscin is the stuff that age spots are made of.) Centrophenoxine removes lipofuscin deposits from brain cells and reduces its rate of accumulation in young brain cells. It also rejuvenates the synaptic structure - the area where the actual transfer of information takes place between nerve cells.

    PRECAUTIONS: Centrophenoxine should not be used by persons who are easily excitable, people with severe arterial hypertension, or those subject to convulsions or involuntary musculoskeletal movements. The drug also should not be used by nursing mothers. Adverse effects are rare, but include hyperexcitability, insomnia, tremors, motion sickness, paradoxical drowsiness, and depression. There is no toxicity of Centrophenoxine at therapeutic doses.

    DOSAGE: Take 1000 to 3000mg per day. Centrophenoxine takes effect very quickly. You'll notice an increase in alertness and a slight stimulating quality.

    SOURCES: Centrophenoxine is not sold in the United States. It can be purchased over the counter in Mexico or by mail from the address below. -------------- CHOLINE / LECITHIN:

    Choline can be found in several forms including choline bitartrate, choline chloride, or phosphatidyl choline. Phosphatidyl choline (PC) is the active ingredient of lecithin. All of these forms of choline will produce memory boosting effects, but PC has some unique effects as well.

    Choline compounds, including PC, are able to pass through the blood-brain barrier, where the brain utilizes the choline to make acetylcholine (a neurotransmitter that plays an important role in memory). Thus, choline enhances memory by increasing the amount of acetylcholine available for memory and thought processes.

    PC has some other important health benefits. It functions as a source of structural material for every cell in the human body, particularly those of the brain and nerves. It also aids in the metabolism of fats, regulates blood cholesterol, and nourishes the fat-like sheathes of nerve fibers.

    PRECAUTIONS: Any compound that acts like a precursor to acetylcholine such as choline, PC, or DMAE should not be used by people who are manic depressive because it can deepen the depressive phase. Choline bitartrate and choline chloride can sometimes cause a fishy odor or diarrhea. PC, however, does not have either of these effects.

    DOSAGE: Take 3 grams of choline per day in three divided doses. If you're taking lecithin you need to take a lot more because only part of the lecithin is choline. Often the label will provide information on the quantity of choline per tablespoon. All forms of choline should be taken with one gram per day of vitamin B-5 so that the choline can be converted into acetylcholine.

    SOURCES: Choline and lecithin are considered nutritional supplements and can be found at health food or drug stores. Commercial lecithin usually contains other oils and phosphatides besides phosphatidyl choline. Look at the label before you buy and make sure the product contains more than 30% phosphatidyl choline. Also, you should taste your lecithin and make sure it does not taste bitter (this indicates rancidity). Much lecithin on the market is rancid. The best form of lecithin I know is Twin Labs brand "PC 55" - it contains 55% PC and is always very fresh.

    DHEA:

    Dehydroepiandosterone (pronounced dee-hi-dro-epp-ee-an-dro-ster-own) is a steroid hormone produced in the adrenal gland. DHEA is the most abundant steroid in the human bloodstream. Research has found it to have significant anti-obesity, anti-tumor, anti-aging, and anti-cancer effects. DHEA levels naturally drop as people age and there is a good reason to think that taking a DHEA supplement may extend your life and make you more youthful while you're alive. Additionally, DHEA may be an important player in cognitive enhancement.

    DHEA is involved in protecting brain neurons from senility-associated degenerative conditions like Alzheimer's disease. Not only does the neuronal degenerative condition occur most frequently at the time of lowest DHEA levels, but brain tissue contains more DHEA than is found in the bloodstream. In an experiment with brain cell tissue cultures, Dr. Eugene Roberts found that very low concentrations of DHEA were found to "increase the number of neurons, their ability to establish contacts, and their differentiation." DHEA also enhanced long-term memory in mice undergoing avoidance training. Perhaps it plays a similar role in human brain function.

    DOSAGE of DHEA ranges from 50 mg to 2000 mg per day. There is no solid information indicating an optimal dosage for humans, but, if you want to get serious, you can get your DHEA levels checked every few months (for about $65), each time raising the amount of DHEA you take. When your blood levels reach what is normal for a 20-year-old human, then you're taking enough.

    SOURCES: DHEA is now being used by many people with AIDS because of its immune enhancement and antiviral effects. DHEA is not FDA approved but AIDS buyers groups are able to sell it to members because the FDA has a policy of looking the other way when it comes to the activity of these groups. Try contacting these buyer's groups: Alliance 7, 617/281-5360 in San Diego; or Healing Alternatives Foundation, 415/626/2316 in San Francisco.

    HYDERGINE (ERGOLOID MESYLATES):

    Research in other countries has shown that Hydergine improves mental function, prevents damage to brain cells, and may even be able to reverse existing damage to brain cells. Hydergine acts in several ways to enhance mental capabilities and slow down or reverse the aging processes in the brain. Its wide variety of effects include the following:

    1. Increases in blood supply to the brain.

    2. Increases the amount of oxygen delivered to the brain.

    3. Enhances metabolism in brain cells.

    4. Protects the brain from damage during periods of decreased and/or insufficient oxygen supply.

    5. Slows the deposit of age pigment (lipofuscin) in the brain.

    6. Prevents free radical damage to brain cells.

    7. Increases intelligence, memory, learning and recall.

    8. Normalizes systolic blood pressure.

    9. lowers abnormal high cholesterol levels in some cases.

    10. Reduces symptoms of tiredness, dizziness, and tinnitus (ringing in the ears).

    One way that Hydergine may enhance memory and learning is by mimicking the effect of a substance called nerve growth factor (NGF). NGF stimulates protein synthesis that results in the growth of dendrites in brain cells. Dendrites facilitate communication throughout the central nervous system and are necessary for memory and learning. New learning requires new dendritic growth.

    PRECAUTIONS: If too large a dose is used when first taking Hydergine. it may cause slight nausea, gastric disturbance, or headache. Overall, Hydergine does not produce any serious side effects, it is non-toxic even at very large doses, and it is contraindicated only for individuals who have chronic or acute psychosis.

    DOSAGE: The US recommended dosage is 3 mg per day; however, the European recommended dosage is 9 mg per day, taken in three divided doses. Most of the research has been done at levels of 9 to 12 mg per day. It may take several weeks before you notice the effects of hydergine.

    SOURCES: Hydergine is available in the United States and you can buy it if you have a doctor's prescription, but keep in mind that your doctor may not be familiar with the uses I have discussed. It can also be purchased over the counter in Mexico or by mail from overseas (see below).

    SULBUTIAMINE (ARCALION):

    Sulbutiamine is a new compound that has been described as being like Hydergine only better. It has been shown to facilitate wakefulness, improve long-term memory, speed up reaction time, decrease anxiety, and increase overall resistance to stress.

    DOSAGE: To combat fatigue take two 200mg tablets per day, always with breakfast or an AM meal, for a period of 20 days. Do not exceed three tablets at any time as this very powerful substance may cause severe headaches. Other than this, Sulbutiamine has no known adverse side effects.

    SOURCES: Sulbutiamine is not sold in the United States. It can be purchased by mail order from the address below.

    VASOPRESSIN (DIAPID):

    Vasopressin is a brain hormone that is released by the pituitary gland. It improves attention, concentration, memory retention, and recall (both short-term and long-term). Vasopressin facilitates more effective learning by helping to "imprint" new information in the memory centers of the brain, a function which cannot be achieved without the action of vasopressin.

    Cocaine, LSD, amphetamines, Ritalin, and Cylert (pemoline) cause a release of vasopressin. Frequent use of these drugs can deplete levels of vasopressin with a result of making you slow and dopey. If you feel burnt out, a whiff of vasopressin can transform your experience in about 10 seconds because it is a direct application of the specific brain chemical that has been depleted.

    Alcohol and marijuana, however, inhibit the release of vasopressin. A whiff of vasopressin when using these drugs will compensate for much of the dopiness caused by them.

    Vasopressin is very useful in situation where there is a large amount of new information to learn. It increases your ability to memorize and recall specific factual information.

    PRECAUTIONS: Vasopressin usually produces the following side effects: runny nose, nasal congestion, itch or irritation of the nasal passages, headache, abdominal cramps, and increased bowel movements. Vasopressin has not been proven safe for use during pregnancy.

    DOSAGE: Vasopressin usually comes in a nasal spray bottle. Most studies showing memory improvement have been done with a dose of 12 to 16 USP per day or about two whiffs three or four times per day. Vasopressin produces a noticeable effect within seconds.

    SOURCES: Vasopressin is available in the United States. You can buy it if you have a doctor's prescription, but keep in mind that your doctor may not be familiar with the uses I have discussed. It can also be purchased over the counter in Mexico or by mail from overseas (see below).

    VINPOCETINE (CAVINTON):

    Vinpocetine, like Piracetam, is a nootropic drug and a powerful memory enhancer. It facilitates cerebral metabolism by improving cerebral microcirculation (blood flow), stepping up brain cells' production of ATP (the cellular energy molecule), increasing the brain's use of glucose, and increasing the brain's oxygen utilization.

    Vinpocetine is often used for the treatment of cerebral circulatory disorders such as memory problems, aphasia, apraxia, motor disorders, dizziness, and headache.

    PRECAUTIONS: Adverse effects are rare, but include hypotension and tachycardia. It has no drug interactions, no toxicity, and is generally very safe.

    DOSAGE: One or two 5 mg. tablets per day.

