- 05-06-2003, 02:50 PM
Short-Term Glucosamine Infusion Does Not Affect Insulin Sensitivity in Humans
Marie-Jose J. Pouwels, Judith R. Jacobs, Paul N. Span, Jos A. Lutterman, Paul Smits and Cees J. Tack
Overactivity of the hexosamine biosynthetic pathway may underlie hyperglycemia-associated insulin resistance, but to date human studies are lacking. Hexosamine pathway activation can be mimicked by glucosamine (GlcN). In the present placebo-controlled study we determined whether GlcN infusion affects insulin resistance in vivo. In 18 healthy subjects, we applied the double forearm balance technique (infused arm vs. control arm) combined with the euglycemic hyperinsulinemic clamp (60 mU/m2·min insulin) for at least 300 min. During the clamp, subjects received infusions in the brachial artery of 4 µmol/dL·min GlcN from 90–240 min (n = 6) or from 0–300 min (n = 6) or saline (placebo; n = 6). We studied the effects of GlcN on forearm glucose uptake (FGU; infused arm vs. control arm, and vs. placebo experiments) and on whole body glucose uptake.
GlcN infusion raised the plasma GlcN concentration in the infusion arms to 0.42 ± 0.14 and 0.81 ± 0.46 mmol/L; plasma GlcN remained very low (<0.07 mmol/L) in the control arms and in the placebo group. GlcN infusion did not change forearm blood flow. During insulin, FGU increased more than 10-fold. At all time points, FGU was similar in the GlcN-infused arm compared with the control arm and was not different from FGU in the placebo experiments. Similar results were obtained for forearm arteriovenous glucose differences or extraction and for whole body glucose uptake. Thus, despite relevant GlcN concentrations for 5 h in the infused forearm, GlcN had no effect on insulin-induced glucose uptake. These results do not support involvement of the hexosamine pathway in the regulation of insulin sensitivity in humans, at least not in the short-term setting.
- 05-06-2003, 03:18 PM
OK I do HIGH supplementation with glucosamine.
I also have done slin in the past and can go hypo on as little as 6 IUS.
I also feel the onset of hypo with just 500mg of ALA if my carbs are low.Sleep Supplement 3Z BCAA: Red Raspberry and Lemon flavors
HGH/sleep enhancer: HGHpro
Test Booster: TestoPRO and STOKED!
Preworkout: MANIAC Fruit Punch and Pink Lemonade
07-08-2004, 10:00 PM
i've got a kilo of glucosamine from "Kilosports" & according to the label one t-spoon is 7 grams.
if i put 1/3 of a t-spoon in my post w/o shake with whey & creatine how is this going to affect anything?
i was thinking it may be a benefit!! now i'm extremely confused.
07-08-2004, 11:48 PM
If you look on avant, they are pretty much saying the opposite things. In fact, Glucosamine HCL is one of the biggest ingredients in Leptigen. So take it for what its worth.
07-09-2004, 05:43 PM
can anyone put this in plain english? i have a elbow injury and have just started taking this. What problems will I encounter?
07-12-2004, 09:56 AM
i just had a bit of a browse through the thread i think you mean.Originally Posted by Scottyo
i think they were talking about best results occurring while in a calorie deficit. also Spook mentioned that it may not be a good idea for endomorphs.
for some reason i can't post the link!!!
07-12-2004, 02:37 PM
07-12-2004, 11:21 PM
07-12-2004, 11:44 PM
Seriously, don't worry about glucosamine and negative impacts. Almost all studies that had these used ridiculously high levels. Par, Spook, and Nandi have all commented on it, and thats enough for me.
07-12-2004, 11:53 PM
I can tell you from personal experience that glucosamine will make you fat in no time. It messes up glucose metabolism really fast. Even small doses. At least it does for me. I had to kiss my 5% bodyfat goodbye when I started taking it and I even improved my diet while taking Glucosamine because I have gotten an increace in BF from it before, but it's hopless. I will never use it again.
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