Bro, the depletion was in skeletal muscle, not the heart. I'm defending them because you said they have a bad reputation. Syntrax was the one who put glycocyamine into Isomatrix then claimed you NEED a methylating agent. Syntrax is the one who posted under false names bashing another company. MS and J both said they worked for SAN. They were honest and upfront. Syntrax was not. They are ones who put a product out with possible health problems (i don't beleive it anyway) before SAN did. You do the math. You not reading the posts. Please re-read them.