    SOURCES: Vinpocetine is not sold in the United States. It can be purchased by mail from the address below.

    MAIL ORDER:

    A little known FDA ruling now allows the importation of a three-month personal supply of drugs as long as they are regarded as safe in other countries. Ordering safe but unapproved drugs is now legal under the new FDA pilot guidelines, Chapter 971. This compromise was made under pressure from AIDS political action groups because the were being denied access to potentially life-saving substances.

    INTERLAB, a mail order pharmacy in England, was established in response to this new FDA ruling. INTERLAB carries a wide variety of drugs for cognitive enhancement, life extension, and the treatment of AIDS which are not available in the United States. They even carry Retin-A for the skin.

    All of the drugs I have discussed here can be purchased without a prescription from them. You can request a price sheet by writing to: INTERLAB, PO Box 587, Newport Pagnell, Bucks MK16 8AA, England. Their prices are reasonable and, on some items, quite low. If you want to order right away send a personal check for the amount of the item(s) you want plus $6 for shipping (or $10 for accelerated shipping).

    * Centrophenoxine (60 x 250 mg. tablets) $29
    * Hydergine (100 x 5 mg. oral tablets) $39
    * Piracetam (60 x 800 mg. tablets) $30
    * Sulbutiamine (20 x 200 mg. tablets) $11
    * Vasopressin (12 ml nasal spray) $22
    * Xanthinol Nicotinate (60 x 150 mg. tablets) $9

    You must include the following signed statement with your order:

    "I hereby declare that the products I am purchasing are not for commercial resale. They are for my own personal use only. The supply ordered does not exceed three months usage and they are used with the consent of my physician."

    * Other cognitive enhancers include: xanthinol nicotinate, fenozolone (Ordinator), idebenone, Ginko biloba, acetyl-1-carnitine, DMAE, pyroglutamate, RNA (ribonucleic acid), isoprinosine, phenylalanine, phenytoin (Dilantin), pemoline, Ritalin, vitamin B-12, ACTH 4-10, L-prolyl L leucyl glycine amide, niacin, vitamin C, ginseng, GH3 (Gerovital), PRL-8-53, R-58-735, ISF-2522, THA, metrazol and strychnine (the last two are very dangerous). We will be reporting on some of the more exotic members of the tribe in upcoming issues.

    John Morgenthaler is the founder of the Cognitive Enhancement Research Institute (CERI). Send communications to John Morgenthaler, CERI, PO Box 483, Santa Cruz, CA 96061. If you would like a copy of the CERI newsletter, send $1 (for handling) along with a self-addressed, stamped envelope.







    shawn74797 Posted: Jan 23 2006, 10:19 AM
    Advanced Member


    Group: Advanced Members
    Posts: 316
    Member No.: 74797
    Joined: 21-May 05
    Warn: (10%)



    Your Ad Here

    About


    Community


    Bad Ideas


    Drugs
    Booze - The Legal Drug
    Legal Issues of Drug Use
    Marijuana
    Miscellaneous Drug Information
    Nitrous
    OTC Drugs and Household Items
    Psychedelics
    Rare and Exotic Drugs
    Speedy Drugs


    Ego


    Erotica


    Fringe




    Piracetam
    pyrogluamate
    Vinpocetine
    Acetyl-L-carnitine
    Centrophenoxine (lucidril)
    Choline
    AL721 (egg lecithin)
    DHEA (alliance 7 San diego 619-291-5360, HAF San fran 415-626-2316 &
    PDA New York 212-532-0363 )
    Deaner (DMAE)
    GEROVITAL (GH-3)
    Hydergine
    Phenytoin (Dilantin)
    Propranolol Hydrochloride (Inderal)
    Vasopressin (Diapid) nasal spray only
    Vincamine
    Xanthinol Nicotinate
    L-tryptophan
    L-Phenylalanine

    And a host of Aminos, Vitamins and assorted goodies. GOOD LUCK!!

    PS - new book, "Smart drugs & nutrients" Ward Dean, M.D. & john Morgenthaler
    Addr - B&J Publication, P.O. Box 483, Santa Cruz, CA 95061-0483
    IF YOU SEND A SASE, THEY WILL SEND YOU A LIST OF PHYSICIANS KNOWLEDGEABLE
    ABOUT SMART DRUGS & NUTRIENTS !! PLUS THEY HAVE A NEWLETTER FOR FREE!!!

    ***************************** Article Separation ******************************

    Earlier, there were some questions about amino acids on alt.drugs.
    I posted a scanty summary of some of aminos I was interested in.
    More questions appeared after that, posted and in my mail box.
    This file is quite a bit more complete but still doesn't list
    many of the 22 or so AAs. (eg. alanine, histidine, idoleucine,
    proline, serine, threonine, valine... these are all common, but
    i haven't found much info on them).
    Documentation and sources are missing, so please don't take this
    file too seriously. I probably won't create another version of
    this for a while.

    (Note that this is a Folded file, for those with MSDOS machines and
    the shareware editor.)

    =============================
    AMINO ACIDS AND THEIR EFFECTS
    =============================
    Version 1.1
    Compiled by: Bj Krawchuk (krawchuk@cpsc.ucalgary.ca)
    Several sources have been used and may be requested from above.

    (*@/// Phenylalanine *)
    (*@/// L-phenylalanine *)
    L-phenylalanine
    - converted into tyrosine which is
    precursor to noradrenaline (NE) and dopamine
    - like all amino acids best taken on empty stomach since it competes
    with proteins to cross the blood brain barrier.
    - requires vitamins C and B-6 for the conversion to NE.
    - Dosage: 500 - 1000mg along with 1g C, 30-50mg B-6
    - phenylalanine also stimulates the release of
    cholecystokinin, which is the body's own appetite-suppressant,
    - can increase sexual interest
    - improves memory and mental alertness
    - antidepressant
    - do not use L-phenylalanine or L-tyrosine if you are
    using MAO inhibitors for depression (it can cause a
    major elevation in blood pressure).
    (*@\\\*)
    (*@/// DL-phenylalanine *)
    DL-phenylalanine
    - combination of synthetic (D) and natural (L) phenylalanine
    - produces endorphins and stimulates their use
    - thus, effective painkiller, often better than the
    opiate derivatives such as morphine.
    - nonaddictive, nontoxic
    - reverse-tolerance effect (pain relief gets better)
    - strong anti-depressant effect
    - can be combined with other pain-killers
    with few bad interactions
    (*@\\\*)
    (*@\\\*)
    (*@/// Tyrosine *)
    L-tyrosine
    - precursor to norepinephrine and dopamine
    - non-essential amino acid (since PA is converted into it first)
    - has been studied as an effective aid to cocaine withdrawal
    - (see L-phenylalanine)
    (*@\\\*)
    (*@/// Tryptophan *)
    L-tryptophan
    - precursor to the neurotransmitter serotonin along with
    B6, niacin, and magnesium.
    - (actually immediate precursor to 5-hydroxytryptophan (5HTP)
    which is the precursor to serotonin (5HT))
    - prolongs slow-wave sleep
    - reduces pain sensitivity
    - no effect or increases REMS
    - has some hypnotic effects
    - useful for some types of endogenous depression
    (has been found as useful as imipramine and amitriptyline)
    - aids in reducing anxiety and tension
    - an appetite supressant
    - dosages have been studied up to 15g
    - Major Food Sources:
    Cottage cheese, milk, meat, fish, turkey, bananas,
    dried dates, peanuts, all protein-rich foods.
    (*@\\\*)
    (*@/// Lysine *)

    L-lysine
    - needed for growth and enzyme, hormone, antibody production
    - aids concentration
    - treatment for some sterility problems
    - treatment and prevention for herpes infections
    - aids fatty acid -> energy conversion
    (*@\\\*)
    (*@/// Arginine *)
    L-arginine
    - used to increase sperm counts
    (semen contains up to 80% of arginine)
    - aids immune response and healing of wounds
    - helps stored fat metabolism
    - helps to tone muscle tissue
    - used for weight-loss in combination with L-ornithine
    - one amino acid required for production of growth hormone
    (*@\\\*)
    (*@/// Ornithine *)
    L-ornithine
    - similar to arginine
    - growth hormone (which acts as a fat metabolizer) is
    stimulated to be released by ornithine and arginine.
    - can be used as a slimming technique (while you sleep -
    GH is released by the pituitary gland then)
    (*@\\\*)
    (*@/// Glutamine *)

    L-glutamine
    - converted to glutamic acid, the brain's emergency source of
    energy when glucose is in short supply.
    - precursor to the neurotransmitter GABA
    - neutralizes excess ammonia (which can inhibit proper
    brain function)
    - improves intelligence
    - helps to control alcoholism
    - helps to speed ulcer healing
    - alleviates fatigue, depression, impotence,
    schizophrenia, senility
    (*@\\\*)
    (*@/// Aspartic Acid *)
    L-aspartic acid
    - ammonia neutralizer
    - a study showed improved stamina and endurance in atheletes
    (*@\\\*)
    (*@/// Cysteine *)

