grapefruit juice

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    grapefruit juice


    i hear unsweetened gf juice works great with viagra/cialis/levitra/nasutra as well as most other orals.......makes em more effective

    any TRUTH to this?

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    It is true that grapefruit juice increases the absorption of said orals.
    cc
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    It's either naringin or another naturally occurring chemical that enhances absorbtion of most oral products.. Ever make the mistake of drinking grapefruit juice with an ephedra product? I have, oh man that was a fun day..
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    So...would Grapefruit juice increase something like superdrols' effects? (even if it did, it would probably be ten times as toxic to the liver...so probably not a good idea...Just curious though)
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    Faster absorbtion, not stronger effect..
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    Naringin is also in energy drinks, so a monster drink would do the same i guess.
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    Quote Originally Posted by jjohn
    Naringin is also in energy drinks, so a monster drink would do the same i guess.
    Not quite, it's dose-specific in those RTD's so it wouldn't matter.. Straight grapefruit juice works fine..
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    Quote Originally Posted by bigpetefox
    Not quite, it's dose-specific in those RTD's so it wouldn't matter.. Straight grapefruit juice works fine..
    Ah!! LOL.. ok then
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    cant wait to experiment
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    Quote Originally Posted by bigpetefox
    Faster absorbtion, not stronger effect..
    In regards to your comments, I agree wholeheartedly. However, is it possible that the QUALITY of absorption by using the gf juice could be better than the quality of absortion without the gf joice? In which case, if this could be true, then it could lead to a stronger overall effect possibly...?...?....?...

    It don't think of it as an effect greater than what 100% perfect absortion would yield; that wouldn't happen, I agree. However, I am just wondering if it could lead to an overall better absorption when compared to not using the gf joice.

    Any ideas, or am I "out there" on this one....
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    If you took Advil with gf juice, the absorbtion would be faster and would take effect sooner.. Just becuase something absorbs faster doesn't mean it would work better..
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    Hope this helps some and clears up a few things..

    TUESDAY, May 9 (HealthDay News)
    -- Researchers say they've identified the substances in grapefruit juice that can produce unwanted side effects when the juice is taken with certain drugs.

    The discovery may make it possible to offer grapefruit juice that is free of these substances, called furanocoumarins, or add them to drugs to boost their effect, the researchers say.

    People are routinely told by their doctors to avoid drinking grapefruit juice while taking a variety of medications because of potentially dangerous side effects. For instance, the beverage should be avoided when taking certain blood-pressure or cholesterol-lowering drugs, as well as HIV medications, organ-transplant drugs and sedatives.

    The reason: Grapefruit juice can cause these drugs to enter the blood stream more efficiently, thereby increasing the dose and effect -- and the potential for undesirable and even dangerous side effects.
    It had been thought that the flavonoids that give grapefruit juice its bitter taste caused the drug interaction, said study lead researcher Dr. Paul Watkins, director of the General Clinical Research Center at the University of North Carolina at Chapel Hill.

    "What this study shows is that if you leave all that stuff in and take out a group of substances called furanocoumarins, you get rid of this property of the juice," Watkins said.

    The study findings appear in the May issue of the American Journal of Clinical Nutrition.
    In their study, Watkins and his colleagues compared orange juice, whole grapefruit juice and grapefruit juice that had the furanocoumarins removed. "We found that once you took the furanocoumarins out, the juice behaved like orange juice," he said. "That's certainly pretty convincing evidence that these are the active ingredients in the juice."

    According to Watkins, there are three implications to the finding.

    First, since the substances that cause drug interactions have been found, researchers can look at a number of other fruits to see if they contain furanocoumarins and predict whether they will cause the same problem.

    Second, manufacturers of grapefruit juice could offer a version of the juice that has the furanocoumarins removed, eliminating the potential for drug interaction,
    Watkins said. "If there were a market, it would be possible to offer furanocoumarin-free grapefruit juice for people taking certain drugs, just as there is lactose-free milk," he said. "It doesn't affect the taste very much."

    Third, furanocoumarins could be added to certain drugs to improve their "bioavailability," or ability to enter the blood stream, Watkins said. "The effect of grapefruit juice is to boost entry of these drugs into the body, and that can be a good thing if you can control it," he said. "It turns out that you don't just get more, you get a more reliable delivery -- there is less variation from one person to another when you do this," he said.

    One expert thinks that adding furanocoumarins to medications might be the most important potential development to come out of this study.

    "The ability to produce grapefruit juice free of the chemicals that interact with drugs is in some ways trivial, as few people would find avoiding grapefruit juice a true hardship," said Dr. David L. Katz, an associate professor of public health and director of the Prevention Research Center at Yale University School of Medicine.

    But, the potential to use these chemicals in grapefruit juice to adjust drug levels is of real interest, Katz said. "As unknowns, chemicals in grapefruit juice interacting with drugs were merely a potential hazard. Now that they have been identified, they may be useful therapeutic agents in their own right," he said.

    http://www.forbes.com/forbeslife/hea...out532584.html

    Users of the following classes of drugs should be especially careful:
    Cholesterol lowering (Lipitor)
    Blood pressure meds (Calcium channel blockers)
    Anticonvulsants (Tegretol)
    Antipychotic (Halcion)--Good stuff here
    GI stimulants (Propulsid)
    Immunosuppressants (Cyclosporine)
    Methadone
    Viagra

    More studies on the topic here: using grapefruit juice to increase oral AS absorption - Anabolic Steroids - Steroid.com / Anabolic Review Forums

    Anyone interested in Drug/Food interactions should by one of these pocket guides: [ame]http://www.amazon.com/gp/product/097...43913?n=283155[/ame]

    Almost every drug reacts with different foods. You can learn how to eat to get the most out of your drugs while reducing the side effects. This includes all the SERMs and other research chems bodybuilders take. Ideally, every household should have one, IMO. Great reference...
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    Quote Originally Posted by bigpetefox
    If you took Advil with gf juice, the absorbtion would be faster and would take effect sooner.. Just becuase something absorbs faster doesn't mean it would work better..
    I understand that, but thank you. I simply wondered if the gf juice could cause BETTER absorption (more reliable delivery per the article, see quote below).

    Quote:
    Third, furanocoumarins could be added to certain drugs to improve their "bioavailability," or ability to enter the blood stream, Watkins said. "The effect of grapefruit juice is to boost entry of these drugs into the body, and that can be a good thing if you can control it," he said. "It turns out that you don't just get more, you get a more reliable delivery -- there is less variation from one person to another when you do this," he said.
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    Better absorbtion, not better action of the product..
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    Quote Originally Posted by bigpetefox
    Better absorbtion, not better action of the product..
    I'll stop arguing with you now . However, I still do believe BETTER absorption could cause a person to react better (but yes, the product itself would not be any different).

    I think it could be a cardinal sin for a newbie to the board (not newbie to the "scene") to challenge a veteran , but I'll do it once in a while
  

  
 

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