Idebenone (QSA-10, derivative of CoQ10) superior to CoQ10

[LakeMountD]

A lot of people have been asking why we aren't including CoQ10 in Cycle Support. The reason is because Idebenone has been shown to be a more effective derivative.


Idebenone protects hepatic microsomes against oxygen radical-mediated damage in organ preservation solutions.

Wieland E, Schutz E, Armstrong VW, Kuthe F, Heller C, Oellerich M.

Abteilung Klinische Chemie, Georg-August-Universitat Gottingen, Germany.

The ability of the benzoquinone coenzyme Q-10 or its derivative QSA-10 (idebenone) to protect against lipid peroxidation and protein damage mediated by the pro-oxidative system NADPH/ADP/Fe3+ was tested in a rat liver microsomal model incubated in University of Wisconsin (UW) or histidine-tryptophan-ketoglutarate (HTK) solutions. Lipid peroxidation, as followed by direct determination of lipid hydroperoxides and by monitoring of malondialdehyde equivalents, was 1.8-fold enhanced in HTK and 3-fold attenuated in UW compared with HEPES buffer. Function and integrity of microsomal enzymes were investigated using glutathione S-transferase and cytochrome P-450 IIIA activity as assessed by lidocaine N-deethylation to monoethylglycinexylidide as well as by Western blot analysis of the cytochrome P-450 IIIA protein. Glutathione S-transferase activity was reduced by about 70% in HEPES compared with 50% in HTK and 36% in UW. Cytochrome P-450 IIIA was inactivated by about 75% in HEPES and HTK, compared with 55% in UW. The enzyme inactivation was paralleled by a loss of immunoreactive cytochrome P-450 IIIA protein. Supplementation of HTK with 0.1 mumol/L QSA-10(idebenone) offered complete protection against lipid peroxidation, compared with 100 mumol/L with Q-10. QSA-10(idebenone) (20 mumol/L) prevented protein damage in both preservation solutions, whereas Q-10 (20 mumol/L) offered only partial protection in UW and had no effect in HTK. The use of QSA-10 during liver transplantation may therefore have the potential of increasing the efficacy of organ preservation, maintaining donor organ quality, and preventing reperfusion injury. It is suitable for human use and has energy-conserving properties in addition to its antioxidant nature.

 

[ersatz]

Good to see the inclusion of Ideb and I think we'll see it included in more people's supp regimine as people begin to realize its benefits.

 

[Iron Warrior]

So could we theoretically substitute Co-Q 10 with Idebenone, or would there be merit to taking both ?

 

[LakeMountD]

So could we theoretically substitute Co-Q 10 with Idebenone, or would there be merit to taking both ?

From the studies I read, it appears that it can replace CoQ10.

 

[Iron Warrior]

From the studies I read, it appears that it can replace CoQ10.

Thanks Lake. Too bad I can't rep you right now, I gotta find other peeps to rep first

 

[strategicmove]

So could we theoretically substitute Co-Q 10 with Idebenone, or would there be merit to taking both ?

The recommendation by many researchers is to add Idebenone to a CoQ10 supplementation program to get the very best of both compounds.

Here is a contribution I made to a similar thread "CoQ10 retards neurodegenerative diseases" in the Supplement Articles forum:

As is well known, Idebenone, as an analog of CoQ10, can replace CoQ10 in the process of cellular energy production. Idebenone is also, like CoQ10, a powerful antioxidant. However, Idebenone is more water-soluble than CoQ10 and its cellular distribution and antioxidant structure also differ from those of CoQ10, making idebenone superior to CoQ10 in neutralizing some types of free free radicals, but inferior in fighting other types. In particular, idebnone is more effective than CoQ10 in protecting cells from the free radical damage resulting from reduced (abnormal) blood flow. In fact, some studies indicate idebenone is 30-100 times more effective than vitamin E or vinpocetine as a free radical quencher.
Furthermore, Idebenone protects under hypoxic conditions, a situation where CoQ10 may not be an adequate replacement. In addition, Idebenone (unlike CoQ10) has been shown to increase Nerve Growth Factor and enhance cholinergic activity, thus conferring Idebenone with cognitive enhancement abilities.
To continue, Idebenone is a potent anti-oxidant for protecting the very important mitochondria, by both surpressing free radical activity and protecting the unique mitochondrial DNA (mtDNA). This is unique as mtDNA is only derived from our mother's genes.
Finally, when organs are "harvested" for transplant to another patient, it is often the case that Idebenone is used to protect it from damage.

It must be noted that most of the comparison between Idebenone and CoQ10 employed the standard Ubiquinone form of CoQ10, not Ubiquinol.

Most researchers suggest that a combined ingestion of both is superior to one regime only.

 

[Outside Backer]

Thanks Lake. Too bad I can't rep you right now, I gotta find other peeps to rep first

ill take it lol