    L-cysteine
    - cystine is its stable form
    - antioxidant
    - contains sulfur
    - protects cellular membranes from "free radical damage"
    - prevents alcohol and cigarette smoke damage to the brain
    - stimulant to immune system
    - believed to be good for antiaging
    - effective against copper toxicity (eg. Wilson's disease)
    - protects against X-ray and nuclear radiation
    - warning: may affect insulin effectiveness
    (*@\\\*)
    (*@/// Methionine *)
    L-methionine
    - antioxidant
    - contains sulfur
    - prevents damage of brain cells from toxic heavy metals
    - important in producing neurotransmitters and energy
    - lowers blood level of histamine
    (this may help some types of schizophrenia)
    - combined with choline and folic acid, can prevent some
    types of tumors
    - deficiencies: hair loss, atherosclerosis, cholestorol deposits,
    edema, poor urine processing
    (*@\\\*)
    (*@/// Glycine *)
    L-glycine
    - treatment for poor pituitary functioning
    - supplies creatine which is essential for muscle function
    (effective against muscular dystrophy)
    - treatment for hypoglycemia
    - stimulates glucagon which metabolizes glycogen into glucose
    - antacid
    - treatment for low blood pH
    - treatment for leucine imbalance-causing body odor and halitosis
    (*@\\\*)
    (*@/// Leucine *)
    L-taurine
    - nonessential amino acid
    - aids efficient conduction of electrical impulses
    along nerve pathways
    - anticonvulsant (esp in combo with glutamic, aspartic acids)
    (*@\\\*)
    (*@/// Glutathione *)
    L-Glutathione
    - tripeptide amino acid made of cysteine, glutamic acid and glycine
    - "triple threat" antiaging
    - antioxidant
    - anti-tumor agent
    - respiratory accelerator in the brain
    - used in the treatment of: allergies, cataracts, diabetes,
    hypoglycemia, arthritis
    - prevents some side effects of chemotherapy and X-ray radiation
    - protects against some harmful side-effects of cigarrette smoke
    and alcohol
    (*@\\\*)
    (*@/// Carnatine *)
    L-carnatine
    - newly discovered amino acid
    - aids stored fat -> energy conversion
    - helps: hypoglycemia, reduces angina attacks, diabetes,
    liver disease, kidney disease
    - deficiency causes heart tissue damage
    (*@\\\*)

    ***************************** Article Separation ******************************

    Tyrosine is available in a free form base from Vitamin Research Products
    based in Mountain View, CA. call (415) 555-1212 for number. Suggestion
    would be to start with 100mg of tyrosine at first, then to increase (weekly)
    to 300mg. Overdose symptoms include irratibility. This will need to be taken
    with several precursor vitamins like C B-5,6,12, for uptake into the
    blood/brain barrier. This amino wil compete with protein uptake, so take it
    on an empty stomach - see the book 'Life Extension" D. Pearson & S. Shaw -

    ***************************** Article Separation ******************************

    A safe stimulant which is not caffiene does exist and it available as
    a non-prescription drug from many health food stores. It's called
    Dimethylaminoethanol, or DMAE. It works pretty well as a stimulant and
    also increases levels of acetylcholine (it's a precursor). It also
    makes rats perform significantly better on maze tests, because the
    increased acetylcholine assists in some aspects of memory.

    Another way to decrease need for sleep is to raise brain levels of
    dopamine, which can be done by taking phenylalanine. It should be
    taken on an empty stomach (500 mg to 1 gram is a reasonable dose)
    with 1g vitamin C and 50 mg vitamin B-6 to assist in the conversion of
    phenylalanine to dopamine. Another way to take the phenylalanine
    is to place a small amount between the upper lip and gum about halfway back
    in the mouth. There are blood vessels there which go directly to the brain.
    If you're using this method, you should try a smaller dose (100 mg), as it is
    more effective when taken in this manner.

    Using these and other "safe" (i.e. adjusting the body's own chemicals
    rather than introducing something new; not necessarily safe but a priori
    a better bet than most traditional stimulants) I have been able to
    cut my need for sleep by 4 hours per day without discomfort for weeks at a
    time. I have no reason to believe that they would not be effective if
    used longer, but circumstances of class work seldom required me to cut
    sleep for longer periods than this.

    Be advised, however, that these methods will not be as powerful as,
    say, amphetamines or even high-dose caffiene, but they are not likely to
    mess you up either. But if you are trying to stay up for two nights
    to finish some huge project, you might be better off sticking with
    caffiene and cold showers.

    ****************************** Article Separation *****************************

    Yes, aspartame is the methyl ester of phenylalanine and aspartic acid,
    two amino acids. According to Richard Wurtman of MIT, you can get
    increases in brain levels of phenylalanine if low-protein foods such
    as soft drinks are consumed on an empty stomach.

    The brain requires vitamins B-6 and C to convert phenylalanine into
    the natural stimulant noradrenaline and another important brain chemical,
    dopamine (which is also, among other things, a stimulant and euphoric)

    Thus even if you are taking no supplemental phenylalanine, you can
    still get beneficial effects on mood, etc., by taking C and B-6
    because your brain will become more efficient at converting the
    phenylalanine that is already present in your diet.

    Speaking of diets, phenylalanine also stimulates the release of
    cholecystokinin, which is the body's own appetite-suppressant,
    used to tell the brain when the stomach has had enough. So phenylalanine
    acts indirectly as an appetite-suppressant.

    Note that all of the effects of phenylalanine are greatly enhanced if
    it is taken either on an empty stomach or with low-protein foods,
    because various proteins compete with phenylalanine for transport
    across the blood-brain barrier.

    Dosage: 500mg to 1g phenylalanine, plus 1g C, 30 to 50mg B-6.

    WARNING: Do NOT use phenylalanine:
    *If you are using MAO inhibitors, unless they are the extremely
    selective types such as deprenyl (selegiline);
    *If you have a cardiac arrythmia;
    *If you have hypertension;
    *If you have phenylketonuria;
    *If you have a psychosis;
    *If you have a pigmented malignant melanoma-type cancer;
    *If you have a violent temper.

    If you are taking other stimulants such as phenylpropanolamine, ephedrine,
    or even, potentially, caffiene or theophylline, you should monitor your
    blood pressure carefully because there is a possiblity of blood pressure
    rise and other problems characteristic of adrenaline-like drug oversoda.

    ***************************** Article Separation ******************************

    Phenylalanine and many other amino acid supplements are available
    mail-order from Vitamin Research Products, 2044 Old Middlefield Way,
    Mountain View, CA 94043 USA.
    Tryptophan is currently banned for sale in the US, due to the
    contamination scare of last year. The source of the contamination
    was found (an experimental genetically-engineered bacteria used by
    _one_ Japanese firm to manufacture the Tryptophan) but the FDA has
    still refused to lift the ban.

    ***************************** Article Separation ******************************

    A little-known FDA ruling now allows the importation af a 3 month personal
    supply of drugs as long as they are regarded as safe in other countries.
    INTERLAB a mail order pharmacy was established in response to this new
    FDA ruling. Interlab carries a wide range of drugs for cognitive
    enhancement, life extension, and treatment of AIDS not available in
    America.
    All of the drugs briefly discuussed here can be pruchased without a
    prescription fron them. You can request a price sheet by writing to


    Some Highly regarded Chemicals include:

    HYDERGINE (Ergoloid Mesylates)- Improves mental function, prevents
    hypoxia and other damage to brain cells,increases blood supply to brain,
    enhances brain metabolism, slows deposit of aging pigment and other
    posistive effects
    PRECAUTIONS- Too large inital dose may cause nausea, gastric
    disturbance or headache. Non-toxic even at very high dosages.
    Contraindicated for individuals with acute or chronic psychosis.
    DOSE- 9-12 mg/Day
    COST- 100 x 5mg. oral tablets $39

    SULBUTIAMINE (Arcalion)- Described as being like hydergine only better.
    Facilitates wakefullness, inproves long-term memory, speeds reaction time
    .
    decreases anxiety.
    PRECAUTIONS- Do not exceed 3 x 200mg tablets at any time as may
    cause severe headaches. Other than this has no other adverse affects.
    DOSE- 2 x 200mg. tablets for 20 days.
    COST- 20 X 200 mg. tablets $11

    VASSOPRESSIN (Diapid)- A brain hormone released by the pituitary.
    Improve attention, concentration, memory and reacall.
    Cocaine, LSD, amphetamines, Ritalin, and Cylert(pemoline) cause depletion
    of
    vassopressin. Marijuana and alchohol inhibit the release of vassopressin.
    A
    Whiff of vassopressin can transform your experience in about 10 seconds
    when using these drugs as it is an application of the specific hormone
    being
    affected.
    PRECAUTIONS- Vassopressin occasionall produces the following side
    affects;
    runny nose, nasal congestion, itch or irritation of the nasal cavities,
    headach
    abdominal cramps and increased bowel movements. Safety during
    pregnancy unknown.
    DOSE- Comes in a nasal spray bottle. 2-4 whiffs 3-4 time2 a day will
    produce
    noticeable affects in seconds.
    COST- 12 ml. nasal spray $22

    Send $6 with order for shipping, $10 for accelerated shiping

    These are just a small cross section of the Interlab product line, but
    they
    have found favor with me and mine.
    You may find the newletter of the Cognitive Enhancement Research
    Institute helpful. Send $1.00 to
    CERI
    PO Box 483
    Santa Cruz, CA 96061

    ****************************** Article Separation *****************************

    Some friends of mine make a vitamin formula that they sell to drug treatment
    clinics to combat the neurotransmitter deficit caused by stimulant abuse...
    It really works,a lot of people have been helped off cocaine with it.

    There are two separate preparations, an AM and PM formula,
    The PM formula used to contain tryptophan,but now does not,obviously,
    However,they have had some sucess with a formula that maximizes the conversion
    of dietary tryptophan into serotonin.

