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Cellular and in vivo hepatotoxicity caused by green tea phenolic acids and catechins

yeahright

yeahright

Well-known member
Cellular and in vivo hepatotoxicity caused by green tea phenolic acids and catechins

Giuseppe Galati, Alison Lin, Amira Sultan, Peter J. O’Brien
Free Radical Biology & Medicine 40 (2006) 570 – 580
[Stukje van abstract]

Epigallocatechin-3-gallate

In the following, the cytotoxicities of these major tea phenolics toward isolated rat hepatocytes have been ranked and the mechanisms of cytotoxicity evaluated. The order of cytotoxic effectiveness found was epigallocatechin-3-gallate > propyl gallate > epicatechin-3-gallate > gallic acid, epigallocatechin > epicatechin.

Using gallic acid as a model tea phenolic and comparing it with the tea catechins and gallic acid-derivative food supplements, the major cytotoxic mechanism found with hepatocytes was mitochondrial membrane potential collapse and ROS formation.

Epigallocatechin-3-gallate was also the most effective at collapsing the mitochondrial membrane potential and inducing ROS formation. Liver injury was also observed in vivo when these tea phenolics were administered ip to mice, as plasma alanine aminotransferase levels were significantly increased.
 
You are missing a lot of details in this study such as dosages. I can assure you that the amount of green tea one of us could consume in one day is NOTHING near what those mice were subject to and our livers are 100x+ larger. That is the problem with rat studies, they overdose the heck out of them to find out maximal effect and so they can shorter the duration of the study. Your liver could easily recover from the small damage (if any) that green tea would due to you, and the anti-oxident anti-cancer properties of green tea definitely outweighs this.
 
The liver has amazing regenerative abilities, perhaps the best of any organ. As I have said before, if the arcitechture of the liver remains unchanged it can repair itself.
Most of these types of studies are done at high dosages with the intent of developing and IC50 of the drug/compound in question. Did the paper mention any of this ?
cc
 
canadian champ said:
Most of these types of studies are done at high dosages with the intent of developing and IC50 of the drug/compound in question. Did the paper mention any of this ?
cc
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Yeah that was sort of the point I was trying to make as well. You have to read the full text article sometimes, the abstracts can be tricky. I remember reading one that had IGF-1 administered to mice and they gave it like 1mg every few hours or something, insane.
 
I don't have access to any proprietary medical databases. This is the best I could come up as far as a fuller explanation of the study:

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We can probably look at the effects of green tea on people in the place that green tea originated from. Lo and behold, the ones that have been drinking this stuff for centuries aren't dying, they're thriving!!
 
DazzlinJack said:
We can probably look at the effects of green tea on people in the place that green tea originated from. Lo and behold, the ones that have been drinking this stuff for centuries aren't dying, they're thriving!!
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everyone dies
 
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