    Here is the formula...

    AM......

    L-tyrosine 250 mg.
    D,L phenylalanine 125 mg.
    Pantothenic acid 25 mg.
    PABA 25 mg.
    DMAE 25 mg.
    Rubidium Cl 25 mg.
    Tocopherol acetate 12.5 mg.
    Beta carotene 2.5 mg.
    Manganese (gluconate) 2.5 mg.
    Folic acid 0.1 mg
    Copper gluconate .125 mg
    Selenium .25 mg.

    PM.......

    Niacinamide (ascorbate) 250 mg.
    Taurine 50 mg.
    Magnesium oxide 50 mg.
    Pyridoxine 25 mg.
    Niacin 12.5 mg.
    Riboflavin 12.5 mg
    Zinc 2.5 mg.
    Beta carotene 2.5 mg.
    Chromium (GTF) .025 mg.
    Vitamin B12 .0125 mg.


    This is basically a neurotransmitter boosting formula and benefits those
    who dont have a drug abuse problem too.

    *************************** Article Separation ****************************** ***

    I was recently lucky enough to be given several ounces of pure DMAE
    (dimethylaminoethanol) and boy,is it ever a lot better than the Twinlab
    stuff,which I had previously been using...

    I use it in combination with tyrosine in the morning and it has dramatically
    improved my memory (and an interesting sideffect is the induction of lucid
    dreams...)

    A good source for DMAE are the AIDS buying clubs that have popped up in
    major cities..(although thats not where I got this..)

    For anyone interested in neurotransmitter precursor supplementation
    (DMAE,a relative of choline,is a precursor of acetylcholine)
    this one REALLY works..

    **************************** Article Separation ****************************** *

    ---------------------------------
    004 ARCALION (Sulbutiamine) Servier 30 x 200mg tablets US$ 14.00
    013 CENTROPHENOXINE (Lucidril) Loyd Anphar 60 x 250mg tablets US$ 18.00
    014 DEPRENYL (Jumex) 50 x 5mg tablets US$ 49.00
    025 DILANTIN (Phenytoin) generic 300 x 100mg tablets US$ 14.00

    024 FIPEXIDE (Vigilor) 30 x 200mg tablets US$ 16.00
    012 GEROVITAL GH3 injectable (Aslan formula) 12 x 5cc US$ 25.00
    001 HYDERGINE (Sandoz) 28 x 4.5mg tablets US$ 18.00
    011 KH3 Oral Procaine Formula Farmitalia 100 x 50mg tablets US$ 9.50

    009 MENTIS (Pirisudanol Dimaleato) Menarini 24 x 300mg tablets US$ 11.50
    008 PARLODEL (Bromocriptine) Sandoz 30 x 2.5mg tablets US$ 19.75
    002 PIRACETAM (generic) 60 x 800mg tablets US$ 16.75
    026 PIRACETAM (generic) 60 x 1200mg tablets US$ 25.00

    019 RETIN A 0,05% (acid A vit) Roche 20 gram tube creme US$ 7.00
    007 SINAMET (250mg 1-dopa & Merk Sharp & Dome 60 tablets US$ 32.00
    25mg carbidopa)

    022 THYMUS EXTRACT-THX Regenersen-Injectable 5 ml vial US$ 30.00
    023 THYMUS EXTRACT-Thym-uvocal Injectable Mulli 10 x 2 ml vials US$ 96.00
    003 VASOPRESSIN (Sandoz) 5 ml spray US$ 11.00
    010 VINCAMINE (Oxicebral) Pfizer 30 x 20 mg tablets US$ 9.50
    -------------------------------------------------------------------------------


    This month's legal high is not a single substance, but a subject...
    SMART DRUGS. If you regularly read MONDO 2000 or alt.cyberpunk, just
    skip this posting because you already know it all... otherwise, read on!

    Many of you might have heard of Smart Drugs, via NPR, or the Nightly News
    (and also Nightline). Smart Drugs are a *new* breed of drugs termed
    *nootropic*. Nootropic comes from the Greek word meaning "acting on
    the mind". Nootropic drugs have in common.... (1) They all work on
    the brain and/or blood/brain barrier and (2) They all have *fairly* low
    toxicity levels.

    Smart Drugs can do things like:

    1) Improve mental functioning and even increase IQ (lots of arguments
    on the IQ increasing - but research is proving it true)
    2) Increase lifespan (30% or higher)
    3) Decrease some of the *bad* degenerative effects of aging
    4) Increase mental clarity
    5) Done in combination with *illegal drugs*, Smart Drugs can undo
    some of the less-desirable effects (eg., foggyness, dizzyness,
    tiredness etc..).

    On Toxicity:

    Many of the nootropic drugs are SO nontoxic that the PDR lists them as
    having no known overdose levels, and no known symptoms or contradictions.
    THIS IS NOT TO SAY that ALL smart drugs are safe. Certainly not... and
    you should be fairly knowledgable about them before you do them - especially
    in combination! A couple of the nootropic drugs do have contradictions
    so PLEASE be careful in experimentation. (Note, certain combinations of
    nootropic drugs, done together, will have unpleasant, if not dangerous
    effects - PLEASE BE CAREFUL - never experiment with them together, until
    you have experimented with them each, individually, over a period of time.
    Make SURE you read the PDR on each of them, because some of them do have
    contradictions, especially if you have other conditions (eg., angina, etc..)).

    What Do They Do?

    Here is a partial (very partial) list of some smart drugs. ALL these
    drugs are available, in the US, by prescription. ALL of these drugs
    are available, outside of the US, without prescription AND MAY LEGALLY
    BE BROUGHT INTO THE US by you (more on this at the end of the article).

    The following table lists SOME of the drugs, their use as smart drugs,
    the NORMAL dose, and their use in the US, as indicated by the FDA. Blank
    items are because I don't have all my reference material at my side. Note
    that most of this information came via Mondo 2000, and other books.

    Drug Name Trade Name Dose Remarks
    --------- ---------- ---- -------
    Centrophenoxine Lucidril 1000 to Intelligence Booster and
    3000 mg/day Antiaging. Improvements in
    memory function and 30% increase
    in lifespan of mice. Removes
    Lipofuscin deposits in the brain.
    * This drug has contradictions *
    Choline 3 g/day Helps the brain make acetylcholine
    (also Lecithin) DO NOT DO if manic depressive
    Dehydroepiandrosterone DHEA 50 to Anti-tumor, Anti-aging, Anti-
    2000 mg/day obesity. Protects brain neurons
    from senility degenerative
    conditions. Naturally present
    in the body, but decreases with
    age.
    Ergoloid Mesylates Hydergine 3 to 9 Increases blood supply to brain.
    mg/day Increases oxygen to brain
    Protects brain from oxygen starv-
    ation. Reduces tiredness and
    dizziness. Normalizes systolic
    pressure. Increases intelligence.
    Gingko 20 mg Blood vessel dilators.
    Piracetam Nootropyl 2400 to Cognitive enhancer and memory
    8000 mg/day improver.
    Sulbutiamine Arcalion 400 mg/day Facilitate wakefulness and
    improve long term memory. Increase
    resistance to stress.
    Vasopressin Diapid A blast up Helps you learn new memories.
    each nose Improves attention, concentration
    and recall. Made by SANDOZ!
    Helps undo the foggyness of
    alcohol and marijuna, and can undo
    the 'slowness' of coke, lsd etc..
    Vincamine Oxicebral low dose Alertness / activity.
    Vinpocetine Cavinton 5 mg/day Memory enhancer.

    How To Get Them:

    Most of these drugs are available in the US, by prescription. They are
    usually approved by the FDA for uses NOT IN THE LIST ABOVE (for example,
    Vasopressin is used in the US for bladder control, but it has NOT been
    approved in the US for its memory functions, which require it to go through
    the multi-year cycle (and millions of dollars) for approval for that use).

    HOWEVER, due to the AIDS situation, the FDA has loosened the laws governing
    what you can bring in from other countries. It is now LEGAL to purchase
    a PERSONAL SUPPLY (not to exceed 3 months) of these (and other) drugs from
    firms in Europe, as long as they are regarded as safe in other countries.
  3. Registered User
    Dr Liftalot's Avatar
    Join Date
    May 2006
    Location
    Washington
    Posts
    588
    Rep Power
    10908

    This information shows how ADD/ADHD can be treated with Nootripic's, even if you don't have ADHD/ADD you may very well find this intresting and useful.

    Hyperactivity—
    normal behavior or ADHD?
    Affecting 3 to 5% of school-aged children, attention deficit-hyperactivity disorder (ADD or ADHD) is age-inappropriate, excessive physical activity. Since “normal” childhood behavior is not easily defined, it may be unclear whether a child truly suffers from ADHD or is just more rambunctious than another.

    ADHD often goes undiagnosed—Many affected children grow into adults unaware of their condition
    ADHD can affect learning—Learning disabilities or emotional problems often go hand in hand with ADHD

    Where do I focus?
    Self-care for ADHD can be approached in a number of ways—but it can be hard to know just where to start. To make it easier, our doctors recommend trying these simple steps first:

    Check out L-carnitine
    To improve behavior, take 100 mg for each 2.2 pounds of body weight a day, with a maximum of 4 grams a day
    Supplement with essential fatty acids
    Getting approximately 186 mg of EPA (eicosapentaenoic acid), 480 mg of DHA (docosahexaenoic acid), 96 mg of GLA (gamma-linolenic acid), 864 mg of linoleic acid, and 42 mg of arachidonic acid supplies fatty acids important to brain function
    Try the Feingold diet
    Work with the Feingold Association or a knowledgeable practitioner to reduce or eliminate additives and other food issues that may affect ADHD
    Give magnesium a go
    200 mg a day can address possible magnesium deficiency that may influence ADHD
    These recommendations are not comprehensive and are not intended to replace the advice of your doctor or pharmacist. Continue reading the full ADHD article for more in-depth, fully-referenced information on medicines, vitamins, herbs, and dietary and lifestyle changes that may be helpful.

    Skip to:
    About
    Checklist
    Symptoms
    Treatments
    Dietary changes
    Lifestyle changes
    Supplements
    References
    About ADHD
    Attention deficit-hyperactivity disorder (ADD or ADHD) is defined as age-inappropriate impulsiveness, lack of concentration, and sometimes excessive physical activity.

    ADHD has been associated with learning difficulties and lack of social skills. Obviously what constitutes “normal” in these areas covers a wide spectrum; thus it is unclear which child suffers true ADHD and which child is just more rambunctious or rebellious than another. No objective criteria exist to accurately confirm the presence of ADHD. ADHD often goes undiagnosed if not caught at an early age, and it affects many adults who may not be aware of their condition.

    Checklist for Attention Deficit–Hyperactivity Disorder

    Rating Nutritional Supplements Herbs
    Essential fatty acids
    L-carnitine
    Magnesium
    Zinc
    B vitamins
    Evening primrose oil
    Vitamin B6
    Reliable and relatively consistent scientific data showing a substantial health benefit.
    Contradictory, insufficient, or preliminary studies suggesting a health benefit or minimal health benefit.
    For an herb, supported by traditional use but minimal or no scientific evidence. For a supplement, little scientific support and/or minimal health benefit.

    What are the symptoms of ADHD?
    ADHD is generally recognized by a pattern of inattention, distractibility, impulsivity, and hyperactivity estimated to affect 3 to 5% of school-aged children. Learning disabilities or emotional problems often accompany ADHD. Children with ADHD experience an inability to sit still and pay attention in class, and they often engage in disruptive behavior.

    Medical treatments
    The most commonly prescribed prescription drugs, methylphenidate (Ritalin®, Metadate®) and amphetamine mixtures (Adderall®), are considered stimulant drugs, though they produce a paradoxical calming effect in people with ADHD. Another medication less frequently used is pemoline (Cylert®).

    Dietary changes that may be helpful
    The two most studied dietary approaches to ADHD are the Feingold diet and a hypoallergenic diet. The Feingold diet was developed by Benjamin Feingold, M.D., on the premise that salicylates (chemicals similar to aspirin that are found in a wide variety of foods) are an underlying cause of hyperactivity. In some studies, this hypothesis does not appear to hold up.1 However, in studies where markedly different levels of salicylates were investigated, a causative role for salicylates could be detected in some hyperactive children.2 As many as 10 to 25% of children may be sensitive to salicylates.3 Parents of ADHD children can contact local Feingold Associations for more information about which foods and medicines contain salicylates.

    The Feingold diet also eliminates synthetic additives, dyes, and chemicals, which are commonly added to processed foods. The yellow dye tartrazine has been specifically shown to provoke symptoms in controlled studies of ADHD-affected children.4 Again, not every child reacts, but enough do so that a trial avoidance may be worthwhile. The Feingold diet is complex and requires guidance from either the Feingold Association or a healthcare professional familiar with the Feingold diet.

    In one study, children diagnosed with ADHD were put on a hypoallergenic diet, and those children who improved (about one-third) were then challenged with food additives. All of them experienced an aggravation of symptoms when given these additives.5 Other studies have shown that eliminating individual allergenic foods and additives from the diet can help children with attention problems.6 7

    Some parents believe that consuming sugar may aggravate ADHD. One study found that avoiding sugar reduced aggressiveness and restlessness in hyperactive children.8 Girls who restrict sugar have been reported to improve more than boys.9 However, a study using large amounts of sugar and aspartame (NutraSweet®) found that negative reactions to these substances were limited to just a few children.10 While most studies have not found sugar to stimulate hyperactivity, except in rare cases,11 the experimental design of these studies may not have been ideal for demonstrating an adverse effect of sugar on ADHD, if one exists. Further studies are needed.

    Lifestyle changes that may be helpful
    Smoking during pregnancy should be avoided, as it appears to increase the risk of giving birth to a child who develops ADHD.12

    Lead13 and other heavy-metal exposures14 have been linked to ADHD. If other therapies do not seem to be helping a child with ADHD, the possibility of heavy-metal exposure can be explored with a health practitioner.

    Nutritional supplements that may be helpful
    Some children with ADHD have lowered levels of magnesium. In a preliminary, controlled trial, children with ADHD and low magnesium status were given 200 mg of magnesium per day for six months.15 Compared with 25 other magnesium-deficient ADHD children, those given magnesium supplementation had a significant decrease in hyperactive behavior.

    In a double-blind study, children with ADHD who received 15 mg of zinc per day for six weeks showed significantly greater behavioral improvement, compared with children who received a placebo.16 This study was conducted in Iran, and zinc deficiency has been found to be quite common in certain parts of that country. It is not clear, therefore, to what extent the results of this study apply to children living in other countries.

    In a double-blind study, supplementation with L-carnitine for eight weeks resulted in clinical improvement in 54% of a group of boys with ADHD, compared with a 13% response rate in the placebo group.17 The amount of L-carnitine used in this study was 100 mg per 2.2 pounds of body weight per day, with a maximum of 4 grams per day. No adverse effects were seen, although one child developed an unpleasant body odor while taking L-carnitine. Researchers have found that this uncommon side effect of L-carnitine can be prevented by supplementing with riboflavin. Although no serious side effects were seen in this study, the safety of long-term L-carnitine supplementation in children has not been well studied. This treatment should, therefore, be monitored by a physician.

    A deficiency of several essential fatty acids has been observed in some children with ADHD compared with unaffected children.18 19 One study gave children with ADHD evening primrose oil supplements in an attempt to correct the problem.20 Although a degree of benefit was seen, results were not pronounced. In a 12-week double-blind study, children with ADHD were given either a placebo or a fatty-acid supplement providing daily: 186 mg of eicosapentaenoic acid (EPA), 480 mg of docosahexaenoic acid (DHA), 96 mg of gamma-linolenic acid (GLA), 864 mg of linoleic acid, and 42 mg of arachidonic acid. Compared with the placebo, the fatty-acid supplement produced significant improvements in both cognitive function and behavioral problems.21 No adverse effects were seen.

    B vitamins, particularly vitamin B6, have also been used for ADHD. Deficient levels of vitamin B6 have been detected in some ADHD patients.22 In a study of six children with low blood levels of the neurotransmitter (chemical messenger) serotonin, vitamin B6 supplementation (15–30 mg per 2.2 pounds of body weight per day) was found to be more effective than methylphenidate (Ritalin®). However, lower amounts of vitamin B6 were not beneficial.23 The effective amount of vitamin B6 in this study was extremely large and could potentially cause nerve damage, although none occurred in this study. A practitioner knowledgeable in nutrition must be consulted when using high amounts of vitamin B6. High amounts of other B vitamins have shown mixed results in relieving ADHD symptoms.24 25

    Are there any side effects or interactions?
    Refer to the individual supplement for information about any side effects or interactions.

    References
    1. Harley JP, Ray RS, Tomasi L, et al. Hyperkinesis and food additives: testing the Feingold hypothesis. Pediatrics 1978;61:818–21.

    2. Levy F, Dumbrell S, Hobbes G, et al. Hyperkinesis and diet: a double-blind crossover trial with a tartrazine challenge. Med J Aust 1978;1:61–4.

    3. Williams JI, Cram DM. Diet in the management of hyperkinesis: a review of the tests of Feingold’s hypotheses. Can Psychiatr Assoc J 1978;23:241–8 [review].

    4. Rowe KS, Rowe KJ. Synthetic food coloring and behavior: a dose response effect in a double-blind, placebo-controlled, repeated-measures study. J Pediatr 1994;125:691–8.

    5. Boris M, Mandel FS. Foods and additives are common causes of the attention deficit hyperactive disorder in children. Ann Allergy 1994;72:462–8.

    6. Carter CM, Urbanowicz M, Hemsley R, et al. Effects of a few food diet in attention deficit disorder. Arch Dis Child 1993;69:564–8.

    7. Egger J, Stolla A, McEwen LM. Controlled trial of hyposensitisation in children with food-induced hyperkinetic syndrome. Lancet 1992;339:1150–3.

    8. Prinz RJ, Roberts WA, Hantman E. Dietary correlates of hyperactive behavior in children. J Consult Clin Psychol 1980;48:760–9.

    9. Rosen LA, Booth SR, Bender ME, et al. Effects of sugar (sucrose) on children’s behavior. J Consult Clin Psychol 1988;56:583–9.

    10. Wolraich ML, Lindgren SD, Stumbo PJ, et al. Effects of diets high in sucrose or aspartame on the behavior and cognitive performance of children. N Engl J Med 1994;330:301–7.

    11. Wolraich ML, Wilson DB, White JW. The effect of sugar on behavior or cognition in children. A meta-analysis. JAMA 1995;274:1617–21.

    12. Milberger S, Biederman J, Faraone SV, et al. Is maternal smoking during pregnancy a risk factor for attention deficit hyperactivity disorder in children? Am J Psychiatry 1996;153:1138–42.

    13. Tuthill RW. Hair lead levels related to children’s classroom attention-deficit behavior. Arch Environ Health 1996;51:214–20.

    14. Krigman MR, Bouldin TW, Mushak P. Metal toxicity in the nervous system. Monogr Pathol 1985;(26):58–100.

    15. Starobrat-Hermelin B, Kozielec T. The effects of magnesium physiological supplementation on hyperactivity in children with attention deficit hyperactivity disorder (ADHD). Positive response to magnesium oral loading test. Magnes Res 1997;10:149–56.

    16. Akhondzadeh S, Mohammadi MR, Khademi M. Zinc sulfate as an adjunct to methylphenidate for the treatment of attention deficit hyperactivity disorder in children: a double blind and randomized trial [ISRCTN64132371]. BMC Psychiatry 2004;4:9.

    17. Van Oudheusden LJ, Scholte HR. Efficacy of carnitine in the treatment of children with attention-deficit hyperactivity disorder. Prostaglandins Leukot Essent Fatty Acids 2002;67:33–8.

    18. Mitchell EA, Aman MG, Turbott SH, Manku M. Clinical characteristics and serum essential fatty acid levels in hyperactive children. Clin Pediatr 1987;26:406–11.

    19. Stevens LJ, Zentall SS, Deck JL, et al. Essential fatty acid metabolism in boys with attention-deficit hyperactivity disorder. Am J Clin Nutr 1995;62:761–8.

    20. Aman MG, Mitchell EA, Turbott SH. The effects of essential fatty acid supplementation by Efamol in hyperactive children. J Abnorm Child Psychol 1987;15:75–90.

    21. Richardson AJ, Puri BK. A randomized double-blind, placebo-controlled study of the effects of supplementation with highly unsaturated fatty acids on ADHD-related symptoms in children with specific learning difficulties. Prog Neuropsychopharmacol Biol Psychiatry 2002;26:233–9.

    22. Bhagavan HN, Coleman M, Coursin DB. The effect of pyridoxine hydrochloride on blood serotonin and pyridoxal phosphate contents in hyperactive children. Pediatrics 1975;55:437–41.

    23. Coleman M, Steinberg G, Tippett J, et al. A preliminary study of the effect of pyridoxine administration in a subgroup of hyperkinetic children: a double-blind crossover comparison with methylphenidate. Biol Psychiatry 1979;14:741–51.

    24. Brenner A. The effects of megadoses of selected B complex vitamins on children with hyperkinesis: controlled studies with long term followup. J Learning Dis 1982;15:258–64.

    25. Haslam RHA. Is there a role for megavitamin therapy in the treatment of attention deficit hyperactivity disorder? Adv Neurol 1992;58:303–10.
    •   
       

  4. Registered User
    Dr Liftalot's Avatar
    Join Date
    May 2006
    Location
    Washington
    Posts
    588
    Rep Power
    10908

    A little quick guide i found for those un-willing to read what i compiled.
    Nootropics - A Quick Guide
    Quick guide to the most popular nootropic supplements. All can be stacked, or taken alone. Neurostim +C is a good premade stack, though I like to add piracetam to it when I need to concentrate in order to learn (only 4 more months of grad school at night, yay). All of these typically take days to weeks to make a noticeable improvement on concentration and focus, and are best taken in longer periods (2-3 months) followed by down time of one month. As with all supplements, start with the basics, and move on from there.


    Piracetam (2-oxo-Pyrrolidine Acetamide) - is a derivative of the neurotransmitter GABA (Gamma Amino Butyric Acid). Chemically related to the amino acid Pyroglutamic Acid (Pyrrolidine Carboxylic acid), which occurs in cerebrospinal fluid and plays an important role in cognitive functioning.

    -Biochemical Effects-
    -Enhances Brain Metabolism (By increasing Glucose Utilization, Blood & Oxygen Flow){Boosts mental energy & cerebral circulation}
    -Increases Cerebral Phospholipids & Cellular Membrane Fluidity (By interacting with the polar head moieties of the phospholipid bilayer) {Supports healthy neuron communication & structure}.
    -Supports Cognitive Receptors (By amplifying the density of the Muscarinic Cholinergic {Frontal Cortex, Striatum, & Hippocampus}, NMDA (N-Methyl-D-Aspartate) {Hippocampus}, & AMPA (Alpha-amino-3-hydroxy-5-Methyl-4-isoxazole-Propionic Acid) Cerebral Cortex Receptors {Strengthens neurotransmitter receptors involved in memory and neuroprotection}
    -Stimulates the Corpus Callosum, an area of the brain that controls communication between the left and right hemispheres (Increases communication between both hemispheres) {Involved in speech and creative thinking}.
    - Stimulates the Locus Coeruleus, (specialized neurons) {Involved in information processing, attention, cortical/behavioral arousal, learning and memory}
    -Inhibits Platelet Aggregation (By increasing Red-White blood cells & Platelet deformability, inhibiting thromboxane A2 synthetase or antagonism of thromboxane A2, reducing von Willebrand's factor & fibrinogen levels) {Supports Healthy Blood Flow}.
    -Decreases EEG complexity (Increases cooperatively of brain functional processing) {Positively effects Neuro-Electrical Functioning}.
    -Has a significant antioxidant effect.

    -Overview-
    Piracetam positively supports healthy cognitive & cardiovascular functioning by a multifaceted means of action.

    -Notes-
    Approved & used since 1970’s worldwide (Europe, Asia, and South American) for various health conditions. Recommended by many healthcare professionals and health organizations, such as the Life Extension Foundation, as a Nootropic.
    Piracetum is the first step in the use of nootropics, it also stacks nicely with all of the following.

    -Dose-
    2-6 grams daily.

    -When can I feel it?-
    Works within an hour to a few days.
    -------------------------------------------------------------

    Aniracetam - Aniracetam (1-Anisoyl-2-pyrrolidinone) is a fat soluble potent analog of Piracetam.
    -Biochemical Effects-
    Similar to Piracetam, but due to its fat solubility its effects last longer and is far more potent.
    - Helps increase communication between your left and right sides of the brain, resulting in improved creatively, perception, and more.
    - Has an more potent AMPA receptor enhancing effect than Piracetam, resulting in better focus and concentration.
    - Been reported to be best ‘cetam for anti-anxiety effects

    -Dose-
    750-1,500 mg daily with meals.

    -When can I feel it?-
    Works within an hour to a few days.
    ---------------------------------------------------------------------------

    Oxiracetam - (4-hydroxy-2-oxo-1-pyrrolidinacetamide) is a potent fast acting water soluble analog of Piracetam. Works faster than all other racetams.

    -Biochemical Effects-
    Similar to Piracetam, but much stronger than Aniracetam and far faster acting. The preferred premium Nootropic for the elite smart drug user.
    - Supports multiple aspects of Cognition
    - Boosts Brain ATP levels (Mental Energy)
    - Increase Choline Acetylcholinetranferase the neuro-enzyme that creates Acetylcholine (in the cerebral cortex, hippocampus and striatum) {Memory Support}

    -Dose-
    800-1,600 mg daily.

    -When can I feel it?-
    Works within an hour to a few days.
    --------------------------------------------------------------

    Pramiracetam
    (N-{2-(diisopropylamino)ethyl}-2-oxo-1-pyrrolidine-acetamide) is a fat soluble potent analog of Piracetam, the most potent Racetam compound being about 15 times stronger than Piracetam.

    -Dose-
    100-300mg daily

    Availability
    Sporadic due to customs issues.
    ---------------------------------------------------------

    L-Huperzine - A is a natural plant alkaloid (extracted from Huperzia serrata), which quickly and potently boosts memory, learning, and concentration. Used worldwide for decades in adults and high school students. Is considered the most potent short term memory enhancer available.

    -Biochemical Effects-
    - Potently raises Acetylcholine (main memory neurotransmitter) by inhibiting its breakdown from Acetylcholinesterase.
    - Strengthens the Brain's NMDA receptors (Enhances Focus, Learning, and Brain Functioning)

    -Dose-
    Take 200-400 mcg daily for best results with meals.

    -When can I feel it?-
    Works within an hour to a few days.
    ------------------------------------------------------------------------

    Alpha GPC (Alpha L-GlycerylPhosphorylCholine), also known as choline alfoscerate, is an unique NeuroActive form of choline that rapidly penetrates the blood brain barrier, naturally found in small amounts in milk and soybeans.

    -Biochemical Effects-
    - A precursor for the neurotransmitter AcetylCholine [Supports Memory].
    - A precursor for PhosphatidylCholine [Supports Brain Structure]

    -Dose-
    300-2000 mg daily.

    -When can I feel it?-
    Works within a few days.
    ------------------------------------------------------------

    Vinpocetine (Ethyl Apovincamine) is a derivative of vincamine (a phytonootropic from periwinkle). While less potent as a mental stimulant than vincamine, Vinpocetine is the preferred nootropic for Enhancing blood flow to the Brain, Eyes, and Ears. Its effects on Cerebral Blood Flow far exceeds all other nootropics.

    -Biochemical Effects-
    -Enhances Brain Metabolism (By increasing Glucose Utilization, Blood & Oxygen Flow) (Boosts mental energy & cerebral circulation)
    - Stimulates the Locus Coeruleus, (specialized neurons) (Involved in information processing, attention, cortical/behavioral arousal, learning and memory)
    -Inhibits Platelet Aggregation (Reduces abnormal blood clots).
    -Has a significant antioxidant effect.

    -Dose-
    20-40 mg daily with meals.
    ------------------------------------------------------

    Theanine (gamma-ethylamino-L-glutamic acid) is an unique amino acid found in trace amounts in green tea. It converts in the brain into GABA, the neurochemical involved in inhibiting over active mental activities, such as stress, anxiety, worrying, and nervousness. Unlike herbs theanine protects & enhances Cognition, without causing sleepy or drowsiness.


    -Biochemical Effects-
    - Instant relaxation due to its potent effects on raising GABA
    - Unlike the supplement GABA it passes through the blood brain barrier readily and has superior GABA raising effects.
    - Has been studied compared to Paxil.

    -Notes-
    In Japan it is used in soft drinks much like caffeine is added in the US, but to relax rather than stimulate the mind.

    -Dose-
    200-1000mg daily.

    -When can I feel it?-
    Works within a few hours.
    -------------------------------------------------

    Acetyl-L-Carnitine (2-Acetoxy-3-(trimethylaminium)butanoic acid) is an amino acid-like compound related to Choline found in high levels in brain cells.

    -Biochemical Effects-
    - Increases Acetylation of Coenzyme A (a precursor to Acetylcholine) [Memory Enhancer]
    - Enhances transport of fatty acids into the mitochondria [Increased Cellular Energy Levels]

    -Dose-
    500-3000mg daily
    ------------------------------------------------------------------

    Choline supplements should be taken during the administration of all nootropics. Lecithin (caps and granules) is a cheap choline source. Lecithin should be taken in doses of 5-8 grams daily to support the nootropics. Alpha GPC (listed above) is another source for choline. It is more effective / more expensive, but only requires dosing in the 1-3 gram range to support choline levels in the brain.

    -------------------------------------------------------------------
    STACKS

    Simple Stack :
    1-2 grams piracetam every 8 hours with 5 grams lecithin daily.

    Study Stack - Simple :
    1-2 grams piracetam every 8 hours / 5 grams lecithin / 10mg Vinpocetine every 8 hours

    Advanced Stack :
    2 grams piracetam every 8 hours
    500 mg aniracetam every 8 hours
    1 gram Alpha GPC every 8 hours

    Study Stack - advanced :
    1.5 grams piracetam every 8 hours
    500 mg aniracetam every 8 hours
    1.5 grams Alpha GPC every 8 hours
    15 mg Vinpocetine every 8 hours
    150 mcg Huperzine every 8 hours

    Anxiety / Concentration Stack :
    500 mg aniracetam every 8 hours
    200 mg theanine every 8 hours (plan for one dose prior to a speech or presentation)

    After all test are done stack :
    500mg Theanine
    1.5 grams Phenibut (do not study on phenibut)
    5 grams lecithin
    ----------------------------------------------------

    Good premixed Nootropics Stacks
    Focus
    Nuerostim+C

    These are very useful for using as bases to homemade stacks and are pretty hard to beat for PreWO mixes. Add a little chocamine or AMP/HEAT and its a potent mix.
  5. Registered User
    excalibur's Avatar
    Join Date
    Apr 2003
    Age
    37
    Posts
    97
    Rep Power
    186

    good read..
  6. Registered User
    Dr Liftalot's Avatar
    Join Date
    May 2006
    Location
    Washington
    Posts
    588
    Rep Power
    10908

    Quote Originally Posted by excalibur
    good read..
    Took me a while to compile the info from various sources and added some of my own data, glad someone made use of it.
  7. Registered User
    rkieltyk's Avatar
    Join Date
    Aug 2006
    Posts
    103
    Rep Power
    150

    great post/read i was really looking into these for college, and you have suggested dosages and stacks which is EXTREMELY helpful.
  8. Registered User
    Markum1's Avatar
    Join Date
    Dec 2004
    Location
    Louisville, KY
    Age
    44
    Posts
    79
    Rep Power
    157

    Great Post!!! Very informative. Thank you.
  9. Banned
    800mrunner's Avatar
    Join Date
    Aug 2006
    Posts
    103
    Rep Power
    0

    this is a great post.
  10. Registered User
    excalibur's Avatar
    Join Date
    Apr 2003
    Age
    37
    Posts
    97
    Rep Power
    186

    Quote Originally Posted by Dr Liftalot
    Took me a while to compile the info from various sources and added some of my own data, glad someone made use of it.

    You got karma!

  11. Registered User
    bigfucer's Avatar
    Join Date
    Jan 2006
    Posts
    36
    Rep Power
    123

    i would also like to thank you for posting this. I am a med student and some of these products are very useful(-racetams, the aa's) looking forward to trying the vasopressin and subliamine.thanks again
  12. Registered User
    John Smeton's Avatar
    Stats
    6'2"  225 lbs.
    Join Date
    Sep 2004
    Age
    33
    Posts
    10,017
    Rep Power
    33557

    Yeah Good Information. No hype This is your kind of thread.

    I have some questions

    So Choline should be taking with all nuero-tropics?

    And Sulbtiamine should only be taking for an extended peroid of time?

    And alcar should be takign for a few months than not taking for a month?

    so many questions i know

    Every Nuero-tropic is different ; therefore it should be ultilized differently right?
  13. Banned
    same_old's Avatar
    Join Date
    Apr 2005
    Age
    35
    Posts
    1,526
    Rep Power
    0

    awesome. thanks.
  14. Registered User
    psywzrd's Avatar
    Join Date
    Jan 2004
    Posts
    312
    Rep Power
    286

    Quote Originally Posted by Dr Liftalot
    EUPHORIA - Well, someone took Pemoline, twisted it around a little bit and put a whole lot of pleasure into the equation. This might be a Dangerous drug! There are lot of different things that seem to happen with Euphoria. The first time I took it (40 milligrams - I've learned since that 25 mg. is considered your basic dose) I got really charged up. This is definitely a High and it comes on suddenly (about 45 minutes after ingestion). My first response upon coming on to it was an experience of an intense rush of perceived personal power. I found myself goosestepping down the busy Berkeley streets thinking about how good I felt, how successful I was destined to be, and knowing that the world was my oyster. After about 15 minutes of this as I found myself leaping down the BART escalator, I had to tell myself to slow down for fear that I would be completely drained later on. Although I didn't really slow down at all during this experience, I did bring myself into a somewhat more humane mindset and I spent the subway ride having an almost methoxylated amphetamine (MDMA, MDA, etc.)-type ideations. In other words, I wasn't just feeling good about myself, I was feeling good about most everybody else. The world was everybody's oyster.

    Arriving at my office, I immediately found myself doing organizational work at about three times the normal rate with far more self-assurance and fewer mistakes than usual. Simultaneously, I was entertaining perspectives on the nature of my true will and making important phonecalls which I had put off for some time. I did about thirty hours worth of work in about ten hours. I literally could not stop. I tried to make myself take a break for about ten minutes. Within a minute, I found my hand going into a drawer to pull out another file which needed reorganizing. Believe me, this is very unusual behavior. I hate organizational work.

    This all might sound like the first blushes of an amphetamine high, but he emotional overtones and the mentation under this substance is of a softer and more inwardly whole (less alienated) quality. As I've already indicated, the Euphoria high seems to have a slight methoxylated amphetamine quality to it. All in all, this was a very powerful experiencing of clarity, self-assurance and cognitive ability. The following day, I experienced the same sort of effects at about one-third the intensity. There was no burnout at all in aftermath.

    Subsequent experiments have shown Euphoria to be predictable as an effective tool for organizing binges, brainstorming sessions and radio talk-show appearances. It also seems to induce ongoing personal growth in terms of clarity of personal will. (I've received three other testimonies in this same direction.) As a writing tool, I've found Euphoria to be variable. It seems that verbal acuity comes on strong but the verbal circuits burn out quickly from intensity of use and one has to move on to less verbally oriented tasks. In other words, this is generally good for creative flashes and outlining grand syntheses but not too good for actual completion of written work. It gives one an impatience for minutiae and the kind of careful faceting that it takes to bring a work to completion. In terms of appreciation and comprehension of aesthetics and information, this seems the opposite of its close cousin Pemoline. The accessing mode favored is visual. One wants to explore a painting or photograph or watch a movie rather than read a book.

    My only complaint about Euphoria is that it lasts 16 hours, which feels about 4 hours too long. In two of my five experiences, the last four hours were spent feeling slightly "headachy" and weary, although there was still no burnout following sleep. I would say, at this point, that Euphoria should not be used more often than once a week since it is so powerful and so much energy is expended in the experience. This is easily the most Fun of the intelligence increasers and, as such, is probably the most likely to be abused.
    I didn't read your entire post, but this part stood out. Is there actually a product that goes by this name (Euphoria)? If so, where can I get it? It sounds like it has effects that are somewhat similar to the old Renewtrient (GBL) and I would love to find a legal substitute.
  15. Registered User
    b unit's Avatar
    Stats
    6'0"  242 lbs.
    Join Date
    Aug 2006
    Location
    New Zealand
    Posts
    2,647
    Rep Power
    1421

    great post, very informative
  16. Superman
    Manu20's Avatar
    Join Date
    Aug 2003
    Location
    TX
    Posts
    4,076
    Rep Power
    2173

    Wow great post...thank you.
  17. Registered User
    somewhatgifted's Avatar
    Stats
    6'2"  210 lbs.
    Join Date
    Jan 2006
    Posts
    4,392
    Rep Power
    2335

    does it mean i have add if i made it through the first 5 lines then scrolled to see how long it was?
  18. Registered User
    juggernaut333's Avatar
    Join Date
    Jan 2005
    Posts
    259
    Rep Power
    246

    good stuff,im a big fan of nootropics.
    what i found ironic was that in that info you had from the AN website was chock full of bad spelling and grammar lol.guess the guy should have dosed a bit higher before creating the website

    ive been running 500mg twice a day of aniracetam and perhaps that is one of the factors in my overall great mood improvement these days.helps with a mental edge as i work online all day and make my board rounds with posts.i really like it and am going to add in another dose to total 1500mg/day as well as add in the lecithin granules again.

    ive used and enjoyed piracetam as well before.now im going to pick up some pramiracetam as that seems to be one of the kings,and give that a go.also will be snagging some oxiracetam and trying that as well and will post results.

    i was all excited reading the first part,then u had ppl relaying info apparently contradicting things ,especially the safety of the various substances.i suppose more research is in order.the vasopressin especially was interesting but ill have to do more reading before delving into that.that euphoria stuff certainly sounded pretty neat as well,though i worry about the negative sides the other person claimed...
  19. Registered User
    Leggo my Ego's Avatar
    Stats
    5'8"  212 lbs.
    Join Date
    Apr 2006
    Location
    Goodyear, AZ
    Age
    34
    Posts
    1,487
    Rep Power
    845

    R EPS
  20. Registered User
    John Smeton's Avatar
    Stats
    6'2"  225 lbs.
    Join Date
    Sep 2004
    Age
    33
    Posts
    10,017
    Rep Power
    33557

    Euphoria-DMT. Google it. I dont think I'll mess with it unless i find out more. Stuart Wilde recommends it. He says It's useful for spiritual people. While i consider myself spiritual it might be useful. Im not going to knock something I havnt tryed. I think It's mostly found in South Africa or America(One of the two)
  21. Registered User
    East1600Plus's Avatar
    Join Date
    Nov 2006
    Location
    Nebraska
    Age
    25
    Posts
    562
    Rep Power
    376

    my brain cant handle it
  22. Registered User
    John Smeton's Avatar
    Stats
    6'2"  225 lbs.
    Join Date
    Sep 2004
    Age
    33
    Posts
    10,017
    Rep Power
    33557

    Quote Originally Posted by East1600Plus
    my brain cant handle it
    Have you tryed it? If so what's the expirence you notice on it?
  23. Registered User
    East1600Plus's Avatar
    Join Date
    Nov 2006
    Location
    Nebraska
    Age
    25
    Posts
    562
    Rep Power
    376

    Quote Originally Posted by smeton_yea
    Have you tryed it? If so what's the expirence you notice on it?
    ha no didnt mean it like htat...i cant process all whats written...i hate reading
  24. Registered User
    Skigazzi's Avatar
    Join Date
    Feb 2004
    Location
    Philly
    Age
    36
    Posts
    625
    Rep Power
    17461

    Quote Originally Posted by Dr Liftalot
    A little quick guide i found for those un-willing to read what i compiled.
    Dude...I wrote that entire post on 12/3/05 (just that one post, not everything you posted) originally ...but I'll take it as a compliment that you thought highly enough of it to post it on this forum.

    (For another big nootropic thread, go to the other "Bodybuilding" forum and search for threads started by me, and containing the word Nootropics, its 5 pages of good stuff)
    "I am on a drug, it's called Charlie Sheen. It's not available, 'cause if you try it once, you will die. Your face will melt off and your children will weep over your exploded body." - Charlie Sheen
  25. Registered User
    Dr Liftalot's Avatar
    Join Date
    May 2006
    Location
    Washington
    Posts
    588
    Rep Power
    10908

    Quote Originally Posted by Skigazzi
    Dude...I wrote that entire post on 12/3/05 (just that one post, not everything you posted) originally ...but I'll take it as a compliment that you thought highly enough of it to post it on this forum.

    (For another big nootropic thread, go to the other "Bodybuilding" forum and search for threads started by me, and containing the word Nootropics, its 5 pages of good stuff)

    Haha That was you, i believe i asked about your stack and adding a few goodies from the longer list.

    GOOD TO SEE YOU AGAIN SIR!

    ;-)
    :bb2:
  26. Registered User
    Skigazzi's Avatar
    Join Date
    Feb 2004
    Location
    Philly
    Age
    36
    Posts
    625
    Rep Power
    17461

    Quote Originally Posted by Dr Liftalot
    GOOD TO SEE YOU AGAIN SIR!
    That made me think of Fight Club....
    "I am on a drug, it's called Charlie Sheen. It's not available, 'cause if you try it once, you will die. Your face will melt off and your children will weep over your exploded body." - Charlie Sheen
  27. Board Supporter
    Cardinal's Avatar
    Join Date
    Nov 2002
    Location
    TX
    Posts
    623
    Rep Power
    455

    Thanks for the info. I have piracetam, choline and some alcar. If piracetam works within a week, I may give it a shot. I need the brain power Lord knows.

    I am however concerned about being able to note its effects. When I use anabolic steroids like tren I know it has its own effects on brain chemistry and I wouldn't want to confuse sharpened mental capacities from tren with piracetam. If the difference is huge though, then I will be able to tell within a weeks time. I think I'll study normally for a few weeks to kick off the semester then try a short experiment.
  28. Registered User
    Skigazzi's Avatar
    Join Date
    Feb 2004
    Location
    Philly
    Age
    36
    Posts
    625
    Rep Power
    17461

    Quote Originally Posted by Cardinal
    Thanks for the info. I have piracetam, choline and some alcar. If piracetam works within a week, I may give it a shot. I need the brain power Lord knows.
    In all honesty, Id give Piracetam a month to take full effect. Aniracetam would likely work in a week though.
    "I am on a drug, it's called Charlie Sheen. It's not available, 'cause if you try it once, you will die. Your face will melt off and your children will weep over your exploded body." - Charlie Sheen
  29. Banned
    same_old's Avatar
    Join Date
    Apr 2005
    Age
    35
    Posts
    1,526
    Rep Power
    0

    Quote Originally Posted by Skigazzi
    Dude...I wrote that entire post on 12/3/05 (just that one post, not everything you posted) originally ...but I'll take it as a compliment that you thought highly enough of it to post it on this forum.
    yikes...Dr L you need to be sure to credit those who originally posted your "re-posts"...plagiarism (whether intentional or not) hurts a person's reputation, and just looks bad. good thing skigazzi is the easygoing type

    but naturally we all appreciate the compilation. thanks.
  30. Registered User
    Dr Liftalot's Avatar
    Join Date
    May 2006
    Location
    Washington
    Posts
    588
    Rep Power
    10908

    Quote Originally Posted by same_old
    yikes...Dr L you need to be sure to credit those who originally posted your "re-posts"...plagiarism (whether intentional or not) hurts a person's reputation, and just looks bad. good thing skigazzi is the easygoing type

    but naturally we all appreciate the compilation. thanks.

    Well I had three versions of the easy mans stack. Each from a different source without a name. A screen name is hardly what I'd consider a source. I thought of that one as the best, I had no idea whether or not, skigazzi had just ripped it from somewhere else. I in no way care about credit, just sharing the good word of cognitive thinking. ( not to say, I don't want to give credit where credit is due.)


    If I had not added in one of the easier stacks, allot of people would have just overlooked the whole thing. Sorry if i un-intentionally re-posted your post. But i felt it was the best written out of the lot of them.



    Not to mention allot of the data I've compiled and somewhat re-written has come from many many sources. Most don't even give a name, if i was lucky a screen name. Which didn't source where they had gotten it ether.

    Hopefully this clears things up a bit.


    Dr liftalot
  31. Registered User
    Skigazzi's Avatar
    Join Date
    Feb 2004
    Location
    Philly
    Age
    36
    Posts
    625
    Rep Power
    17461

    Quote Originally Posted by Dr Liftalot
    I had no idea whether or not, skigazzi had just ripped it from somewhere else.

    It was a combination of ripping and writing I believe (its been a couple years now)..but like I said, I dont really care, its just funny to see yourself pop up in writing so to speak.

    I started a chain email once in college, something stupid about Christmas...and 3 years later I got it at Christmas from someone who didnt know me in college...I found that amazing.
    "I am on a drug, it's called Charlie Sheen. It's not available, 'cause if you try it once, you will die. Your face will melt off and your children will weep over your exploded body." - Charlie Sheen
  •   

      
     

Similar Forum Threads

  1. All You need to Know about PCT!!!!
    By DRSTRISMADAST in forum Anabolics
    Replies: 119
    Last Post: 05-03-2012, 07:22 PM
  2. All you need to know about bloodwork
    By Skeletor in forum Anabolics
    Replies: 8
    Last Post: 04-12-2012, 02:50 AM
  3. Replies: 20
    Last Post: 03-24-2011, 12:42 PM
  4. All You Need To Know About Fina!
    By Blindfaith in forum Anabolics
    Replies: 48
    Last Post: 05-03-2006, 06:30 AM
  5. Replies: 39
    Last Post: 05-12-2004, 04:48 PM

Posting Permissions

  • You may not post new threads
  • You may not post replies
  • You may not post attachments
  • You may not edit your posts
  •  

Log in

Log in